1. Impact of concomitant surgical interventions on outcomes of septal myectomy in obstructive hypertrophic cardiomyopathy.
- Author
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Altibi, Ahmed M., Sapru, Abharika, Ghanem, Fares, Zhao, Yuanzi, Alani, Ahmad, Cigarroa, Joaquin, Nazer, Babak, Song, Howard K., and Masri, Ahmad
- Abstract
Septal myectomy (SM) is offered to symptomatic patients with obstructive hypertrophic cardiomyopathy (oHCM) despite medical therapy. Frequently, patients undergo concomitant planned or ad-hoc mitral valve replacement (MVR), aortic valve replacement (SAVR), or coronary artery bypass grafting (CABG). We sought to assess characteristics and outcomes of patients with oHCM undergoing concomitant surgical interventions at the time of SM. The National Readmission Databases were used to identify all SM admissions in the United States (2010–2019). Patients undergoing SM were stratified into: isolated SM (±MV repair), SM + CABG only, SM + MVR, SM + SAVR, and SM + MVR + SAVR. Primary outcomes were in-hospital mortality, in-hospital adverse events, and 30-day readmission. 12,063 encounters of patients who underwent SM were included (56.1% isolated SM, 9.0% SM + CABG only, 17.5% SM + MVR, 13.1% SM + SAVR, and 4.3% SM + MVR + SAVR). Patients who underwent isolated SM were younger (54.3 vs. 67.1 years-old, p < 0.01) and had lower overall comorbidity burden. In-hospital mortality was lowest in isolated SM, followed by CABG only, SM + SAVR, SM + MVR, and SM + SAVR+MVR groups (2.3% vs. 3.7% vs. 5.3% vs. 6.7% vs. 13.7%, p < 0.01), respectively. SM with combined surgical interventions was associated with higher adverse in-hospital events (24.3% vs. 11.1%, p < 0.01) and 30-day readmissions (16.9% vs. 10.4%, p < 0.01). MV repair performed concomitantly with SM was not associated with increased in-hospital mortality (3.9% vs. 3.4%, p = 0.72; aOR 0.99; 95% CI: 0.54–1.80, p = 0.97]) or adverse clinical events. In SM for oHCM, patients undergoing concomitant surgical interventions were characteristically distinct. Aside from MV repair, concomitant interventions were associated with worse in-hospital death, adverse in-hospital events, and 30-day readmission. Central Illustration : Septal myectomy (SM) with or without concomitant surgical interventions between 2010–2019 (n=12,036). Isolated SM refers to myectomy without coronary artery bypass graft (CABG), surgical aortic valve replacement (SAVR), or mitral valve replacement (MVR). CABG group refers to SM with CABG, but without SAVR or MVR. [Display omitted] • Key Question: In patients with obstructive hypertrophic cardiomyopathy (oHCM) undergoing septal myectomy (SM), how are the outcomes of SM differ in those with concomitant surgical interventions (coronary artery bypass or valve replacement surgery) as compared to isolates SM? • Key Finding: In a nationwide cohort of 12,063 patients undergoing SM, SM with concomitant surgical interventions had higher in-hospital mortality (6.2% vs. 2.3%, p < 0.01), in-hospital adverse events (24.3% vs. 11.1%, p < 0.01), and 30-day readmission (16.9% vs. 10.4%, p < 0.01) compared to isolated SM. • Take Home Message: In patients undergoing SM for oHCM, concomitant surgical interventions at the time of SM were associated with worse in-hospital death, adverse in-hospital events, and 30-day readmission. Studies focusing on isolated SM underestimate complications rate of all patients with oHCM undergoing SM. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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