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2. A View from the past into our collective future: the oncofertility consortium vision statement.

Author

Woodruff, Teresa K, Ataman-Millhouse, Lauren, Acharya, Kelly S, Almeida-Santos, Teresa, Anazodo, Antoinette, Anderson, Richard A, Appiah, Leslie, Bader, Joy, Becktell, Kerri, Brannigan, Robert E, Breech, Lesley, Bourlon, Maria T, Bumbuliene, Žana, Burns, Karen, Campo-Engelstein, Lisa, Campos, Jacira R, Centola, Grace M, Chehin, Mauricio Barbour, Chen, Diane, De Vos, Michel, Duncan, Francesca E, El-Damen, Ahmed, Fair, Douglas, Famuyiwa, Yemi, Fechner, Patricia Y, Fontoura, Paula, Frias, Olivia, Gerkowicz, Sabrina A, Ginsberg, Jill, Gracia, Clarisa R, Goldman, Kara, Gomez-Lobo, Veronica, Hazelrigg, Brent, Hsieh, Michael H, Hoyos, Luis R, Hoyos-Martinez, Alfonso, Jach, Robert, Jassem, Jacek, Javed, Murid, Jayasinghe, Yasmin, Jeelani, Roohi, Jeruss, Jacqueline S, Kaul-Mahajan, Nalini, Keim-Malpass, Jessica, Ketterl, Tyler G, Khrouf, Mohamed, Kimelman, Dana, Kusuhara, Atsuko, Kutteh, William H, Laronda, Monica M, Lee, Jung Ryeol, Lehmann, Vicky, Letourneau, Joseph M, McGinnis, Lynda K, McMahon, Eileen, Meacham, Lillian R, Mijangos, Monserrat Fabiola Velez, Moravek, Molly, Nahata, Leena, Ogweno, George Moses, Orwig, Kyle E, Pavone, Mary Ellen, Peccatori, Fedro Alessandro, Pesce, Romina Ileana, Pulaski, Hanna, Quinn, Gwendolyn, Quintana, Ramiro, Quintana, Tomas, de Carvalho, Bruno Ramalho, Ramsey-Goldman, Rosalind, Reinecke, Joyce, Reis, Fernando M, Rios, Julie, Rhoton-Vlasak, Alice S, Rodriguez-Wallberg, Kenny A, Roeca, Cassandra, Rotz, Seth J, Rowell, Erin, Salama, Mahmoud, Saraf, Amanda J, Scarella, Anibal, Schafer-Kalkhoff, Tara, Schmidt, Deb, Senapati, Suneeta, Shah, Divya, Shikanov, Ariella, Shnorhavorian, Margarett, Skiles, Jodi L, Smith, James F, Smith, Kristin, Sobral, Fabio, Stimpert, Kyle, Su, H Irene, Sugimoto, Kouhei, Suzuki, Nao, Thakur, Mili, Victorson, David, Viale, Luz, Vitek, Wendy, and Wallace, W Hamish

Subjects
Fertility preservation, Oncofertility, cancer, Genetics, Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine
Abstract

PurposeToday, male and female adult and pediatric cancer patients, individuals transitioning between gender identities, and other individuals facing health extending but fertility limiting treatments can look forward to a fertile future. This is, in part, due to the work of members associated with the Oncofertility Consortium.MethodsThe Oncofertility Consortium is an international, interdisciplinary initiative originally designed to explore the urgent unmet need associated with the reproductive future of cancer survivors. As the strategies for fertility management were invented, developed or applied, the individuals for who the program offered hope, similarly expanded. As a community of practice, Consortium participants share information in an open and rapid manner to addresses the complex health care and quality-of-life issues of cancer, transgender and other patients. To ensure that the organization remains contemporary to the needs of the community, the field designed a fully inclusive mechanism for strategic planning and here present the findings of this process.ResultsThis interprofessional network of medical specialists, scientists, and scholars in the law, medical ethics, religious studies and other disciplines associated with human interventions, explore the relationships between health, disease, survivorship, treatment, gender and reproductive longevity.ConclusionThe goals are to continually integrate the best science in the service of the needs of patients and build a community of care that is ready for the challenges of the field in the future.

Published
2021

4. In vitro effects of antidepressants on human sperm function.

Author

Santos, Rita António, Sousa, Ana Paula, Almeida-Santos, Teresa, Ramalho-Santos, João, and Tavares, Renata Santos

Abstract

Depression currently affects about 280 million people worldwide and its prevalence has been increasing dramatically, especially among the young and people of reproductive age, which consequently leads to an increase in antidepressant consumption. Antidepressants are associated with sexual dysfunction in both men and women; however, their role in male fertility has been scarcely studied. Fluoxetine and sertraline, two serotonin reuptake inhibitors (SSRIs), are among the most prescribed antidepressants worldwide. To determine their possible effects, human sperm cells were exposed to either sertraline or fluoxetine at concentrations previously found in blood and seminal fluid of patients undergoing treatment. Spermatozoa were incubated for up to 24 h at 37°C and 5% CO2, and important functional parameters such as sperm motility, viability, mitochondrial membrane potential, cellular reactive oxygen species (ROS) production, chromatin/DNA integrity, acrosome status, and tyrosine phosphorylation were assessed. At low levels, fluoxetine consistently decreased progressive motility throughout time while promoting fluctuations in ROS levels and sperm capacitation. Nevertheless, it did not affect viability, mitochondrial membrane potential, acrosome reaction nor chromatin/DNA integrity. Sertraline, on the other hand, had little to nonsignificant impact at low doses, but affected almost all tested parameters at supratherapeutic concentrations. Altogether, our results suggest that both antidepressants may impair sperm function, possibly through different mechanisms of action, but fluoxetine is the only exhibiting mild negative effects at doses found in vivo. [ABSTRACT FROM AUTHOR]

Published
2025
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13. New Insights on Sperm Function in Male Infertility of Unknown Origin: A Multimodal Approach

Author

Pacheco, Rita I., primary, Cristo, Maria I., additional, Anjo, Sandra I., additional, Silva, Andreia F., additional, Sousa, Maria Inês, additional, Tavares, Renata S., additional, Sousa, Ana Paula, additional, Almeida Santos, Teresa, additional, Moura-Ramos, Mariana, additional, Caramelo, Francisco, additional, Manadas, Bruno, additional, Ramalho-Santos, João, additional, and Amaral, Sandra Gomes, additional

Published
2023
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15. Mitochondrial Dysfunction in Advanced Maternal Aged Cumulus Cells: A Possible Link to ATP Synthase Impairment?

Author

Almeida-Reis, Sandra, Carvalho, Alexandra, Dias, Conceição, Brito, Raquel, Silva, Rita, Almeida-Santos, Teresa, Ramalho-Santos, João, and Sousa, Ana Paula

Subjects
ADENOSINE triphosphatase, MITOCHONDRIAL DNA, MITOCHONDRIA, MATERNAL age, ADENOSINE triphosphate, REACTIVE oxygen species, OLDER women
Abstract

Age-related changes in the mitochondrial status of human cumulus cells (hCCs) impact oocyte quality; however, the relationship between hCC mitochondrial (dys)function and reproductive aging remains poorly understood. This study aimed to establish the interplay between hCC mitochondrial dysfunction and women's reproductive potential. In this investigation, 266 women were enrolled and categorized into two groups based on their age: a young group (<35 years old) and an advanced maternal age (AMA) group (≥35 years old). Comprehensive analysis of reproductive outcomes was conducted in our population. Various mitochondrial-related parameters were analyzed across distinct subsets. Specifically, mitochondrial membrane potential (∆Ψm) and mitochondrial mass were examined in 53 samples, mtDNA content in 25 samples, protein levels in 23 samples, bioenergetic profiles using an XF24 Extracellular Flux Analyzer in 6 samples, and levels of reactive oxygen species (ROS) and adenosine triphosphate (ATP) in 39 and 43 samples, respectively. In our study, the reproductive potential of AMA women sharply decreased, as expected. Additionally, an impairment in the mitochondrial function of hCCs in older women was observed; however, no differences were found in terms of mitochondrial content. Regarding oxidative phosphorylation, metabolic profiling of hCCs from AMA women indicated a decrease in respiratory capacity, which was correlated with an age-dependent decrease in the ATP synthase (ATP5A1) protein level. However, intracellular ROS and ATP levels did not differ between groups. In conclusion, our study indicates that age-related dysfunction in hCCs is associated with impaired mitochondrial function, and, although further studies are required, ATP synthase could be relevant in this impairment. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Optimization of Platelet-Rich Plasma Preparation for Regenerative Medicine: Comparison of Different Anticoagulants and Resuspension Media.

Author

Carvalho, Alexandra, Ferreira, Ana Filipa, Soares, Maria, Santos, Susana, Tomé, Patrícia, Machado-Simões, Juliana, Pais, Ana Sofia, Sousa, Ana Paula, Paiva, Artur, and Almeida-Santos, Teresa

Subjects
VASCULAR endothelial growth factors, REGENERATIVE medicine, ANTICOAGULANTS, ETHYLENEDIAMINETETRAACETIC acid
Abstract

Platelet-rich plasma (PRP) has emerged as a promising therapy in regenerative medicine. However, the lack of standardization in PRP preparation protocols presents a challenge in achieving reproducible and accurate results. This study aimed to optimize the PRP preparation protocol by investigating the impact of two different anticoagulants, sodium citrate (SC) and ethylenediaminetetraacetic acid (EDTA), and resuspension media, plasma versus sodium chloride (NaCl). Platelet recovery rates were calculated and compared between groups, in addition to platelet activity and vascular endothelial growth factor (VEGF) released into plasma after PRP activation. The platelet recovery rate was higher with EDTA in comparison to SC (51.04% vs. 29.85%, p = 0.005). Platelet activity was also higher, with a higher expression of two platelet antibodies, platelet surface P-Selectin (CD62p) and PAC-1, in the EDTA group. The concentration of VEGF was higher with SC in comparison to EDTA (628.73 vs. 265.44 pg/mL, p = 0.013). Platelet recovery rates and VEGF levels were higher in PRP resuspended in plasma when compared to NaCl (61.60% vs. 48.61%, p = 0.011 and 363.32 vs. 159.83 pg/mL, p = 0.005, respectively). Our study reinforces the superiority of EDTA (as anticoagulant) and plasma (for resuspension) in obtaining a higher platelet recovery and preserving platelet functionality during PRP preparation. [ABSTRACT FROM AUTHOR]

Published
2024
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19. In Vitro Fertilization in Polycystic Ovary Syndrome: Treatment Individualization Based on Genetic Singularities

Author

Carreira, Ana, primary, Vieira, Ines, additional, Reis, Sandra, additional, Carvalho, Alexandra, additional, Dias, Conceicao, additional, Fernandes, Silvana, additional, Ferreira, Ana, additional, Rodrigues, Dircea, additional, Sousa, Ana, additional, Ramalho-Santos, Joao, additional, Cortesao, Paulo, additional, Almeida-Santos, Teresa, additional, Ramalhinho, Ana, additional, Moura-Ramos, Mariana, additional, Melo, Miguel, additional, and Paiva, Isabel, additional

Published
2023
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23. Fertility preservation in women with haematological malignancies.

Author

Ferro, Rafael, Pais, Ana Sofia, Sousa, Ana Paula, and Almeida Santos, Teresa

Subjects
FOLLICLE-stimulating hormone, RETROSPECTIVE studies, FISHER exact test, OVARIAN reserve, T-test (Statistics), HEMATOLOGIC malignancies, FERTILITY preservation, PSYCHOLOGY of women, SEX hormones, DESCRIPTIVE statistics, DATA analysis software
Abstract

The incidence of haematological malignancies is increasing in women of childbearing age. Survival rates accompany this increase, making it essential to assess the impact of treatments on their future quality of life, evaluate the impact of each treatment on ovarian reserve and define the fertility preservation techniques used by women with haematologic malignancies. A retrospective study was conducted after data collection from 61 women diagnosed with haematological malignancies and followed-up in a fertility preservation centre between January 2008 and June 2019. Cancer treatments caused a decrease in ovarian reserve, demonstrated by an increase in FSH levels and a decrease in AMH levels. When assessing which treatments have the greatest impact on AMH levels, we found that the BEACOPP regimen, and the agents vincristine, etoposide, procarbazine, prednisone and the haematopoietic stem cell transplantation were mainly responsible. Regarding pregnancy after oncological treatments, of the eleven women who became pregnant, ten did so spontaneously. This study reinforces the importance of referring patients to a fertility preservation consultation before starting oncological treatment, as most of them opt to preserve fertility. This work also helps to clarify the impact of each chemotherapeutic agent on the ovarian reserve. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Medical Grade Honey as a Promising Treatment to Improve Ovarian Tissue Transplantation

Author

Azevedo, Ana Rita, primary, Pais, Ana Sofia, additional, Almeida-Santos, Teresa, additional, Pires, Virgínia M. R., additional, Pessa, Pedro, additional, Marques, Carla C., additional, Nolasco, Sofia, additional, Castelo-Branco, Pedro, additional, Prates, José A. M., additional, Lopes-da-Costa, Luís, additional, Laranjo, Mafalda, additional, Botelho, Maria Filomena, additional, Pereira, Rosa M. L. N., additional, and Pimenta, Jorge M. B. G. A., additional

Published
2022
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32. Functional ovarian reserve in women with infertility and euthyroidism: what is the role of thyroid autoimmunity?

Author

Alexandra, Festas Silva Diana, primary, Carvalho, Tânia, additional, Maresch, Ângela, additional, Catarino, Diana, additional, Fadiga, Lúcia, additional, Reis, Guiomar Joana, additional, Gomes, Leonor, additional, Leitão, Fátima, additional, Cortesão, Paulo, additional, Almeida, Santos Teresa, additional, and PAIVA, Isabel, additional

Published
2021
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34. A View from the past into our collective future: the oncofertility consortium vision statement.

Author

UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - (SLuc) Service de gynécologie et d'andrologie, Woodruff, Teresa K, Ataman-Millhouse, Lauren, Acharya, Kelly S, Almeida-Santos, Teresa, Anazodo, Antoinette, Anderson, Richard A, Appiah, Leslie, Bader, Joy, Becktell, Kerri, Brannigan, Robert E, Breech, Lesley, Bourlon, Maria T, Bumbuliene, Žana, Burns, Karen, Campo-Engelstein, Lisa, Campos, Jacira R, Centola, Grace M, Chehin, Mauricio Barbour, Chen, Diane, De Vos, Michel, Duncan, Francesca E, El-Damen, Ahmed, Fair, Douglas, Famuyiwa, Yemi, Fechner, Patricia Y, Fontoura, Paula, Frias, Olivia, Gerkowicz, Sabrina A, Ginsberg, Jill, Gracia, Clarisa R, Goldman, Kara, Gomez-Lobo, Veronica, Hazelrigg, Brent, Hsieh, Michael H, Hoyos, Luis R, Hoyos-Martinez, Alfonso, Jach, Robert, Jassem, Jacek, Javed, Murid, Jayasinghe, Yasmin, Jeelani, Roohi, Jeruss, Jacqueline S, Kaul-Mahajan, Nalini, Keim-Malpass, Jessica, Ketterl, Tyler G, Khrouf, Mohamed, Kimelman, Dana, Kusuhara, Atsuko, Kutteh, William H, Laronda, Monica M, Lee, Jung Ryeol, Lehmann, Vicky, Letourneau, Joseph M, McGinnis, Lynda K, McMahon, Eileen, Meacham, Lillian R, Mijangos, Monserrat Fabiola Velez, Moravek, Molly, Nahata, Leena, Ogweno, George Moses, Orwig, Kyle E, Pavone, Mary Ellen, Peccatori, Fedro Alessandro, Pesce, Romina Ileana, Pulaski, Hanna, Quinn, Gwendolyn, Quintana, Ramiro, Quintana, Tomas, de Carvalho, Bruno Ramalho, Ramsey-Goldman, Rosalind, Reinecke, Joyce, Reis, Fernando M, Rios, Julie, Rhoton-Vlasak, Alice S, Rodriguez-Wallberg, Kenny A, Roeca, Cassandra, Rotz, Seth J, Rowell, Erin, Salama, Mahmoud, Saraf, Amanda J, Scarella, Anibal, Schafer-Kalkhoff, Tara, Schmidt, Deb, Senapati, Suneeta, Shah, Divya, Shikanov, Ariella, Shnorhavorian, Margarett, Skiles, Jodi L, Smith, James F, Smith, Kristin, Sobral, Fabio, Stimpert, Kyle, Su, H Irene, Sugimoto, Kouhei, Suzuki, Nao, Thakur, Mili, Victorson, David, Viale, Luz, Vitek, Wendy, Wallace, W Hamish, Wartella, Ellen A, Westphal, Lynn M, Whiteside, Stacy, Wilcox, Lea H, Wyns, Christine, Xiao, Shuo, Xu, Jing, Zelinski, Mary, UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - (SLuc) Service de gynécologie et d'andrologie, Woodruff, Teresa K, Ataman-Millhouse, Lauren, Acharya, Kelly S, Almeida-Santos, Teresa, Anazodo, Antoinette, Anderson, Richard A, Appiah, Leslie, Bader, Joy, Becktell, Kerri, Brannigan, Robert E, Breech, Lesley, Bourlon, Maria T, Bumbuliene, Žana, Burns, Karen, Campo-Engelstein, Lisa, Campos, Jacira R, Centola, Grace M, Chehin, Mauricio Barbour, Chen, Diane, De Vos, Michel, Duncan, Francesca E, El-Damen, Ahmed, Fair, Douglas, Famuyiwa, Yemi, Fechner, Patricia Y, Fontoura, Paula, Frias, Olivia, Gerkowicz, Sabrina A, Ginsberg, Jill, Gracia, Clarisa R, Goldman, Kara, Gomez-Lobo, Veronica, Hazelrigg, Brent, Hsieh, Michael H, Hoyos, Luis R, Hoyos-Martinez, Alfonso, Jach, Robert, Jassem, Jacek, Javed, Murid, Jayasinghe, Yasmin, Jeelani, Roohi, Jeruss, Jacqueline S, Kaul-Mahajan, Nalini, Keim-Malpass, Jessica, Ketterl, Tyler G, Khrouf, Mohamed, Kimelman, Dana, Kusuhara, Atsuko, Kutteh, William H, Laronda, Monica M, Lee, Jung Ryeol, Lehmann, Vicky, Letourneau, Joseph M, McGinnis, Lynda K, McMahon, Eileen, Meacham, Lillian R, Mijangos, Monserrat Fabiola Velez, Moravek, Molly, Nahata, Leena, Ogweno, George Moses, Orwig, Kyle E, Pavone, Mary Ellen, Peccatori, Fedro Alessandro, Pesce, Romina Ileana, Pulaski, Hanna, Quinn, Gwendolyn, Quintana, Ramiro, Quintana, Tomas, de Carvalho, Bruno Ramalho, Ramsey-Goldman, Rosalind, Reinecke, Joyce, Reis, Fernando M, Rios, Julie, Rhoton-Vlasak, Alice S, Rodriguez-Wallberg, Kenny A, Roeca, Cassandra, Rotz, Seth J, Rowell, Erin, Salama, Mahmoud, Saraf, Amanda J, Scarella, Anibal, Schafer-Kalkhoff, Tara, Schmidt, Deb, Senapati, Suneeta, Shah, Divya, Shikanov, Ariella, Shnorhavorian, Margarett, Skiles, Jodi L, Smith, James F, Smith, Kristin, Sobral, Fabio, Stimpert, Kyle, Su, H Irene, Sugimoto, Kouhei, Suzuki, Nao, Thakur, Mili, Victorson, David, Viale, Luz, Vitek, Wendy, Wallace, W Hamish, Wartella, Ellen A, Westphal, Lynn M, Whiteside, Stacy, Wilcox, Lea H, Wyns, Christine, Xiao, Shuo, Xu, Jing, and Zelinski, Mary

Abstract

Today, male and female adult and pediatric cancer patients, individuals transitioning between gender identities, and other individuals facing health extending but fertility limiting treatments can look forward to a fertile future. This is, in part, due to the work of members associated with the Oncofertility Consortium. The Oncofertility Consortium is an international, interdisciplinary initiative originally designed to explore the urgent unmet need associated with the reproductive future of cancer survivors. As the strategies for fertility management were invented, developed or applied, the individuals for who the program offered hope, similarly expanded. As a community of practice, Consortium participants share information in an open and rapid manner to addresses the complex health care and quality-of-life issues of cancer, transgender and other patients. To ensure that the organization remains contemporary to the needs of the community, the field designed a fully inclusive mechanism for strategic planning and here present the findings of this process. This interprofessional network of medical specialists, scientists, and scholars in the law, medical ethics, religious studies and other disciplines associated with human interventions, explore the relationships between health, disease, survivorship, treatment, gender and reproductive longevity. The goals are to continually integrate the best science in the service of the needs of patients and build a community of care that is ready for the challenges of the field in the future.

Published
2021

36. Comparative in vitro study on the local tolerance and efficacy of benzalkonium chloride, myristalkonium chloride and nonoxynol-9 as active principles in vaginal contraceptives

Author

Alfaiate, Maria Inês, primary, António Santos, Rita, additional, Silva, Andreia Filipa, additional, Sousa, Ana Paula, additional, Almeida-Santos, Teresa, additional, Gendron, Célia, additional, Jabbour, Violaine, additional, Mas, Yana, additional, Verriere, François, additional, Ramalho-Santos, João, additional, and Tavares, Renata Santos, additional

Published
2021
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40. Survey of Third-Party Parenting Options Associated With Fertility Preservation Available to Patients With Cancer Around the Globe

Author

Rashedi, Alexandra S., primary, de Roo, Saskia F., additional, Ataman, Lauren M., additional, Edmonds, Maxwell E., additional, Silva, Adelino Amaral, additional, Scarella, Anibal, additional, Horbaczewska, Anna, additional, Anazodo, Antoinette, additional, Arvas, Ayse, additional, Ramalho de Carvalho, Bruno, additional, Sartorio, Cassio, additional, Beerendonk, Catharina C.M., additional, Diaz-Garcia, Cesar, additional, Suh, Chang Suk, additional, Melo, Cláudia, additional, Andersen, Claus Yding, additional, Motta, Eduardo, additional, Greenblatt, Ellen M., additional, Van Moer, Ellen, additional, Zand, Elnaz, additional, Reis, Fernando M., additional, Sánchez, Flor, additional, Terrado, Guillermo, additional, Rodrigues, Jhenifer K., additional, Marcos de Meneses e Silva, Joao, additional, Smitz, Johan, additional, Medrano, Jose, additional, Lee, Jung Ryeol, additional, Winkler-Crepaz, Katharina, additional, Smith, Kristin, additional, Ferreira Melo e Silva, Lígia Helena, additional, Wildt, Ludwig, additional, Salama, Mahmoud, additional, del Mar Andrés, María, additional, Bourlon, Maria T., additional, Vega, Mario, additional, Chehin, Maurício Barbour, additional, De Vos, Michel, additional, Khrouf, Mohamed, additional, Suzuki, Nao, additional, Azmy, Osama, additional, Fontoura, Paula, additional, Campos-Junior, Paulo Henrique Almeida, additional, Mallmann, Peter, additional, Azambuja, Ricardo, additional, Marinho, Ricardo M., additional, Anderson, Richard A., additional, Jach, Robert, additional, Antunes, Roberto de A., additional, Mitchell, Rod, additional, Fathi, Rouhollah, additional, Adiga, Satish Kumar, additional, Takae, Seido, additional, Kim, Seok Hyun, additional, Romero, Sergio, additional, Grieco, Silvana Chedid, additional, Shaulov, Talya, additional, Furui, Tatsuro, additional, Almeida-Santos, Teresa, additional, Nelen, Willianne, additional, Jayasinghe, Yasmin, additional, Sugishita, Yodo, additional, and Woodruff, Teresa K., additional

Published
2020
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41. Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe

Author

Rashedi, Alexandra S., primary, de Roo, Saskia F., additional, Ataman, Lauren M., additional, Edmonds, Maxwell E., additional, Silva, Adelino Amaral, additional, Scarella, Anibal, additional, Horbaczewska, Anna, additional, Anazodo, Antoinette, additional, Arvas, Ayse, additional, Ramalho de Carvalho, Bruno, additional, Sartorio, Cassio, additional, Beerendonk, Catharina C.M., additional, Diaz-Garcia, Cesar, additional, Suh, Chang Suk, additional, Melo, Cláudia, additional, Yding Andersen, Claus, additional, Motta, Eduardo, additional, Greenblatt, Ellen M., additional, Van Moer, Ellen, additional, Zand, Elnaz, additional, Reis, Fernando M., additional, Sánchez, Flor, additional, Terrado, Guillermo, additional, Rodrigues, Jhenifer K., additional, de Meneses e Silva, João Marcos, additional, Smitz, Johan, additional, Medrano, Jose, additional, Lee, Jung Ryeol, additional, Winkler-Crepaz, Katharina, additional, Smith, Kristin, additional, Ferreira Melo e Silva, Lígia Helena, additional, Wildt, Ludwig, additional, Salama, Mahmoud, additional, del Mar Andrés, María, additional, Bourlon, Maria T., additional, Vega, Mario, additional, Chehin, Maurício Barbour, additional, De Vos, Michel, additional, Khrouf, Mohamed, additional, Suzuki, Nao, additional, Azmy, Osama, additional, Fontoura, Paula, additional, Campos-Junior, Paulo Henrique Almeida, additional, Mallmann, Peter, additional, Azambuja, Ricardo, additional, Marinho, Ricardo M., additional, Anderson, Richard A., additional, Jach, Robert, additional, Antunes, Roberto de A., additional, Mitchell, Rod, additional, Fathi, Rouhollah, additional, Adiga, Satish Kumar, additional, Takae, Seido, additional, Kim, Seok Hyun, additional, Romero, Sergio, additional, Chedid Grieco, Silvana, additional, Shaulov, Talya, additional, Furui, Tatsuro, additional, Almeida-Santos, Teresa, additional, Nelen, Willianne, additional, Jayasinghe, Yasmin, additional, Sugishita, Yodo, additional, and Woodruff, Teresa K., additional

Published
2020
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42. Creating a Global Community of Practice for Oncofertility

Author

Ataman, Lauren M., primary, Rodrigues, Jhenifer K., additional, Marinho, Ricardo M., additional, Caetano, João P.J., additional, Chehin, Maurício B., additional, Alves da Motta, Eduardo L., additional, Serafini, Paulo, additional, Suzuki, Nao, additional, Furui, Tatsuro, additional, Takae, Seido, additional, Sugishita, Yodo, additional, Morishige, Ken-Ichiro, additional, Almeida-Santos, Teresa, additional, Melo, Cláudia, additional, Buzaglo, Karen, additional, Irwin, Kate, additional, Wallace, W. Hamish, additional, Anderson, Richard A., additional, Mitchell, Roderick T., additional, Telfer, Evelyn E., additional, Adiga, Satish K., additional, Anazodo, Antoinette, additional, Stern, Catharyn, additional, Sullivan, Elizabeth, additional, Jayasinghe, Yasmin, additional, Orme, Lisa, additional, Cohn, Richard, additional, McLachlan, Rob, additional, Deans, Rebecca, additional, Agresta, Franca, additional, Gerstl, Brigitte, additional, Ledger, William L., additional, Robker, Rebecca L., additional, de Meneses e Silva, João M., additional, Melo e Silva, Lígia H.F., additional, Lunardi, Franciele O., additional, Lee, Jung R., additional, Suh, Chang S., additional, De Vos, Michael, additional, Van Moer, Ellen, additional, Stoop, Dominic, additional, Vloeberghs, Veerle, additional, Smitz, Johan, additional, Tournaye, Herman, additional, Wildt, Ludwig, additional, Winkler-Crepaz, Katharina, additional, Andersen, Claus Y., additional, Smith, Brigid M., additional, Smith, Kristin, additional, and Woodruff, Teresa K., additional

Published
2020
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44. Survey of third-party parenting options associated with fertility preservation available to patients with cancer around the globe

Author

Rashedi, Alexandra S., de Roo, Saskia F., Ataman, Lauren M., Edmonds, Maxwell E., Silva, Adelino Amaral, Scarella, Anibal, Horbaczewska, Anna, Anazodo, Antoinette, Arvas, Ayse, de Carvalho, Bruno Ramalho, Sartorio, Cassio, Beerendonk, Catharina C.M., Diaz-Garcia, Cesar, Suk Suh, Chang, Melo, Claudia, Andersen, Claus Yding, Motta, Eduardo, Greenblatt, Ellen M., Van Moer, Ellen, Zand, Elnaz, Reis, Fernando M., Sanchez, Flor, Terrado, Guillermo, Rodrigues, Jhenifer K., de Meneses e Silva, Joao Marcos, Smitz, Johan, Medrano, Jose, Lee, Jung Ryeol, Winkler-Crepaz, Katharina, Smith, Kristin, Ferreira Melo e Silva, Ligia Helena, Wildt, Ludwig, Salama, Mahmoud, del Mar Andres, Maria, Bourlon, Maria T., Vega, Mario, Chehin, Mauricio Barbour, De Vos, Michel, Khrouf, Mohamed, Suzuki, Nao, Azmy, Osama, Fontoura, Paula, Almeida Campos-Junior, Paulo Henrique, Mallmann, Peter, Azambuja, Ricardo, Marinho, Ricardo M., Anderson, Richard A., Jach, Robert, de A. Antunes, Roberto, Mitchell, Rod, Fathi, Rouhollah, Adiga, Satish Kumar, Takae, Seido, Kim, Seok Hyun, Romero, Sergio, Grieco, Silvana Chedid, Shaulov, Talya, Furui, Tatsuro, Almeida-Santos, Teresa, Nelen, Willianne, Jayasinghe, Yasmin, Sugishita, Yodo, Woodruff, Teresa K., Centre for Reproductive Medicine - Gynaecology, Pathology/molecular and cellular medicine, Clinical Biology, Follicle Biology, and Surgical clinical sciences

Subjects
Cancer Research, medicine.medical_specialty, Resource (biology), fertility preservation, Psychological intervention, MEDLINE, Globe, Reproductive technology, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Supportive Care and Quality of Life, Neoplasms, Surveys and Questionnaires, Original Reports, Journal Article, medicine, Global health, Humans, Fertility preservation, Referral and Consultation, Cancer, Oncofertility, 030219 obstetrics & reproductive medicine, Parenting, business.industry, Health Services and Outcomes, Public relations, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], 3. Good health, Surgery, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, business, reproductive medicine
Abstract

Purpose In the accompanying article, “Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe,” we showed that specific fertility preservation services may not be offered at various sites around the world because of cultural and legal barriers. We assessed global and regional experiences as well as the legal status of third-party reproduction and adoption to serve as a comprehensive international data set and resource for groups that wish to begin oncofertility interventions. Methods We provide data on the legalities of third-party assisted reproductive technologies and other family-building options in the 28 oncofertility-practicing countries surveyed. Results We found regional and country differences that will be important in the development of tailored resources for physicians and for patient brochures that are sensitive to these local restrictions and cultural norms. Conclusion Because many patients first consult Web-based materials, the formal assessment of the availability of these options provides members of the global oncofertility community with data to which they might otherwise not have ready access to better serve their patients.

Published
2020
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46. Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe

Author

Rashedi, Alexandra S., de Roo, Saskia F., Ataman, Lauren M., Edmonds, Maxwell E., Silva, Adelino Amaral, Scarella, Anibal, Horbaczewska, Anna, Anazodo, Antoinette, Arvas, Ayse, de Carvalho, Bruno Ramalho, Sartorio, Cassio, Beerendonk, Catharina C. M., Diaz-Garcia, Cesar, Suh, Chang Suk, Melo, Claudia, Andersen, Claus Yding, Motta, Eduardo, Greenblatt, Ellen M., Van Moer, Ellen, Zand, Elnaz, Reis, Fernando M., Sanchez, Flor, Terrado, Guillermo, Rodrigues, Jhenifer K., de Meneses e Silva, Joao Marcos, Smitz, Johan, Medrano, Jose, Lee, Jung Ryeol, Winkler-Crepaz, Katharina, Smith, Kristin, Ferreira Melo e Silva, Ligia Helena, Wildt, Ludwig, Salama, Mahmoud, del Mar Andres, Maria, Bourlon, Maria T., Vega, Mario, Chehin, Mauricio Barbour, De Vos, Michel, Khrouf, Mohamed, Suzuki, Nao, Azmy, Osama, Fontoura, Paula, Almeida Campos-Junior, Paulo Henrique, Mallmann, Peter, Azambuja, Ricardo, Marinho, Ricardo M., Anderson, Richard A., Jach, Robert, Antunes, Roberto de A., Mitchell, Rod, Fathi, Rouhollah, Adiga, Satish Kumar, Takae, Seido, Kim, Seok Hyun, Romero, Sergio, Grieco, Silvana Chedid, Shaulov, Talya, Furui, Tatsuro, Almeida-Santos, Teresa, Nelen, Willianne, Jayasinghe, Yasmin, Sugishita, Yodo, Woodruff, Teresa K., Rashedi, Alexandra S., de Roo, Saskia F., Ataman, Lauren M., Edmonds, Maxwell E., Silva, Adelino Amaral, Scarella, Anibal, Horbaczewska, Anna, Anazodo, Antoinette, Arvas, Ayse, de Carvalho, Bruno Ramalho, Sartorio, Cassio, Beerendonk, Catharina C. M., Diaz-Garcia, Cesar, Suh, Chang Suk, Melo, Claudia, Andersen, Claus Yding, Motta, Eduardo, Greenblatt, Ellen M., Van Moer, Ellen, Zand, Elnaz, Reis, Fernando M., Sanchez, Flor, Terrado, Guillermo, Rodrigues, Jhenifer K., de Meneses e Silva, Joao Marcos, Smitz, Johan, Medrano, Jose, Lee, Jung Ryeol, Winkler-Crepaz, Katharina, Smith, Kristin, Ferreira Melo e Silva, Ligia Helena, Wildt, Ludwig, Salama, Mahmoud, del Mar Andres, Maria, Bourlon, Maria T., Vega, Mario, Chehin, Mauricio Barbour, De Vos, Michel, Khrouf, Mohamed, Suzuki, Nao, Azmy, Osama, Fontoura, Paula, Almeida Campos-Junior, Paulo Henrique, Mallmann, Peter, Azambuja, Ricardo, Marinho, Ricardo M., Anderson, Richard A., Jach, Robert, Antunes, Roberto de A., Mitchell, Rod, Fathi, Rouhollah, Adiga, Satish Kumar, Takae, Seido, Kim, Seok Hyun, Romero, Sergio, Grieco, Silvana Chedid, Shaulov, Talya, Furui, Tatsuro, Almeida-Santos, Teresa, Nelen, Willianne, Jayasinghe, Yasmin, Sugishita, Yodo, and Woodruff, Teresa K.

Abstract

PurposeOncofertility focuses on providing fertility and endocrine-sparing options to patients who undergo life-preserving but gonadotoxic cancer treatment. The resources needed to meet patient demand often are fragmented along disciplinary lines. We quantify assets and gaps in oncofertility care on a global scale.MethodsSurvey-based questionnaires were provided to 191 members of the Oncofertility Consortium Global Partners Network, a National Institutes of Health-funded organization. Responses were analyzed to measure trends and regional subtleties about patient oncofertility experiences and to analyze barriers to care at sites that provide oncofertility services.ResultsSixty-three responses were received (response rate, 25%), and 40 were analyzed from oncofertility centers in 28 countries. Thirty of 40 survey results (75%) showed that formal referral processes and psychological care are provided to patients at the majority of sites. Fourteen of 23 respondents (61%) stated that some fertility preservation services are not offered because of cultural and legal barriers. The growth of oncofertility and its capacity to improve the lives of cancer survivors around the globe relies on concentrated efforts to increase awareness, promote collaboration, share best practices, and advocate for research funding.ConclusionThis survey reveals global and regional successes and challenges and provides insight into what is needed to advance the field and make the discussion of fertility preservation and endocrine health a standard component of the cancer treatment plan. As the field of oncofertility continues to develop around the globe, regular assessment of both international and regional barriers to quality care must continue to guide process improvements. (c) 2020 by American Society of Clinical Oncology

Published
2020

47. Survey of Third-Party Parenting Options Associated With Fertility Preservation Available to Patients With Cancer Around the Globe

Author

Rashedi, Alexandra S, de Roo, Saskia F, Ataman, Lauren M, Edmonds, Maxwell E, Silva, Adelino Amaral, Scarella, Anibal, Horbaczewska, Anna, Anazodo, Antoinette, Arvas, Ayse, Ramalho de Carvalho, Bruno, Sartorio, Cassio, Beerendonk, Catharina C M, Diaz-Garcia, Cesar, Suh, Chang Suk, Melo, Cláudia, Andersen, Claus Yding, Motta, Eduardo, Greenblatt, Ellen M, Van Moer, Ellen, Zand, Elnaz, Reis, Fernando M, Sánchez, Flor, Terrado, Guillermo, Rodrigues, Jhenifer K, Marcos de Meneses E Silva, Joao, Smitz, Johan, Medrano, Jose, Lee, Jung Ryeol, Winkler-Crepaz, Katharina, Smith, Kristin, Ferreira Melo E Silva, Lígia Helena, Wildt, Ludwig, Salama, Mahmoud, Del Mar Andrés, María, Bourlon, Maria T, Vega, Mario, Chehin, Maurício Barbour, De Vos, Michel, Khrouf, Mohamed, Suzuki, Nao, Azmy, Osama, Fontoura, Paula, Campos-Junior, Paulo Henrique Almeida, Mallmann, Peter, Azambuja, Ricardo, Marinho, Ricardo M, Anderson, Richard A, Jach, Robert, Antunes, Roberto de A, Mitchell, Rod, Fathi, Rouhollah, Adiga, Satish Kumar, Takae, Seido, Kim, Seok Hyun, Romero, Sergio, Grieco, Silvana Chedid, Shaulov, Talya, Furui, Tatsuro, Almeida-Santos, Teresa, Nelen, Willianne, Jayasinghe, Yasmin, Sugishita, Yodo, Woodruff, Teresa K, Rashedi, Alexandra S, de Roo, Saskia F, Ataman, Lauren M, Edmonds, Maxwell E, Silva, Adelino Amaral, Scarella, Anibal, Horbaczewska, Anna, Anazodo, Antoinette, Arvas, Ayse, Ramalho de Carvalho, Bruno, Sartorio, Cassio, Beerendonk, Catharina C M, Diaz-Garcia, Cesar, Suh, Chang Suk, Melo, Cláudia, Andersen, Claus Yding, Motta, Eduardo, Greenblatt, Ellen M, Van Moer, Ellen, Zand, Elnaz, Reis, Fernando M, Sánchez, Flor, Terrado, Guillermo, Rodrigues, Jhenifer K, Marcos de Meneses E Silva, Joao, Smitz, Johan, Medrano, Jose, Lee, Jung Ryeol, Winkler-Crepaz, Katharina, Smith, Kristin, Ferreira Melo E Silva, Lígia Helena, Wildt, Ludwig, Salama, Mahmoud, Del Mar Andrés, María, Bourlon, Maria T, Vega, Mario, Chehin, Maurício Barbour, De Vos, Michel, Khrouf, Mohamed, Suzuki, Nao, Azmy, Osama, Fontoura, Paula, Campos-Junior, Paulo Henrique Almeida, Mallmann, Peter, Azambuja, Ricardo, Marinho, Ricardo M, Anderson, Richard A, Jach, Robert, Antunes, Roberto de A, Mitchell, Rod, Fathi, Rouhollah, Adiga, Satish Kumar, Takae, Seido, Kim, Seok Hyun, Romero, Sergio, Grieco, Silvana Chedid, Shaulov, Talya, Furui, Tatsuro, Almeida-Santos, Teresa, Nelen, Willianne, Jayasinghe, Yasmin, Sugishita, Yodo, and Woodruff, Teresa K

Abstract

Purpose: In the accompanying article, "Survey of Fertility Preservation Options Available to Patients With Cancer Around the Globe," we showed that specific fertility preservation services may not be offered at various sites around the world because of cultural and legal barriers. We assessed global and regional experiences as well as the legal status of third-party reproduction and adoption to serve as a comprehensive international data set and resource for groups that wish to begin oncofertility interventions.Methods: We provide data on the legalities of third-party assisted reproductive technologies and other family-building options in the 28 oncofertility-practicing countries surveyed.Results: We found regional and country differences that will be important in the development of tailored resources for physicians and for patient brochures that are sensitive to these local restrictions and cultural norms.Conclusion: Because many patients first consult Web-based materials, the formal assessment of the availability of these options provides members of the global oncofertility community with data to which they might otherwise not have ready access to better serve their patients.

Published
2020

50. The Development of an International Oncofertility Competency Framework: A Model to Increase Oncofertility Implementation

Author

Anazodo, Antoinette, primary, Laws, Paula, additional, Logan, Shanna, additional, Saunders, Carla, additional, Travaglia, Jo, additional, Gerstl, Brigitte, additional, Bradford, Natalie, additional, Cohn, Richard, additional, Birdsall, Mary, additional, Barr, Ronald, additional, Suzuki, Nao, additional, Takae, Seido, additional, Marinho, Ricardo, additional, Xiao, Shuo, additional, Chen, Qiong-Hua, additional, Mahajan, Nalini, additional, Patil, Madhuri, additional, Gunasheela, Devika, additional, Smith, Kristen, additional, Sender, Leonard, additional, Melo, Cláudia, additional, Almeida-Santos, Teresa, additional, Salama, Mahmoud, additional, Appiah, Leslie, additional, Su, Irene, additional, Lane, Sheila, additional, Woodruff, Teresa K., additional, Pacey, Allan, additional, Anderson, Richard A., additional, Shenfield, Francoise, additional, Sullivan, Elizabeth, additional, and Ledger, William, additional

Published
2019
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