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Bernard-Soulier syndrome (BSS) is a rare autosomal recessive condition that is defined by low platelet count and platelet dysfunction characterized by the absence or dysfunction of the  GpIb V/IX  complex on the platelet surface. It is characterized by large defective platelets and thrombocytopenia. BSS is usually presented early in life. Clinical manifestations of BSS include bleeding that affects both the skin and mucous membranes, including purpura, nasal, and gum bleeding. Also, it can present with symptoms, such as menometrorrhagia or gastrointestinal bleeding. Herein, we describe the case of a five-year-old girl with a novel variant of the  GP9  gene resulting in BSS type C, with silent clinical manifestation with the exception of a pattern of easy bruising., Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Alasmari et al.)