Search

Your search keyword '"Amoah, Linda"' showing total 404 results
Start Over Author "Amoah, Linda"
404 results on '"Amoah, Linda"'

2. Comparison of microscopic and xpert MTB diagnoses of presumptive mycobacteria tuberculosis infection: retrospective analysis of routine diagnosis at Cape Coast Teaching Hospital

Author

Asare, Kwame Kumi, Azumah, Daniel Edem, Adu-Gyamfi, Czarina Owusua, Opoku, Yeboah Kwaku, Adela, Edward Morkporkpor, Afful, Philip, Abotsi, Godwin Kwami, Abban, Ernest Awuakye, Duntu, Paul Ekow, Anyamful, Akwasi, Moses, Alberta Bedford, Botchway, Emmanuel, Mwintige, Philimon, Kyei, Samuel, Amoah, Linda Eva, and Ekuman, Emmanuel Owusu

Published
2024
Full Text
View/download PDF

3. Diagnostic performance of an ultra-sensitive RDT and a conventional RDT in malaria mass testing, treatment and tracking interventions in southern Ghana

Author

Amoah, Linda Eva, Cheng, Ndong Ignatius, Acquah, Festus Kojo, Adu-Amankwah, Susan, Bredu, Dorcas Gyama, Mensah, Benedicta A., Anang, Sherik-fa, Abban, Bernice Cubson, Busayomi, Abena, Kwarpong, Sebastian Shine, Tey, Prosper Kofi, Cudjoe, Elizabeth, Asamoah, Alexander, Holden, Tobias McKenzie, Gerardin, Jaline, Nonvignon, Justice, and Ahorlu, Collins

Published
2024
Full Text
View/download PDF

7. Genetic Diversity and Population Structure of Anopheles funestus in Western Kenya Based on Mitochondrial DNA Marker COII

Author

Debrah, Isaiah, Ochwedo, Kevin O, Otambo, Wilfred O, Machani, Maxwell G, Magomere, Edwin O, Onyango, Shirley A, Zhong, Daibin, Amoah, Linda E, Githeko, Andrew K, Afrane, Yaw A, and Yan, Guiyun

Subjects
Biological Sciences, Ecology, Genetics, Infectious Diseases, Rare Diseases, Malaria, Vector-Borne Diseases, Infection, Good Health and Well Being, Anopheles funestus, COII, gene flow, genetic diversity, western Kenya, Zoology
Abstract

The mitochondrial marker, COII, was employed to assess the genetic structure and diversity of Anopheles funestus, a very important malaria vector in Africa that adapt and colonize different ecological niches in western Kenya. Mosquitoes were collected using mechanical aspirators in four areas (Bungoma, Port Victoria, Kombewa, and Migori) in western Kenya. Following morphological identification, PCR was used to confirm the species. The COII gene was amplified, sequenced, and analyzed to determine genetic diversity and population structure. A total of 126 (Port Victoria-38, Migori-38, Bungoma-22, and Kombewa-28) sequences of COII were used for population genetic analysis. Anopheles funestus had a high haplotype diversity (Hd = 0.97 to 0.98) but low nucleotide diversity (Π = 0.004 to 0.005). The neutrality test revealed negative Tajima's D and Fs values indicating an excess of low-frequency variation. This could be attributed to either population expansion or negative selection pressure across all the populations. No genetic or structural differentiation (Fst = -0.01) and a high level of gene flow (Gamma St, Nm = 17.99 to 35.22) were observed among the populations. Population expansion suggests the high adaptability of this species to various ecological requirements, hence sustaining its vectorial capacity and malaria transmission.

Published
2023

11. Larval ecology and bionomics of Anopheles funestus in highland and lowland sites in western Kenya.

Author

Debrah, Isaiah, Afrane, Yaw A, Amoah, Linda E, Ochwedo, Kevin O, Mukabana, Wolfgang R, Zhong, Daibin, Zhou, Guofa, Lee, Ming-Chieh, Onyango, Shirley A, Magomere, Edwin O, Atieli, Harrysone, Githeko, Andrew K, and Yan, Guiyun

Subjects
Animals, Humans, Anopheles, Plasmodium falciparum, Malaria, Falciparum, Insecticides, Ecology, Mosquito Control, Larva, Kenya, Insecticide-Treated Bednets, Mosquito Vectors, Rare Diseases, Infectious Diseases, Vector-Borne Diseases, Malaria, Infection, Good Health and Well Being, General Science & Technology
Abstract

BackgroundAn. funestus is a major Afrotropical vector of human malaria. This study sought to investigate the larval ecology, sporozoite infection rates and blood meal sources of An. funestus in western Kenya.MethodsLarval surveys were carried out in Bungoma (Highland) and Kombewa (lowland) of western Kenya. Aquatic habitats were identified, characterized, georeferenced and carefully examined for mosquito larvae and predators. Indoor resting mosquitoes were sampled using pyrethrum spray catches. Adults and larvae were morphologically and molecularly identified to species. Sporozoite infections and blood meal sources were detected using real-time PCR and ELISA respectively.ResultsOf the 151 aquatic habitats assessed, 62/80 (78%) in Bungoma and 58/71(82%) in Kombewa were positive for mosquito larvae. Of the 3,193 larvae sampled, An. funestus larvae constitute 38% (1224/3193). Bungoma recorded a higher number of An. funestus larvae (85%, 95%, CI, 8.722-17.15) than Kombewa (15%, 95%, CI, 1.33-3.91). Molecular identification of larvae showed that 89% (n = 80) were An. funestus. Approximately 59%, 35% and 5% of An. funestus larvae co-existed with An. gambiae s.l, Culex spp and An. coustani in the same habitats respectively. Of 1,221 An. funestus s.l adults sampled, molecular identifications revealed that An. funestus constituted 87% (n = 201) and 88% (n = 179) in Bungoma and Kombewa, respectively. The Plasmodium falciparum sporozoite rate of An. funestus in Bungoma and Kombewa was 2% (3/174) and 1% (2/157), respectively, and the human blood index of An. funestus was 84% (48/57) and 89% (39/44) and for Bungoma and Kombewa, respectively.ConclusionMan-made ponds had the highest abundance of An. funestus larvae. Multiple regression and principal component analyses identified the distance to the nearest house as the key environmental factor associated with the abundance of An. funestus larvae in aquatic habitats. This study serves as a guide for the control of An. funestus and other mosquito species to complement existing vector control strategies.

Published
2021

12. Evaluating circulating soluble markers of endothelial dysfunction and risk factors associated with PE: A multicentre longitudinal case control study in northern Ghana

Author

Ahenkorah, Benjamin, Sakyi, Samuel Asamoah, Fondjo, Linda Ahenkorah, Helegbe, Gideon, Owiredu, Eddie-Williams, Der, Edmund Muonir, Amoah, Linda Eva, Kusi, Kwadwo Asamoah, Obiri, Dorotheah, Amoani, Benjamin, Bimpong, Samuel, Ofosu, Winfred, Obirikorang, Christian, Odame, Enoch, Larbie, Christopher, Arthur-Johnson, Priscilla, Quaye, Isaac, Ametefe, Emmanuel Mawuli, Okai, Bernard Kwaku, Anormah, Rasheed, Akorli, Emmanuel, Simono Charadan, Ana Maria, Aboubacar, Robilu Mikdad, Amesewu, Emmanuel, and Gyan, Ben

Published
2023
Full Text
View/download PDF

15. Plasmodium falciparum AMA1 and CSP antigen diversity in parasite isolates from southern Ghana

Author

Kusi, Kwadwo A., primary, Amoah, Linda E., additional, Acquah, Festus Kojo, additional, Ennuson, Nana Aba, additional, Frempong, Abena F., additional, Ofori, Ebenezer A., additional, Akyea-Mensah, Kwadwo, additional, Kyei-Baafour, Eric, additional, Osei, Frank, additional, Frimpong, Augustina, additional, Singh, Susheel K., additional, Theisen, Michael, additional, Remarque, Edmond J., additional, Faber, Bart W., additional, Belmonte, Maria, additional, Ganeshan, Harini, additional, Huang, Jun, additional, Villasante, Eileen, additional, and Sedegah, Martha, additional

Published
2024
Full Text
View/download PDF

17. Naturally acquired antibody response to a Plasmodium falciparum chimeric vaccine candidate GMZ2.6c and its components (MSP-3, GLURP, and Pfs48/45) in individuals living in Brazilian malaria-endemic areas

Author

Baptista, Barbara Oliveira, de Souza, Ana Beatriz Lopes, Riccio, Evelyn Kety Pratt, Bianco-Junior, Cesare, Totino, Paulo Renato Rivas, Martins da Silva, João Hermínio, Theisen, Michael, Singh, Susheel Kumar, Amoah, Linda Eva, Ribeiro-Alves, Marcelo, Souza, Rodrigo Medeiros, Lima-Junior, Josué Costa, Daniel-Ribeiro, Cláudio Tadeu, and Pratt-Riccio, Lilian Rose

Published
2022
Full Text
View/download PDF

21. Expression patterns of immune checkpoint proteins and Plasmodium falciparum‐induced cytokines in chronic hepatitis B virus‐infected and uninfected individuals: A cross‐sectional study.

Author

Segbefia, Selorm P., Asandem, Diana A., Pobee, Abigail, Asare, Bright, Prah, Ahu Diana, Baba‐Adam, Rawdat, Amponsah, Jones Amo, Kyei‐Baafour, Eric, van der Puije, William, Osei, Frank, Teye‐Adjei, Doreen, Agyemang, Seth, Brenko, Theophilus, Bentum‐Ennin, Lutterodt, Tetteh, John K. A., Bonney, Kofi J. H., Sakyi, Samuel Asamoah, Amoah, Linda E., and Kusi, Kwadwo A.

Subjects
IMMUNE checkpoint proteins, CHRONIC hepatitis B, HEPATITIS B virus, PROGRAMMED cell death 1 receptors, HEPATITIS B, CYTOKINES, PSYCHONEUROIMMUNOLOGY
Abstract

Background and Aim: Chronic hepatitis B virus (CHB) infection remains a major public health problem. The American Association for the Study of Liver Diseases (AASLD) 2018 Hepatitis B Guidelines provide that CHB individuals not requiring antiviral therapy yet are monitored to determine the need for antiviral therapy in the future; however, these tests do not include measurement of cytokines and immune cell characterization. This case‐control study compared the cytokine and immune checkpoint protein expression profiles between CHB individuals not yet on antiviral treatment and hepatitis B virus (HBV)‐negative individuals. Methods: CD4 and CD8 T cells from CHB and HBV‐negative individuals were characterized for immune checkpoint proteins programmed cell death‐1 (PD1), T cell Immunoglobulin domain and mucin domain‐containing protein 3 (TIM‐3), and cytotoxic T lymphocyte‐associated antigen 4 (CTLA‐4) (CD152), and a memory marker CXCR3 (CD183) using flow cytometry. Malaria‐induced cytokine expression levels were determined by stimulating their blood cells with Plasmodium falciparum 3D7 strain antigens (CSP, AMA‐1, and TRAP) in whole blood assays, and cytokine levels were measured using a 13‐plex Luminex kit. Results: HBV‐negative and CHB individuals had comparable levels of CD4+ and CD8+ T cells. However, a proportion of the CD4+ and CD8+ populations from both groups, which were CXCR3+, expressed PD‐1 and CD152. The ability to produce cytokines in response to malaria antigen stimulation was not significantly different between the groups. Conclusion: These findings support excluding CHB individuals from antiviral therapy at this stage of infection. However, CHB individuals require regular monitoring to determine the need for later antiviral treatment. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

26. The Pan African Vivax and Ovale Network (PAVON): Refocusing on Plasmodium vivax, ovale and asymptomatic malaria in sub-Saharan Africa

Author

Quaye, Isaac K., Aleksenko, Larysa, Oeuvray, Claude, Yewhalaw, Delenasaw, Duah, Nancy, Gyan, Ben, Haiyambo, Daniel H., Dongho, Ghyslaine Bruna Djeunang, Torgby, Ruth-Ayanful, Amoah, Linda, Hamid, Mahdi Abdel, Worku, Solomon, Bahiti, Assefa Ashenafi, Pasquale, Harriet Akello, Bitshi, Mimie, Troare, Isidore, Diarra, Amidou, Njunju, Eric, Cisse, Mamoudou, Soulama, Issiaka, Savadogo, Ragnessi Justin, Issifou, Saadou, Niangaly, Amadou, Dembele, Laurent, and Greco, Beatrice

Published
2021
Full Text
View/download PDF

28. Correction: Genotypic glucose-6-phosphate dehydrogenase (G6PD) deficiency protects against Plasmodium falciparum infection in individuals living in Ghana

Author

Amoah, Linda Eva, primary, Asare, Kwame Kumi, additional, Dickson, Donu, additional, Abankwa, Joana, additional, Busayo, Abena, additional, Bredu, Dorcas, additional, Annan, Sherifa, additional, Asumah, George Adu, additional, Peprah, Nana Yaw, additional, Asamoah, Alexander, additional, and Malm, Keziah Laurencia, additional

Published
2023
Full Text
View/download PDF

34. Cytokine gene polymorphisms implicated in the pathogenesis of Plasmodium falciparum infection outcome.

Author

Segbefia, Selorm Philip, Asandem, Diana Asema, Eva Amoah, Linda, and Kusi, Kwadwo Asamoah

Subjects
GENETIC polymorphisms, PLASMODIUM falciparum, MALARIA vaccines, CYTOKINES, IMMUNE response
Abstract

Cytokines play a critical role in the immune mechanisms involved in fighting infections including malaria. Polymorphisms in cytokine genes may affect immune responses during an infection with Plasmodium parasites and immunization outcomes during routine administration of malaria vaccines. These polymorphisms can increase or reduce susceptibility to this deadly infection, and this may affect the physiologically needed balance between antiinflammatory and pro-inflammatory cytokines. The purpose of this review is to present an overview of the effect of selected cytokine gene polymorphisms on immune responses against malaria. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

38. World Hepatitis day 2021 –screening and vaccination against Hepatitis B virus in Accra, Ghana

Author

Kusi, Kwadwo Asamoah, primary, van der Puije, William, additional, Asandem, Diana A., additional, Baba-Adam, Rawdat, additional, Agbevey, Hardy, additional, Asare, Bright, additional, Segbefia, Philip, additional, Bentum-Ennin, Lutterodt, additional, Annan, Audrey, additional, Osei, Frank, additional, Teye-Adjei, Doreen, additional, Galevo, Elsie Sutaya, additional, Odame, Gifty, additional, Ansa, Gloria, additional, Amoah, Linda, additional, and Bonney, Joseph Humphrey Kofi, additional

Published
2023
Full Text
View/download PDF

40. Sensitive Detection of Asymptomatic and Symptomatic Malaria with Seven Novel Parasite-Specific LAMP Assays and Translation for Use at Point-of-Care

Author

Malpartida-Cardenas, Kenny, primary, Moser, Nicolas, additional, Ansah, Felix, additional, Pennisi, Ivana, additional, Ahu Prah, Diana, additional, Amoah, Linda Eva, additional, Awandare, Gordon, additional, Hafalla, Julius Clemence R., additional, Cunnington, Aubrey, additional, Baum, Jake, additional, Rodriguez-Manzano, Jesus, additional, and Georgiou, Pantelis, additional

Published
2023
Full Text
View/download PDF

45. Nationwide Surveillance of Pfhrp2 Exon 2 Diversity in Plasmodium falciparum Circulating in Symptomatic Malaria Patients Living in Ghana

Author

Bredu, Dorcas G., Ahadzi, George K., Donu, Dickson, Peprah, Nana Y., Asamoah, Alexander, Asumah, George A., Abuaku, Benjamin, Asare, Kwame K., Obiri-Yeboah, Dorcas, Ford, Colby T., Lo, Eugenia, Malm, Keziah L., and Amoah, Linda E.

Subjects
Infectious Diseases, Virology, Parasitology, Research Article
Abstract

Reports of increasing false-negative HRP2-based rapid diagnostic test results across Africa require constant monitoring of factors associated with these false-negative outcomes, as failure of this diagnostic tool will have severe consequences on malaria treatment and control programs. This study characterized the extent of genetic diversity in the Plasmodium falciparum histidine-rich protein 2 (Pfhrp2) gene in P. falciparum isolates from symptomatic malaria patients across the regions of Ghana. Exon 2 of Pfhrp2 was amplified from gDNA using polymerase chain reaction. All Pfhrp2-negative samples were subjected to Pf18S rRNA and Pfmsp2 gene amplifications. The amplified Pfhrp2 exon 2 fragments from clonal samples were sent for commercial Sanger sequencing. The type and number of PfHRP2 repeats, classified based on repeat types previously reported, were estimated from the sequence data and compared among geographical regions. About 81% (2,333/2,890) of the original microscopy positive dried blood spot (DBS) samples were available and used in this study. The Pfhrp2 exon 2 amplification was successful in 98.5% (2,297/2,333) of the tested samples, with band size ranging from 400 bp to 1,050 bp. A total of 13 out of the 24 previously reported repeat types were identified among the samples, with three samples lacking both type 2 and type 7 repeat motifs. This study suggested that the genetic diversity of Pfhrp2 exon 2 identified in P. falciparum circulating in symptomatic malaria patients in Ghana is unlikely to influence the sensitivity and specificity of HRP2 RDT-based diagnosis.

Published
2022

46. B-Cell Epitope Mapping of the Plasmodium falciparum Malaria Vaccine Candidate GMZ2.6c in a Naturally Exposed Population of the Brazilian Amazon

Author

Baptista, Barbara de Oliveira, primary, Souza, Ana Beatriz Lopes de, additional, Oliveira, Luana Santos de, additional, Souza, Hugo Amorim dos Santos de, additional, Barros, Jenifer Peixoto de, additional, Queiroz, Lucas Tavares de, additional, Souza, Rodrigo Medeiros de, additional, Amoah, Linda Eva, additional, Singh, Susheel Kumar, additional, Theisen, Michael, additional, Rodrigues-da-Silva, Rodrigo Nunes, additional, Riccio, Evelyn Kety Pratt, additional, Totino, Paulo Renato Rivas, additional, Lima-Junior, Josué da Costa, additional, Daniel-Ribeiro, Cláudio Tadeu, additional, and Pratt-Riccio, Lilian Rose, additional

Published
2023
Full Text
View/download PDF

47. Immunodominant T cell peptides from four candidate malarial antigens as biomarkers of protective immunity against malaria

Author

Belmonte, Maria, primary, Ganeshan, Harini, additional, Huang, Jun, additional, Belmonte, Arnel, additional, Inoue, Sandra, additional, Velasco, Rachel, additional, Acheampong, Neda, additional, Ofori, Ebenezer Addo, additional, Akyea-Mensah, Kwadwo, additional, Frimpong, Augustina, additional, Ennuson, Nana Aba, additional, Frempong, Abena Fremaah, additional, Kyei-Baafour, Eric, additional, Amoah, Linda Eva, additional, Edgel, Kimberly, additional, Peters, Bjoern, additional, Villasante, Eileen, additional, Kusi, Kwadwo Asamoah, additional, and Sedegah, Martha, additional

Published
2023
Full Text
View/download PDF

48. Genetic Diversity and Population Structure of Anopheles funestus in western Kenya Based on Mitochondrial DNA Marker mtDNA-COII

Author

Debrah, Isaiah, primary, Ochwedo, Kevin O., additional, Otambo, Wilfred O., additional, Machani, Maxwell G., additional, Magomere, Edwin O., additional, Onyango, Shirley A., additional, Zhong, Daibin, additional, Amoah, Linda Eva, additional, Githeko, Andrew Karanja, additional, Afrane, Yaw Asare, additional, and Yan, Guiyun, additional

Published
2023
Full Text
View/download PDF

49. Correction: Antischistosomal, antionchocercal and antitrypanosomal potentials of some Ghanaian traditional medicines and their constituents

Author

Twumasi, Emmanuella Bema, primary, Akazue, Pearl Ihuoma, additional, Kyeremeh, Kwaku, additional, Gwira, Theresa Manful, additional, Keiser, Jennifer, additional, Cho-Ngwa, Fidelis, additional, Flint, Adrian, additional, Anibea, Barbara, additional, Bonsu, Emmanuel Yeboah, additional, Amewu, Richard K., additional, Amoah, Linda Eva, additional, Appiah-Opong, Regina, additional, and Osei-Safo, Dorcas, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results