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Objectives: This longitudinal within subject controlled randomized observational investigation studied the impacts of three‐sided sonic‐powered toothbrush versus conventional manual toothbrush on oral health‐ and oral health‐related quality of life (OHRQoL) and assessed the relationship between personality factors and OHRQoL. Methods: A total of 96 participants (48 females and 48 males; mean age = 22.61 years, SD = 1.21) were recruited into this investigation and were randomly allocated into two groups. The participants were instructed to control oral hygiene for 1 month using either a three‐sided sonic brush (Triple Bristle, Dayton, Tennessee, USA) (sonic group) or a conventional manual toothbrush (manual group). Dental plaque was assessed via Turesky‐Modified Quigley–Hein Plaque Index (TMQHPI). Bleeding on probing (BOP) was recorded as 1 if present and zero if absent. The NEO Five‐Factor Inventory (NEO‐FFI) and Oral Health Impact Profile (OHIP‐14) were used to assess personality factors and OHRQoL, respectively. TMQHPI, BOP and OHIP were assessed at study baseline and 1 month later. Results: The TMQHPI, BOP and OHIP‐14 scores were reduced after 1 month in both groups (p < 0.05), and were more reduced among the three‐sided sonic brush users (p > 0.05). Higher neuroticism scores were associated with worse OHRQoL (p < 0.05) in both groups after 1 month. Conclusions: The three‐sided sonic‐powered toothbrush was associated with superior oral health and OHRQoL in comparison with the conventional manual toothbrush. Utilizing three‐sided sonic toothbrush, less plaque deposits and lower neuroticism scores contributed towards and predicted better OHRQoL after 1 month of oral hygiene maintenance. [ABSTRACT FROM AUTHOR]