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9 results on '"Altera, Anna Maria Gerarda"'

1. Booster dose of SARS-CoV-2 messenger RNA vaccines strengthens the specific immune response of patients with rheumatoid arthritis: A prospective multicenter longitudinal study

Author

Farroni, Chiara, Aiello, Alessandra, Picchianti-Diamanti, Andrea, Laganà, Bruno, Petruccioli, Elisa, Agrati, Chiara, Garbuglia, Anna Rosa, Meschi, Silvia, Lapa, Daniele, Cuzzi, Gilda, Petrone, Linda, Vanini, Valentina, Salmi, Andrea, Altera, Anna Maria Gerarda, Repele, Federica, Grassi, Germana, Bettini, Aurora, Vita, Serena, Mariano, Andrea, Damiani, Arianna, Infantino, Maria, Grossi, Valentina, Manfredi, Mariangela, Niccoli, Laura, Puro, Vincenzo, Rosa, Roberta Di, Salemi, Simonetta, Sesti, Giorgio, Scolieri, Palma, Bruzzese, Vincenzo, Benucci, Maurizio, Cantini, Fabrizio, Nicastri, Emanuele, and Goletti, Delia

Published
2022
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2. Accuracy of QuantiFERON SARS-CoV-2 research use only assay and characterization of the CD4+ and CD8+ T cell-SARS-CoV-2 response: comparison with a homemade interferon-γ release assay

Author

Aiello, Alessandra, Coppola, Andrea, Vanini, Valentina, Petrone, Linda, Cuzzi, Gilda, Salmi, Andrea, Altera, Anna Maria Gerarda, Tortorella, Carla, Gualano, Gina, Gasperini, Claudio, Scolieri, Palma, Beccacece, Alessia, Vita, Serena, Bruzzese, Vincenzo, Lorenzetti, Roberto, Palmieri, Fabrizio, Nicastri, Emanuele, and Goletti, Delia

Published
2022
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3. Dynamic Evolution of Humoral and T-Cell Specific Immune Response to COVID-19 mRNA Vaccine in Patients with Multiple Sclerosis Followed until the Booster Dose

Author

Ruggieri, Serena, primary, Aiello, Alessandra, additional, Tortorella, Carla, additional, Navarra, Assunta, additional, Vanini, Valentina, additional, Meschi, Silvia, additional, Lapa, Daniele, additional, Haggiag, Shalom, additional, Prosperini, Luca, additional, Cuzzi, Gilda, additional, Salmi, Andrea, additional, Quartuccio, Maria Esmeralda, additional, Altera, Anna Maria Gerarda, additional, Garbuglia, Anna Rosa, additional, Ascoli Bartoli, Tommaso, additional, Galgani, Simonetta, additional, Notari, Stefania, additional, Agrati, Chiara, additional, Puro, Vincenzo, additional, Nicastri, Emanuele, additional, Gasperini, Claudio, additional, and Goletti, Delia, additional

Published
2023
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4. Longitudinal characterisation of B and T-cell immune responses after the booster dose of COVID-19 mRNA-vaccine in people with multiple sclerosis using different disease-modifying therapies

Author

Aiello, Alessandra, primary, Coppola, Andrea, additional, Ruggieri, Serena, additional, Farroni, Chiara, additional, Altera, Anna Maria Gerarda, additional, Salmi, Andrea, additional, Vanini, Valentina, additional, Cuzzi, Gilda, additional, Petrone, Linda, additional, Meschi, Silvia, additional, Lapa, Daniele, additional, Bettini, Aurora, additional, Haggiag, Shalom, additional, Prosperini, Luca, additional, Galgani, Simonetta, additional, Quartuccio, Maria Esmeralda, additional, Bevilacqua, Nazario, additional, Garbuglia, Anna Rosa, additional, Agrati, Chiara, additional, Puro, Vincenzo, additional, Tortorella, Carla, additional, Gasperini, Claudio, additional, Nicastri, Emanuele, additional, and Goletti, Delia, additional

Published
2022
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5. Evaluation of the immunomodulatory effects of interleukin-10 on peripheral blood immune cells of COVID-19 patients: Implication for COVID-19 therapy

Author

Najafi-Fard, Saeid, primary, Petruccioli, Elisa, additional, Farroni, Chiara, additional, Petrone, Linda, additional, Vanini, Valentina, additional, Cuzzi, Gilda, additional, Salmi, Andrea, additional, Altera, Anna Maria Gerarda, additional, Navarra, Assunta, additional, Alonzi, Tonino, additional, Nicastri, Emanuele, additional, Palmieri, Fabrizio, additional, Gualano, Gina, additional, Carlini, Valentina, additional, Noonan, Douglas McClain, additional, Albini, Adriana, additional, and Goletti, Delia, additional

Published
2022
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6. Kinetics of the B- and T-Cell Immune Responses After 6 Months From SARS-CoV-2 mRNA Vaccination in Patients With Rheumatoid Arthritis

Author

Farroni, Chiara, primary, Picchianti-Diamanti, Andrea, additional, Aiello, Alessandra, additional, Nicastri, Emanuele, additional, Laganà, Bruno, additional, Agrati, Chiara, additional, Castilletti, Concetta, additional, Meschi, Silvia, additional, Colavita, Francesca, additional, Cuzzi, Gilda, additional, Casetti, Rita, additional, Grassi, Germana, additional, Petrone, Linda, additional, Vanini, Valentina, additional, Salmi, Andrea, additional, Repele, Federica, additional, Altera, Anna Maria Gerarda, additional, Maffongelli, Gaetano, additional, Corpolongo, Angela, additional, Salemi, Simonetta, additional, Di Rosa, Roberta, additional, Nalli, Gabriele, additional, Sesti, Giorgio, additional, Vaia, Francesco, additional, Puro, Vincenzo, additional, and Goletti, Delia, additional

Published
2022
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7. ImmunosuppressiveTherapies Differently Modulate Humoral- and T-Cell-Specific Responses to COVID-19 mRNA Vaccine in Rheumatoid Arthritis Patients

Author

Picchianti-Diamanti, Andrea, primary, Aiello, Alessandra, additional, Laganà, Bruno, additional, Agrati, Chiara, additional, Castilletti, Concetta, additional, Meschi, Silvia, additional, Farroni, Chiara, additional, Lapa, Daniele, additional, Najafi Fard, Saeid, additional, Cuzzi, Gilda, additional, Cimini, Eleonora, additional, Grassi, Germana, additional, Vanini, Valentina, additional, Di Rosa, Roberta, additional, Salemi, Simonetta, additional, Nalli, Gabriele, additional, Salmi, Andrea, additional, Repele, Federica, additional, Altera, Anna Maria Gerarda, additional, Maffongelli, Gaetano, additional, Palazzolo, Claudia, additional, Vita, Serena, additional, Leone, Sara, additional, Puro, Vincenzo, additional, Capobianchi, Maria Rosaria, additional, Ippolito, Giuseppe, additional, Nicastri, Emanuele, additional, and Goletti, Delia, additional

Published
2021
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8. Longitudinal characterisation of B and T-cell immune responses after the booster dose of COVID-19 mRNA-vaccine in people with multiple sclerosis using different disease-modifying therapies

Author

Aiello, Alessandra, Coppola, Andrea, Ruggieri, Serena, Farroni, Chiara, Altera, Anna Maria Gerarda, Salmi, Andrea, Vanini, Valentina, Cuzzi, Gilda, Petrone, Linda, Meschi, Silvia, Lapa, Daniele, Bettini, Aurora, Haggiag, Shalom, Prosperini, Luca, Galgani, Simonetta, Quartuccio, Maria Esmeralda, Bevilacqua, Nazario, Garbuglia, Anna Rosa, Agrati, Chiara, Puro, Vincenzo, Tortorella, Carla, Gasperini, Claudio, Nicastri, Emanuele, and Goletti, Delia

Abstract

BackgroundThe decline of humoral response to COVID-19 vaccine led to authorise a booster dose. Here, we characterised the kinetics of B-cell and T-cell immune responses in patients with multiple sclerosis (PwMS) after the booster dose.MethodsWe enrolled 22 PwMS and 40 healthcare workers (HCWs) after 4–6 weeks from the booster dose (T3). Thirty HCWs and 19 PwMS were also recruited 6 months (T2) after the first dose. Antibody response was measured by anti-receptor-binding domain (RBD)-IgG detection, cell-mediated response by an interferon (IFN)-γ release assay (IGRA), Th1 cytokines and T-cell memory profile by flow cytometry.ResultsBooster dose increased anti-RBD-IgG titers in fingolimod-treated, cladribine-treated and IFN-β-treated patients, but not in ocrelizumab-treated patients, although antibody titres were lower than HCWs. A higher number of fingolimod-treated patients seroconverted at T3. Differently, T-cell response evaluated by IGRA remained stable in PwMS independently of therapy. Spike-specific Th1-cytokine response was mainly CD4+T-cell-mediated, and in PwMS was significantly reduced (p<0.0001) with impaired IL-2 production compared with HCWs at T3. In PwMS, total Th1 and IFN-γ CD4+T-cell responders to spike protein were increased from T2 to T3.Compared with HCWs, PwMS presented a higher frequency of CD4+and CD8+terminally differentiated effector memory cells and of CD4+effector memory (TEM) cells, independently of the stimulus suggesting the association of this phenotype with MS status. CD4+and CD8+TEMcell frequency was further increased at T3 compared with T2.ConclusionsCOVID-19 vaccine booster strengthens humoral and Th1-cell responses and increases TEMcells in PwMS.

Published
2023
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9. Humoral- and T-Cell–Specific Immune Responses to SARS-CoV-2 mRNA Vaccination in Patients With MS Using Different Disease-Modifying Therapies

Author

Tortorella, Carla, Aiello, Alessandra, Gasperini, Claudio, Agrati, Chiara, Castilletti, Concetta, Ruggieri, Serena, Meschi, Silvia, Matusali, Giulia, Colavita, Francesca, Farroni, Chiara, Cuzzi, Gilda, Cimini, Eleonora, Tartaglia, Eleonora, Vanini, Valentina, Prosperini, Luca, Haggiag, Shalom, Galgani, Simona, Quartuccio, Maria Esmeralda, Salmi, Andrea, Repele, Federica, Altera, Anna Maria Gerarda, Cristofanelli, Flavia, D'Abramo, Alessandra, Bevilacqua, Nazario, Corpolongo, Angela, Puro, Vincenzo, Vaia, Francesco, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Nicastri, Emanuele, Goletti, Delia, Lapa, Daniele, Francalancia, Massimo, Bettini, Aurora, Gramigna, Giulia, Forbici, Federica, Gall`ı, Paola, Marani, Alessandra, Possi, Adriano, Capri, Andrea, Santoro, Annapaola, Orchi, Nicoletta, Butera, Ornella, Fard, Saeid Najafi, Petrone, Linda, and Petruccioli, Elisa

Published
2022
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