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Nurses play a crucial role in the management and treatment of acne, providing education and support to patients of all ages. They are often the first point of contact in healthcare settings, allowing them to assess the severity of acne and recommend appropriate treatments. Through patient education, nurses can help individuals understand the underlying causes of acne, which include factors like hormonal changes, dietary influences, and skincare products. By empowering patients with knowledge about their condition, nurses promote adherence to treatment regimens, enhance self-care practices, and foster a positive attitude towards managing acne. In addition to education, nurses offer vital emotional support to individuals struggling with acne, which can significantly impact mental health and self-esteem. They create a safe environment for patients to express their concerns and feelings about their condition, providing reassurance and understanding. Nurses can also facilitate discussions about the psychological effects of acne, encouraging patients to seek further support when needed, such as counseling or support groups. This holistic approach not only addresses the physical aspects of acne treatment but also prioritizes the overall well-being of the patient, making nurses essential allies in the journey to clearer skin.

The anticancer activity of silver nanoparticles (AgNPs) is well known to be synthesized using green-synthesized methods, although its mechanism of action is not understood fully. Moringa oleifera leaves were used as reducing and stabilizing agents to synthesize AgNPs. Green-synthesized AgNPs were characterized using ultraviolet-visible spectroscopy, dynamic light scattering, transmission electronic microscopy, scanning electronic microscopy, Fourier transform infrared, and energy-dispersive X-ray spectroscopy analyses. The synthesized nanoparticles were then characterized by their anticancer properties by performing a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The real-time polymerase chain reaction was used to check the expression levels of the four genes (β-catenin, adenomatous polyposis coli (APC), and lipoprotein receptor-related proteins 5 and 6 (LRP5/6)). The synthesized nanoparticles were 25 nm on average and spherical in shape and aggregated form. Noteworthy cytotoxicity is how green-synthesized M. oleifera–AgNPs were observed in comparison with the M. oleifera leaf extract against a cancerous cell line. The M. oleifera–AgNPs decreased the expression of CTNNB1 and LRP6 genes, while the LRP5 gene expression increased in both cell lines. With treatment, the APC gene expression decreased in SW480 but increased in HTC116. Our results imply that AgNPs synthesized by M. oleifera extract could be an ideal strategy to combat colon cancer.

Abstract Background Rodent models may guide investigations towards identifying either environmental neuro-toxicants or drugs with neuro-therapeutic effects. This work aims to study the therapeutic effects of bee pollen on brain glutamate excitotoxicity and the impaired glutamine-glutamate- gamma amino butyric acid (GABA) circuit induced by propionic acid (PPA), a short chain fatty acid, in rat pups. Methods Twenty-four young male Western Albino rats 3–4 weeks of age, and 45–60 g body weight were enrolled in the present study. They were grouped into four equal groups: Group 1, the control received phosphate buffered saline at the same time of PPA adminstration; Group 2, received 750 mg/kg body weight divided into 3 equal daily doses and served as acute neurotoxic dose of PPA; Group 3, received 750 mg/kg body weight divided in 10 equal doses of 75 mg/kg body weight/day, and served as the sub-acute group; and Group 4, the therapeutic group, was treated with bee pollen (50 mg/kg body weight) for 30 days after acute PPA intoxication. GABA, glutamate and glutamine were measured in the brain homogenates of the four groups. Results The results showed that PPA caused multiple signs of excitotoxicity, as measured by the elevation of glutamate and the glutamate/glutamine ratio and the decrease of GABA, glutamine and the GABA/glutamate ratio. Bee pollen was effective in counteracting the neurotoxic effects of PPA to a certain extent. Conclusion In conclusion, bee pollen demonstrates ameliorating effects on glutamate excitotoxicity and the impaired glutamine-glutamate-GABA circuit as two etiological mechanisms in PPA-induced neurotoxicity.

This study investigates motivation types of Saudi and Chines EFL learners and gender role differences. I selected these two groups because they constituted the most dominant groups that study English abroad. The descriptive and correlational approaches were used to examine the participants' motivation by collecting the data through questionnaire and interviews. Twenty-five Saudi and Chinese college level English language students were selected as samples for collecting data for answering the research questions. The findings showed that both groups have extrinsic and intrinsic motivation as well integrative and instrumental motivation. The Chinese group's intrinsic motivation is stronger than the extrinsic motivation.

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Enterprises rely more and more on well-qualified and highly specialized IT professionals. Although the increasing availability of IT jobs is a good indicator for IT graduates, they nonetheless may find themselves confused about the most appropriate career for their future. In this paper, a recommendation system called CareerRec is proposed, which uses machine learning algorithms to help IT graduates select a career path based on their skills. CareerRec was trained and tested using a dataset of 2255 employees in the IT sector in Saudi Arabia. We conducted a performance comparison between five machine learning algorithms to assess their accuracy for predicting the best-suited career path among 3 classes. Our experiments demonstrate that the XGBoost algorithm outperforms other models and gives the highest accuracy (70.47%). [ABSTRACT FROM AUTHOR]

Objective: Electronic Health Records (EHRs) have become a key enabler to improving patient safety, improving healthcare quality, and increasing healthcare efficiency. Governments in various countries have moved beyond the local implementation of EHRs in different healthcare organizations to the national implementation and integration of EHRs. The Kingdom of Saudi Arabia (KSA) has lagged behind significantly in this regard, with only few hospitals have implemented the EHR. The purpose of this study is to identify barriers to the adoption of EHRs in the KSA using a systematic literature review. Methods: We searched for relevant articles using six search engines (PubMed, EBSCO Host, Web of Science, ACM, IEEE and Google Scholar). The search criteria focused on peer reviewed, empirical studies conducted in the KSA. The final set that met the inclusion criteria was twelve studies. The authors extracted, analyzed, summarized, and categorized empirical results related to EHR barriers in these studies. Results: After categorization and analysis, we identified the following twelve main barriers to EHR adoption: lack of computer experience by healthcare professionals (18%), lack of perceived usefulness by healthcare professionals (15%), lack of perceived ease of by healthcare professionals (15%), technical limitations of the software system (15%), lack of user support (9%), confidentiality concerns (9%), user resistance to change (6%), lack of quality in patients' information (3%), lack of EHR standards (3%), uncertainty about EHR vendors (3%), hospital size (3%), and hospital's level of care (3%). Conclusion: The findings of this study will be of great potential to policy makers and EHR vendors in the KSA. They can inform strategies to design systems and tailor implementation strategies toward factors that motivate adoption. A second important contribution of this study is that it provides evidence that the extant technology adoption theories like the Technology Acceptance Model (TAM) are not sufficient in explaining EHR adoption, as only 30% of identified barriers could be categorized according to TAM. There is a need for creating a new model for EHR adoption. [ABSTRACT FROM AUTHOR]

Background:  Vagal nerve stimulation (VNS) is an adjunctive therapy to pharmacologic treatment in patients with drug-resistant epilepsy. This study aimed to assess the efficacy of VNS therapy for seizure frequency reduction and improving the quality-of-life (QOL) measures in children with refractory epilepsy and to evaluate the correlation between the perspectives of families and those of the treating team., Methods:  This was a prospective cohort study conducted at Abha Maternity and Children's Hospital, Saudi Arabia, from 2018 to 2022. A total of 21 pediatric patients who completed 1 year of follow-up after VNS implantation were included. Patients were aged between 2 and 14 years, with a mean age of 8.14 ± 3.92 years; 11 (52.4%) patients were females. Family and physician assessments were collected blinded to each other using the Clinical Global Impression of Improvement (CGI-I) scores and QOL assessments to evaluate the correlation between the families' and treating team's perspectives on VNS outcomes., Results:  In this study, VNS showed significant efficacy in reducing the frequency of seizures. VNS significantly reduced the number of seizures per week from a baseline median of 35 to a median of 0.25 at the end of the follow-up period, representing a dramatic reduction of 99.3% ( p  < 0.001). The number of emergency department visits per year decreased from a baseline median of 12 to a median of 2, a reduction of 83.3% ( p  < 0.001), while the number of hospital admissions per year decreased from a baseline median of 3 to a median of 1, a 66.7% decrease ( p  < 0.001). The number of antiepileptic medications taken decreased from a median of four to three ( p  < 0.001). Notably, 28.57% of the patients achieved complete seizure freedom, and 38% exhibited significant improvement, with at least 50% reduction in seizure frequency. Importantly, none of the patients experienced an increase in seizure frequency following VNS treatment. The family and physician assessments showed varying degrees of alignment in perceptions, with "concentration" exhibiting a significant positive correlation ( r  = 0.498, p  = 0.022), indicating noteworthy agreement, whereas verbal communication did not show a substantial correlation ( r  = - 0.062, p  = 0.791), indicating a divergence of views., Conclusion:  VNS is a promising and well-tolerated therapy for individuals with intractable seizures, offering clinical benefits and potential enhancements in various aspects of QOL. The varying perceptions between family and physician assessments highlight the importance of considering multiple perspectives when evaluating treatment outcomes., Competing Interests: None declared., (Thieme. All rights reserved.)