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Exploring cultural diversity and socio-economic factors offers a holistic approach to fostering sustainable safety practices within the construction industry. This study investigates the relationship between cultural and socio-economic factors and their influence on safety practices within the construction industry, focusing specifically on Saudi Arabian construction. Employing a comparative research design, data were gathered through a questionnaire distributed among various stakeholders, including construction workers, safety officers, project managers, supervisors, and other professionals involved in construction projects. Structural equation modeling (SEM) was utilized to analyze the relationships between cultural, socio-economic, and safety practices. The findings showed significant associations of cultural and socio-economic factors with safety practices and attitudes. Specifically, positive workplace norms and values, effective communication styles, higher income levels, and better education and literacy levels were found to positively influence adherence to safety guidelines and the effectiveness of training programs. Conversely, job insecurity exhibited a negative impact on safety-related outcomes and training effectiveness. This study demonstrates the importance of fostering a positive safety culture within organizations, emphasizing leadership commitment, effective communication, and employee engagement. It also highlights the significance of addressing socio-economic factors, such as job security, income levels, and education, to promote a safer work environment and enhance safety practices. Practical implications derived from the research findings offer actionable insights for organizations to develop targeted interventions aimed at improving sustainable safety practices and training effectiveness within the construction industry in Saudi Arabia. [ABSTRACT FROM AUTHOR]

Background: Gentamicin is used for the treatment of serious gram-negative infections and has low therapeutic index. This may lead to several side effects, though therapeutic drug monitoring (TDM) is important in gentamicin therapy. Aim: To report the pharmacokinetics of gentamicin using a once-daily dosing regimen. Clinical presentation and intervention: The patient was a 78-year-old male. His weight was 78 kg and he was 1.75 m in height. He was admitted to the hospital complaining of an infected wound secondary to chronic limb ischaemia. Once-daily dosing of gentamicin (360 mg by infusion over 30 minutes) was prescribed to this patient, in combination with flucloxacillin. A gentamicin blood sample was taken every day for four days (day 1 = 1.4 mg/L, day 2 = 2.1 mg/L, day 3 = 2.1 mg/L, day 4 = 1.6 mg/L). The patient's serum creatinine was 88 μmol/L during the four days. The Hartford nomogram was used to estimate the dosage and interval for administration of gentamicin. Conclusion: The Hartford nomogram is a valid tool to monitor the once-daily dosing regimen of gentamicin. [ABSTRACT FROM AUTHOR]