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4. International Experience of Implementing Cognitive Remediation for People With Psychotic Disorders.

Author

Dark, Frances L, Amado, Isabelle, Erlich, Matthew D, and Ikezawa, Satoru

Abstract

Background Cognitive remediation (CR) is an effective therapy for the cognitive impact of mental illness, especially schizophrenia. Global efforts are being made to implement CR into routine mental health services with the aim of improving functional outcomes for the population of people recovering from mental illness. Implementation and dissemination of CR in heterogeneous settings require knowledge gleaned from formal implementation research and pragmatic experiential learning. This article describes cross-cultural approaches to CR implementation, focusing on initiatives in France, the United States, Australia, and Japan. Method Key leaders in the implementation of CR in France, the United States, Australia, and Japan were asked to describe the implementation and dissemination process in their settings with respect to the categories of context, implementation, outcomes, facilitators, and barriers. Results All 4 sites noted the role of collaboration to leverage the implementation of CR into mental health rehabilitation services. In France, high-level, government organizational backing enhanced the dissemination of CR. Academic and clinical service partnerships in the United States facilitated the dissemination of programs. The advocacy from service users, families, and carers can aid implementation. The support from international experts in the field can assist in initiating programs but maintenance and dissemination require ongoing training and supervision of staff. Conclusions CR is an effective intervention for the cognitive impact of schizophrenia. Programs can be implemented in diverse settings globally. Adaptations of CR centering upon the core components of effective CR therapy enhance outcomes and enable programs to integrate into diverse settings. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Effect of an adapted physical activity program on stress, anxiety, depression in patients with schizophrenia: study protocol of a randomized-controlled trial.

Author

Venet-Kelma, Lucie, Morvan, Yannick, Romain, Ahmed Jérôme, Mendy, Mauricette, Meslier, Marjorie, Thoisy, Isabelle, Mulin, Emmanuel, Chirio-Espitalier, Marion, Dadi, Ghita, Moualla, Mona, Amado, Isabelle, and Kern, Laurence

Subjects
PHYSICAL activity, MENTAL depression, ANXIETY, PEOPLE with schizophrenia, PHYSICAL fitness
Abstract

Physical activity (PA) is recommended to optimize well-functioning in people with schizophrenia. PA has been found to improve quality of life, general symptomatology, depression, anxiety and stress symptoms, global and social functioning. In PA research, most of the interventions are based on one-on-one interventions but there is poor information about group-based PA interventions. Using a randomized controlled, clinician-blinded trial, subjects are randomized into two arms: the PA group or control group. Our first objective is about to evaluate the effects of a multimodal 6 week collective PA intervention on depression, anxiety, and stress symptoms in people with schizophrenia. Our second objective is about to evaluate these effects on secondary outcomes especially smoking, well-being, physical fitness and on care utilization. All participants are evaluated before and after the 6 week intervention period, and only participants in the PA group are called in a follow-up interview 3 and 6 months after the intervention. Trial registration Individual Protection Committee of Ile-de-France II, n ID RCB: 2018- A00583-52. Registered on 8 April 2018. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Eye Movements in Psychiatry

Author

Smyrnis, Nikolaos, Amado, Isabelle, Krebs, Marie-Odile, Sweeney, John A., Reuter, Martin, Series Editor, Montag, Christian, Series Editor, Klein, Christoph, editor, and Ettinger, Ulrich, editor

Published
2019
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9. ClaCoS: Presentation of a functional evaluation battery of social cognition in adult psychiatry

Author

Brénugat, Lindsay, additional, Boulenger, Hugues, additional, Danset-Alexandre, Charlotte, additional, Peyroux, Elodie, additional, Prost, Zelda, additional, Morel-Kohlmeyer, Shasha, additional, Thillay, Alix, additional, Carteau-Martin, Isabelle, additional, Gaudelus, Baptiste, additional, Graux, Jérôme, additional, Plasse, Julien, additional, Houy-Durand, Emmanuelle, additional, Franck, Nicolas, additional, Bonnet-Brilhault, Frédérique, additional, Krebs, Marie-Odile, additional, and Amado, Isabelle, additional

Published
2023
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12. A tablet-based quantitative assessment of manual dexterity for detection of early psychosis

Author

Le Boterff, Quentin, primary, Rabah, Ayah, additional, Carment, Loïc, additional, Bendjemaa, Narjes, additional, Térémetz, Maxime, additional, Alouit, Anaëlle, additional, Levy, Agnes, additional, Tanguy, Guillaume, additional, Morin, Valentine, additional, Amado, Isabelle, additional, Cuenca, Macarena, additional, Turc, Guillaume, additional, Maier, Marc A., additional, Krebs, Marie-Odile, additional, and Lindberg, Påvel G., additional

Published
2023
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24. Auteurs

Author

Abdel-Baki, Amal, primary, Amado, Isabelle, additional, Arfeuillère, Sophie, additional, Arnaud, Ingrid, additional, Arthur, Maïté, additional, Babinet, Marie-Noëlle, additional, Bazin, Nadine, additional, Bellier-Teichmann, Tanja, additional, Bismuth, Corinne, additional, Blain-Pierre, Fabienne, additional, Bloch, Pascal, additional, Bogey, Alice, additional, Bonilla-Guerrero, Julien, additional, Bonsack, Charles, additional, Borrel, Béatrice, additional, Boulon, Yann, additional, Bourlier, Emmanuelle, additional, Bralet, Marie-Cécile, additional, Brana, Armando, additional, Brénugat-Herné, Lindsay, additional, Brousse, Georges, additional, Brunet, Éric, additional, Bulzacka, Eva, additional, Cady, Florian, additional, Callot, Jérémy, additional, Caria, Aude, additional, Cellard, Caroline, additional, Cervello, Sophie, additional, Chambon, Valérian, additional, Charrier, Philippe, additional, Chatelard, Fabienne, additional, Conus, Philippe, additional, Corbière, Marc, additional, Danset-Alexandre, Charlotte, additional, Deegan, Patricia, additional, Delourme, Gwenaelle, additional, Dematteis, Maurice, additional, Demily, Caroline, additional, Destaillats, Jean-Marc, additional, Duboc, Chloé, additional, Dubreucq, Julien, additional, Dubrulle, Aurélie, additional, Dupuis, Marie, additional, Durand, Bernard, additional, Ensenlaz, Xavier, additional, Faraldo, Mégane, additional, Farhat, Sarah-Lise, additional, Favre, Émilie, additional, Favrod, Jérôme, additional, Franck, Nicolas, additional, François, Guillaume, additional, Frankhauser, Adeline, additional, Fredericks, Jennifer, additional, Frobert, Laurent, additional, Fulachier, Delphine, additional, Gabayet, Franck, additional, Gaudelus, Baptiste, additional, Gautier, Corinne, additional, Gayton, Roger, additional, Giordana, Jean-Yves, additional, Baro, Élisabeth Giraud, additional, Gobbo, Julien, additional, Gozlan, Guy, additional, Greacen, Tim, additional, Gremaud, Katya, additional, Grivet, Isabelle, additional, Guy, Cyrielle, additional, Germaneau, Ghina Harika, additional, Hochard, Christophe, additional, Hodé, Yann, additional, Ismailaj, Alban, additional, Jaafari, Nematollah, additional, Jobert, Éliane, additional, Jossserand, Anne-Claire, additional, Jouet, Emmanuelle, additional, Kaliuzhna, Mariia, additional, Khazaal, Yasser, additional, Klein, Rémy, additional, Koubichkine, Alexandra, additional, Kulsa, Mila Kirstie, additional, Lagasse, Stéphanie, additional, Lama-Lama, Pablo, additional, Lambert, Thierry, additional, Lançon, Christophe, additional, Launay, Corinne, additional, Lecardeur, Laurent, additional, Le Cardinal, Patrick, additional, Lecomte, Tania, additional, Leguay, Denis, additional, Leignier, Sylvain, additional, Lindenmayer, Jean-Pierre, additional, Loubières, Céline, additional, Lucas, Thierry, additional, Maillebuau, Mathilde, additional, Malangin, Brigitte, additional, Marsili, Massimo, additional, Martin, Brice, additional, Martin, Juliette, additional, Massoubre, Catherine, additional, Maugiron, Philippe, additional, Medalia, Alice, additional, Melis, Fanny, additional, Meunier-Cussac, Sophie, additional, Morandi, Stéphane, additional, Morin, Laurent, additional, Ngakui, Anne, additional, Nguyen, Alexandra, additional, Oker, Ali, additional, Orens, Sandrine, additional, Pachoud, Bernard, additional, Passerieux, Christine, additional, Pellet, Jacques, additional, Pellet, Joanie, additional, Penn, David, additional, Pennel, Lucie, additional, Périer, Claire-Cécile, additional, Petitjean, François, additional, Peyroux, Élodie, additional, de Pierrefeu, Inès, additional, Planas, Pedro, additional, Plane, Morgane, additional, Pomini, Valentino, additional, Pousthomis, Malgorzata, additional, Prouteau, Antoinette, additional, Quilès, Clélia, additional, Raffard, Stéphane, additional, Rebelle, Sandrine, additional, Reeder, Clare, additional, Regnier, Jennifer, additional, Rengade, Charles-Édouard, additional, Revil, Katia, additional, Ridders, Jean-François, additional, Rigaut, Bérangère, additional, Rivet, Amandine, additional, R-Mercier, Alexandra, additional, Rochet, Cécile, additional, Roelandt, Jean-Luc, additional, Roussel, Céline, additional, Roux, Paul, additional, Salas-Toquero, Caroline, additional, Schoendorff, Marianne, additional, Staedel, Bérénice, additional, Thibaudeau, Élisabeth, additional, Todd, Aurélia, additional, Todoroff, Floriane, additional, Van der Henst, Jean-Baptiste, additional, Vanzetti, Marie, additional, Verdoux, Hélène, additional, Vianin, Pascal, additional, Vidon, Gilles, additional, Willard, Dominique, additional, Wykes, Til, additional, and Younès, Nadia, additional

Published
2018
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29. Psychiatric symptoms and mortality in older adults with major psychiatric disorders: results from a multicenter study.

Author

Chene, Margaux, Sánchez-Rico, Marina, Blanco, Carlos, De Raykeer, Rachel Pascal, Hanon, Cécile, Vandel, Pierre, Limosin, Frédéric, Hoertel, Nicolas, CSA Study group, Adès, Jean, Alezrah, Charles, Amado, Isabelle, Amar, Gilles, Andréi, Ovidiu, Arbault, Denis, Archambault, Georges, Aurifeuille, Gilles, Barrière, Sarah, Béra-Potelle, Céline, and Blumenstock, Yvonne

Subjects
OLDER people, MENTAL illness, PSYCHIATRIC rating scales, MENTAL depression
Abstract

Prior research suggests that certain psychiatric symptoms could be associated with increased risk of death. However, it remains unclear whether this association could rely on all or specific symptoms. In this report, we used data from a multicenter 5-year prospective study (N = 641) of older adults with an ICD-10 diagnosis of schizophrenia, bipolar disorder or major depressive disorder, recruited from French community psychiatric departments. We used a latent variable approach to disentangle the effects shared by all psychiatric symptoms (i.e., general psychopathology factor) and those specific to individual psychiatric symptoms, while adjusting for sociodemographic and clinical factors. Psychiatric symptoms were assessed face-to-face by psychiatrists trained to semi-structured interviews using the Brief Psychiatric Rating Scale (BPRS). Among older adults with major psychiatric disorders, we found that all psychiatric symptoms were associated with increased mortality, and that their effect on the 5-year mortality were exerted mostly through a general psychopathology dimension (β = 0.13, SE = 0.05, p < 0.05). No BPRS item or lower order factor had a significant effect on mortality beyond and above the effect of the general psychopathology factor. Greater number of medical conditions, older age, male sex, and being hospitalized or institutionalized at baseline were significantly associated with this risk beyond the effect of the general psychopathology factor. Since psychiatric symptoms may affect mortality mainly through a general psychopathology dimension, biological and psychological mechanisms underlying this dimension should be considered as promising targets for interventions to decrease excess mortality of older individuals with psychiatric disorders. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Specific vs general cognitive remediation for executive functioning in schizophrenia: A multicenter randomized trial

Author

Franck, Nicolas, Duboc, Chloé, Sundby, Charlotte, Amado, Isabelle, Wykes, Til, Demily, Caroline, Launay, Corinne, Le Roy, Vincent, Bloch, Pascal, Willard, Dominique, Todd, Aurélia, Petitjean, François, Foullu, Sandrine, Briant, Patrick, Grillon, Marie-Laure, Deppen, Patricia, Verdoux, Hélène, Bralet, Marie-Cécile, Januel, Dominique, Riche, Benjamin, Roy, Pascal, and Vianin, Pascal

Published
2013
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34. Influence of polygenic risk scores for schizophrenia and resilience on the cognition of individuals at-risk for psychosis

Author

He, Qin, Jantac Mam-Lam-Fook, Célia, Chaignaud, Julie, Danset-Alexandre, Charlotte, Iftimovici, Anton, Gradels Hauguel, Johanna, Houle, Gabrielle, Liao, Calwing, Amado, Isabelle, Bourgin, Julie, Daban-Huard, Claire, Magaud, Emilie, Plaze, Marion, Rivollier, Fabrice, Dion, Patrick, Rouleau, Guy, Kebir, Oussama, Krebs, Marie-Odile, Chaumette, Boris, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and ANR-17-CE37-0003,EPI_young,Dysrégulation de l'épigenome en lien avec l'usage de substances et santé mentale des jeunes(2017)

Subjects
Psychosis, Trail Making Test, Neurosciences. Biological psychiatry. Neuropsychiatry, Neuropsychological Tests, behavioral disciplines and activities, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Cognition, Wisconsin Card Sorting Test, Risk Factors, mental disorders, medicine, Verbal fluency test, Humans, Biological Psychiatry, 030304 developmental biology, 0303 health sciences, Intelligence quotient, Comparative genomics, Wechsler Adult Intelligence Scale, medicine.disease, Psychiatry and Mental health, Psychotic Disorders, Schizophrenia, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, sense organs, Psychology, Neurocognitive, 030217 neurology & neurosurgery, RC321-571, Clinical psychology
Abstract

Cognitive impairment is a core feature of schizophrenia which precedes the onset of full psychotic symptoms, even in the ultra-high-risk stage (UHR). Polygenic risk scores (PRS) can be computed for many psychiatric disorders and phenotyping traits, including scores for resilience. We explored the correlations between several PRS and neurocognition in UHR individuals. We included 107 UHR individuals; 29.9% of them converted to psychosis (UHR-C) while 57.0% did not (UHR-NC) during the 1-year follow-up. Cognitive performances were assessed with the Wechsler Adult Intelligence Scale estimating the Intelligence Quotient (IQ), the Trail Making Test, the verbal fluency, the Stroop test, and the Wisconsin card sorting test. Linear regression models were used to test their association with the PRS for schizophrenia, bipolar disorder, major depression, ADHD, cross-disorders, cognitive performance, intelligence, education attainment, and resilience to schizophrenia. UHR-C had a lower IQ than UHR-NC. The PRS for schizophrenia negatively correlated with IQ, while the PRS for cognitive performance and for resilience positively correlated with IQ. PRS for schizophrenia showed a significant correlation with working memory and processing speed indices. PRS for schizophrenia showed a higher effect on IQ in UHR-NC, and UHR-NC with high PRS for schizophrenia had a similar IQ as UHR-C. Conversely, UHR-C with a high PRS for resilience performed as well as UHR-NC. Our findings suggest that cognitive deficits may predate the onset of psychosis. The genetic architecture of schizophrenia seems to impacts the cognition in UHR-NC. Cognition is also mediated by PRS for resilience.

Published
2021

36. When Alterations in Social Cognition Meet Subjective Complaints in Autism Spectrum Disorder: Evaluation With the 'ClaCoS' Battery

Author

Morel-Kohlmeyer, Shasha, Thillay, Alix, Roux, Sylvie, Amado, Isabelle, Brenugat, Lindsay, Carteau-Martin, Isabelle, Danset-Alexandre, Charlotte, Gaudelus, Baptiste, Graux, Jérôme, Peyroux, Elodie, Prost, Zelda, Krebs, Marie-Odile, Franck, Nicolas, Bonnet-Brilhault, Frédérique, and Houy-Durand, Emmanuelle

Subjects
Psychiatry, Autism Spectrum Disorder, subjective complaints, assessment, adults, social cognition, Original Research
Abstract

Background: Deficit in social communication is a core feature in Autism Spectrum Disorder but remains poorly assessed in classical clinical practice, especially in adult populations. This gap between needs and practice is partly due to a lack of standardized evaluation tools. The multicentric Research group in psychiatry GDR3557 (Institut de Psychiatrie) developed a new battery for social cognitive evaluation named “ClaCoS,” which allows testing the main components of social cognition: Emotion Recognition, Theory of Mind, Attributional Style, and Social Perception and Knowledge. It further provides an assessment of subjective complaints in social cognition. Methods: We compared the social cognition abilities of 45 adults with Autism Spectrum Disorder without intellectual disability and 45 neurotypically developed volunteers using the “ClaCoS” battery, in order to determine its relevance in the evaluation of social cognition impairments in autism. A correlational approach allowed us to test the links between subjective complaints and objectively measured impairments for the different components of social cognition. Results: As expected, the Autism Spectrum Disorder group showed deficits in all four components of social cognition. Moreover, they reported greater subjective complaints than controls regarding their social abilities, correlated to the neuropsychological assessments. Conclusion: The “ClaCoS” battery is an interesting tool allowing to assess social impairments in autism and to specify the altered components, for a better adjustment of tailored social cognition training programs. Our results further suggest that people with Autism Spectrum Disorder have a good social cognitive insight, i.e., awareness into social cognitive functioning, and may thus benefit from social cognitive training tools.

Published
2021

41. Predictive saccades are impaired in biological nonpsychotic siblings of schizophrenia patients

Author

Amado, Isabelle, Landgraf, Steffen, Bourdel, Marie-Chantal, Leonardi, Sabinien, and Krebs, Marie-Odile

Subjects
Schizophrenics -- Family, Brothers and sisters -- Psychological aspects, Eye -- Movements, Eye -- Medical examination
Abstract

Objective: Although impairments in predictive saccades have been reported in patients with schizophrenia, this has never been explored in their biological relatives. We examined predictive saccades in age- and sex-matched [...]

Published
2008

44. Neural noise and cortical inhibition in schizophrenia

Author

Carment, Loïc, primary, Dupin, Lucile, additional, Guedj, Laura, additional, Térémetz, Maxime, additional, Cuenca, Macarena, additional, Krebs, Marie-Odile, additional, Amado, Isabelle, additional, Maier, Marc A., additional, and Lindberg, Påvel G., additional

Published
2020
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45. Employment, Studies and Feelings: Two to Nine Years After a Personalized Program of Cognitive Remediation in Psychiatric Patients

Author

Amado, Isabelle, primary, Moualla, Mona, additional, Jouve, Julia, additional, Brénugat-Herné, Lindsay, additional, Attali, David, additional, Willard, Dominique, additional, Rigaut, Bérangère, additional, Malangin, Brigitte, additional, Kern, Laurence, additional, Meyniel, Clementine, additional, Gaillard, Raphaël, additional, Plaze, Marion, additional, Perquier, Florence, additional, and Yannick, Morvan, additional

Published
2020
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48. A Transnosographic Self-Assessment of Social Cognitive Impairments (ACSO): First Data

Author

Graux, Jérôme, primary, Thillay, Alix, additional, Morlec, Vivien, additional, Sarron, Pierre-Yves, additional, Roux, Sylvie, additional, Gaudelus, Baptiste, additional, Prost, Zelda, additional, Brénugat-Herné, Lindsay, additional, Amado, Isabelle, additional, Morel-Kohlmeyer, Shasha, additional, Houy-Durand, Emmanuelle, additional, Franck, Nicolas, additional, Carteau-Martin, Isabelle, additional, Danset-Alexandre, Charlotte, additional, and Peyroux, Elodie, additional

Published
2019
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