Search

Your search keyword '"Almirall, Jose"' showing total 243 results
Start Over Author "Almirall, Jose"
243 results on '"Almirall, Jose"'

14. An interlaboratory study evaluating the interpretation of forensic glass evidence using refractive index measurements and elemental composition

Author

Corzo, Ruthmara, Hoffman, Tricia, Ernst, Troy, Trejos, Tatiana, Berman, Ted, Coulson, Sally, Weis, Peter, Stryjnik, Aleksandra, Dorn, Hendrik, “Chip” Pollock, Edward, Scott Workman, Michael, Jones, Patrick, Nytes, Brendan, Scholz, Thomas, Xie, Huifang, Igowsky, Katherine, Nelson, Randall, Gates, Kris, Gonzalez, Jhanis, Voss, Lisa-Mareen, and Almirall, Jose

Published
2021
Full Text
View/download PDF

15. Scaling Up Patient-Centered Interdisciplinary Care for Multimorbidity: A Pragmatic Mixed-Methods Randomized Controlled Trial

Author

Fortin, Martin, Stewart, Moira, Ngangue, Patrice, Almirall, Jose, Belanger, Mathieu, Brown, Judith Belle, Couture, Martine, Gallagher, Frances, Katz, Alan, Loignon, Christine, Ryan, Bridget L., Sampalli, Tara, Wong, Sabrina T., and Zwarenstein, Merrick

Subjects
Health care teams -- Methods -- Management, Comorbidity -- Care and treatment, Primary health care -- Methods, Company business management, Health, Science and technology
Abstract

PURPOSE To measure the effectiveness of a 4-month interdisciplinary multifaceted intervention based on a change in care delivery for patients with multimorbidity in primary care practices. METHODS A pragmatic randomized controlled trial with a mixed-methods design in patients aged 18 to 80 years with 3 or more chronic conditions from 7 family medicine groups (FMGs) in Quebec, Canada. Health care professionals (nurses, nutritionists, kinesiologists) from the FMGs were trained to deliver the patient-centered intervention based on a motivational approach and self-management support. Primary outcomes: self-management (Health Education Impact Questionnaire); and self-efficacy. Secondary outcomes: health status, quality of life, and health behaviors. Quantitative analyses used multi-level mixed effects and generalized linear mixed models controlling for clustering within FMGs. We also conducted in-depth interviews with patients, family members, and health care professionals. RESULTS The trial randomized 284 patients (144 in intervention group, 140 in control group). The groups were comparable. After 4 months, the intervention showed a neutral effect for the primary outcomes. There was significant improvement in 2 health behaviors (healthy eating with odds ratios [OR] 4.36; P = .006, and physical activity with OR 3.43; P = .023). The descriptive qualitative evaluation revealed that the patients reinforced their self-efficacy and improved their self-management which was divergent from the quantitative results. CONCLUSIONS Quantitatively, this intervention showed a neutral effect on the primary outcomes and substantial improvement in 2 health behaviors as secondary outcomes. Qualitatively, the intervention was evaluated as positive. The combination of qualitative and quantitative designs proved to be a good design for evaluating this complex intervention. Key words: interdisciplinary research; multimorbidity; patient care team; pragmatic clinical trial, INTRODUCTION Much effort has been deployed internationally to improve care and outcomes for persons with multimorbidity in primary care. The Patient-Centered Innovations for Persons with Multimorbidity research program, funded by [...]

Published
2021
Full Text
View/download PDF

35. An interlaboratory study to evaluate the utility of gas chromatography‐mass spectrometry and gas chromatography‐infrared spectroscopy spectral libraries in the forensic analysis of fentanyl‐related substances.

Author

Ferguson, Kimiko, Perr, Jeannette, Tupik, Sherri, Gilbert, Michael, Newman, Reta, Winokur, Agnes, Vallejo, Ivette, Hokanson, Stephen, Pothier, Matthew, Knapp, Brook, Icard, Misty, Kramer, Kevin, and Almirall, Jose

Subjects
NALOXONE, GAS chromatography/Mass spectrometry (GC-MS), GAS companies, IONS, MASS spectrometry, CRIME laboratories, SPECTROMETRY
Abstract

Synthetic opioids such as fentanyl account for over 71,000 of the approximately 107,000 overdose deaths reported in the United States in 2021. Fentanyl remains the fourth most identified drug by state and local forensic laboratories, and the second most identified drug by federal laboratories. The unambiguous identification of fentanyl‐related substances (FRS) is challenging due to the absence or low abundance of a molecular ion in a typical gas chromatography‐mass spectrometry (GC‐MS) analysis and due to a low number of fragment ions that are similar among the many potential isomers of FRS. This study describes the utility of a previously reported gas chromatography‐infrared (GC‐IR) library for the identification of FRS within a blind, interlaboratory study (ILS) involving seven forensic laboratories. Twenty FRS reference materials, including those with isomer pairs in the library, were selected based on either their presence in the NIST library and/or some similarity of the mass spectra information produced. The ILS participants were requested to use the Florida International University (FIU) GC‐MS and GC‐IR libraries supplied by FIU to search for matches to their unknown spectra generated from in‐house GC‐MS and GC‐IR analysis. The laboratories reported improvement in the positive identification of unknown FRS from ~75% using GC‐MS alone to 100% correct identification using GC‐IR analysis. One laboratory participant used solid phase IR analysis, which produced spectra incompatible with the vapor phase GC‐IR library to generate a good comparison spectrum. However, this improved when searched against a solid phase IR library. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results