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In this study, chlorophenyl-substituted pyrazolone derivatives (5a–5c) were synthesized via the Baylis-Hillman acetate reaction. Comprehensive physicochemical characterization was conducted using 1H-NMR, FT-IR, and mass spectroscopy. Density Functional Theory (DFT) calculations at the B3LYP/6-31(G) level was employed to optimize molecular geometries and investigate electronic properties, revealing predominantly planar structures, with notable deviations in the pyrazole group. The HOMO and LUMO analyses showed π-delocalization across the entire molecule, with charge-transfer transitions dominating the excited states. Global Chemical Reactivity Descriptors (GCRD), including chemical potential, hardness, and electrophilicity index, were used to assess molecular stability and reactivity, indicating the molecules’ resistance to electron cloud deformation. Biological evaluations revealed exceptional antimicrobial and antifungal activities of the derivatives, with compound 5a demonstrating the highest efficacy against S. aureus, E. coli, A. niger and C. albicans. Furthermore, antiproliferative studies against HepG2 liver carcinoma cells showed that compound 5a exhibited superior anticancer activity (IC50 = 6 μg/mL), attributed to its structural features, such as chlorophenyl groups and a piperidin-4-one moiety. These moieties enhance the compound’s lipophilicity, facilitating cell membrane penetration and ROS generation, which contribute to apoptosis and inhibition of cancer cell growth. The findings suggest that chlorophenyl-pyrazolone derivatives, particularly 5a, hold promise as potent candidates for antimicrobial and anticancer therapies, paving the way for further pharmaceutical development.

The work presented a facile, one-step procedure as a green assembly process for preparing silver tungstate nanorod by hydrothermal technique via a chemical reaction between silver nitrate and sodium tungstate. The synthesized precipitate was characterized using X-ray diffraction (XRD) transmission electronic microscope (TEM) and scanning electron microscopy (SEM) to ensure the formation of crystallization and single-phase material. The prepared nanorods undergo a catalytic evaluation to synthesize tetrahydrobenzo[a] xanthene-11-one derivatives by a one-pot reaction of β-naphthol, dimedone, and aromatic aldehyde with a catalytic amount of silver tungstate under the solvent-free condition at 60–70 °C. ArgC is one of the L-arginine biosynthetic pathways of mycobacterium tuberculosis. The molecular docking explains that all the synthesized compounds presented high ligand ability for the targeted enzyme compared with xanthene-9-carboxylic acid as a reference.

In reaction to the expanding predominance of diabetes mellitus, curcumin nanoparticles stacked on carboxymethyl cellulose (CMC) composite were effectively synthesized, characterized, and examined utilizing UV/Vis and FTIR spectroscopy combined with transmission electron microscopy (TEM). The bioactivity of curcumin (Cur), carboxymethyl cellulose (CMC), and curcumin nanoparticles stacked with carboxymethyl cellulose (CUR-CMC) was tried through atomic docking approval as an α-amylase and α-glucosidase inhibitor. The conclusion illustrated that the curcumin-supported CMC is more potent than CUR itself self the validation presented is compared with acarbose as a reference molecule and then CUR-CMC can presented as promising in curing hyperglycemia by decreasing the absorption of glucose.

Meticulous electrode design is pivotal in advancing greener and more sustainable electro‐organic synthesis practices. In this research, our team designed and synthesized a copper‐doped electrode on multiwalled carbon nanotubes (MWCNTs) and characterized it using Fourier transform infrared spectroscopy (FT‐IR), scanning electron microscopy (SEM), energy‐dispersive X‐ray spectroscopy (EDS), thermogravimetric analysis (TGA), Brunauer–Emmett–Teller (BET) analysis, X‐ray diffraction (XRD) analysis, X‐ray photoelectron spectroscopy (XPS), and cyclic voltammetry (CV) analysis. Subsequently, this electrode was utilized as a catalyst at the electrode surface, serving as a cathode in electro‐oxidation reactions in the presence of phenylacetylene, sodium azide (NaN3), and benzyl halide for the production of 1,2,3‐triazole derivatives under ambient temperature, within a 30‐min reaction time, and at atmospheric pressure, achieving an efficiency level ranging from good to excellent, specifically between 88% and 96%. The synthesized 1,2,3‐triazole derivatives were identified using proton nuclear magnetic resonance (1H NMR) spectroscopy, CHN elemental analysis, and melting point. In this paper, choline chloride/urea deep eutectic solvents (DES) serve multiple roles in the reaction mechanism. They function as solvents and co‐catalysts, generate weak bases, and provide numerous advantages in green chemistry. These advantages include low toxicity, reduced environmental risks, improved atom economy, and non‐volatility, making them safer alternatives to traditional organic solvents. [ABSTRACT FROM AUTHOR]

Restricted biodegradability, toxicity, and carcinogenicity of basic fuchsin dye are the principal reasons that motivate scientists to find methods to remove it. Photocatalytic degradation technology is simple, environmentally friendly, inexpensive, efficient, and does not yield secondary pollution. Most of the catalysts used to degrade basic fuchsin dye require expensive chemicals to prepare. Therefore, the novelty in our work comes from the utilisation of low-cost chemicals for the facile synthesis of Mn0.5Zn0.5Fe2O4/Fe2O3 nanocomposite using the pechini sol-gel method. The synthesised samples at 300, 600, and 900°C were encoded as F300, F600, and F900, respectively. The XRD confirmed that the average crystallite size of the F300, F600, and F900 samples is 95.08, 122.32, and 160.21 nm, respectively. Hence, as the calcination temperature increases, the crystallite size increases as a result of coagulation that occurs at higher temperatures. The FE-SEM images showed that the F300, F600, and F900 samples consist of spherical, (polyhedral and spherical), and (hexagonal and spherical) shapes with an average diameter of 258.64, 470.12, and 625.32 nm, respectively. This change in morphology at different temperatures is due to the discrepancy in the rate of liberation of organic matter at different temperatures. In the presence of hydrogen peroxide, 0.05 g of the Mn0.5Zn0.5Fe2O4/Fe2O3 nanocomposite degrade 100% of 25 mL of 25 mg/L of basic fuchsin dye at pH = 8 within 25 min. Consequently, the other side of the novelty of our work is the ability of the synthesised nanocomposite to effectively degrade a high concentration of the basic fuchsin dye in a short time. [ABSTRACT FROM AUTHOR]

In this work, copper carbonate/cobalt carbonate/manganese carbonate and copper oxide/cobalt manganese oxide/manganese oxide new nanocomposites were fabricated via precipitation of Cu(II)/Co(II)/Mn(II) solution using sodium carbonate and ignition of precipitate at 600°C for 3 h, respectively. Several instruments, including UV–Vis spectrophotometer, X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscope (TEM), nitrogen gas sorption analyser, and field emission scanning electron microscope (FE-SEM), were used to characterise the fabricated nanocomposites. Energy dispersive X-ray investigation confirmed that the composite produced owing to precipitation by sodium carbonate comprises carbon, oxygen, manganese, cobalt, and copper where the weight percentages are equal to 27.15, 52.49, 5.59, 5.75, and 9.02%, respectively. In addition, the composite produced owing to ignition at 600°C for 3 h comprises oxygen, manganese, cobalt, and copper where the weight percentages are equal to 8.62, 31.50, 38.58, and 21.30%, respectively. Transmission electron microscope examination confirmed that the composites produced owing to precipitation by sodium carbonate and ignition at 600°C for 3 h comprise polyhedral and spherical shapes with an average diameter of 36.85 and 22.34 nm, respectively. The BET surface area, average pore size, and total pore volume of the composite produced owing to precipitation by sodium carbonate are 29.8662 m2/g, 2.1634 nm, and 0.0323 cc/g, respectively. In addition, the BET surface area, average pore size, and total pore volume of the composite produced owing to ignition at 600°C for 3 h are 33.3714 m2/g, 5.2308 nm, and 0.0873 cc/g, respectively. 0.06 g of the fabricated nanocomposites degrade 100% of 60 mL of 15 mg/L of crystal violet dye solution within 20 min in the presence of hydrogen peroxide under UV irradiation. [ABSTRACT FROM AUTHOR]