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613 results on '"Allan, David S."'

18. Optimizing Access to Unrelated Donors in Canada: Re-Examining the Importance of Donor Factors on Outcomes Following Hematopoietic Cell Transplantation.

Author

Parmar, Gaganvir, Seftel, Matthew D., Ganz, Kathy, Blake, John, Holovati, Jelena L., and Allan, David S.

Subjects
HEMATOPOIETIC stem cell transplantation, ABO blood group system, GRAFT versus host disease, TREATMENT effectiveness
Abstract

HLA-matched allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for many patients. Unrelated HLA-matched donors are the most frequently used donor for HCT. When more than one donor transplant option is available, transplant centers can select donors based on non-HLA factors. With improved ability to prevent and treat immune complications, such as graft-versus-host disease and infections, it may be possible to proceed more often using HLA-mismatched donors, allowing greater consideration of non-HLA factors, such as donor age, CMV serostatus, and ABO blood group matching, which have demonstrated important impacts on transplant outcomes. Additional factors to consider are donor availability rates and the usage of domestic donors to optimize outcomes. A review of non-HLA factors and considerations on the selection of optimal unrelated donors for HCT are provided within this updated current context. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Hematopoietic Cell Transplantation Trends and Outcomes in Canada: A Registry-Based Cohort Study

Author

Seftel, Matthew D., primary, Pasic, Ivan, additional, Parmar, Gaganvir, additional, Bucher, Oliver, additional, Allan, David S., additional, Bhella, Sita, additional, Hay, Kevin Anthony, additional, Ikuomola, Oluwaseun, additional, Musto, Grace, additional, Prica, Anca, additional, Richardson, Erin, additional, Truong, Tony H., additional, and Paulson, Kristjan, additional

Published
2023
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39. Comparison of Allogeneic Hematopoietic Cell Transplantation Outcomes from Younger Matched Unrelated Donor Versus Older Sibling Donor for Acute Myeloid Leukemia

Author

Abid, Muhammad Bilal, primary, Estrada-Merly, Noel, additional, Zhang, Mei-Jie, additional, Chen, Karen, additional, Allan, David S., additional, Bredeson, Christopher, additional, Sabloff, Mitchell, additional, Litzow, Mark R., additional, Kebriaei, Partow, additional, and Saber, Wael, additional

Published
2022
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40. Younger Matched Unrelated Donors Confer a Decreased Relapse Risk As Compared to Older Sibling Donors for Adult B-Cell ALL Patients Undergoing Allogeneic Hematopoietic Cell Transplantation

Author

Bilal Abid, Muhammad, primary, Estrada-Merly, Noel, additional, Zhang, Mei-Jie, additional, Chen, Karen, additional, Bredeson, Christopher, additional, Allan, David S., additional, Sabloff, Mitchell, additional, Litzow, Mark R., additional, Kebriaei, Partow, additional, and Saber, Wael, additional

Published
2022
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50. Modeling unrelated blood stem cell donor recruitment using simulated registrant cohorts: Assessment of human leukocyte antigen matching across ethnicity groups.

Author

Blake, John T., Parmar, Gaganvir, Ganz, Kathy, Seftel, Matthew D., and Allan, David S.

Subjects
HLA histocompatibility antigens, STEM cell donors, HEMATOPOIETIC stem cell transplantation, BLOOD cells, PATIENT selection
Abstract

Background: Human leukocyte antigen (HLA)‐matched unrelated donors are not available for some patients considered for allogeneic hematopoietic cell transplantation, particularly among certain ethnic groups. Simulated recruitment modeling can inform efforts to find new matches for more patients. Methods: Simulated recruits were generated by assigning a pair of donor HLA haplotypes from historical data files and matched against HLA data of patient searches in the Canadian Blood Services Stem Cell Registry. Recruitment cohorts reflected the proportion of five specific ethnic groups in the 2016 Canadian census data. Results: Novel 8/8 HLA matches between simulated recruits and patients increased linearly with larger recruitment cohorts. The proportion of novel 8/8 HLA matches from Caucasian, Hispanic, and Native American/First Nations recruits was equal to or greater than their relative proportion in the recruited cohort (match to: recruit ratio (MRR) ≥ 1). In contrast, African American and Asian & Pacific Islander recruits represented a smaller proportion of novel matches relative to their percentage of the recruited cohort (MRR <1). The proportion of novel 7/8 HLA‐matches from each ethnic group was approximately the same as their proportion in the recruited cohort (MRR ~ 1) and high rates of 7/8 HLA‐matching already exist within the Canadian Blood Services registry for all ethnic groups. Conclusion: Continued large recruitment cohorts are needed to add new 8/8 HLA matches to registry inventories. Likelihoods of novel HLA matches varied across ethnic groups, reflecting varied HLA haplotype frequencies across groups. Simulated cohort modeling can inform recruitment strategies that will generate new donor options for patients. [ABSTRACT FROM AUTHOR]

Published
2023
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