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A diagnosis of CS was made, while mother received diagnosis of ordinary scabies. (b) Complete resolution of cutaneous lesions during the post-discharge follow-up. (c) Laboratory investigation during the observation. gl This history and the characteristics of lesions drew our attention to a possible skin infestation. As for treatment, oral ivermectin is reserved for recurrent, difficult-to-treat cases, or CS.8 Due to severe presentation and to the refractoriness of the condition with topical treatment, our patient required this off-label treatment. [Extracted from the article]

SUMMARY Phenotypical and radiologic features of two unrelated patients with the syndrome Tricho- Rhino-Phalangeal syndrome type I (TRP I) and one with the syndrome TRP I1 are reported. All three cases were sporadic and the parents were non-consanguineous. The interstitial deletion of the chromosome 8q, evaluated on pro-. metaphases chromosomes, was not observed in any of the patients. [ABSTRACT FROM AUTHOR]

SUMMARY A case of cranio-metaphyseal dysplasia (CMD) with unusual radiographic Findings and multiple spontaneous fractures is presented. The parental consanguinity is in favour of an autosomal recessive form. The differential diagnosis of this case among the various genetic entities with metaphyseal flaring and/or cranial hyperostosis is discussed. [ABSTRACT FROM AUTHOR]

Consumptive hypothyroidism (CH) is a rare and potentially overlooked complication of hepatic hemangiomas (HH) overexpressing the enzyme deiodinase, which converts thyroxine (T4) to reverse triiodothyronine (rT3)., Materials and Methods: Here, we report a case series of 3 patients and a systematic review of the literature., Results: Hypothyroidism (mean serum TSH 52.03 mIU/L) was detected at a mean age of 4.6 months (range 3-6) in 3 infants with infantile hepatic hemangiomas, treated with thyroxine (mean dose 12 µg/kg/day). All received treatment with propranolol (1-3 mg/kg/day) from the mean age of 4 months. Hormonal treatment was stopped at a mean age of 20 months (range 12-30). Hypothyroidism reoccurred in a patient concurrently with the increase of liver lesions, requiring liver transplantation (LT) at age 39 months.Literature review retrieved 42 studies (48 patients): HH (n = 43) were isolated in 24 infants and associated with cutaneous hemangiomas in 19. Hemangiomas were only cutaneous in 5.In the first 43 patients, hypothyroidism was detected at a mean age of 1 month; 21 of 43 patients were prescribed propranolol alone (n = 8) or associated with other medicaments (n = 13); 2 of 43 patients underwent LT. Hormonal treatment consisted of T4 in 35 of 43 patients and T3 in 10.CH associated with only cutaneous and extrahepatic visceral hemangiomas (n = 5), detected at a mean age of 7 months (TSH mean levels at diagnosis of 150.3 mIU/L). Three of 5 patients received treatment with propranolol ± other medicaments. All 5 patients were treated with T4., Conclusions: Periodical thyroid function assessment is necessary in patients with hepatic hemangiomas, particularly when lesions' size and number increase rapidly., Competing Interests: The authors report funding and no conflicts of interest., (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.)

Angioma serpiginosum (AS) is a rare benign vascular lesion that typically arises in early childhood, with a prevalence in female, and then grow up over a period of months/years. It is characterized by small asymptomatic purple-red dots that cluster together and they do not disappear on diascopy. It is mainly localized on the arms but some cases on face and neck have been reported. The etiology of AS is unknown, dermoscopy may aid in the diagnosis but usually the biopsy is necessary. We report 2 cases: one male and one female with angioma serpiginosum, aged 13 and 8 years old., Competing Interests: Conflict of interest: The authors declare no potential conflict of interest., (©Copyright: the Author(s).)

Competing Interests: Competing interests: The authors have no conflicts of interest to disclose.

Background: Psoriasis is one of the most common inflammatory skin diseases. There seem to be an increasing interest in childhood psoriasis in recent years., Methods: We conducted a survey among pediatricians in Italy. 50 pediatricians from different areas in Italy (north, center and south) were invited to participate, 37 were responding and active in data collection. Doctors were asked to review their databases and to fill a form providing a series of information about all patients diagnosed with psoriasis attending their ambulatory., Results: The total number of patients referring to the responding doctors was 28086. Of these, 66 were diagnosed with psoriasis. Mean age was 5.7, (6.3 in males and 5.1 in females). The majority of patients presented plaque psoriasis (N.=44; 66.7%), followed by inverse (N.=9; 13.6%), and guttate psoriasis (N.=7; 10.6%). The main site of presentation was the trunk (51.5%), followed by scalp (15.2%) and napkin area (12.1%). Fifteen patients presented nail psoriasis (22.7%). In the majority of cases no family history was reported (83.3%), first degree relatives presented psoriatic lesions in only 7 cases (10.6%). The comorbidity most frequently reported was overweight (N.=16, 25.4%), followed by atopic dermatitis (N.=12; 18.2%). Differences in the main pattern of presentation were found between male and female patients, in particular, a plaque type psoriasis was more frequent in males (79.4% vs. 53.1%; P=0.048). Female patients presented psoriasis of the napkin area more frequently than males (21.9% vs. 2.9%, P=0.025)., Conclusions: Peculiar pattern of presentation can be detected in childhood psoriasis. Further studies are needed to validate these findings.

A 17-year-old female patient affected by systemic lupus erythematosus (SLE) (who had been taking 300 mg/die of hydroxychloroquine for 3 years), Graves' disease (treated with 10 mg/die of tapazole), and celiac disease came to our attention for urticarial vasculitis. She had been taking prednisone (25 mg/die) for 3 days, and her blood tests showed high levels of Mycoplasma pneumoniae IgM and IgG antibodies. The association between urticaria and M. pneumoniae infections can be present in up to 7% of the cases and, to the best of our knowledge, only two reports of urticarial vasculitis and M. pneumoniae in adults are available in the literature. Urticarial vasculitis can also be a rare cutaneous manifestation of SLE (affecting 2% of the patients), and our case is the first in the literature describing the coexistence of M. pneumoniae infection, SLE, and urticarial vasculitis in a pediatric patient, a case that rises an important differential diagnosis issue about the origin of urticarial vasculitis: SLE reactivation or urticarial vasculitis due to M. pneumoniae infection?

Background: Families of children affected with atopic dermatitis (AD) often report fear and anxiety regarding treatment with topical corticosteroids (TCS), which may lead to reduced compliance. The objective of our study was to measure, through a standardized questionnaire, fear of TCS in families of pediatric patients with AD and to identify items associated with fear., Methods: Families of pediatric patients with AD were enrolled in 9 Italian centers of pediatric dermatology. Enrolled parents were invited to fill in a questionnaire including questions on sociodemographic and clinical characteristics and 3 sets of questions on corticosteroid phobia (general fear, specific fears, behaviours regarding TCS). Determinants of the level of general fear were investigated through multivariable analysis., Results: A total of 300 outpatients with AD were enrolled. Most parents (80%) had a high instruction level. Eighty-one percent reported to have a certain amount of fear of TCS. At the multivariable analysis, fear of TCS was associated with the following items: believing that TCS treatment advantages do not overweight disadvantages (P = 0.011); believing that TCS may be dangerous independently from the specific side effect (P < 0.001). Moreover, TCS fear was associated with fear of applying too much cream (P = 0.001)., Conclusion: TCS phobia is widespread among Italian families of children with AD. Fear of TCS is associated with fear of applying too much cream, thus increasing the risk of poor compliance and treatment failure. Therapeutic education of families on the use of TCS should be implemented.