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Introduction The secretome, also known as conditioned medium, is a collection of proteins and other molecules secreted by Mesenchymal stem cells (MSCs), has been increasingly studied for its potential applications in dermatology practice. However, there has been limited bibliometric analysis to understand the global trends in this field. The objective of this study is to analyze the global trends and publication activity related to secretome in dermatology practice through bibliometrics analysis. Methods A systematic search was performed using the Web of Science Core Collection database to identify relevant publications on secretome in dermatology practice from 2003 to 2023. Statistical analyses were performed using Excel and VOSviewer software. Various bibliometric indicators were analyzed to evaluate the publication trends, research topics, and collaboration networks. Results A total of 304 articles with H-index 45 and 20,74 citations per paper related to secretome in dermatology practice were identified. The annual publication output showed an upward trend, with a peak in 2022. The United States (57) had the highest number of publications, followed by China (37) and Germany (37). The most common research topics were wound healing, skin regenerative & rejuvenation, inflammatory skin diseases, skin cancer and hair growth. For promising hotspots, “exosomes and regenerative medicine” showed the highest, followed by “senescence”, “photoaging”, and “wound repair”. Conclusion Our bibliometric analysis demonstrates that secretome research in dermatology practice has been an increasingly studied field with potential applications in the development of novel therapeutics for skin disorders. Collaboration among researchers and countries is crucial for advancing secretome research in dermatology practice. [ABSTRACT FROM AUTHOR]

Monkeypox is a viral zoonotic disease. It has evolved into human-to-human transmission with similar characteristics to smallpox. In contrast with the previous endemic outbreak, this 2022 multinational outbreak found numerous data of different skin lesions, predilections and populations. Furthermore, recent findings regarding monkeypox revealed the possibility of sexual transmission. As a basis for future monkeypox diagnosis guidelines, providing comprehensive data on the symptoms, predilections, age at presentation, previous history of sexual activities, comorbidities, range of incubation period from the time of sexual activity until the symptoms occured, as criteria for diagnosis of sexual transmitted disease. We performed a comprehensive search on a topic that assesses the outbreak of monkeypox disease in 2022 regarding the route of transmission from inception up until September 2022. There were 1310 patients from 10 studies who had monkeypox disease in 2022. Patients were mostly found in European countries, with averaging in their 30s, and were 99.54% male. Vesiculopustular lesions and ulcers with central umbilication appeared prior to prodromal signs were characteristic. Approximately 90% were transmitted during sexual intercourse and in homosexual group (MSM/Men who have sex with men), and 5-10% between bisexuals. Approximately 40.84% cases also had HIV as a comorbid disease and 15.42% have concurrent or history of sexually transmitted infection (STI) including syphilis, gonorrhea, chlamydia, herpes simplex, mixed, and other STIs. Homosexual and bisexual populations are the most high risk populations in the 2022 outbreak of monkeypox disease. The epidemiology, clinical manifestation, and type of skin lesion were different from the previous outbreak. The findings in this review may supplement information to further establish clinical guidelines on the new presentation of monkeypox disease. Further largescale studies are necessary to further describe and verify the data with higher levels of evidence. [ABSTRACT FROM AUTHOR]