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2. INFLUENCE OF THE 4D ROBUST PLANNING APPROACH ON THE COMPARISON BETWEEN PHOTON AND PROTON FOR THE TREATMENT OF STAGE III LUNG CANCER: A DOSIMETRIC AND RADIOBIOLOGICAL STUDY

Author

Widesott, L., primary, Landoni, V., additional, Dionisi, F., additional, Siniscalchi, B., additional, Nardangeli, A., additional, Fracchiolla, F., additional, Turkaj, A., additional, Soriani, A., additional, Righetto, R., additional, Goanta, L., additional, Farace, P., additional, Petrongari, M.G., additional, Trianni, A., additional, Amelio, D., additional, Lorentini, S., additional, Cianchetti, M., additional, and Sanguineti, G., additional

Published
2023
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3. Clinical Outcomes and Dosimetric Predictive Factors in Patients Undergoing Reirradiation for Recurrent Meningiomas

Author

Desideri, I., primary, Scartoni, D., additional, Morelli, I., additional, Banini, M., additional, Visani, L., additional, Greto, D., additional, Detti, B., additional, Perini, Z., additional, Zivelonghi, E., additional, Bulgarelli, G., additional, Pinzi, V., additional, Pierina, N., additional, Clerici, E., additional, Ascolese, A.M., additional, Anselmo, P., additional, Amelio, D., additional, Osti, M.F., additional, Minniti, G., additional, and Livi, L., additional

Published
2023
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6. PD-0652 Re-irradiation of recurrent intracranial meningiomas: an Italian multicenter retrospective study

Author

Desideri, I., primary, Morelli, I., additional, Visani, L., additional, Greto, D., additional, Detti, B., additional, Perini, Z., additional, Zivelonghi, E., additional, Bulgarelli, G., additional, Pinzi, V., additional, Navarria, P., additional, Clerici, E., additional, Ascolese, A.M., additional, Anselmo, P., additional, Amelio, D., additional, Osti, M.F., additional, Minniti, G., additional, Livi, L., additional, and Scartoni, D., additional

Published
2023
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10. Quercetin and its derivative Q2 modulate chromatin dynamics in adipogenesis and Q2 prevents obesity and metabolic disorders in rats

Author

Nettore IC (1), Rocca C (2), Mancino G (1), Albano L(3, Amelio D (2), Grande F(5), Puoci F(5), Pasqua T(2), Desiderio S(1), Mazza R(2), Terracciano D(3), Colao A(1), Bèguinot F(3, Russo GL(6), Dentice M(1), Macchia PE(1), Sinicropi MS(5), Angelone T(2, Ungaro P(4)., Nettore, I. C., Rocca, C., Mancino, G., Albano, L., Amelio, D., Grande, F., Puoci, F., Pasqua, T., Desiderio, S., Mazza, R., Terracciano, D., Colao, A., Beguinot, F., Russo, G. L., Dentice, M., Macchia, P. E., Sinicropi, M. S., Angelone, T., and Ungaro, P.

Subjects
Male, 0301 basic medicine, Cell Survival, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Biological Availability, Diet, High-Fat, Biochemistry, Chromatin remodeling, Epigenesis, Genetic, Histones, Mice, 03 medical and health sciences, Histone H3, 0302 clinical medicine, 3T3-L1 Cells, Adipocytes, Animals, Benzopyrans, Obesity, Rats, Wistar, Molecular Biology, Epigenomics, Adipogenesi, Adipogenesis, Nutrition and Dietetics, biology, Chemistry, Epigenetic, Polyphenols, Lipid Metabolism, Chromatin, Cell biology, PPAR gamma, 030104 developmental biology, Histone, 030220 oncology & carcinogenesis, CCAAT-Enhancer-Binding Proteins, Histone modifications, biology.protein, Demethylase, Quercetin, Anti-Obesity Agents, Histone modification, Chromatin immunoprecipitation
Abstract

Recently the attention of the scientific community has focused on the ability of polyphenols to counteract adverse epigenetic regulation involved in the development of complex conditions such as obesity. The aim of this study was to investigate the epigenetic mechanisms underlying the anti-adiposity effect of Quercetin (3,3′,4′,5,7-pentahydroxyflavone) and of one of its derivatives, Q2 in which the OH groups have been replaced by acetyl groups. In 3 T3-L1 preadipocytes, Quercetin and Q2 treatment induce chromatin remodeling and histone modifications at the 5′ regulatory region of the two main adipogenic genes, c/EBPα and PPARγ. Chromatin immunoprecipitation assays revealed a concomitant increase of histone H3 di-methylation at Lys9, a typical mark of repressed gene promoters, and a decrease of histone H3 di-methylation at Lys 4, a mark of active transcription. At the same time, both compounds inhibited histone demethylase LSD1 recruitment to the 5′ region of c/EBPα and PPARγ genes, a necessary step for adipogenesis. The final effect is a significant reduction in c/EBPα and PPARγ gene expression and attenuated adipogenesis. Q2 supplementation in rats reduced the gain in body weight and in white adipose tissue, as well as the increase in adipocyte size determined by high fat diet. Moreover, Q2 improved dyslipidemia, glucose tolerance and decreased the hepatic lipid accumulation by activating the expression of beta-oxidation related genes. Our data suggest that Q2, as well as Quercetin, has the potential to revert the unfavorable epigenomic profiles associated with obesity onset. This opens the possibility to use these compounds in targeted prevention strategies against obesity.

Published
2019

20. AngII-dependent morpho-functional remodelling of the zebrafish heart

Author

Filice M, Barca A, Amelio D, Verri T, Cerra MC, Imbrogno S., Filice, M, Barca, A, Amelio, D, Verri, T, Cerra, Mc, and Imbrogno, S.

Abstract

Programme and Abstracts of the 68th National Congress of the Italian Physiological Society (Società Italiana di Fisiologia)

Published
2018

23. Policies for reirradiation of recurrent high-grade gliomas: a survey among Italian radiation oncologists

Author

Furlan, C, Arcangeli, S, Avanzo, M, Mirri, MA, Munoz, F, Giudici, S, Perrone, A, Amelio, D, Tornio, L, Draghini, L, DELI, ANIKO' MARIA, Pavanato, G, Giuliano, FM, Pontoriero, A, Ciammella, P, Navarria, P, Lannalfi, A, Buglione, M, Guida, C, Cammelli, S, Lorio, V, Cardinali, M, Genovesi, D, Barsacchi, L, Balducci, M, Bagnoli, R, Berti, F, Montesi, G, Pasqualetti, F, Bonome, P, Santoni, R, Doino, D, Schirru, P, Pinzi, V, Borzillo, V, Ferrarese, F, Ferro, M, De Cicco, L, Krengli, M, Scoccianti, S, Donato, V, PINZI, VALENTINA, Furlan, Carlo, Arcangeli, Stefano, Avanzo, Michele, Mirri, Maria A, Munoz, Fernando, Giudici, Stefania, Perrone, Antonio, Amelio, Dante, Tomio, Luigi, Draghini, Loredana, Deli, Aniko M, Pavanato, Giovanni, Giugliano, Francesca M, Pontoriero, Antonio, Ciammella, Patrizia, Navarria, Pierina, Iannalfi, Alberto, Buglione, Michela, Guida, Cesare, Cammelli, Silvia, Iorio, Vincenzo, Cardinali, Massimo, Genovesi, Domenico, Barsacchi, Lucia, Balducci, Mario, Bagnoli, Rita, Berti, Franco, Montesi, Giampaolo, Pasqualetti, Francesco, Bonome, Paolo, Santoni, Riccardo, Doino, Daniela, Schirru, Patrizia, Pinzi, Valentina, Borzillo, Valentina, Ferrarese, Fabio, Ferro, Marica, De Cicco, Luigi, Krengli, Marco, Scoccianti, Silvia, Donato, Vittorio, Furlan, C, Arcangeli, S, Avanzo, M, Mirri, M, Munoz, F, Giudici, S, Perrone, A, Amelio, D, Tornio, L, Draghini, L, Deli, A, Pavanato, G, Giuliano, F, Pontoriero, A, Ciammella, P, Navarria, P, Lannalfi, A, Buglione, M, Guida, C, Cammelli, S, Lorio, V, Cardinali, M, Genovesi, D, Barsacchi, L, Balducci, M, Bagnoli, R, Berti, F, Montesi, G, Pasqualetti, F, Bonome, P, Santoni, R, Doino, D, Schirru, P, Pinzi, V, Borzillo, V, Ferrarese, F, Ferro, M, De Cicco, L, Krengli, M, Scoccianti, S, and Donato, V

Subjects
Oncology, Male, Cancer Research, medicine.medical_specialty, Adolescent, medicine.medical_treatment, gliomas (HGG), Radiosurgery, 030218 nuclear medicine & medical imaging, Re-Irradiation, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Glioma, Surveys and Questionnaires, Reirradiation, gliomas (HGG), Medicine, Humans, dose, glioblastoma, glioma, IMRT, radiosurgery, reirradiation, IMRT, Reirradiation, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Salvage Therapy, RECURRENT HIGH GRADE GLIOMA, business.industry, Dose, Glioblastoma, Radiation Oncologists, General Medicine, medicine.disease, Combined Modality Therapy, SURVEY, Current management, Italy, 030220 oncology & carcinogenesis, Female, Neoplasm Recurrence, Local, business
Abstract

Purpose: To assess the contribution of Italian radiation oncologists in the current management of recurrent high-grade gliomas (HGG), focusing on a reirradiation (reRT) approach. Methods: In 2015, the Reirradiation and the Central Nervous System Study Groups on behalf of the Italian Association of Radiation Oncology (AIRO) proposed a survey. All Italian radiation oncologists were individually invited to complete an online questionnaire regarding their clinical management of recurrent HGG, focusing on a reRT approach. Results: A total of 37 of 210 questionnaires were returned (18% of all centers): 16 (43%) from nonacademic hospitals, 14 (38%) from academic hospitals, 5 (13%) from private institutions, and 2 (6%) from hadron therapy centers. The majority of responding centers (59%) treated ≤5 cases per year. Performance status at the time of recurrence, along with a target diameter Conclusions: Although there were wide variations in the clinical practice of reRT across the 37 centers, the core activities were reasonably consistent. These findings provide a basis for encouraging a national collaborative study to develop, implement, and monitor the use of reRT in this challenging clinical setting.

Published
2017

27. EP-1837 A new hybrid approach to allow robust Monte Carlo-based multi-field optimization in proton therapy

Author

Tommasino, F., primary, Widesott, L., additional, Fracchiolla, F., additional, Lorentini, S., additional, Righetto, R., additional, Algranati, C., additional, Scifoni, E., additional, Dionisi, F., additional, Scartoni, D., additional, Amelio, D., additional, Cianchetti, M., additional, Schwarz, M., additional, Amichetti, M., additional, and Farace, P., additional

Published
2019
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34. P01.069 Re-irradiation for recurrent glioma: outcome evaluation, toxicity and prognostic factors assessment. A multicenter retrospective study by the Brain-Study-Group of the Radiation Oncology Italian Association (AIRO)

Author

Navarria, P, primary, Minniti, G, additional, Pinzi, V, additional, Draghini, L, additional, Borzillo, V, additional, Ciammella, P, additional, Scoccianti, S, additional, Amelio, D, additional, Krengli, M, additional, and Buglione di Monale, M, additional

Published
2018
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45. Protective Role of GPER Agonist G-1 on Cardiotoxicity Induced by Doxorubicin

Author

De Francesco, E. M., Rocca, C., Scavello, F., Amelio, D., Pasqua, T., Rigiracciolo, D. C., Scarpelli, A., Avino, S., Cirillo, F., Amodio, N., Cerra, M. C., Maggiolini, M., and Angelone, T.

Subjects
Male, Cardiotonic Agents, Interleukin-1beta, Wistar, Myocardial Ischemia, Blood Pressure, Ligands, Receptors, G-Protein-Coupled, G-Protein-Coupled, Diastole, Receptors, Animals, Humans, Ventricular Function, Myocytes, Cardiac, Rats, Wistar, Inflammation, Myocytes, L-Lactate Dehydrogenase, Tumor Necrosis Factor-alpha, Cardiotoxicity, Rats, Oxidative Stress, Doxorubicin, Heart Function Tests, Quinolines, Reactive Oxygen Species, Cardiac, Biomarkers
Abstract

The use of Doxorubicin (Dox), a frontline drug for many cancers, is often complicated by dose-limiting cardiotoxicity in approximately 20% of patients. The G-protein estrogen receptor GPER/GPR30 mediates estrogen action as the cardioprotection under certain stressful conditions. For instance, GPER activation by the selective agonist G-1 reduced myocardial inflammation, improved immunosuppression, triggered pro-survival signaling cascades, improved myocardial mechanical performance, and reduced infarct size after ischemia/reperfusion (I/R) injury. Hence, we evaluated whether ligand-activated GPER may exert cardioprotection in male rats chronically treated with Dox. 1 week of G-1 (50 μg/kg/day) intraperitoneal administration mitigated Dox (3 mg/kg/day) adverse effects, as revealed by reduced TNF-α, IL-1β, LDH, and ROS levels. Western blotting analysis of cardiac homogenates indicated that G-1 prevents the increase in p-c-jun, BAX, CTGF, iNOS, and COX2 expression induced by Dox. Moreover, the activation of GPER rescued the inhibitory action elicited by Dox on the expression of BCL2, pERK, and pAKT. TUNEL assay indicated that GPER activation may also attenuate the cardiomyocyte apoptosis upon Dox exposure. Using ex vivo Langendorff perfused heart technique, we also found an increased systolic recovery and a reduction of both infarct size and LDH levels in rats treated with G-1 in combination with Dox respect to animals treated with Dox alone. Accordingly, the beneficial effects induced by G-1 were abrogated in the presence of the GPER selective antagonist G15. These data suggest that GPER activation mitigates Dox-induced cardiotoxicity, thus proposing GPER as a novel pharmacological target to limit the detrimental cardiac effects of Dox treatment. J. Cell. Physiol. 232: 1640-1649, 2017. © 2016 Wiley Periodicals, Inc.

Published
2016

46. The role of stereotactic ablative radiotherapy in oncological and non-oncological clinical settings: Highlights from the 7th Meeting of AIRO - Young Members Working Group (AIRO Giovani)

Author

Franco P., De Bari B., Ciammella P., Fiorentino A., Chiesa S., Amelio D., Pinzi V., Bonomo P., Vagge S., Fiore M., Comito T., Cecconi A., Mortellaro G., Bruni A., Trovo M., Filippi A. R., Greto D., Alongi F., Franco, P, De Bari, B, Ciammella, P, Fiorentino, A, Chiesa, S, Amelio, D, Pinzi, V, Bonomo, P, Vagge, S, Fiore, M, Comito, T, Cecconi, A, Mortellaro, G, Bruni, A, Trovo, M, Filippi, A, Greto, D, and Alongi, F

Subjects
Image-guide radiotherapy, Male, MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Evidence-Based Medicine, Intensity-modulated radiotherapy, Stereotactic body radiotherapy, Lymph Node, Bone Neoplasm, Radiosurgery, Brain Neoplasm, Lung Neoplasm, Liver Neoplasm, Prostatic Neoplasm, Hypofractionation, Neoplasm, Stereotactic ablative radiotherapy, Human
Abstract

Stereotactic ablative radiotherapy is a modern cancer treatment strategy able to deliver highly focused radiation in one or a few fractions with a radical intent in several clinical settings. Young radiation oncologists need a constant and tailored update in this context to improve patient care in daily clinical practice. A recent meeting of AIRO Giovani (AIRO - Young Members Working Group) was specifically addressed to this topic, presenting state-of-the-art knowledge, based on the latest evidence in this field. Highlights of the congress are summarized and presented in this report, including thorough contributions of the speakers dealing with the role of stereotactic ablative radiotherapy in both oncological and non-oncological diseases, divided according to anatomical and clinical scenarios: intra-cranial settings (brain malignant primary tumors, metastases, benign tumors and functional disorders) and extra-cranial indications (lung primary tumors and metastases, thoracic re-irradiation, liver, lymph node and bone metastases, prostate cancer). With literature data discussed during the congress as a background, stereotactic ablative radiotherapy has proved to be a consolidated treatment approach in specific oncological and non-oncological scenarios, as well as a promising option in other clinical settings, requiring a further prospective validation in the near future. We herein present an updated overview of stereotactic ablative radiotherapy use in the clinic

Published
2014

50. HSP90 AND ENOS PARTIALLY CO-LOCALIZE AND CHANGE CELLULAR LOCALIZATION IN RELATION TO DIFFERENT ECM COMPONENTS IN 2D AND 3D CULTURES OF ADULT RAT CARDIOMYOCYTES

Author

DI FELICE, Valentina, ARDIZZONE, Nella Maria, MACALUSO, Filippo, Catanese, Patrizia, Minervini, Fabrizio Celestino, PERI, Giovanni, ZUMMO, Giovanni, MONTALBANO A, DE LUCA A, MARINO GAMMAZZA, Antonella, COLORITO M, AMELIO D, CERRA MC, DI FELICE V, MONTALBANO A, ARDIZZONE NM, DE LUCA A, MACALUSO F, MARINO-GAMMAZZA A, COLORITO M, CATANESE P, MINERVINI F, AMELIO D, CERRA MC, PERI G, and ZUMMO G

Published
2007

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