Introduction: Acute appendicitis is one of the most common indications for urgent surgical intervention in children. An open appendectomy has been applying since the end of the XIX century, but for the last thirty years, laparoscopic appendectomy became an alternative. There is no consensus among surgeons, which method is suitable for pediatric patients. Aim: The aim of the research is to establish which of these two methods has therapeutic advantages in children, analyzing comparatively their operative and postoperative course in the treatment of acute appendicitis. Material and methods: The study includes 330 children with acute appendicitis. Patients were divided into 2 groups: operated by the method of open appendectomy (OA) and laparoscopic surgery (LA). Analyzed parameters were: methods of operation, age and sex of patients, intraoperative findings, duration of surgery, length of hospital stay, intraoperative and postoperative complications, preoperative levels of leukocytes, duration of antibiotic therapy and pain therapy. Results: In total of 330 children with acute appendicitis, 255 (77%) were operated by OA and 75 (23%) by LA. Catarrhal appendicitis is significantly more frequent intraoperative finding in LA (61%, p < 0.05), while phlegmonous is in OA (49%, p < 0.05). Mean operative time is 61 minutes in LA, compared with 38 minutes in OA. Mean length of hospital stay is 4.2 days after both operative techniques. Antibiotic treatment lasts as the hospital stay. Mean length of pain treatment is 1.3 days after LA and 1.5 days after OA. Conclusion: More children and especially with severe forms of acute appendicitis were treated by OA. Lesser number of patients and less severe forms of acute appendicitis were treated by LA. Total length of hospital stay, antibiotic and pain therapy are shorter in laparoscopic comparing to OA.