1. Antihypertensive and antihyperlipemic of spirulina (Arthrospira platensis) sauce on patients with hypertension: A randomized triple‐blind placebo‐controlled clinical trial
- Author
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Mohammad Hossein Rahmani, Pouya Rostamizadeh, Seyed Mohammad Mazloomi, Mehran Nouri, Javad Kojuri, Mohsen Azadian, Reza Golchin Vafa, Elham Ashrafi-Dehkordi, Zohreh Ghaem Far, Siavash Babajafari, Alireza Zareifard, and Salman Mohammadi
- Subjects
medicine.medical_specialty ,Placebo ,Gastroenterology ,Body Mass Index ,law.invention ,Randomized controlled trial ,law ,Internal medicine ,Spirulina ,Humans ,Medicine ,Stroke ,Antihypertensive Agents ,Hypolipidemic Agents ,Pharmacology ,Spirulina (genus) ,medicine.diagnostic_test ,biology ,business.industry ,medicine.disease ,biology.organism_classification ,Clinical trial ,Blood pressure ,Heart failure ,Dietary Supplements ,Hypertension ,business ,Lipid profile - Abstract
Systemic arterial hypertension is an independent risk factor for coronary heart disease, stroke, heart failure, and chronic kidney diseases. Spirulina is microalgae with nutritious ingredients and has potential attenuating effects on chronic diseases including hypertension. Spirulina can be added to food products in order to develop functional foods. The aim of this study was to assess the effects of 8-week consumption of a salad dressing containing 2 g of spirulina platensis powder versus a placebo dressing on patients with hypertension. In this triple-blind randomized clinical trial, 48 patients with hypertension were enrolled to receive daily either spirulina-fortified dressing or placebo for 2 months. A total of 41 patients completed this study. We observed that the consumption of spirulina dressing significantly reduced systolic blood pressure (p = .02), diastolic blood pressure (p = .03), serum triglyceride (p = .01), total cholesterol, and low-density lipoprotein (LDL) levels, compared to nonsignificant changes in the placebo group. Significant changes in TAC and hs-CRP levels were observed in none of the groups. According to our findings, spirulina-fortified dressing as a functional food can be used a supportive treatment for patients with hypertension along with standard antihypertensive drugs. However, further investigations are required for a more comprehensive conclusion.
- Published
- 2021