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El presente proyecto de investigación presenta una temática relacionada con el desarrollo del Turismo en Tamazunchale, San Luis Potosí, México, con el fin de establecer de diversos esquemas de promoción y crecimiento de parajes turísticos. Se desarrollo una propuesta de estructura de proyecto de desarrollo local con la información proporcionada por el Ayuntamiento de Tamazunchale y con los resultados obtenidos de la matriz FODA, aunado a lo anterior, también se realizó un muestreo no probabilístico por conveniencia para recolectar información de los empresarios que se dedican a este giro del turismo y se les entrevisto.

La presente investigación fue realizada en base al tema “la problemática de la rotación del personal en los pequeños negocios de Ciudad Valles”. Es de vital importancia comprender cuáles son las causas que provocan la alta rotación de personal, ya que al detectarlas nos permitirá buscar soluciones para reducir la alta rotación y las consecuencias negativas que esto contrae hacia las empresas. El principal objetivo de esta investigación es la obtención de resultados que sirven de base para formular recomendaciones a fin de reducir el alto índice de rotación presente en los pequeños negocios de Cd. Valles.

El presente proyecto de investigación fue un trabajo realizado para estudiar el comportamiento de la población de un ejido ante la oportunidad del crecimiento económico de las familias, esta investigación arrojo resultados en donde los habitantes de este ejido han sabido aprovechar las convocatorias que emite el gobierno federal para la apertura de un negocio familiar y que beneficie a la zona y pueda tener derrama económica. Se implemento un estudio cualitativo cuyo diseño comprende de una investigación exploratoria y descriptiva. A los habitantes del ejido zocohuite se les aplico una encuesta por medio de un muestreo no probabilístico. Dando como resultado que la población si ha tenido un crecimiento económico a raíz de los proyectos productivos que se ejercen en la zona, sin embargo, es necesario mencionar que aún existen limitantes al momento de su difusión esto debido a que los canales de información sobre las convocatorias no se enteran la población y por lo tanto no participan.

Introduction: Identifying effective drugs for Coronavirus disease 2019 (COVID-19) is urgently needed. An efficient approach is to evaluate whether existing approved drugs have anti-SARS-CoV-2 effects. The antiviral properties of lithium salts have been studied for many years. Their anti-inflammatory and immune-potentiating effects result from the inhibition of glycogen synthase kinase-3.& nbsp;Aims: To obtain pre-clinical evidence on the safety and therapeutic effects of lithium salts in the treatment of COVID-19.& nbsp;Results: Six different concentrations of lithium, ranging 2-12 mmol/L, were evaluated. Lithium inhibited the replication of SARS-CoV-2 virus in a dose-dependent manner with an IC50 value of 4 mmol/L. Lithium-treated wells showed a significantly higher percentage of monolayer conservation than viral control, particularly at concentrations higher than 6 mmol/L, verified through microscopic observation, the neutral red assay, and the determination of N protein in the supernatants of treated wells. Hamsters treated with lithium showed less intense disease with fewer signs. No lithium-related mortality or overt signs of toxicity were observed during the experiment. A trend of decreasing viral load in nasopharyngeal swabs and lungs was observed in treated hamsters compared to controls.& nbsp;Conclusions: These results provide pre-clinical evidence of the antiviral and immunotherapeutic effects of lithium against SARS-CoV-2, which supports an advance to clinical trials on COVID-19 & PRIME;s patients. The authors are indebted to CICDC staff for their collaborative support and dedication during the experiments. We are grateful to YJ Gonzalez ´ for her technical support, constructive discussions, and scientific input. We also thank J Delgado and SR Paez from Empresa Central de Laboratorios “Jos´e Isaac del Corral”, Havana, Cuba, for their invaluable contribution. We also thank JF Infante for the anatomopathological evaluation of hamsters. CE Rudd is supported by a grant from the Canadian Institutes of Health Research (CIHR).

The disordered crystal structure of tri­phenyl­methanol features tetra­hedral chiral clusters formed through weak hydrogen bonds, leading to the formation of three-dimensional supra­molecular motifs having left or right handedness., The crystal structure of tri­phenyl­methanol, C19H16O, has been redetermined using data collected at 295 and 153 K, and is compared to the model published by Ferguson et al. over 25 years ago [Ferguson et al. (1992 ▸). Acta Cryst. C48, 1272–1275] and that published by Serrano-González et al., using neutron and X-ray diffraction data [Serrano-González et al. (1999 ▸). J. Phys. Chem. B, 103, 6215–6223]. As predicted by these authors, the hy­droxy groups are involved in weak inter­molecular hydrogen bonds in the crystal, forming tetra­hedral tetra­­mers based on the two independent mol­ecules in the asymmetric unit, one of which is placed on the threefold symmetry axis of the R space group. However, the reliable determination of the hy­droxy H-atom positions is difficult to achieve, for two reasons. Firstly, a positional disorder affects the full asymmetric unit, which is split over two sets of positions, with occupancy factors of ca 0.74 and 0.26. Secondly, all hy­droxy H atoms are further disordered, either by symmetry, or through a positional disorder in the case of parts placed in general positions. We show that the correct description of the hydrogen-bonding scheme is possible only if diffraction data are collected at low temperature. The pro­chiral character of the hydrogen-bonded tetra­meric supra­molecular clusters leads to enanti­omorphic three-dimensional graphs in each tetra­mer. The crystal is thus a racemic mixture of sup S and sup R motifs, consistent with the centro­symmetric nature of the R space group.

The title compound, C22H33NO12·CHCl3, was obtained as a product of a double aza-Michael addition of hydroxylamine on a Chiron with a known absolute configuration. The enantiopure compound crystallized as a chloroform solvate, in space group P1, and diffraction data were collected at room temperature with Ag Kα radiation. The Flack parameter refined to x = −0.01 (16); however, the Flack and Watkin 2AD plot clearly shows that differences between Friedel opposites (the D component of the plot) do not carry any reliable information about resonant scattering of Cl atoms, and are rather dominated by random and systematic errors. The RD factor calculated using 1941 acentric Friedel pairs is RD = 0.995. On the other hand, the 2A component of the plot, related to average intensities of Friedel pairs, shows that data are of good quality (RA = 0.069). This example illustrates that while using Ag Kα radiation (λ = 0.56083 Å), scatterers heavier than Cl should be present in a chiral crystal in order to determine confidently the absolute structure of the crystal.

The title compound, C

El objetivo de este trabajo fue estudiar si se podía aumentar la competitividad sexual de machos estériles de inoculados con bacterias comensales aisladas de machos silvestres.

México carece de proyectos de innovación que representen una oportunidad de progreso para las personas, son pocos los que cuentan con bases sólidas y que tengan como prioridad ayudar a los clientes. Uno de los principales objetivos de Ofici Home Services es apoyar a las personas que trabajan de forma independiente ofreciéndoles una alternativa a los medios de difusión tradicionales que generalmente manejan precios que resultan elevados, en contraste con el promedio de ingresos que percibe un prestador de oficios. Ofici Home Services es una plataforma Web que sirve como un enlace entre clientes y prestadores de servicios u oficios y permite activar la economía con la prestación y contratación de estos servicios, diseñando un espacio donde puedan presentar mediante fotografías y descripciones, sus trabajos o servicios realizados, así como recibir evaluaciones por parte de los clientes, generando así confianza a quien les contrate.

Milk curds are a semisolid structure resulting from the enzymatic coagulation of milk, consisting mainly of paracasein micelles, fat globules, and whey. This gel undergoes a series of changes in its composition and structure during setting and curing, affecting curd density. The present study investigated the composition and density of inoculated and noninoculated milk curds during a 60-min curing period conducted at 30, 35, and 40°C. The purpose of the study was to determine the density changes occurring in the protein phase of curds during curing under different conditions of temperature and pH to understand the nature of the structural changes happening in the paracasein matrix. Noninoculated curd density values oscillated between 1.0247 and 1.0294 g/cm3 after 60 min of curing, whereas inoculated treatments showed values between 1.0222 and 1.0321 g/cm3. This small difference in density between the studied samples was surprising because the whey content of samples differed greatly. Density of the protein phase reached values of 1.8002 and 1.4388 g/cm3 for noninoculated and inoculated curds, respectively, after 60 min of curing. Two independent mechanisms involved in the development of the protein-based structure of curds were identified upon comparison of the development of protein phase density in inoculated and noninoculated curds. Although the larger increase in protein phase density observed in noninoculated curds was probably due to the concurrent action of calcium-mediated electrostatic bonds and temperature-dependent hydrophobic bonds, inoculated curds showed a lower protein phase density caused by calcium solubilization and by a decrease in the net charge of paracasein micelles induced by pH reduction.

“El secuestro es un tema de actualidad que pareciera ser exclusivo de estos tiempos en los que se ve problemas de desempleo, pobreza, corrupción, bajo crecimiento económico y hasta incertidumbre política. Se sabe que éste no es un fenómeno de una región, país o período de tiempo, es algo de hace muchos años y que ha ido creciendo en el mundo entero como Latinoamérica, Asia y Europa, basta ver los diarios internacionales para darse cuenta de la magnitud del problema. El secuestro cuando se estudia desde el punto de vista de los comportamientos, conductas motivaciones de los sujetos considerados como planificadores o bien desde el ámbito criminológico conocidos como intelectuales, da información primordial acerca de todos aquellos factores que coadyuvan a estructurar la personalidad de quien planifica un secuestro, dado que se requiere de una serie de habilidades, características, cualidades para elegir a la víctima, ejecución del secuestro, el reclutamiento del personal operativo, la planificación del modus operandi, y la forma de negociación con respecto a la víctima”.

RESUMEN En el presente trabajo se presenta un estudio que describe los diferentes tipos de fallas, las formas características de las señales que generan y los métodos de diagnóstico en máquinas eléctricas. Además, efectúa un comparativo de las ventajas de cada uno de los diferentes métodos de detección de fallas en función de la información que requieren para el diagnóstico, el número e importancia de las fallas que pueden detectar, la rapidez con la que son capaces de anticipar una falla y el grado de certeza en el diagnóstico final. En particular, dicho estudio ayudará a proporcionar una visión rápida y clara acerca de los últimos trabajos y las nuevas investigaciones en el área. ABSTRACT In this work a careful a survey describing different type of failures in electrical machines, their characteristic signals generated and the methods of diagnosis are performed. Additionally a comparison of the advantages between the known failure detection methods based on the information required for diagnosis, the occurrence and importance of failures detection, the effectiveness for anticipating a malfunction or failure and the final diagnosis accuracy is also made. Particularly this survey will help to provide a straightforward up date about the most recent work and research in the field.

A national telemedicine network was established in Mexico, based on satellite transmission. Six remote hospitals were connected during the first phase in 1997. The network applications included distance learning and administration. In addition, 476 clinical consultations were carried out in the first six months to March 1998 . Clinical problems were solved in the teleconsultation in 159 cases 33 . The patient was transferred in 217 cases 46 . The 16 most common specialties at the six remote sites accounted for 274 teleconsultations, and cardiology and orthopaedics accounted for just over half of all teleconsultations. One of the six remote sites accounted for 41 of the teleconsultations.

Cognitive deterioration is a frequent finding in patients who have had a cerebral infarct which affected their quality of life. The prognostic factors associated with this are still not completely clear.To determine the frequency of cognitive deterioration following cerebral infarct and the prognostic factors associated with its appearance.We made a study of a prospective pohort in the Hospital Clínico Quirúrgico Hermanos Ameijeiras de Ciudad de La Habana, Cuba, in 401 patients with the confirmed diagnosis of cerebral infarct during the period March 1997 February 2000. A questionnaire was completed for all patients. This contained the possible variables for prognosis. The neuropsychological tests were done 3 and 6 months after the cerebral infarct occurred to determine the appearance of cognitive deterioration. Statistical analysis included the c2 test, relative risk estimation, and multiple logistic regression analysis.The frequency of cognitive deterioration 3 and 6 months after the cerebral infarct occurred was 22.2% and 6.9% respectively. Multiple logistic regression analysis showed prognostic variables of cognitive deterioration to be arterial hypertension (p=0.001, RR:2.0) and the number of current cerebral infarcts shown on computerized axial tomography (p=0.000, RR:5.2).Cognitive deterioration was a frequent complication after a cerebral infarct and several prognostic factors were associated with its appearance.

Summary. Introduction. Cognitive deterioration is a frequent finding in patients who have had a cerebral infarct which affected their quality of life. The prognostic factors associated with this are still not completely clear. Objectives. To determine the frequency of cognitive deterioration following cerebral infarct and the prognostic factors associated with its appearance. Patients and methods. We made a study of a prospective pohort in the Hospital Clinico Quirurgico Hermanos Ameijeiras de Ciudad de La Habana, Cuba, in 401 patients with the confirmed diagnosis of cerebral infarct during the period March 1997-February 2000. A questionnaire was completed for all patients. This contained the possible variables for prognosis. The neuropsychological tests were done 3 and 6 months after the cerebral infarct occurred to determine the appearance of cognitive deterioration. Statistical analysis included the χ 2 test, relative risk estimation, and multiple logistic regression analysis. Results. The frequency of cognitive deterioration 3 and 6 months after the cerebral infarct occurred was 22.2% and 6.9% respectively. Multiple logistic regression analysis showed prognostic variables of cognitive deterioration to be arterial hypertension (p=0.001, RR:2.0) and the number of current cerebral infarcts shown on computerized axial tomography (p=0.000, RR:5.2). Conclusions. Cognitive deterioration was a frequent complication after a cerebral infarct and several prognostic factors were associated with its appearance. [REV NEUROL 2002; 34: 223-31]

Sperm samples subjected to cryopreservation are vulnerable, reflecting changes in membrane integrity, mobility and DNA.To assess the rate of DNA fragmentation, sperm mobility and recovery viability in capacitated semen samples after cryopreservation for over 10 years.Longitudinal, prospective, observational study of 19 seminal samples cryopreserved for more than 10 years, in a mexican fertility center. The sample was divided into 4 groups: Group CX (Surgery), Group IVF (in vitro fertilization), OAT Group (Oligo- astheno-teratozoospermia) and QX Group (Chemotherapy), in order to compare variables such as: recovery in mobility, DNA fragmentation index and sperm viability. Continuous variables were designated as means ± SD, and categorical variables as frequencies and percentages. JMP-V9 program was used.There is no difference in storage time and initial volume. The concentration, total mobility, total motile cells and morphology in OAT group are different from the rest. There is difference in initial morphology of the tail, showing more altered parameters in CX and IVF groups. In the CX, FIV and OAT Groups was achieving a mobility recovery of 27.34%, 30.02% and 55.24% respectively. The QX group presented no change. By analyzing the viability only OAT group presented50% intact sperm. For DNA fragmentation CX Groups and IVF showed the lowest rate (3.5.± 2.5 and 3.5 ± 3.01 respectively) compared with OAT Groups and QX (9.8 ± 0.2 and 12, 17 ± 3.9).It is possible to store semen samples for a long period of time, retrieving suitable viability sperm useful for assisted reproduction techniques.