11 results on '"Amanor I"'
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2. Disease Pandemics in Africa and Food Security: An Introduction
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Baffour-Awuah, E., Amanor, I. N., Sarpong, N. Y. S., Aigbavboa, Clinton, editor, Mojekwu, Joseph N., editor, Thwala, Wellington Didibhuku, editor, Atepor, Lawrence, editor, Adinyira, Emmanuel, editor, Nani, Gabriel, editor, and Bamfo-Agyei, Emmanuel, editor
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- 2023
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3. Post-harvest Losses of Coconut in Abura/asebu/kwamankese District, Central Region, Ghana
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Baffour-Awuah, E., Sarpong, N. Y. S., Amanor, I. N., Aigbavboa, Clinton, editor, Mojekwu, Joseph N., editor, Thwala, Wellington Didibhuku, editor, Atepor, Lawrence, editor, Adinyira, Emmanuel, editor, Nani, Gabriel, editor, and Bamfo-Agyei, Emmanuel, editor
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- 2023
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4. Determination of Overall Coefficient of Heat Transfer of Building Wall Envelopes
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Baffour-Awuah, E., Sarpong, N. Y. S., Amanor, I. N., Bentum, E., Aigbavboa, Clinton, editor, Mojekwu, Joseph N., editor, Thwala, Wellington Didibhuku, editor, Atepor, Lawrence, editor, Adinyira, Emmanuel, editor, Nani, Gabriel, editor, and Bamfo-Agyei, Emmanuel, editor
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- 2023
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5. Optimization of Solar and Hybrid Electric Tricycle Design Features Based on Stakeholders’ Requirements
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Anane-Fenin, K., Agbesi, W. E. K., Sarpong, N. Y. S., Ossei-Bremang, R. N., Oppon, C. E. O., Appiah, F. K., Amanor, I. N., Garriba, S., Boakye, J., Akwada, D. R., Cavas-Martínez, Francisco, Editorial Board Member, Chaari, Fakher, Series Editor, di Mare, Francesca, Editorial Board Member, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Editorial Board Member, Ivanov, Vitalii, Series Editor, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Narasimhan, N. Lakshmi, editor, Bourouis, Mahmoud, editor, and Raghavan, Vasudevan, editor
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- 2023
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6. Optimization of Solar and Hybrid Electric Tricycle Design Features Based on Stakeholders’ Requirements
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Anane-Fenin, K., primary, Agbesi, W. E. K., additional, Sarpong, N. Y. S., additional, Ossei-Bremang, R. N., additional, Oppon, C. E. O., additional, Appiah, F. K., additional, Amanor, I. N., additional, Garriba, S., additional, Boakye, J., additional, and Akwada, D. R., additional
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- 2022
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7. Assessment of Tractor Maintenance Practices of Tractor Operators at Ejura, Ghana
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Aikins, K. A., primary, Afriyie, J. K., additional, Amanor, I. N., additional, Ackah, S. M., additional, and Bobobee, E. Y. H., additional
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- 2016
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8. A loop-mediated isothermal amplification test for yaws: a multi-country diagnostic accuracy evaluation.
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Handley BL, González-Beiras C, Tchatchouang S, Hugues KA, Basing LA, Sylla A, Kouamé-Sina MS, Amanor I, Ndzomo P, Aloumba A, Bakheit M, Müller C, Borst N, Landmann E, Gmoser H, Härpfer T, Becherer L, Lüert S, Frischmann S, Burl S, Tabah EN, Crucitti T, Kouadio AT, Arhinful DK, Awondo P, Kakou SN, Eyangoh S, Addo KK, Knauf S, Mitjà O, Harding-Esch EM, and Marks M
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- Humans, Cameroon, Female, Male, Prospective Studies, Adolescent, Child, Adult, Young Adult, Treponema pallidum isolation & purification, Treponema pallidum genetics, Congo, Cote d'Ivoire, Ghana, Yaws diagnosis, Nucleic Acid Amplification Techniques methods, Nucleic Acid Amplification Techniques economics, Sensitivity and Specificity, Molecular Diagnostic Techniques methods, Molecular Diagnostic Techniques economics
- Abstract
Background: To meet the WHO target of eradicating yaws by 2030, highly sensitive and specific diagnostic tools are needed. A multiplex Treponema pallidum-Haemophilus ducreyi loop-mediated isothermal amplification (TPHD-LAMP) test holds promise as a near-patient diagnostic tool for yaws and H ducreyi. We conducted a prospective evaluation in Cameroon, Côte d'Ivoire, Ghana, and the Republic of the Congo to determine the diagnostic accuracy of the TPHD-LAMP test, as well as to assess its acceptability, feasibility, and cost., Methods: Active case searching within schools and communities was used to locate participants with clinically suspicious laws-like lesions. Individuals with serologically confirmed active yaws provided paired lesion swabs between March, 2021, and April, 2023. For each participant, one swab was tested with the TPHD-LAMP at a local district laboratory and the other with reference quantitative PCR (qPCR) tests conducted at national reference laboratories. The primary outcome was TPHD-LAMP test sensitivity and specificity compared with qPCR. Laboratory technicians were interviewed using a multiple-choice survey to gauge acceptability and feasibility of the TPHD-LAMP test. Costs of each test were calculated., Findings: Of 3085 individuals with at least one suspected yaws lesion, 531 (17%) were serologically confirmed. We enrolled 493 participants with seropositive yaws and a further 32 with negative serology. The sensitivity of the TPHD-LAMP test for detecting T pallidum was 63% (95% CI 56-70) and the specificity was 66% (95% CI 61-71). Sensitivity and specificity for T pallidum improved to 73% (63-82; p=0·0065) and 75% (68-80; p=0·0003), respectively, in H ducreyi-negative samples. Interviews highlighted challenges in user-friendliness and practicality of the TPHD-LAMP test. The cost of the test per sample was one third of that of qPCR, although the TPHD-LAMP test entailed higher costs to establish the assay., Interpretation: This was the first multi-country diagnostic evaluation of a molecular test for yaws. The TPHD-LAMP testing, in its current form, falls short of the WHO target product profile criteria for yaws diagnostics. These findings highlight the importance of assessing new diagnostics in real-world conditions to ensure their suitability for programmatic use., Funding: The EDCTP2 programme supported by the EU., Competing Interests: Declaration of interests SF, MB, and EL are employees of Mast Diagnostica, which produces and sells LAMP products. A patent covering the mediator displacement probe technique, a component of the TPHD-LAMP assay described in this study, has been applied for by the University of Freiburg and Hahn-Schickard. All other authors declare no competing interests., (Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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9. An integrated active case detection and management of skin NTDs in yaws endemic health districts in Cameroon, Côte d'Ivoire and Ghana.
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Tchatchouang S, Basing LA, Kouadio-Aboh H, Handley BL, G-Beiras C, Amanor I, Ndzomo P, Bakheit M, Becherer L, Knauf S, Müller C, Njih-Tabah E, Njamnshi T, Crucitti T, Borst N, Lüert S, Frischmann S, Gmoser H, Landmann E, Sylla A, Kouamé-Sina MS, Arhinful D, Awondo P, Menguena G, Harding-Esch EM, Tano A, Kaloga M, Koffi-Aboa P, Konama-Kotey N, Mitjà O, Eyangoh S, Kwasi-Addo K, Ngazoa-Kakou S, and Marks M
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- Humans, Cote d'Ivoire epidemiology, Ghana epidemiology, Cameroon epidemiology, Adolescent, Child, Female, Male, Adult, Child, Preschool, Endemic Diseases, Young Adult, Infant, Middle Aged, Skin Diseases epidemiology, Skin Diseases diagnosis, Yaws epidemiology, Yaws diagnosis, Neglected Diseases epidemiology, Neglected Diseases diagnosis
- Abstract
Background: Integrated approaches to mapping skin Neglected Tropical Diseases (NTDs) may be cost-effective way to guide decisions on resource mobilization. Pilot studies have been carried out, but large-scale data covering multiple countries endemic for skin NTDs are lacking. Within the LAMP4YAWS project, we collected integrated data on the burden of multiple skin NTDs., Methods: From March 2021 to March 2023, integrated case searches for yaws alongside other skin conditions were performed in endemic health districts of yaws in Cameroon, Côte d'Ivoire, and Ghana. Integrated activities included training, social mobilization and active case detection. Initial screening involved a brief clinical examination of participants to determine if any skin conditions were suspected. Cases of skin NTDs were then referred to a health facility for appropriate management., Results: Overall 61,080 individuals screened, 11,387 (18.6%) had skin lesions. The majority of individuals (>90%) examined were children aged 15 years old and under. The proportion of serologically confirmed yaws cases was 8.6% (18/210) in Cameroon, 6.8% (84/1232) in Côte d'Ivoire, and 26.8% (440/1643) in Ghana. Other skin conditions based on clinical examination included: scabies, Buruli ulcer, leprosy, lymphatic filariasis (lymphoedema and hydrocele), tungiasis, and fungal infections. The most common conditions were scabies and superficial fungal infections. In Cameroon, scabies and superficial fungal infections accounted for 5.1% (214/4204) and 88.7% (3730/4204) respectively, 25.2% (1285/5095) and 50.4% (2567/5095) in Côte d'Ivoire. In Ghana, 20% (419/2090) of individuals had scabies but superficial fungal infections were not routinely recorded and were reported in only 1.3% (28/2090). Other skin NTDs were less common across all three countries., Conclusion: This study confirms that integrated screening allows simultaneous detection of multiple skin NTDs, maximising use of scarce resources., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Tchatchouang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2024
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10. Endemic infectious cutaneous ulcers syndrome in the Oti Region of Ghana: Study of cutaneous leishmaniasis, yaws and Haemophilus ducreyi cutaneous ulcers.
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Akuffo RA, Sanchez C, Amanor I, Amedior JS, Kotey NK, Anto F, Azurago T, Ablordey A, Owusu-Antwi F, Beshah A, Amoako YA, Phillips RO, Wilson M, Asiedu K, Ruiz-Postigo JA, Moreno J, and Mokni M
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- Humans, Ulcer epidemiology, Ghana epidemiology, Cross-Sectional Studies, Haemophilus ducreyi, Yaws epidemiology, Skin Ulcer epidemiology, Leishmaniasis, Cutaneous diagnosis, Leishmaniasis, Cutaneous epidemiology, Skin Diseases, Infectious, Leishmania, Mycobacterium ulcerans
- Abstract
Background: A recent study detected cutaneous leishmaniasis (CL) in 31.9% of persons with skin ulcers in the Oti Region of Ghana, resulting in a need to investigate other potential causes of the unexplained skin ulcers., Methodology/principal Findings: A community based cross-sectional study was conducted in the Oti region to investigate skin ulcers of undetermined aetiologies. To confirm a diagnosis of cutaneous leishmaniasis, Buruli ulcer, Haemophilus ducreyi ulcers, or yaws, DNA obtained from each patient skin ulcer sample was systematically subjected to polymerase chain reaction (PCR) for Leishmania spp., Mycobacterium ulcerans, Haemophilus ducreyi, and Treponema pallidum sub species pertenue. A total of 101 skin ulcer samples were obtained from 101 persons. Co-infection of more than one organism was observed in 68.3% of the samples. Forty (39.6%) participants had a positive result for Leishmania spp., 68 (67.3%) for Treponema pallidum sub. Sp. pertenue, and 74 (73.3%) for H. ducreyi. Twenty (19.8%) of the patient ulcers were simultaneously infected with Leishmania spp., Treponema pallidum sub. Sp. pertenue, and H. ducreyi. None of the patients' lesions yielded a positive result for Mycobacterium ulcerans., Conclusions/significance: This study detected single and mixed occurrence of the causative organisms of CL, yaws, and H. ducreyi cutaneous ulcers in CL endemic communities of the Oti Region in Ghana. These findings emphasize the importance of integrating multiple skin diseases on a common research platform and calls for the development of a comprehensive guideline for diagnosing and treating tropical ulcers in the study areas., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2023 Akuffo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2023
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11. LAMP4yaws: Treponema pallidum , Haemophilus ducreyi loop mediated isothermal amplification - protocol for a cross-sectional, observational, diagnostic accuracy study.
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Handley BL, González-Beiras C, Tchatchouang S, Basing LA, Hugues KA, Bakheit M, Becherer L, Ries C, Njih Tabah E, Crucitti T, Borst N, Lüert S, Frischmann S, Haerpfer T, Landmann E, Amanor I, Sylla A, Kouamé-Sina MS, Ndzomo-Ngono JP, Tano A, Arhinful D, Awondo P, Ngazoa Kakou S, Eyangoh S, Addo KK, Harding-Esch EM, Knauf S, Mitjà O, and Marks M
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- Cross-Sectional Studies, Ghana, Humans, Molecular Diagnostic Techniques, Nucleic Acid Amplification Techniques, Observational Studies as Topic, Real-Time Polymerase Chain Reaction, Treponema, Treponema pallidum genetics, Haemophilus ducreyi genetics, Skin Ulcer, Yaws diagnosis, Yaws epidemiology, Yaws microbiology
- Abstract
Introduction: Yaws, caused by the bacterium Treponema pallidum subsp. pertenue, is a neglected tropical disease targeted for eradication by 2030. Improved diagnostics will be essential to meet this goal. Diagnosis of yaws has relied heavily on clinical and serological tools. However, the presence of coendemic cutaneous skin ulcer diseases, such as lesions caused by Haemophilus ducreyi ( HD ), means these techniques do not provide a reliable diagnosis. Thus, new diagnostic tools are needed. Molecular tools such as PCR are ideal, but often expensive as they require trained technicians and laboratory facilities, which are often not available to national yaws programmes., Methods and Analysis: The LAMP4yaws project is a cross-sectional, observational, diagnostic accuracy study of a combined Treponema pallidum ( TP ) and HD loop mediated isothermal amplification (TPHD-LAMP) test performed under real world conditions in three endemic countries in West Africa. Individuals with serologically confirmed yaws will be recruited in Cameroon, Côte d'Ivoire and Ghana. Each participant will provide paired swabs, one of which will be sent to the respective national reference laboratory for yaws quantitative PCR and the other will be tested for both TP and HD using the TPHD-LAMP test at local district laboratories. Sensitivity and specificity of the TPHD-LAMP test will be calculated against the reference standard qPCR. We will also assess the acceptability, feasibility and cost-effectiveness of the test. We anticipate that results from this study will support the adoption of the TPHD-LAMP test for use in global yaws eradication efforts., Ethics and Dissemination: We have received ethical approval from all relevant institutional and national ethical committees. All participants, or their parents or guardians, must provide written informed consent prior to study enrolment. Study results will be published in an open access journal and disseminated with partners and the World Health Organization., Trial Registration Number: NCT04753788., Competing Interests: Competing interests: BLH, GCB, ST, LAB, KOH, LB, NB, TC, TH, SL, CR, IA, AS, MSKS, JPNN, PA, AT, ENT, DKA, SNK, SE, KWA, EMHE, SK, OM and MM declare no competing interests. SF, MB and EL are employees of Mast Diagnostics GmbH, which produce and sell the TPHD LAMP kits and products. A patent covering the mediator displacement probe technique a component of the TPHD-LAMP assay described in the paper has been applied for by the University of Freiburg and Hahn-Schickard., (© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2022
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