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Objectives: In our research study Secondary school students, ages (from 15 to 19) were included to find out the handling strategies for stress. Youngsters affected with anxiety, stress and depression in their early life, are prone to suffer from depression in upcoming future lives, by using inappropriate methods for its cure. Methods: This research is a cross sectional survey among 1028 young students who were managed at Mayo Hospital, Lahore (September, 2016 to November, 2017). Results: Among the participants About (26%) narrated that they shout, (20%) listen music, (13%) eating, (11%) like isolation, (13%) recite the Holy Quran, (8%) start fighting, (3%) exercise, and (6%) like talking to a person. Conclusion: Maximum of our secondary school students, in the survey have focus on emotional responses due to stress instead of focusing problem resolving. Due to this there is a bigger chance to develop depression in the upcoming life. There is need for making strategies for early diagnosis of the stress. It is found that talking with friends and relatives can serve as a good tool against stress. Handling tactics for stress used by high school students were seen and put into two cadres, one focusing on problem and the other, focusing on emotions. In the cadre, problem focus, person works to change the conditions which are producing stressed for example putting extra efforts towards exam stress and working hard to gain marks. In the cadre, focusing on emotion, the person puts efforts to reduce the stress such as relaxing himself, yelling etc. Various researches have reported depression among student but the aspect of handling strategies to overcome their depression needs to be discussed. Our study aims to advise on better techniques for the young students to handle stress. Keywords: Coping strategies, Adolescents and Stress.

Objective: Our objective in this research was the assessment and evaluation of L-Methyl folate efficacy in the combine form along with the escitalopram in comparison to the escitalopram monotherapy in the depression. Place and Duration of Study: The study was carried out from Jan, 18 to Jun, 18 in 6 months at Mayo Hospital Lahore. Material and Methods: The number of patients was 260 which were having Major Depression’s primary diagnosis along with score above fourteen on depression (Hamilton rating scale) i.e. HAM-D & they were selected in this study of Randomized Controlled Trial. The patients were classified in two groups & then Group-A was given ten milligram (Escitalopram) in addition to placebo while group B was given ten milligram (Escitalopram) in addition to L-Methyl folate in the form of a dose of 15 mg. Group-A and Group-B were assessed again after 1 month & the scores of HAM-D were measured. Results: In the total number of 260 patients, the response was there in 70.8 percent i.e. 184 & 29.2 percent i.e. 76 never responded to the treatment. The patients were 82 at 63.1 percent which have shown response to treatment but 48 patients at 36.9 percent never responded and these patients were total 130 which were treated along with SSRI. In total 130 patients which were treated with escitalopram & L-Methyl folate, 28 at 21.5 percent never responded and 102 at 78.5 percent showed response to treatment. With a confidence interval of 95 percent, the P-value was observed as (0.006) which showed that primary difference of both interventions was statistically significant. Conclusion: Our final result was that a combination of L-Methyl folate & SSRI in depression may prove to be more efficient as compared to the Escitalopram monotherapy. Keywords: Major depressive disorder, Escitalopram, L-Methyl folate.