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Your search keyword '"Alireza Motamedzadeh"' showing total 4 results
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4 results on '"Alireza Motamedzadeh"'

1. Epigenetic regulation in myocardial infarction: Non-coding RNAs and exosomal non-coding RNAs

Author

Sara Fadaei, Fatemeh Zarepour, Mehrnoosh Parvaresh, Alireza Motamedzadeh, Seyed Saeed Tamehri Zadeh, Amirhossein Sheida, Mohammad Shabani, Michael R. Hamblin, Mehdi Rezaee, Maryam Zarei, and Hamed Mirzaei

Subjects
myocardial infarction, non-coding RNAs, microRNAs, long non-coding RNAs, circular RNAs, exosome, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Myocardial infarction (MI) is one of the leading causes of deaths globally. The early diagnosis of MI lowers the rate of subsequent complications and maximizes the benefits of cardiovascular interventions. Many efforts have been made to explore new therapeutic targets for MI, and the therapeutic potential of non-coding RNAs (ncRNAs) is one good example. NcRNAs are a group of RNAs with many different subgroups, but they are not translated into proteins. MicroRNAs (miRNAs) are the most studied type of ncRNAs, and have been found to regulate several pathological processes in MI, including cardiomyocyte inflammation, apoptosis, angiogenesis, and fibrosis. These processes can also be modulated by circular RNAs and long ncRNAs via different mechanisms. However, the regulatory role of ncRNAs and their underlying mechanisms in MI are underexplored. Exosomes play a crucial role in communication between cells, and can affect both homeostasis and disease conditions. Exosomal ncRNAs have been shown to affect many biological functions. Tissue-specific changes in exosomal ncRNAs contribute to aging, tissue dysfunction, and human diseases. Here we provide a comprehensive review of recent findings on epigenetic changes in cardiovascular diseases as well as the role of ncRNAs and exosomal ncRNAs in MI, focusing on their function, diagnostic and prognostic significance.

Published
2022
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2. The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy

Author

Mohammad Behnam, Alireza Motamedzadeh, Marzieh Aalinezhad, Ehsan Dadgostar, Fatemeh Zahra Rashidi Noshabad, Mohammad Pourfridoni, Maedeh Raei, Hamed Mirzaei, Michael Aschner, and Omid Reza Tamtaji

Subjects
Aquaporin 4, Gene Expression Regulation, Neoplastic, Brain Neoplasms, Cell Line, Tumor, Genetics, Humans, General Medicine, Glioma, Molecular Biology
Abstract

Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO-Kyn-AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.

Published
2022

3. The Role of Vitamin D in the Age of COVID-19: A Systematic Review and Meta-Analysis

Author

Amir Shamshirian, Meghdad Sedaghat, Morteza Behnamfar, Hamed Jafarpour, Reza Alizadeh-Navaei, Danial Shamshirian, Bahman Zarandi, Arash Rezaei Shahmirzadi, Keyvan Heydari, Nazanin Razzaghi, Marzieh Aalinezhad, Roya Ghasemian, Vahid Yaghoubi Naei, Mohammad Malekan, Soheil Azizi, Benyamin Seyfari, Mohammad Ali Ebrahimzadeh, Alireza Motamedzadeh, Anahita Asadi, Amirhossein Hessami, Ali Reza Mohseni, Mehrdad Khodabandeh, and Ehsan Dadgostar

Subjects
medicine.medical_specialty, business.industry, Cochrane Library, medicine.disease, vitamin D deficiency, Meta-analysis, Internal medicine, Diabetes mellitus, medicine, Vitamin D and neurology, Dementia, business, Depression (differential diagnoses), Kidney disease
Abstract

BackgroundEvidence recommends that vitamin D might be a crucial supportive agent for the immune system, mainly in cytokine response regulation against COVID-19. Hence, we carried out a systematic review and meta-analysis in order to maximize the use of everything that exists about the role of vitamin D in the COVID-19.MethodsA systematic search was performed in PubMed, Scopus, Embase, and Web of Science up to December 18, 2020. Studies focused on the role of vitamin D in confirmed COVID-19 patients were entered into the systematic review.ResultsTwenty-three studies containing 11901participants entered into the meta-analysis. The meta-analysis indicated that 41% of COVID-19 patients were suffering from vitamin D deficiency (95% CI, 29%-55%), and in 42% of patients, levels of vitamin D were insufficient (95% CI, 24%-63%). The serum 25-hydroxyvitamin D concentration was 20.3 ng/mL among all COVID-19 patients (95% CI, 12.1-19.8). The odds of getting infected with SARS-CoV-2 is 3.3 times higher among individuals with vitamin D deficiency (95% CI, 2.5-4.3). The chance of developing severe COVID-19 is about five times higher in patients with vitamin D deficiency (OR: 5.1, 95% CI, 2.6-10.3). There is no significant association between vitamin D status and higher mortality rates (OR: 1.6, 95% CI, 0.5-4.4).ConclusionThis study found that most of the COVID-19 patients were suffering from vitamin D deficiency/insufficiency. Also, there is about three times higher chance of getting infected with SARS-CoV-2 among vitamin D deficient individuals and about 5 times higher probability of developing the severe disease in vitamin D deficient patients. Vitamin D deficiency showed no significant association with mortality rates in this population.

Published
2020
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4. The Effects of Synbiotic Supplementation on Metabolic Status in Diabetic Patients Undergoing Hemodialysis: a Randomized, Double-Blinded, Placebo-Controlled Trial

Author

Vahidreza Ostadmohammadi, Zatollah Asemi, Maryam Tajabadi-Ebrahimi, Elaheh Amirani, Fereshteh Bahmani, Malihe Zarrati Mojarrad, Alireza Motamedzadeh, and Alireza Soleimani

Subjects
Adult, Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, medicine.medical_treatment, 030106 microbiology, Placebo-controlled study, Synbiotics, Placebo, Microbiology, Gastroenterology, Diabetes Complications, Young Adult, 03 medical and health sciences, Insulin resistance, Renal Dialysis, Malondialdehyde, Diabetes mellitus, Internal medicine, Humans, Medicine, Molecular Biology, Aged, Glycemic, Aged, 80 and over, business.industry, Insulin, Quantitative insulin sensitivity check index, Middle Aged, medicine.disease, Glutathione, Oxidative Stress, C-Reactive Protein, 030104 developmental biology, Dietary Supplements, Kidney Failure, Chronic, Molecular Medicine, Female, Hemodialysis, business
Abstract

This study was conducted to evaluate the effects of synbiotic supplementation on metabolic profiles in diabetic patients undergoing hemodialysis (HD). This randomized, double-blinded, placebo-controlled clinical trial was performed in 60 diabetic HD patients. Participants were randomly assigned into two groups to receive either synbiotic capsule, containing Lactobacillus acidophilus, Lactobacillus casei, and Bifidobacterium bifidum (2 × 109 CFU/g each), plus 0.8 g/day of inulin (n = 30) or placebo (n = 30) for 12 weeks. Synbiotic supplementation significantly decreased fasting plasma glucose (β − 13.56 mg/dL; 95% CI, − 23.82, − 3.30; P = 0.01), insulin levels (β − 5.49 μIU/mL; 95% CI, − 6.92, − 4.05; P

Published
2018
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