44 results on '"Alsenani, Faisal"'
Search Results
2. Antibiotics efficacy in clinical and microbiological cure of uncomplicated urinary tract infection: a systematic review and network meta-analysis
3. Anti-Alzheimer potential of Solanum lycopersicum seeds: in vitro, in vivo, metabolomic, and computational investigations
4. Spectrofluorometric determination of ascorbic acid in the plasma matrix: Exploring correlation with autism spectrum disorder
5. Unraveling potential neuroprotective mechanisms of herbal medicine for Alzheimer’s diseases through comprehensive molecular docking analyses
6. Spectrofluorimetric determination of vitamin D in the serum of autistic and healthy children using functionalized graphene quantum dots
7. Egyptian mandarin peel oil's anti-scabies potential via downregulation-of-inflammatory/immune-cross-talk: GC–MS and PPI network studies
8. In vitro Assessment of the Antimicrobial Properties of Orthodontic Bonding Materials
9. Comparative Analysis of the Frictional Resistance of Various Archwire-Ligature Combinations in Orthodontics
10. Successful manual detorsion of testicular torsion in an elderly patient: A case report
11. Potential natural candidates in the treatment of coronavirus infections
12. Evaluation of microalgae and cyanobacteria as potential sources of antimicrobial compounds
13. Cytotoxic metabolites from Sinularia levi supported by network pharmacology
14. Transcriptome-wide analysis of Chlorella reveals auxin-induced carotenogenesis pathway in green microalgae
15. Gene expression profiling of astaxanthin and fatty acid pathways in Haematococcus pluvialis in response to different LED lighting conditions
16. A comprehensive review on phytoconstituents, bioactivities, and clinical studies on Ficus carica L. (Moraceae) and its role in human health and disease management
17. Abelmoschus eculentus Seed Extract Exhibits In Vitro and In Vivo Anti-Alzheimer’s Potential Supported by Metabolomic and Computational Investigation
18. Anti-Alzheimer Potential of a New (+)-Pinitol Glycoside Isolated from Tamarindus indica Pulp: In Vivo and In Silico Evaluations
19. Vitis vinifera leaf extract liposomal Carbopol gel preparation's potential wound healing and antibacterial benefits: in vivo, phytochemical, and computational investigation
20. The Protective and Therapeutic Anti-Alzheimer Potential of Olea europaea L. cv. Picual: An In Silico and In Vivo Study
21. Coping With Diabetes During the COVID-19 Lockdown in Saudi Arabia: Lessons Learned in the Post-pandemic Era
22. Microalgae as a Sustainable Source of Nutraceuticals
23. Metabolic profiling and biological potential of the marine sponge associated Nocardiopsis sp. UR67 along with docking studies.
24. Metabolomic profiling and cytotoxic potential of three endophytic fungi of the genera Aspergillus, Penicillium and Fusarium isolated from Nigella sativa seeds assisted with docking studies.
25. Metabolomic profiling and cytotoxic potential of three endophytic fungi of the genera Aspergillus, Penicillium and Fusarium isolated from Nigella sativa seeds assisted with docking studies
26. Anti-Inflammatory and Antioxidant Properties of Malapterurus electricus Skin Fish Methanolic Extract in Arthritic Rats: Therapeutic and Protective Effects
27. Network Pharmacological Analysis of the Red Sea Sponge Hyrtios erectus Extract to Reveal Anticancer Efficacy of Corresponding Loaded Niosomes
28. Impact of Clinical Pharmacist Intervention on Clinical Outcomes in the Critical Care Unit, Taif City, Saudi Arabia: A Retrospective Study
29. New Halogenated Compounds from Halimeda macroloba Seaweed with Potential Inhibitory Activity against Malaria
30. Metabolic profiling and biological potential of the marine sponge associated Nocardiopsis sp. UR67 along with docking studies
31. Antioxidant and Wound Healing Potential of Vitis vinifera Seeds Supported by Phytochemical Characterization and Docking Studies
32. Evaluate the Effectiveness of Outpatient Parenteral Antimicrobial Therapy (OPAT) Program in Saudi Arabia: A Retrospective Study
33. aolic profiling and biological potential of the marine sponge associated Nocardiopsis sp. UR67 along with docking studies
34. Nutraceuticals from Microalgae
35. A qualitative insight into the perceptions and COVID-19 vaccine hesitancy among Pakistani pharmacists
36. The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches
37. The Public Knowledge, Attitude, and Practice of Using Herbal Medicines in Makkah Province
38. Wound Healing Metabolites from Peters’ Elephant-Nose Fish Oil: An In Vivo Investigation Supported by In Vitro and In Silico Studies
39. Anti-Alzheimer potential of Solanum lycopersicumseeds: in vitro, in vivo, metabolomic, and computational investigations
- Abstract
Background: Solanum lycopersicum Linn.(Tomato, Family Solanaceae) is one of the fruits that are most consumed worldwide. The current research intends to emphasise the possibility of positive and therapeutic effects of S. lycopersicumseed extract (SLSE) on Alzheimer's disease's neurodegeneration effects being reversed in a study utilising rats exposed to aluminium chloride. Investigations were done on the cholinesterase and antioxidant in vitro activity of SLSE. Rats with Alzheimer's disease were given SLSE, and donepezil (500, and 10 mg/kg.b.wt., daily for six weeks, respectively) to test SLSE biological activity. Beam-balance and T-maze tests, as well as serum levels of AChE, norepinephrine, dopamine, serotonin, IL-6, glycated end product, BDNF, MDA, TAC, and GSH were assessed, accompanied with histological investigation. To impact the effectiveness of this extract, bioinformatics study was validated. Results: Crude SLSE showed in vitro DPPH scavenging and AChE inhibition activities, indicating the extract might have anti-Alzheimer potential, which was validated using an aluminium-intoxicated rat model, in vivo. In Alzheimer's rats, in vivo studies showed considerable improvements, as seen by improved beam balance, and T-maze tests and decreased serum levels of AChE, norepinephrine, dopamine, serotonin, IL-6, glycated end product, BDNF, and MDA, with increasing in TAC, and GSH levels. Brain tissue histological tests revealed a largely typical pattern of collagen fibre distribution. LC–HRESIMS metabolomic profiling of crude SLSE identified 33 compounds. Furthermore, the bioinformatics study discovered 378 targets related to the major identified compounds, of which only 133 were related to Alzheimer's and memory disorders, with APP, AChE, and PSEN2 targets which were marked as the top genes. Gene enrichment analysis identified the arachidonic acid metabolism and PPAR signalling pathway as the biological pathways enriched by all the gene sets under investigation. Conclusion: As a result, the study findings are expected to pave the way for the creation of dietary supplements for Alzheimer's disease management. Graphic abstract:
40. Ureteroscopic lithotripsy of ureteric stone using thulium fiber laser in a pregnant patient, case report
41. Transcriptome-wide analysis of auxin-induced carotenoid accumulation in Chlorella microalgae
42. Expression of concern: The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches.
43. Identification and induced biosynthesis of natural health compounds in microalgae
44. Phosphoinositide 3-Kinase Inhibitors from Gladiolus Segetum Ker-Gawl Corms Supported by Network Pharmacology.
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