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1. Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey

Author

Izzo, Raffaele, Trimarco, Valentina, Mone, Pasquale, Aloè, Teresita, Capra Marzani, Massimo, Diana, Antonio, Fazio, Giovanni, Mallardo, Mario, Maniscalco, Mauro, Marazzi, Giuseppe, Messina, Nunzia, Mininni, Simone, Mussi, Chiara, Pelaia, Girolamo, Pennisi, Alfio, Santus, Pierachille, Scarpelli, Francesco, Tursi, Francesco, Zanforlin, Alessandro, Santulli, Gaetano, and Trimarco, Bruno

Published
2022
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2. Neurological long-COVID in the outpatient clinic: Two subtypes, two courses

Author

Grisanti, Stefano Giuseppe, Garbarino, Sara, Barisione, Emanuela, Aloè, Teresita, Grosso, Marco, Schenone, Cristina, Pardini, Matteo, Biassoni, Erica, Zaottini, Federico, Picasso, Riccardo, Morbelli, Silvia, Campi, Cristina, Pesce, Giampaola, Massa, Federico, Girtler, Nicola, Battaglini, Denise, Cabona, Corrado, Bassetti, Matteo, Uccelli, Antonio, Schenone, Angelo, Piana, Michele, and Benedetti, Luana

Published
2022
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5. The added value of lung perfusion scintigraphy semiquantitative measures in post-COVID patients with persistent dyspnea without pulmonary embolism

Author

Lanfranchi, Francesco, primary, Maggio, Sara, additional, Delucchi, Carlo, additional, Bertoldi, Francesca, additional, Corica, Ferdinando, additional, De Feo, Maria Silvia, additional, Marini, Cecilia, additional, Aloè, Teresita, additional, Frantellizzi, Viviana, additional, De Vincentis, Giuseppe, additional, Morbelli, Silvia, additional, Sambuceti, Gianmario, additional, Barisione, Emanuela, additional, and Bauckneht, Matteo, additional

Published
2023
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6. Prevalence of Long COVID Symptoms Related to SARS-CoV-2 Strains

Author

Aloè, Teresita, primary, Novelli, Federica, additional, Puppo, Gianfranco, additional, Pinelli, Valentina, additional, Barisione, Emanuela, additional, Trucco, Elisa, additional, Costanzo, Roberta, additional, Covesnon, Maria Grazia, additional, Grillo, Federica, additional, Zoccali, Patrizia, additional, Milanese, Manlio, additional, Maniscalco, Sara, additional, Tagliabue, Elena, additional, Piroddi, Ines Maria Grazia, additional, Venturi, Simonetta, additional, Serra, Maria, additional, Scordamaglia, Francesca, additional, Ferrari, Marta, additional, and Serafini, Antonella, additional

Published
2023
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7. Endothelial dysfunction in long-COVID: New insights from the nationwide multicenter LINCOLN Study

Author

Trimarco, Valentina, primary, Izzo, Raffaele, additional, Zanforlin, Alessandro, additional, Tursi, Francesco, additional, Scarpelli, Francesco, additional, Santus, Pierachille, additional, Pennisi, Alfio, additional, Pelaia, Girolamo, additional, Mussi, Chiara, additional, Mininni, Simone, additional, Messina, Nunzia, additional, Marazzi, Giuseppe, additional, Maniscalco, Mauro, additional, Mallardo, Mario, additional, Fazio, Giovanni, additional, Diana, Antonio, additional, Capra Marzani, Massimo, additional, Aloè, Teresita, additional, Mone, Pasquale, additional, Trimarco, Bruno, additional, and Santulli, Gaetano, additional

Published
2022
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8. Combining L-Arginine with Vitamin C Improves Long-COVID Symptoms: The Nationwide Multicenter LINCOLN Study

Author

Izzo, Raffaele, Trimarco, Valentina, Mone, Pasquale, Aloè, Teresita, Marzani, Massimo Capra, Diana, Antonio, Fazio, Giovanni, Mallardo, Mario, Maniscalco, Mauro, Marazzi, Giuseppe, Messina, Nunzia, Mininni, Simone, Mussi, Chiara, Pelaia, Girolamo, Pennisi, Alfio, Santus, Pierachille, Scarpelli, Francesco, Tursi, Francesco, Zanforlin, Alessandro, Santulli, Gaetano, Trimarco, Bruno, Izzo, Raffaele, Trimarco, Valentina, Mone, Pasquale, Aloè, Teresita, Marzani, Massimo Capra, Diana, Antonio, Fazio, Giovanni, Mallardo, Mario, Maniscalco, Mauro, Marazzi, Giuseppe, Messina, Nunzia, Mininni, Simone, Mussi, Chiara, Pelaia, Girolamo, Pennisi, Alfio, Santus, Pierachille, Scarpelli, Francesco, Tursi, Francesco, Zanforlin, Alessandro, Santulli, Gaetano, and Trimarco, Bruno

Subjects
Oxidative stress, Ascorbic acid, COVID-19, Endothelial dysfunction, Long-COVID, L-Arginine
Abstract

Recent evidence suggests that oxidative stress and endothelial dysfunction play critical roles in the pathophysiology of COVID-19 and Long-COVID. We hypothesized that a supplementation combining L-Arginine (to improve endothelial function) and Vitamin C (to reduce oxidation) could have favorable effects on Long-COVID symptoms.

Published
2022

9. Intravenous methylprednisolone pulses in hospitalised patients with severe COVID-19 pneumonia, A double-blind, randomised, placebo-controlled trial

Author

Salvarani, C, Massari, M, Costantini, M, Franco Merlo, D, Lucia Mariani, G, Viale, P, Nava, S, Guaraldi, G, Dolci, G, Boni, L, Savoldi, L, Bruzzi, P, Turrà, C, Catanoso, M, Maria Marata, A, Barbieri, C, Valcavi, A, Franzoni, F, Cavuto, S, Mazzi, G, Corsini, R, Trapani, F, Bartoloni, A, Barisione, E, Jole Burastero, G, Pan, A, Inojosa, W, Scala, R, Burattini, C, Luppi, F, Codeluppi, M, Eldin Tarek, K, Cenderello, G, Salio, M, Foti, G, Dongilli, R, Bajocchi, G, Alberto Negri, E, Ciusa, G, Fornaro, G, Bassi, I, Zammarchi, L, Aloè, T, Facciolongo, N, Salvarani, Carlo, Massari, Marco, Costantini, Massimo, Franco Merlo, Domenico, Lucia Mariani, Gabriella, Viale, Pierluigi, Nava, Stefano, Guaraldi, Giovanni, Dolci, Giovanni, Boni, Luca, Savoldi, Luisa, Bruzzi, Paolo, Turrà, Caterina, Catanoso, Mariagrazia, Maria Marata, Anna, Barbieri, Chiara, Valcavi, Annamaria, Franzoni, Francesca, Cavuto, Silvio, Mazzi, Giorgio, Corsini, Romina, Trapani, Fabio, Bartoloni, Alessandro, Barisione, Emanuela, Jole Burastero, Giulia, Pan, Angelo, Inojosa, Walter, Scala, Raffaele, Burattini, Cecilia, Luppi, Fabrizio, Codeluppi, Mauro, Eldin Tarek, Kamal, Cenderello, Giovanni, Salio, Mario, Foti, Giuseppe, Dongilli, Roberto, Bajocchi, Gianluigi, Alberto Negri, Emanuele, Ciusa, Giacomo, Fornaro, Giacomo, Bassi, Ilaria, Zammarchi, Lorenzo, Aloè, Teresita, Facciolongo, Nicola, Salvarani, C, Massari, M, Costantini, M, Franco Merlo, D, Lucia Mariani, G, Viale, P, Nava, S, Guaraldi, G, Dolci, G, Boni, L, Savoldi, L, Bruzzi, P, Turrà, C, Catanoso, M, Maria Marata, A, Barbieri, C, Valcavi, A, Franzoni, F, Cavuto, S, Mazzi, G, Corsini, R, Trapani, F, Bartoloni, A, Barisione, E, Jole Burastero, G, Pan, A, Inojosa, W, Scala, R, Burattini, C, Luppi, F, Codeluppi, M, Eldin Tarek, K, Cenderello, G, Salio, M, Foti, G, Dongilli, R, Bajocchi, G, Alberto Negri, E, Ciusa, G, Fornaro, G, Bassi, I, Zammarchi, L, Aloè, T, Facciolongo, N, Salvarani, Carlo, Massari, Marco, Costantini, Massimo, Franco Merlo, Domenico, Lucia Mariani, Gabriella, Viale, Pierluigi, Nava, Stefano, Guaraldi, Giovanni, Dolci, Giovanni, Boni, Luca, Savoldi, Luisa, Bruzzi, Paolo, Turrà, Caterina, Catanoso, Mariagrazia, Maria Marata, Anna, Barbieri, Chiara, Valcavi, Annamaria, Franzoni, Francesca, Cavuto, Silvio, Mazzi, Giorgio, Corsini, Romina, Trapani, Fabio, Bartoloni, Alessandro, Barisione, Emanuela, Jole Burastero, Giulia, Pan, Angelo, Inojosa, Walter, Scala, Raffaele, Burattini, Cecilia, Luppi, Fabrizio, Codeluppi, Mauro, Eldin Tarek, Kamal, Cenderello, Giovanni, Salio, Mario, Foti, Giuseppe, Dongilli, Roberto, Bajocchi, Gianluigi, Alberto Negri, Emanuele, Ciusa, Giacomo, Fornaro, Giacomo, Bassi, Ilaria, Zammarchi, Lorenzo, Aloè, Teresita, and Facciolongo, Nicola

Abstract

Rationale Pulse glucocorticoid therapy is used in hyperinflammation related to coronavirus disease 2019 (COVID-19). We evaluated the efficacy and safety of pulse intravenous methylprednisolone in addition to standard treatment in COVID-19 pneumonia. Methods In this multicentre, randomised, double-blind, placebo-controlled trial, 304 hospitalised patients with COVID-19 pneumonia were randomised to receive 1 g of methylprednisolone intravenously for three consecutive days or placebo in addition to standard dexamethasone. The primary outcome was the duration of patient hospitalisation, calculated as the time interval between randomisation and hospital discharge without the need for supplementary oxygen. The key secondary outcomes were survival free from invasive ventilation with orotracheal intubation and overall survival. Results Overall, 112 (75.4%) out of 151 patients in the pulse methylprednisolone arm and 111 (75.2%) of 150 in the placebo arm were discharged from hospital without oxygen within 30 days from randomisation. Median time to discharge was similar in both groups (15 days, 95% CI 13.0–17.0 days and 16 days, 95% CI 13.8–18.2 days, respectively; hazard ratio (HR) 0.92, 95% CI 0.71–1.20; p=0.528). No significant differences between pulse methylprednisolone and placebo arms were observed in terms of admission to intensive care unit with orotracheal intubation or death (20.0% versus 16.1%; HR 1.26, 95% CI 0.74–2.16; p=0.176) or overall mortality (10.0% versus 12.2%; HR 0.83, 95% CI 0.42–1.64; p=0.584). Serious adverse events occurred with similar frequency in the two groups. Conclusions Methylprenisolone pulse therapy added to dexamethasone was not of benefit in patients with COVID-19 pneumonia.

Published
2022

10. Intravenous methylprednisolone pulses in hospitalised patients with severe COVID-19 pneumonia: a double-blind, randomised, placebo-controlled trial

Author

Salvarani, Carlo, primary, Massari, Marco, additional, Costantini, Massimo, additional, Merlo, Domenico Franco, additional, Mariani, Gabriella Lucia, additional, Viale, Pierluigi, additional, Nava, Stefano, additional, Guaraldi, Giovanni, additional, Dolci, Giovanni, additional, Boni, Luca, additional, Savoldi, Luisa, additional, Bruzzi, Paolo, additional, Turrà, Caterina, additional, Catanoso, Mariagrazia, additional, Marata, Anna Maria, additional, Barbieri, Chiara, additional, Valcavi, Annamaria, additional, Franzoni, Francesca, additional, Cavuto, Silvio, additional, Mazzi, Giorgio, additional, Corsini, Romina, additional, Trapani, Fabio, additional, Bartoloni, Alessandro, additional, Barisione, Emanuela, additional, Burastero, Giulia Jole, additional, Pan, Angelo, additional, Inojosa, Walter, additional, Scala, Raffaele, additional, Burattini, Cecilia, additional, Luppi, Fabrizio, additional, Codeluppi, Mauro, additional, Tarek, Kamal Eldin, additional, Cenderello, Giovanni, additional, Salio, Mario, additional, Foti, Giuseppe, additional, Dongilli, Roberto, additional, Bajocchi, Gianluigi, additional, Negri, Emanuele Alberto, additional, Ciusa, Giacomo, additional, Fornaro, Giacomo, additional, Bassi, Ilaria, additional, Zammarchi, Lorenzo, additional, Aloè, Teresita, additional, and Facciolongo, Nicola, additional

Published
2022
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15. Clinical characteristics, management and in-hospital mortality of patients with COVID-19 In Genoa, Italy

Author

Vena, Antonio, Giacobbe, DANIELE ROBERTO, DI BIAGIO, Antonio, Mikulska, MALGORZATA KAROLINA, Taramasso, Lucia, DE MARIA, Andrea, Ball, Lorenzo, Brunetti, Iole, Loconte, Maurizio, Patroniti, Nicolò A., Robba, Chiara, Delfino, Emanuele, Dentone, Chiara, Magnasco, Laura, Nicolini, LAURA AMBRA, Federica, Toscanini, Bavastro, Martina, Cerchiaro, Matteo, Barisione, Emanuela, Giacomini, Mauro, Mora, Sara, Baldi, Federico, Balletto, Elisa, Berruti, Marco, Briano, Federica, Sepulcri, Chiara, Dettori, Silvia, Labate, Laura, Mirabella, Michele, Portunato, Federica, Pincino, Rachele, Russo, Chiara, Tutino, Stefania, Pelosi, PAOLO PASQUALINO, Bassetti, Matteo, Anna, Alessandrini, Marco, Camera, Ferdinando, Dodi, Ferrazin, Antonio, Mazzarello, Giovanni, Schenone, Eva, Nirmala, Rosseti, Sarteschi, Giovanni, Pontremoli, Roberto, Beccati, Valentina, Salvatore, Casciaro, Casu, Massimo, Francesco, Gavaudan, Maria, Ghinatti, Gualco, Elisa, Leoncini, Giovanna, Pitto, Paola, Salam, Kassem, Gratarola, Angelo, Bixio, Mattia, Annalisa, Amelia, Balestra, Andrea, Paola, Ballarino, Bardi, Nicholas, Boccafogli, Roberto, Caserza, Francesca, Calzolari, Elisa, Castelli, Marta, Cenni, Elisabetta, Cortese, Paolo, Cuttone, Giuseppe, Feltrin, Sara, Giovinazzo, Stefano, Giuntini, Patrizia, Natale, Letizia, Orsi, Davide, Pastorino, Matteo, Perazzo, Tommaso, Pescetelli, Fabio, Schenone, Federico, Maria Grazia Serra, Sottano, Marco, Tallone, Roberto, Massimo, Amelotti, Marie Jeanne Majabò, Massimo, Merlini, Perazzo, Federica, Nidal, Ahamd, Paolo, Barbera, Bovio, Marta, Campodonico, Paola, Andrea, Collidà, Cutuli, Ombretta, Agnese, Lomeo, Fezza, Francesca, Nicola, Gentilucci, HUSSEIN EL DIB, Nadia, Malvezzi, Emanuele, Massobrio, Laura, Giula, Motta, Laura, Pastorino, Nicoletta, Pollicardo, Sartini, Stefano, Vacca, Paola, Virga, Valentina, Porto, Italo, Giampaolo, Bezante, Roberta Della Bona, LA MALFA, Giovanni, Alberto, Valbusa, GIL AD, Vered, Michele, Bellotti, Aloè, Teresita, Alessandro, Blanco, Grosso, Marco, Maria Grazia Piroddi, Moscatelli, Paolo, Matteo, Caiti, Magnani, Ottavia, Sukkar, Samir, Ludovica, Cogorno, Gradaschi, Raffaella, Erica, Guiddo, Martino, Eleonora, Pisciotta, Livia, Bruno, Cavagliere, Rossi, Cristina, Farina, Francesca, Garibotto, Giacomo, Esposito, Pasquale, Carmen, Bellezza, Harusha, Emirjona, Rossi, Francesca, Arboscello, Eleonora, Laura, Arzani, Laura De Mattei: Marzia Spadaro, Passalacqua, Giovanni, Bagnasco, Diego, Braido, Fulvio, Annamaria, Riccio, Tagliabue, Elena, Gustavino, Claudio, Ferraiolo, Antonella, Monacelli, Fiammetta, Mahmoud, Mona, Tagliafico, Luca, Napolitano, Armando, Maria, Fiorio, Pizzonia, Monica, Giannotti, Chiara, Nencioni, Alessio, Salvatore, Giuffrida, Nicola, Rosso, Morando, Alessandra, Riccardo, Papalia, Passerini, Donata, Gabriella, Tiberio, Giovanni, Orengo, Battaglini, Alberto, Silvano, Ruffoni, and Sergio, Caglieris

Subjects
Male, Pneumonia, Viral, Article, Betacoronavirus, COVID-19 Testing, Risk Factors, Cause of Death, Humans, Hospital Mortality, Pandemics, Aged, Retrospective Studies, Aged, 80 and over, IL-6, Clinical Laboratory Techniques, SARS-CoV-2, COVID-19, Middle Aged, mortality, ARDS, Sars-COV2, COVID-19 Drug Treatment, Hospitalization, Italy, Female, Coronavirus Infections
Abstract

Objectives To describe clinical characteristics, management and outcome of COVID-19 patients; and to evaluate risk factors for all-cause in-hospital mortality. Methods This retrospective study from a University tertiary care hospital in northern Italy, included hospitalized adult patients with a diagnosis of COVID-19 between February 25th, 2020 and March 25th, 2020. Results Overall, 317 patients were enrolled. Their median age 71 years and 67.2% were males (213/317). The most common underlying diseases were hypertension (149/317; 47.0%), cardiovascular disease (63/317, 19.9%) and diabetes (49/317; 15.5%). Common symptoms at the time of COVID-19 diagnosis included fever (285/317; 89.9%), shortness of breath (167/317; 52.7%) and dry cough (156/317,49.2%). An “atypical” presentation including at least one among mental confusion, diarrhea or nausea and vomiting was observed in 53/317 patients (16.7%). Hypokalemia occurred in 25.8% (78/302) and 18.5% (56/303) had acute kidney injury. During hospitalization, 111/317 patients (35.0%) received non-invasive respiratory support, 65/317 (20.5%) were admitted to the intensive care unit (ICU) and 60/317 (18.5%) required invasive mechanical ventilation. All cause in-hospital mortality, assessed in 275 patients, was 43.6% (120/275). On multivariable analysis, age (per-year increase odds ratio [OR]:1.07; 95% confidence interval [CI] 1.04-1.10, p

Published
2020

16. Anti-IL-5 and IL-5Ra: Efficacy and Safety of New Therapeutic Strategies in Severe Uncontrolled Asthma

Author

Bagnasco, Diego, Caminati, Marco, Ferrando, Matteo, Aloè, Teresita, Testino, Elisa, Canonica, Giorgio Walter, and Passalacqua, Giovanni

Subjects
Article Subject
Abstract

The current developments of the new biological drugs targeting interleukin 5 (IL-5) and IL-5 receptor allowed to expand the treatment options for severe hypereosinophilic asthma. Clinicians will then be able to choose between antibodies targeting either circulating IL-5 or its receptor expressed on eosinophils and basophils. The available clinical trials consistently reported favorable results about the reduction of exacerbations rate, improvement in quality of life, and sparing of the systemic steroid use, with a favorable safety profile. Two of these new drugs are administered subcutaneously, mepolizumab every 4 weeks and benralizumab every 8 weeks, whereas reslizumab is given intravenously monthly on a weigh-based dose. In the future, the research actions will be involved in the identification of a single biomarker or multiple biomarkers for the optimal choice of biological agents to be properly prescribed.

Published
2018
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18. Beyond Covid-19 vaccination-associated pitfalls on [18F]Fluorodeoxyglucose (FDG) PET: a case of a concomitant sarcoidosis.

Author

Bauckneht, Matteo, Aloè, Teresita, Tagliabue, Elena, Cittadini, Giuseppe, Guadagno, Antonio, Morbelli, Silvia, and Barisione, Emanuela

Subjects
*COVID-19, *CORONARY angiography, *SARCOIDOSIS, *CARDIOGRAPHIC tomography, *CORONARY artery disease, *CARDIAC magnetic resonance imaging, *COVID-19 vaccines
Abstract

COVID-19 vaccine as a cause for unilateral lymphadenopathy detected by 18F-FDG PET/CT in a patient affected by melanoma. COVID-19 vaccination induced axillary nodal uptake on [18F]FDG PET/CT. [Extracted from the article]

Published
2021
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19. Endothelial dysfunction in long-COVID: New insights from the nationwide multicenter LINCOLN Study

Author

Valentina Trimarco, Raffaele Izzo, Alessandro Zanforlin, Francesco Tursi, Francesco Scarpelli, Pierachille Santus, Alfio Pennisi, Girolamo Pelaia, Chiara Mussi, Simone Mininni, Nunzia Messina, Giuseppe Marazzi, Mauro Maniscalco, Mario Mallardo, Giovanni Fazio, Antonio Diana, Massimo Capra Marzani, Teresita Aloè, Pasquale Mone, Bruno Trimarco, Gaetano Santulli, Trimarco, Valentina, Izzo, Raffaele, Zanforlin, Alessandro, Tursi, Francesco, Scarpelli, Francesco, Santus, Pierachille, Pennisi, Alfio, Pelaia, Girolamo, Mussi, Chiara, Mininni, Simone, Messina, Nunzia, Marazzi, Giuseppe, Maniscalco, Mauro, Mallardo, Mario, Fazio, Giovanni, Diana, Antonio, Capra Marzani, Massimo, Aloè, Teresita, Mone, Pasquale, Trimarco, Bruno, and Santulli, Gaetano

Subjects
Pharmacology, Settore MED/09 - Medicina Interna, Arginine, Ascorbic acid, COVID-19, Endothelial dysfunction, Oxidative stress, Survey, Settore MED/10 - Malattie dell'Apparato Respiratorio, Antioxidants, Settore MED/34 - Medicina Fisica e Riabilitativa, Vascular, Oxidative stre, Humans, Ascorbic Acid, Oxidative Stress, Endothelium, Vascular, Endothelium, Antioxidant, Human
Published
2022

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