46 results on '"Alley, M. R. K."'
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2. Epetraborole, a leucyl-tRNA synthetase inhibitor, demonstrates murine efficacy, enhancing the in vivo activity of ceftazidime against Burkholderia pseudomallei, the causative agent of melioidosis
3. Complete Genome Sequence of Caulobacter crescentus
4. 1698. Pharmacokinetics/pharmacodynamics of Epetraborole, a Novel Bacterial Leucyl-tRNA Synthetase Inhibitor, and High Intracellular Penetration in the Intracellular Hollow Fiber System Model of Mycobacterium avium Complex Lung Disease
5. 1697. Dose-response Studies of the Novel Bacterial Leucyl-tRNA Synthetase Inhibitor, Epetraborole, in the Intracellular Hollow Fiber System Model of Mycobacterium avium complex Lung Disease
6. 1713. In Vitro Activities of Epetraborole, a Novel Bacterial Leucyl-tRNA Synthetase Inhibitor, Against Mycobacterium avium Complex Isolates
7. 1704. Epetraborole, a Novel Bacterial Leucyl-tRNA Synthetase Inhibitor, Demonstrates Potent Efficacy and Improves Efficacy of Standard of Care Regimen Against Mycobacterium avium complex in a Chronic Mouse Lung Infection Model
8. 1712. In Vitro Activity of Epetraborole, a Novel Bacterial Leucyl-tRNA Synthetase Inhibitor, in Drug Combinations Against Nontuberculous Mycobacteria Including Resistance Frequency and MIC Characterization of Mycobacterium avium ATCC 700898 Epetraborole-resistant Mutants
9. An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site
10. Requirement of the Carboxyl Terminus of a Bacterial Chemoreceptor for Its Targeted Proteolysis
11. Degradation of Caulobacter soluble cytoplasmic chemoreceptor is ClpX dependent
12. Proteolysis of the Caulobacter McpA chemoreceptor is cell cycle regulated by a ClpX-dependent pathway
13. DNA sequence of the Doe retroposon in the white-one mutant of Drosophila melanogaster and of secondary insertions in the phenotypically altered derivatives white honey and white-eosin
14. The highly conserved domain of the Caulobacter McpA chemoreceptor is required for its polar localization
15. Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosis in the C3HeB/FeJ Mouse Model
16. Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656)
17. A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro
18. A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
19. Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase
20. Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase
21. Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase
22. Potency and Spectrum of Activity of AN3365, a Novel Boron-Containing Protein Synthesis Inhibitor, Tested against Clinical Isolates of Enterobacteriaceae and Nonfermentative Gram-Negative Bacilli
23. Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria
24. Mechanism and Inhibition of saFabI, the Enoyl Reductase from Staphylococcus aureus
25. Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis
26. Identification of Borinic Esters as Inhibitors of Bacterial Cell Growth and Bacterial Methyltransferases, CcrM and MenH
27. Degradation of a Caulobacter Soluble Cytoplasmic Chemoreceptor Is ClpX Dependent
28. Proteolysis of the Caulobacter McpA Chemoreceptor Is Cell Cycle Regulated by a ClpX-Dependent Pathway
29. New members of the ctrA regulon: the major chemotaxis operon in Caulobacter is CtrA dependent
30. Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosisThat Target Leucyl-tRNA Synthetase
31. Cryptosporidiumand ToxoplasmaParasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase
32. Antimalarial Benzoxaboroles Target Plasmodium falciparumLeucyl-tRNA Synthetase
33. Proteolysis of the McpA Chemoreceptor Does Not Require the Caulobacter Major Chemotaxis Operon
34. Mechanism and Inhibition of saFabl, the Enoyl Reductase from Staphylococcus aureus.
35. Potency and Spectrum of Activity of AN3365, a Novel Boron-Containing Protein Synthesis Inhibitor, Tested against Clinical Isolates of Enterobacteriaceaeand Nonfermentative Gram-Negative Bacilli
36. Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria
37. Complete genome sequence of Caulobacter crescentus (vol 98, pg 4136, 2001)
38. Efficacy and Improved Resistance Potential of a Cofactor-Independent InhA Inhibitor of Mycobacterium tuberculosisin the C3HeB/FeJ Mouse Model
39. A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosisIn Vitro
40. The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.
41. Tavaborole topical solution, 5% for the treatment of toenail onychomycosis.
42. Synthesis and antibacterial evaluation of a novel tricyclic oxaborole-fused fluoroquinolone.
43. Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center.
44. Characterization of benzoxaborole-based antifungal resistance mutations demonstrates that editing depends on electrostatic stabilization of the leucyl-tRNA synthetase editing cap.
45. Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors.
46. Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles.
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