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2 results on '"Anal cavity"'

1. Anal Melanoma With Neuroendocrine Differentiation: Report of a Case.

Author

Ilardi, Gennaro, Caroppo, Danila, Varricchio, Silvia, Vita, Giulia, Di Lorenzo, Pierpaolo, Insabato, Luigi, De Rosa, Gaetano, and Mascolo, Massimo

Subjects
*ANAL cancer, *NEUROENDOCRINE tumors, *BIOMARKERS
Abstract

Melanoma of the anal cavity is an uncommon malignant tumor with an aggressive clinical behavior. The presence of nonmelanocytic cell or tissue components, designated as divergent differentiation, is an unusual but well-documented phenomenon in melanoma. We experienced a rare case of amelanotic melanoma with neuroendocrine differentiation of the anal canal, occurring in a 68-year old woman. This tumor was characterized by a clear-cut radial growth phase and an invasive component composed of a diffuse small cells population positive for neuroendocrine markers with a focal but convincing co-expression of S100 protein. To the best of our knowledge, this represents the first case of neuroendocrine differentiation in a primary melanoma of the anal cavity. Although anal melanoma with neuroendocrine differentiation is exceptional, clinical practitioners should be aware of its possibility at this site. [ABSTRACT FROM AUTHOR]

Published
2015
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2. Anal melanoma with neuroendocrine differentiation: report of a case

Author

Silvia Varricchio, Massimo Mascolo, Danila Caroppo, Pierpaolo Di Lorenzo, Luigi Insabato, Giulia Vita, Gennaro Ilardi, Gaetano De Rosa, Ilardi, Gennaro, Caroppo, Danila, Varricchio, Silvia, Vita, Giulia, DI LORENZO, Pierpaolo, Insabato, Luigi, DE ROSA, Gaetano, and Mascolo, Massimo

Subjects
Amelanotic melanoma, Pathology, medicine.medical_specialty, Population, S100 protein, Neuroendocrine differentiation, Pathology and Forensic Medicine, Neuroendocrine Cells, medicine, Biomarkers, Tumor, Humans, education, Anal cavity, Melanoma, Anal Melanoma, Aged, education.field_of_study, business.industry, Cell Differentiation, Anal canal, medicine.disease, Anus Neoplasms, Immunohistochemistry, medicine.anatomical_structure, Surgery, Female, Anatomy, business
Abstract

Melanoma of the anal cavity is an uncommon malignant tumor with an aggressive clinical behavior. The presence of nonmelanocytic cell or tissue components, designated as divergent differentiation, is an unusual but well-documented phenomenon in melanoma. We experienced a rare case of amelanotic melanoma with neuroendocrine differentiation of the anal canal, occurring in a 68-year old woman. This tumor was characterized by a clear-cut radial growth phase and an invasive component composed of a diffuse small cells population positive for neuroendocrine markers with a focal but convincing co-expression of S100 protein. To the best of our knowledge, this represents the first case of neuroendocrine differentiation in a primary melanoma of the anal cavity. Although anal melanoma with neuroendocrine differentiation is exceptional, clinical practitioners should be aware of its possibility at this site.

Published
2015

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