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This study focuses on the assessment of the impact of climate change on the efficiency of ambient air aeration and the dynamics of Rhyzopertha dominica, which is a major pest that infests wheat stored in Tunisia. To project future climate conditions for the period 2041–2070, two climate models, namely MPI-ESM1.2 and CNRMCM5.1, were used under two representative concentration pathways (RCP4.5 and RCP8.5). The study examined the historical and projected feasibility of aeration in six natural regions located in northwestern Tunisia, where wheat is the main crop, and investigated the potential consequences of climate change on the dynamics of R. dominica. Using a heat and mass transfer model in an unaerated wheat silo, the temperature and moisture distributions in the grain mass were used to predict the development, reproduction, and survival of R. dominica. The results revealed a decline in favorable aeration hours due to climate change, resulting in an average reduction of 25% across the six regions. This reduction in aerated hours could significantly affect the effectiveness of aeration as a means of pest control. The mean difference comparisons, based on Tukey's honestly significant difference (HSD) test, revealed a significant effect of climate change on the developmental parameters of R. dominica for the period 2041–2070 compared to the period 1970–1997. According to the insect dynamic model, future climate scenarios are expected to induce changes in the development duration, reproduction, and survival rates of R. dominica. The model predicts a (i) 10–15% extension in the development duration, (ii) 20–30% decrease in reproduction, and (iii) 5–10% decrease in survival relative to the historical period. These results underscore the critical importance of implementing adaptive pest management strategies for stored wheat. [ABSTRACT FROM AUTHOR]

Stilbenes are polyphenolic allelochemicals synthesized by plants, especially grapes, peanuts, rhubarb, berries, etc., to defend themselves under stressful conditions. They are now exploited in medicine for their antioxidant, anti-proliferative and anti-inflammatory properties. Inflammation is the immune system's response to invading bacteria, toxic chemicals or even nutrient-deprived conditions. It is characterized by the release of cytokines which can wreak havoc on healthy tissues, worsening the disease condition. Stilbenes modulate NF-κB, MAPK and JAK/STAT pathways, and reduce the transcription of inflammatory factors which result in maintenance of homeostatic conditions. Resveratrol, the most studied stilbene, lowers the Michaelis constant of SIRT1, and occupies the substrate binding pocket. Gigantol interferes with the complement system. Besides these, oxyresveratrol, pterostilbene, polydatin, viniferins, etc., are front runners as drug candidates due to their diverse effects from different functional groups that affect bioavailability and molecular interactions. However, they each have different thresholds for toxicity to various cells of the human body, and thus a careful review of their properties must be conducted. In animal models of autoinflammatory diseases, the mode of application of stilbenes is important to their absorption and curative effects, as seen with topical and microemulsion gel methods. This review covers the diversity seen among stilbenes in the plant kingdom and their mechanism of action on the different inflammatory pathways. In detail, macrophages' contribution to inflamed conditions in the liver, the cardiac, connective and neural tissues, in the nephrons, intestine, lungs and in myriad other body cells is explored, along with detailed explanation on how stilbenes alleviate the symptoms specific to body site. A section on the bioavailability of stilbenes is included for understanding the limitations of the natural compounds as directly used drugs due to their rapid metabolism. Current delivery mechanisms include sulphonamides, or using specially designed synthetic drugs. It is hoped that further research may be fueled by this comprehensive work that makes a compelling argument for the exploitation of these compounds in medicine. [ABSTRACT FROM AUTHOR]