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8 results on '"Alotaibi, Jawaher M."'

3. The Saudi Critical Care Society practice guidelines on the management of COVID-19 in the ICU: Therapy section

Author

Alhazzani, Waleed, Alshahrani, Mohammed, Alshamsi, Fayez, Aljuhani, Ohoud, Eljaaly, Khalid, Hashim, Samaher, Alqahtani, Rakan, Alsaleh, Doaa, Al Duhailib, Zainab, Algethamy, Haifa, Al-Musawi, Tariq, Alshammari, Thamir, Alqarni, Abdullah, Khoujah, Danya, Tashkandi, Wail, Dahhan, Talal, Almutairi, Najla, Alserehi, Haleema A., Al-Yahya, Maytha, Al-Judaibi, Bandar, Arabi, Yaseen M., Abualenain, Jameel, Alotaibi, Jawaher M., Al bshabshe, Ali, Alharbi, Reham, Al-Hameed, Fahad, Elhazmi, Alyaa, Almaghrabi, Reem S., Almaghlouth, Fatma, Abedalthagafi, Malak, Al Khathlan, Noor, Al-Suwaidan, Faisal A., Bunyan, Reem F., Baw, Bandar, Alghamdi, Ghassan, Al Hazmi, Manal, Mandourah, Yasser, Assiri, Abdullah, Enani, Mushira, Alawi, Maha, Aljindan, Reem, Aljabbary, Ahmed, Alrbiaan, Abdullah, Algurashi, Fahd, Alsaawi, Abdulmohsen, Alenazi, Thamer H., Alsultan, Mohammed A., Alqahtani, Saleh A., Memish, Ziad, Al-Tawfiq, Jaffar A., and Al-jedai, Ahmed

Published
2022
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4. Exploring the sedative properties of natural molecules from hop cones (Humulus lupulus) as promising natural anxiolytics through GABA receptors and the human serotonin transporter.

Author

Belal, Amany, Elballal, Mohammed S., Al-Karmalawy, Ahmed A., Hassan, Ahmed H. E., Roh, Eun Joo, Ghoneim, Mohammed M., Ali, Mohamed A. M., Obaidullah, Ahmad J., Alotaibi, Jawaher M., Shaaban, Salwa, Elanany, Mohamed A., Marinho, Emmanuel Silva, and Dimiić, Dusan

Subjects
HOPS, TRANQUILIZING drugs, MOLECULAR dynamics, GABA, PAROXETINE
Abstract

This research work aimed to identify the main components that are responsible for the sedative properties of hop cones and allocate their targets. This investigation was performed through molecular docking, molecular dynamic simulations, root mean square fluctuation (RMSF) analysis, and DFT calculation techniques. The tested compounds from Humulus lupulus were compared to diazepam and paroxetine. Molecular docking showed that two-thirds of the compounds had a good affinity to gamma-aminobutyric acid (GABA), outperforming diazepam, while only three surpassed paroxetine on the SERT. Compounds 3,5-dihydroxy-4,6,6-tris(3-methylbut-2-en-1-yl)-2-(3-methylbuta noyl)cyclohexa-2,4-dien-1-one (5) and (S,E)-8-(3,7-dimethylocta-2,6-dien-1-yl)-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one (15) showed stable binding and favorable energy parameters, indicating their potential for targeting GABA receptors and the SERT. This study provides a basis for future clinical research on these promising compounds. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Antibacterial Efficacy of N-(4-methylpyridin-2-yl) Thiophene-2-Carboxamide Analogues against Extended-Spectrum-β-Lactamase Producing Clinical Strain of Escherichia coli ST 131

Author

Ahmad, Gulraiz, primary, Khalid, Aqsa, additional, Qamar, Muhammad Usman, additional, Rasool, Nasir, additional, Saadullah, Malik, additional, Bilal, Muhammad, additional, Bajaber, Majed A., additional, Obaidullah, Ahmad J., additional, Alotaibi, Hadil Faris, additional, and Alotaibi, Jawaher M., additional

Published
2023
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6. The Saudi Critical Care Society Practice Guidelines on the Management of COVID-19 in the ICU: Therapy Section

Author

Alhazzani, Waleed, primary, Alshahrani, Mohammed, additional, Alshamsi, Fayez, additional, Aljuhani, Ohoud, additional, Eljaaly, Khalid, additional, Hashim, Samaher, additional, Alqahtani, Rakan, additional, Alsaleh, Doaa, additional, Duhailib, Zainab Al, additional, Algethamy, Haifa, additional, Al-Musawi, Tariq, additional, Alshammari, Thamir, additional, Alqarni, Abdullah, additional, Khoujah, Danya, additional, Tashkandi, Wail, additional, Dahhan, Talal, additional, Almutairi, Najla, additional, Alserehi, Haleema A., additional, Al-Yahya, Maytha, additional, Al-Judaibi, Bandar, additional, Arabi, Yaseen M, additional, Abualenain, Jameel, additional, Alotaibi, Jawaher M., additional, Albshabshe, Ali, additional, Alharbi, Reham, additional, Al-Hameed, Fahad, additional, Elhazmi, Alyaa, additional, Almaghrabi, Reem S., additional, Almaghlouth, Fatma, additional, Abedalthagafi, Malak, additional, Khathlan, Noor Al, additional, Al-Suwaidan, Faisal A., additional, Bunyan, Reem F., additional, Baw, Bandar, additional, Alghamdi, Ghassan, additional, Hazmi, Manal Al, additional, Mandourah, Yasser, additional, Assiri, Abdullah, additional, Enani, Mushira, additional, Alawi, Maha, additional, Aljindan, Reem, additional, Aljabbary, Ahmed, additional, Alrbiaan, Abdullah, additional, Algurashi, Fahd, additional, Alsaawi, Abdulmohsen, additional, Alenazi, Thamer H., additional, Alsultan, Mohammed A., additional, Alqahtani, Saleh A., additional, Memish, Ziad, additional, Al-Tawfiq, Jaffar A., additional, and Al-Jedai, Ahmed, additional

Published
2021
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7. Unraveling the Antidiabetic Effect of Alternantera brasiliana(L.) Kuntze: A Combined in Vitroand in VivoApproach

Author

Faloye, Kolade O., Famuyiwa, Funmilayo G., Olanudun, Esther A., Ayoola, Marcus D., Ayoade, Peter T., Ugwo, Jeremiah P., Obaidullah, Ahmad J., Alotaibi, Jawaher M., Akinniyi, Ganiyu, and Famuyiwa, Samson O.

Abstract

Background of the study This study established the antidiabetic efficacy of Alternantera brasiliana in vitroand in vivo, identified the most active fraction and profiled the chemical constituents of the most active fraction.Methodology The leaf of A. brasilianawas air-dried, pulverized and extracted with methanol and evaluated for its α-amylase activity at different concentrations using in vitromethod. The in vivoantidiabetic activity of the extract and glibenclamide was evaluated in glucose loaded and streptozotocin-induced diabetic rats using various doses, while the most active partitioned fraction was identified using glucose loaded method followed by identification of its chemical constituents through GC-MS analysis.Results The extract elicited good α-amylase inhibitory potential with IC50 = 0.45 mg/mL. Also, the 50 mg/kg dose demonstrated the highest percentage blood glucose level reduction and significantly (P> 0.05) comparable to glibenclamide (5 mg/kg) from 0.5 to 4 h. The streptozotocin-induced antidiabetic assay showed that the 50 mg/kg demonstrated better activity than glibenclamide (5 mg/kg) and was significantly comparable on days 10 and 14. The aqueous methanol fraction was the most active fraction with 53% blood glucose level reduction at 4 h. The secondary metabolite profiling identified 30 chemical compounds whereby 1H-Indole-2-carboxylic acid, 6-(4-ethoxyphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-, isopropyl ester, Benzo[h]quinoline, 2,4-dimethyl-, thymol and 13,5-trioxane as the major constituents.Conclusion The antidiabetic activity demonstrated by the A. brasilianaextract established its antidiabetic efficacy

Published
2024
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8. Donor Transmitted Rabies Outbreak Involving Four Transplant Recipients in Kuwait and Saudi Arabia.

Author

Elsiesy, Hussien, Hussain, Iqbal, Abaalkhail, Faisal A., Al-Hamoudi, Waleed K., Al Sebayel, Mohamed I., Broering, Dieter C., Elgohary, Ahmed A., Ahmed, Baderaldeen, Fawaz, Sarah Al, Althawadi, Sahar I., Alotaibi, Jawaher M., Al-Hindi, Hindi, Orciari, Lillian, Velasco-Villa, Andres, Yager, Pamela, Smith, Todd, Carson, Will, Niezgoda, Mike, Wadhwa, Ashutosh, and Condori, Edgar R.

Abstract

An abstract of the article "Donor Transmitted Rabies Outbreak Involving Four Transplant Recipients in Kuwait and Saudi Arabia" by Hussien Elsiesy and others, is presented.

Published
2016

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