1. Targeted elimination of Fusobacterium nucleatum alleviates periodontitis
- Author
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Nil Yakar, Ozge Unlu, Lujia Cen, Hatice Hasturk, Tsute Chen, Wenyuan Shi, Xuesong He, and Alpdogan Kantarci
- Subjects
Antimicrobial agents ,Fusobacterium nucleatum ,periodontal disease ,periodontal bone loss ,hygromycin a ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Background Fusobacterium nucleatum, a pathobiont in periodontal disease, contributes to alveolar bone destruction. We assessed the efficacy of a new targeted antimicrobial, FP-100, in eradicating F. nucleatum from the oral microbial community in vitro and in vivo and evaluated its effectiveness in reducing bone loss in a mouse periodontitis model.Methods A multispecies bacterial community was cultured and treated with two concentrations of FP-100 over two days. Microbial profiles were examined at 24-h intervals using 16S rRNA sequencing. A ligature-induced periodontitis mouse model was employed to test FP-100 in vivo.Results FP-100 significantly reduced Fusobacterium spp. within the in vitro community (p
- Published
- 2024
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