7 results on '"Alzamora, M. Teresa"'
Search Results
2. Genetic Variants at the 9p21.3 Locus Are Associated with Risk for Non-Compressible Artery Disease: Results from the ARTPER Study.
- Author
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Via, Marc, Pera, Guillem, Forés, Rosa, Costa-Garrido, Anna, Heras, Antonio, Baena-Díez, José Miguel, Pedrosa, Edurne, Clemente, Inmaculada C., Lamonja-Vicente, Noemí, Mataró, Maria, Torán-Montserrat, Pere, and Alzamora, M. Teresa
- Subjects
ARTERIAL diseases ,GENETIC variation ,PERIPHERAL vascular diseases ,ANKLE brachial index ,SYMPTOMS - Abstract
Peripheral artery disease (PAD) and non-compressible artery disease (NCAD) constitute predictors of subclinical atherosclerosis easily assessed through the ankle brachial index (ABI). Although both diseases show substantial genetic influences, few genetic association studies have focused on the ABI and PAD, and none have focused on NCAD. To overcome these limitations, we assessed the role of several candidate genes on the ABI, both in its continuous distribution and in the clinical manifestations associated to its extreme values: PAD and NCAD. We examined 13 candidate genomic regions in 1606 participants from the ARTPER study, a prospective population-based cohort, with the ABI assessed through ultrasonography. Association analyses were conducted independently for individuals with PAD (ABI < 0.9) or with NCAD (ABI > 1.4) vs. healthy participants. After including potential covariates and correction for multiple testing, minor alleles in the genetic markers rs10757278 and rs1333049, both in the 9p21.3 region, were significantly associated with a decreased risk of NCAD. Associations with the ABI showed limited support to these results. No significant associations were detected for PAD. The locus 9p21.3 constitutes the first genetic locus associated with NCAD, an assessment of subclinical atherosclerosis feasible for implementation in primary healthcare settings that has been systematically neglected from genetic studies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Relationship between Retinal Microvasculature, Cardiovascular Risk and Silent Brain Infarction in Hypertensive Patients
- Author
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Forés Raurell, Rosa, Manresa, Josep M., López-Lifante, Victor M., Heras, Antonio, Delgado Martínez, María Pilar, Vázquez, Xose, Ruiz, Susana, Alzamora, M. Teresa, Torán Montserrat, Pere, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Forés R, Heras A] Unitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), 08303 Mataró, Spain. Riu Nord-Riu Sud Primary Healthcare Centre, Santa Coloma de Gramenet, Gerència d’Àmbit d’Atenció Primària Metropolitana Nord, Institut Català de la Salut, 08921 Barcelona, Spain. [Manresa JM] Unitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), 08303 Mataró, Spain. [López-Lifante VM] Unitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), 08303 Mataró, Spain. Palau Healthcare Centre, Palau-Solità Plegamans, Gerència d’Àmbit d’Atenció Primària Metropolitana Nord, Institut Català de la Salut, 08124 Barcelona, Spain. [Delgado P] Laboratori de Recerca Neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Unitat de Demència, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Vázquez X] Hospital Municipal de Badalona, Badalona Serveis Assistencials, Secció d’Oftalmologia, Badalona, 08911 Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
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cardiovascular risk ,medicine.medical_specialty ,Hipertensió - Complicacions ,Medicine (General) ,hypertension ,Clinical Biochemistry ,Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Brain Ischemia::Brain Infarction [DISEASES] ,Primary care ,Cardiovascular Diseases::Vascular Diseases::Hypertension [DISEASES] ,enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::isquemia cerebral::infarto encefálico [ENFERMEDADES] ,retinal microvasculature ,030204 cardiovascular system & hematology ,Retinography ,Logistic regression ,Cardiovascular System::Blood Vessels::Retinal Vessels [ANATOMY] ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores] ,0302 clinical medicine ,R5-920 ,Internal medicine ,medicine ,sistema cardiovascular::vasos sanguíneos::vasos retinianos [ANATOMÍA] ,Retina - Vasos sanguinis ,Retinal microvasculature ,Silent brain infarction ,medicine.diagnostic_test ,business.industry ,Retinal ,Magnetic resonance imaging ,Odds ratio ,Cardiovascular risk ,Risk evaluation ,silent brain infarction ,chemistry ,Brain infarction ,Hypertension ,Cardiology ,business ,enfermedades cardiovasculares::enfermedades vasculares::hipertensión [ENFERMEDADES] ,030217 neurology & neurosurgery ,Malalties cerebrovasculars ,Other subheadings::Other subheadings::/complications [Other subheadings] - Abstract
Objective: The aims of this study are to analyze the role of artery-vein ratio AVR assessment using VesselMap 2 software (Imedos Systems) and cardiovascular risk evaluation by means of REGICOR in the prediction of silent brain infarction (SBI) in middle-age hypertensive patients from the ISSYS study. Material and Methods: A cross-sectional study with 695 patients with hypertension aged 50 to 70 years who participated in the project Investigating Silent Strokes in HYpertensives: a Magnetic Resonance Imaging Study (ISSYS), was conducted in two Primary Care Centres of Barcelona. Participants agreed to a retinography and an MRI to detect silent brain infarction (SBI). The IMEDOS software was used for the semiautomatic caliber measurement of retinal arteries and veins, and the AVR was considered abnormal when <, 0.66. The REGICOR score was calculated for all patients. Results: Multivariate logistic regression analysis was used to evaluate the impact of AVR and REGICOR scores on SBI. The OR (odds ratio) for a high REGICOR score and an abnormal AVR were 3.16 and 4.45, respectively. When analysing the interaction of both factors, the OR of an abnormal AVR and moderate REGICOR score was 3.27, whereas with a high REGICOR score it reached 13.07. Conclusions: The measurement of AVR in patients with hypertension and with a high REGICOR score can contribute to the detection of silent brain infarction.
- Published
- 2021
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4. Fiabilidad de la retinografía para la detección de retinopatía hipertensiva en Atención Primaria
- Author
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Manresa, Josep M., primary, Forés, Rosa, additional, Vázquez, Xosé, additional, Alzamora, M. Teresa, additional, Heras, Antonio, additional, Delgado, Pilar, additional, and Torán, Pere, additional
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- 2020
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5. Low, borderline and normal ankle-brachial index as a predictor of incidents outcomes in the Mediterranean based-population ARTPER cohort after 9 years follow-up
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Alzamora, M. Teresa, primary, Forés, Rosa, additional, Pera, Guillem, additional, Baena-Díez, José Miguel, additional, Valverde, Marta, additional, and Torán, Pere, additional
- Published
- 2019
- Full Text
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6. Caminar més d'una hora al dia redueix a la meitat el risc de patir arteriopatia perifèrica
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Ruiz Comellas, Anna, Alzamora, M. Teresa, Forés Raurell, Rosa, Pera, Guillem, Heras, Antonio, Torán Monserrat, Pere, Baena Díez, José Miguel, and Mundet-Tudurí, Xavier
- Abstract
L'arteriopatia perifèrica és el conjunt de signes i símptomes que es manifesten quan es produeix una disminució del flux sanguini a una extremitat, i és un potent predictor d'episodis cardiovasculars i cerebrovasculars. Un estudi realitzat amb 3.207 persones majors de 49 anys de 28 centres de l'àrea metropolitana de Barcelona i el Barcelonès Nord ha demostrat que caminar una hora al dia redueix a la meitat el risc de patir aquesta malaltia i que l'activitat física en pacients ja malalts s'associa a un menor empitjorament. La arteriopatía periférica es el conjunto de signos y síntomas que se manifiestan cuando se produce una disminución del flujo sanguíneo en una extremidad, y es un potente predictor de episodios cardiovasculares y cerebrovasculares. Un estudio realizado con 3.207 personas mayores de 49 años de 28 centros del área metropolitana de Barcelona y el Barcelonés Norte ha demostrado que caminar una hora al día reduce a la mitad el riesgo de padecer esta enfermedad y que la actividad física en pacientes ya enfermos se asocia a un menor empeoramiento.
- Published
- 2016
7. [Reliability of retinography for the detection of hypertensive retinopathy in Primary Care].
- Author
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Manresa JM, Forés R, Vázquez X, Alzamora MT, Heras A, Delgado P, and Torán P
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- Adult, Aged, Cross-Sectional Studies, Diagnostic Techniques, Ophthalmological, Humans, Middle Aged, Primary Health Care, Reproducibility of Results, Hypertensive Retinopathy diagnostic imaging
- Abstract
Objective: High blood pressure is one of the most prevalent diseases in general adult population. Its importance lies in the complications it causes in target organs such as kidney, heart, brain and eye. The aim of this work is to evaluate the agreement in the evaluation and interpretation of retinographies of hypertensive patients by family doctors and ophthalmologists., Material and Methods: This is a multicentric cross-sectional study in which 976 hypertensive patients from 50 to 70 years old were involved. They were participants of the «Investigating Silent Strokes in Hypertensives: a Magnetic Resonance Imaging Study» (ISSYS project) carried out in primary care centers of Barcelona and who agreed to undergo retinography. Six family physicians and 2 ophthalmologists evaluated the presence of retinal lesions through the Keith-Wagener-Barker criteria., Results: The inter/intra-observer Kappa concordance of the evaluations was analyzed. The evaluation of the retinographies under the usual conditions of clinical practice obtained a high subjective component with slight and fair intra-observer concordance values in the Keith-Wagener-Barker criteria. Only the assessment of the microaneurysms showed a moderate concordance and the ratio artery/vein was the worst concordant., Conclusions: The evaluation of the retinographies in habitual conditions of clinical practice has a high subjective component that is reflected in slight and fair inter-intraobserver concordance values. The use of objective reading systems in the assessment of retinography in hypertensive patients would be useful., (Copyright © 2019 The Authors. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2020
- Full Text
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