337,419 results on '"Anand, A"'
Search Results
2. Trigger tool-based detection of adverse drug reactions - A prospective observational study
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Anand, Anjali K., Pereira, Ralph Winson, Shetty, Runi D., Jain, Praneetha, Supriya, P. S., and Shetty, Shraddha
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- 2024
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3. Titanium elastic nails for distal radius-ulna fractures in young dogs
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Sodhi, Harmanpreet Singh, Kumar, Ashwani, Anand, Arun, Sangwan, Vandana, and Gupta, Dhiraj Kumar
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- 2024
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4. Tocopherols and antioxidants assay to understand the mechanism of soybean seed longevity
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Sooganna, Jain, S.K., Lamichaney, Amrit, Saha, Supradip, Anand, Anjali, and Lal, S.K.
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- 2024
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5. Comparison of titanium elastic nailing and end-threaded intramedullary pinning for distal femoral fractures in young dogs
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Sodhi, Harmanpreet Singh, Kumar, Ashwani, Anand, Arun, Sangwan, Vandana, and Singh, Opinder
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- 2023
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6. Evaluation of diagnostic, prognostic indicators and surgical outcome in 20 cases treated for equine intestinal colic
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Khosa, J.S., Anand, Arun, Sangwan, V., Mahajan, S.K., Mohindroo, J., and Singh, S.S.
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- 2023
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7. Radiographic assessment of dogs with congestive heart failure
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Saini, N., Uppal, S.K., and Anand, A.
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- 2023
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8. Evaluation of potential larvicidal and pupicidal activity of Cassia fistula L. synthesized silver nanoparticles against Aedes aegypti
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George, Jincy A., Rajendran, Rajesh, Anand, Asha, and Paari, Kuppusamy Alagesan
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- 2023
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9. Evaluation of clinical, laboratory and ultrasonography variables as prognostic indicators in equine colic surgery
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Singh, Gurpal, Sangwan, Vandana, Anand, Arun, Khosa, Jasmeet Singh, Singh, Simrat Sagar, Mohindroo, Jitender, Gupta, Kuldeep, and Sethi, Ram Saran
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- 2023
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10. Geo-Spatial Tools for Science-Based Management of Inland Aquatic Habitats and Conservation of Fish Genetic Resources
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Krishnan, P, Kantharajan, G, Chandran, Rejani, Anand, A, and Mohindra, Vindhya
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- 2022
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11. Fabrication of indigenous positioners for thoracic radiography in dogs
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Singh, Ravi, Mohindroo, Jitender, Anand, Arun, Khosa, Jasmeet Singh, and Singh, Opinder
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- 2022
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12. Reliability of abdominal focused assessment with sonography of abdominal free fluid in canine trauma patients
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Kumar, Manoj, Mohindroo, J., Devi, N. Umeshwori, Anand, Arun, and Pathak, Devendra
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- 2022
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13. Epidemiological profiling and autopsy findings of neck in suicidal hanging in Bhubaneswar, Odisha-A prospective study
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Chandra, Vikash, Sharma, Mukul, and Anand, Aditya
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- 2023
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14. Economics of oyster mushroom (Pleurotus spp) Production in Bhagalpur district of Bihar
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Kumari, Nitu, Anand, Abhishek, Kumar, Sandeep, Panda, Chandan Kumar, and Kumari, Meera
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- 2022
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15. Counting 3-uple Veronese surfaces
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Deopurkar, Anand and Patel, Anand
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Mathematics - Algebraic Geometry ,14N10, 14N25, 14N15, 51N35 - Abstract
This paper culminates in the count of the number of 3-Veronese surfaces passing through 13 general points. This follows the case of 2-Veronese surfaces discovered by Coble in the 1920's. One important element of the calculation is a direct construction of a space of "complete triangles." Our construction is different from the classical ordered constructions of Schubert, Collino and Fulton, as it occurs directly on the Hilbert scheme of length 3 subschemes of the plane. We transport the enumerative problem into a 26-dimensional Grassmannian bundle over our space of complete triangles, where we perform Atiyah-Bott localization. Several important questions arise, which we collect at the end of the paper.
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- 2024
16. A Singular Integral for a Simplified Clairaut Equation
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Ganesh, Anand and Rajagopalan, Anand
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Mathematics - Classical Analysis and ODEs ,Mathematics - Analysis of PDEs ,35A09 (Primary) 35F20, 35-03 (Secondary) - Abstract
This expository article makes a connection between Euler's homogeneous function theorem and a Lagrange integral for a simplified version of the Clairaut Equation. After describing both solutions in detail, we prove a new result, that the Lagrange solution is strictly more general than Euler's solution. This is shown using a few examples which substitute Euler's homogeneous function with a more general surface. The first rather complicated example is based directly on Goursat's definition of a general integral, while the subsequent simpler examples are based on a suitably expanded notion of the general integral. These new examples, and the expanded notion of the general integral may be of interest. We aim to present these classical PDE concepts to readers with a basic knowledge of multivariable calculus., Comment: 14 pages, 7 figures
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- 2024
17. Effect of magnetic fields due to electric currents in an HTS power cable and estimation of stress
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de Souza, Isaac, Anand, Ankit, Gour, Abhay Singh, and Rao, Vutukuru Vasudeva
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- 2022
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18. Cooling plates heat loss estimation for 50 kJ HTS SMES using coupled magneto-thermal transient analysis with a varying ramp rate
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Anand, Ankit, Gour, Abhay Singh, Datt, T. S., and Rao, Vutukuru Vasudeva
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- 2022
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19. Radiographic Assessment of Dogs with Pulmonary Arterial Hypertension
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Kumar, Tejini M, Saini, Neetu, and Anand, Arun
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- 2021
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20. A clinical study on the incidence and diagnosis of developmental orthopaedic diseases in dogs
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Shameena, K.S., Singh, N., Mahajan, S.K., Mohindroo, J., and Anand, A.
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- 2021
21. EC670488 (EC670488; INGR21011), a Rice (Oryza sativa × O. glaberrima) Germplasm Tolerant to High Temperature Stress (>35°C) at Reproductive Stage with Very High Spikelet Fertility Particularly Under High Temperature Stress
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Krishnan, S Gopala, Singh, Ashok K, Pal, Madan, Nagarajan, M, Bhowmick, Prolay K, Vinod, KK, Ellur, Ranjith K, Bollinedi, Haritha, Ravikiran, KT, Viswanathan, C, and Anand, Anjali
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- 2023
22. Antimicrobial stewardship in veterinary practice: A review
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Kumar, Sanjay, Gupta, Kapil Kumar, Kumar, Rajender, Anand, Atul, and Krishnan, Rahul
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- 2021
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23. Inquest by Sub-Divisional Magistrate- Demographic pattern of deaths of women within seven years of their marriages in Delhi and NCR
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Anand, Aditya, Kumar, Munesh, Navlani, Lakhan Lal, and Gupta, Mohit
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- 2021
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24. Estimation of time since death from morphological changes in red blood cells of human cadaver: An autopsy-based study
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Anand, Aditya, Banerjee, K.K., Kohli, Anil, and Arora, Vinod Kumar
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- 2021
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25. Assessment of seed storability of onion varieties with accelerated ageing test
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Kumar, Sunil, Basu, Sudipta, Anand, Anjali, Lal, Sandeep Kumar, and Tomar, Bhoopal Singh
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- 2021
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26. A scalable adaptive quadratic kernel method for interpretable epistasis analysis in complex traits.
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Fu, Boyang, Anand, Prateek, Anand, Aakarsh, Mefford, Joel, and Sankararaman, Sriram
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Epistasis ,Genetic ,Humans ,Algorithms ,Models ,Genetic ,Quantitative Trait Loci ,Multifactorial Inheritance ,Phenotype ,Polymorphism ,Single Nucleotide ,Genome-Wide Association Study - Abstract
Our knowledge of the contribution of genetic interactions (epistasis) to variation in human complex traits remains limited, partly due to the lack of efficient, powerful, and interpretable algorithms to detect interactions. Recently proposed approaches for set-based association tests show promise in improving the power to detect epistasis by examining the aggregated effects of multiple variants. Nevertheless, these methods either do not scale to large Biobank data sets or lack interpretability. We propose QuadKAST, a scalable algorithm focused on testing pairwise interaction effects (quadratic effects) within small to medium-sized sets of genetic variants (window size ≤100) on a trait and provide quantified interpretation of these effects. Comprehensive simulations show that QuadKAST is well-calibrated. Additionally, QuadKAST is highly sensitive in detecting loci with epistatic signals and accurate in its estimation of quadratic effects. We applied QuadKAST to 52 quantitative phenotypes measured in ≈300,000 unrelated white British individuals in the UK Biobank to test for quadratic effects within each of 9515 protein-coding genes. We detect 32 trait-gene pairs across 17 traits and 29 genes that demonstrate statistically significant signals of quadratic effects (accounting for the number of genes and traits tested). Across these trait-gene pairs, the proportion of trait variance explained by quadratic effects is comparable to additive effects, with five pairs having a ratio >1. Our method enables the detailed investigation of epistasis on a large scale, offering new insights into its role and importance.
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- 2024
27. Leveraging LLMs for Legacy Code Modernization: Challenges and Opportunities for LLM-Generated Documentation
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Diggs, Colin, Doyle, Michael, Madan, Amit, Scott, Siggy, Escamilla, Emily, Zimmer, Jacob, Nekoo, Naveed, Ursino, Paul, Bartholf, Michael, Robin, Zachary, Patel, Anand, Glasz, Chris, Macke, William, Kirk, Paul, Phillips, Jasper, Sridharan, Arun, Wendt, Doug, Rosen, Scott, Naik, Nitin, Brunelle, Justin F., and Thaker, Samruddhi
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Computer Science - Machine Learning ,Computer Science - Software Engineering - Abstract
Legacy software systems, written in outdated languages like MUMPS and mainframe assembly, pose challenges in efficiency, maintenance, staffing, and security. While LLMs offer promise for modernizing these systems, their ability to understand legacy languages is largely unknown. This paper investigates the utilization of LLMs to generate documentation for legacy code using two datasets: an electronic health records (EHR) system in MUMPS and open-source applications in IBM mainframe Assembly Language Code (ALC). We propose a prompting strategy for generating line-wise code comments and a rubric to evaluate their completeness, readability, usefulness, and hallucination. Our study assesses the correlation between human evaluations and automated metrics, such as code complexity and reference-based metrics. We find that LLM-generated comments for MUMPS and ALC are generally hallucination-free, complete, readable, and useful compared to ground-truth comments, though ALC poses challenges. However, no automated metrics strongly correlate with comment quality to predict or measure LLM performance. Our findings highlight the limitations of current automated measures and the need for better evaluation metrics for LLM-generated documentation in legacy systems., Comment: Abbreviated version submitted to LLM4Code 2025 (a workshop co-located with ICSE 2025), 13 pages, 3 figures
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- 2024
28. Probing dark matter halo profiles with multi-band observations of gravitational waves
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Tahelyani, Divya, Bhattacharyya, Arpan, and Sengupta, Anand S.
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General Relativity and Quantum Cosmology ,Astrophysics - Astrophysics of Galaxies ,High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
In this paper, we evaluate the potential of multiband gravitational wave observations to constrain the properties of static dark matter spikes around intermediate-mass ratio inspirals. The influence of dark matter on the orbital evolution of the compact binary is incorporated as a correction to the inspiral Newtonian gravitational waveform. We show that the observations from the proposed space-based detector GWSat, sensitive within the deci-Hz frequency band, when combined with that of the third-generation ground-based detectors like the Einstein Telescope and Cosmic Explorer, will produce significantly improved error estimates for all parameters. In particular, our results demonstrate that the joint multiband approach substantially refines the bounds on the dark matter spike parameters-namely, the power-law index and spike density-by factors of approximately $10^6$ and $10^3$, respectively, compared to observations employing only third-generation gravitational wave detectors., Comment: 13 pages, 5 figures
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- 2024
29. AttentionBreaker: Adaptive Evolutionary Optimization for Unmasking Vulnerabilities in LLMs through Bit-Flip Attacks
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Das, Sanjay, Bhattacharya, Swastik, Kundu, Souvik, Kundu, Shamik, Menon, Anand, Raha, Arnab, and Basu, Kanad
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Computer Science - Cryptography and Security ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Large Language Models (LLMs) have revolutionized natural language processing (NLP), excelling in tasks like text generation and summarization. However, their increasing adoption in mission-critical applications raises concerns about hardware-based threats, particularly bit-flip attacks (BFAs). BFAs, enabled by fault injection methods such as Rowhammer, target model parameters in memory, compromising both integrity and performance. Identifying critical parameters for BFAs in the vast parameter space of LLMs poses significant challenges. While prior research suggests transformer-based architectures are inherently more robust to BFAs compared to traditional deep neural networks, we challenge this assumption. For the first time, we demonstrate that as few as three bit-flips can cause catastrophic performance degradation in an LLM with billions of parameters. Current BFA techniques are inadequate for exploiting this vulnerability due to the difficulty of efficiently identifying critical parameters within the immense parameter space. To address this, we propose AttentionBreaker, a novel framework tailored for LLMs that enables efficient traversal of the parameter space to identify critical parameters. Additionally, we introduce GenBFA, an evolutionary optimization strategy designed to refine the search further, isolating the most critical bits for an efficient and effective attack. Empirical results reveal the profound vulnerability of LLMs to AttentionBreaker. For example, merely three bit-flips (4.129 x 10^-9% of total parameters) in the LLaMA3-8B-Instruct 8-bit quantized (W8) model result in a complete performance collapse: accuracy on MMLU tasks drops from 67.3% to 0%, and Wikitext perplexity skyrockets from 12.6 to 4.72 x 10^5. These findings underscore the effectiveness of AttentionBreaker in uncovering and exploiting critical vulnerabilities within LLM architectures.
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- 2024
30. Detecting electromagnetic counterparts to LIGO/Virgo/KAGRA gravitational wave events with DECam: Neutron Star Mergers
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Kunnumkai, Keerthi, Palmese, Antonella, Farah, Amanda M, Bulla, Mattia, Dietrich, Tim, Pang, Peter T H, Anand, Shreya, Andreoni, Igor, Cabrera, Tomas, and Connor, Brendan O
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Astrophysics - High Energy Astrophysical Phenomena ,General Relativity and Quantum Cosmology - Abstract
With GW170817 being the only multimessenger gravitational wave (GW) event with an associated kilonova (KN) detected so far, there exists a pressing need for realistic estimation of the GW localization uncertainties and rates, as well as optimization of available telescope time to enable the detection of new KNe. For this purpose, we simulate GW events assuming a data-driven, GW-motivated distribution of binary parameters for the LIGO/Virgo/KAGRA (LVK) fourth and fifth observing runs (O4 and O5). For our particular case of estimating KN detection rates in the O4 and O5 runs, we map the binary neutron star (BNS) and neutron star-black hole (NSBH) properties to the optical light curves arising from r-process nucleosynthesis in the ejecta. We use the simulated population of KNe to generate follow-up observing plans, with the primary goal of optimizing detection with the Gravitational Wave Multi-Messenger Astronomy DECam Survey (GW-MMADS). We explore KN detectability as a function of mass, distance, and spin of the binaries. Out of the mergers that produce a KN in our simulations, we expect detectable KNe for DECam-like instruments at a per-year rate of: $1-16$ ($0-1$) for BNS (NSBH) in O4, and $16-165$ ($1-12$) for BNS (NSBH) in O5, using a fiducial exposure time and conditional on the uncertainty on the equation of state (EOS) and volumetric rates of the mergers. Taking into account observability constraints, our scheduler covers the location of the KN $\sim 30-38\%$ of the times for our fiducial EOS. We provide the depths needed to detect a significant fraction of our simulated mergers for the astronomical community to use in their follow-up campaigns., Comment: 18 pages, 10 figures, 10 tables
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- 2024
31. Loss-to-Loss Prediction: Scaling Laws for All Datasets
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Brandfonbrener, David, Anand, Nikhil, Vyas, Nikhil, Malach, Eran, and Kakade, Sham
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language ,Statistics - Machine Learning - Abstract
While scaling laws provide a reliable methodology for predicting train loss across compute scales for a single data distribution, less is known about how these predictions should change as we change the distribution. In this paper, we derive a strategy for predicting one loss from another and apply it to predict across different pre-training datasets and from pre-training data to downstream task data. Our predictions extrapolate well even at 20x the largest FLOP budget used to fit the curves. More precisely, we find that there are simple shifted power law relationships between (1) the train losses of two models trained on two separate datasets when the models are paired by training compute (train-to-train), (2) the train loss and the test loss on any downstream distribution for a single model (train-to-test), and (3) the test losses of two models trained on two separate train datasets (test-to-test). The results hold up for pre-training datasets that differ substantially (some are entirely code and others have no code at all) and across a variety of downstream tasks. Finally, we find that in some settings these shifted power law relationships can yield more accurate predictions than extrapolating single-dataset scaling laws.
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- 2024
32. Rethinking MUSHRA: Addressing Modern Challenges in Text-to-Speech Evaluation
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Varadhan, Praveen Srinivasa, Gulati, Amogh, Sankar, Ashwin, Anand, Srija, Gupta, Anirudh, Mukherjee, Anirudh, Marepally, Shiva Kumar, Bhatia, Ankur, Jaju, Saloni, Bhooshan, Suvrat, and Khapra, Mitesh M.
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Computer Science - Computation and Language ,Computer Science - Machine Learning ,Computer Science - Sound ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
Despite rapid advancements in TTS models, a consistent and robust human evaluation framework is still lacking. For example, MOS tests fail to differentiate between similar models, and CMOS's pairwise comparisons are time-intensive. The MUSHRA test is a promising alternative for evaluating multiple TTS systems simultaneously, but in this work we show that its reliance on matching human reference speech unduly penalises the scores of modern TTS systems that can exceed human speech quality. More specifically, we conduct a comprehensive assessment of the MUSHRA test, focusing on its sensitivity to factors such as rater variability, listener fatigue, and reference bias. Based on our extensive evaluation involving 471 human listeners across Hindi and Tamil we identify two primary shortcomings: (i) reference-matching bias, where raters are unduly influenced by the human reference, and (ii) judgement ambiguity, arising from a lack of clear fine-grained guidelines. To address these issues, we propose two refined variants of the MUSHRA test. The first variant enables fairer ratings for synthesized samples that surpass human reference quality. The second variant reduces ambiguity, as indicated by the relatively lower variance across raters. By combining these approaches, we achieve both more reliable and more fine-grained assessments. We also release MANGO, a massive dataset of 47,100 human ratings, the first-of-its-kind collection for Indian languages, aiding in analyzing human preferences and developing automatic metrics for evaluating TTS systems., Comment: 19 pages, 12 Figures
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- 2024
33. STREAM: A Universal State-Space Model for Sparse Geometric Data
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Schöne, Mark, Bhisikar, Yash, Bania, Karan, Nazeer, Khaleelulla Khan, Mayr, Christian, Subramoney, Anand, and Kappel, David
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning ,Computer Science - Neural and Evolutionary Computing - Abstract
Handling sparse and unstructured geometric data, such as point clouds or event-based vision, is a pressing challenge in the field of machine vision. Recently, sequence models such as Transformers and state-space models entered the domain of geometric data. These methods require specialized preprocessing to create a sequential view of a set of points. Furthermore, prior works involving sequence models iterate geometric data with either uniform or learned step sizes, implicitly relying on the model to infer the underlying geometric structure. In this work, we propose to encode geometric structure explicitly into the parameterization of a state-space model. State-space models are based on linear dynamics governed by a one-dimensional variable such as time or a spatial coordinate. We exploit this dynamic variable to inject relative differences of coordinates into the step size of the state-space model. The resulting geometric operation computes interactions between all pairs of N points in O(N) steps. Our model deploys the Mamba selective state-space model with a modified CUDA kernel to efficiently map sparse geometric data to modern hardware. The resulting sequence model, which we call STREAM, achieves competitive results on a range of benchmarks from point-cloud classification to event-based vision and audio classification. STREAM demonstrates a powerful inductive bias for sparse geometric data by improving the PointMamba baseline when trained from scratch on the ModelNet40 and ScanObjectNN point cloud analysis datasets. It further achieves, for the first time, 100% test accuracy on all 11 classes of the DVS128 Gestures dataset.
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- 2024
34. DESI 2024 VII: Cosmological Constraints from the Full-Shape Modeling of Clustering Measurements
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DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Prieto, C. Allende, Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bahr-Kalus, B., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Bonici, M., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chebat, D., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elbers, W., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Frenk, C. S., Garcia-Quintero, C., Garrison, L. H., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Joyce, R., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kong, H., Koposov, S. E., Kremin, A., Krolewski, A., Lahav, O., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Matthewson, W., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mudur, N., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M. M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Ravoux, C., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Shafieloo, A., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Taylor, P., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Valogiannis, G., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Wilson, M. J., Yi, L., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., Zhuang, T., and Zou, H.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present cosmological results from the measurement of clustering of galaxy, quasar and Lyman-$\alpha$ forest tracers from the first year of observations with the Dark Energy Spectroscopic Instrument (DESI Data Release 1). We adopt the full-shape (FS) modeling of the power spectrum, including the effects of redshift-space distortions, in an analysis which has been validated in a series of supporting papers. In the flat $\Lambda$CDM cosmological model, DESI (FS+BAO), combined with a baryon density prior from Big Bang Nucleosynthesis and a weak prior on the scalar spectral index, determines matter density to $\Omega_\mathrm{m}=0.2962\pm 0.0095$, and the amplitude of mass fluctuations to $\sigma_8=0.842\pm 0.034$. The addition of the cosmic microwave background (CMB) data tightens these constraints to $\Omega_\mathrm{m}=0.3056\pm 0.0049$ and $\sigma_8=0.8121\pm 0.0053$, while further addition of the the joint clustering and lensing analysis from the Dark Energy Survey Year-3 (DESY3) data leads to a 0.4% determination of the Hubble constant, $H_0 = (68.40\pm 0.27)\,{\rm km\,s^{-1}\,Mpc^{-1}}$. In models with a time-varying dark energy equation of state, combinations of DESI (FS+BAO) with CMB and type Ia supernovae continue to show the preference, previously found in the DESI DR1 BAO analysis, for $w_0>-1$ and $w_a<0$ with similar levels of significance. DESI data, in combination with the CMB, impose the upper limits on the sum of the neutrino masses of $\sum m_\nu < 0.071\,{\rm eV}$ at 95% confidence. DESI data alone measure the modified-gravity parameter that controls the clustering of massive particles, $\mu_0=0.11^{+0.45}_{-0.54}$, while the combination of DESI with the CMB and the clustering and lensing analysis from DESY3 constrains both modified-gravity parameters, giving $\mu_0 = 0.04\pm 0.22$ and $\Sigma_0 = 0.044\pm 0.047$, in agreement with general relativity. [Abridged.], Comment: This DESI Collaboration Key Publication is part of the 2024 publication series using the first year of observations (see https://data.desi.lbl.gov/doc/papers/). 55 pages, 10 figures
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- 2024
35. DESI 2024 II: Sample Definitions, Characteristics, and Two-point Clustering Statistics
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DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Brown, Z., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Demina, R., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Frenk, C. S., Garcia-Quintero, C., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Hou, J., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kitaura, F. -S., Kong, H., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mudur, N., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M. M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Ravoux, C., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Scholte, D., Schubnell, M., Seo, H., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Wilson, M. J., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., and Zou, H.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the samples of galaxies and quasars used for DESI 2024 cosmological analyses, drawn from the DESI Data Release 1 (DR1). We describe the construction of large-scale structure (LSS) catalogs from these samples, which include matched sets of synthetic reference `randoms' and weights that account for variations in the observed density of the samples due to experimental design and varying instrument performance. We detail how we correct for variations in observational completeness, the input `target' densities due to imaging systematics, and the ability to confidently measure redshifts from DESI spectra. We then summarize how remaining uncertainties in the corrections can be translated to systematic uncertainties for particular analyses. We describe the weights added to maximize the signal-to-noise of DESI DR1 2-point clustering measurements. We detail measurement pipelines applied to the LSS catalogs that obtain 2-point clustering measurements in configuration and Fourier space. The resulting 2-point measurements depend on window functions and normalization constraints particular to each sample, and we present the corrections required to match models to the data. We compare the configuration- and Fourier-space 2-point clustering of the data samples to that recovered from simulations of DESI DR1 and find they are, generally, in statistical agreement to within 2\% in the inferred real-space over-density field. The LSS catalogs, 2-point measurements, and their covariance matrices will be released publicly with DESI DR1., Comment: This DESI Collaboration Key Publication is part of the 2024 publication series using the first year of observations (see https://data.desi.lbl.gov/doc/papers/)
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- 2024
36. DESI 2024 V: Full-Shape Galaxy Clustering from Galaxies and Quasars
- Author
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DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Garcia-Quintero, C., Garrison, L. H., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kong, H., Koposov, S. E., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M. M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Ravoux, C., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Rodríguez-Martínez, F., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Wilson, M. J., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., and Zou, H.
- Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the measurements and cosmological implications of the galaxy two-point clustering using over 4.7 million unique galaxy and quasar redshifts in the range $0.1
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- 2024
37. Towards Accessible Learning: Deep Learning-Based Potential Dysgraphia Detection and OCR for Potentially Dysgraphic Handwriting
- Author
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D, Vydeki, Bhandari, Divyansh, Patil, Pranav Pratap, and Kulkarni, Aarush Anand
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Dysgraphia is a learning disorder that affects handwriting abilities, making it challenging for children to write legibly and consistently. Early detection and monitoring are crucial for providing timely support and interventions. This study applies deep learning techniques to address the dual tasks of dysgraphia detection and optical character recognition (OCR) on handwriting samples from children with potential dysgraphic symptoms. Using a dataset of handwritten samples from Malaysian schoolchildren, we developed a custom Convolutional Neural Network (CNN) model, alongside VGG16 and ResNet50, to classify handwriting as dysgraphic or non-dysgraphic. The custom CNN model outperformed the pre-trained models, achieving a test accuracy of 91.8% with high precision, recall, and AUC, demonstrating its robustness in identifying dysgraphic handwriting features. Additionally, an OCR pipeline was created to segment and recognize individual characters in dysgraphic handwriting, achieving a character recognition accuracy of approximately 43.5%. This research highlights the potential of deep learning in supporting dysgraphia assessment, laying a foundation for tools that could assist educators and clinicians in identifying dysgraphia and tracking handwriting progress over time. The findings contribute to advancements in assistive technologies for learning disabilities, offering hope for more accessible and accurate diagnostic tools in educational and clinical settings.
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- 2024
38. Label Sharing Incremental Learning Framework for Independent Multi-Label Segmentation Tasks
- Author
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Anand, Deepa, Das, Bipul, Dangeti, Vyshnav, Jerald, Antony, Mullick, Rakesh, Patil, Uday, Sharma, Pakhi, and Sudhakar, Prasad
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence - Abstract
In a setting where segmentation models have to be built for multiple datasets, each with its own corresponding label set, a straightforward way is to learn one model for every dataset and its labels. Alternatively, multi-task architectures with shared encoders and multiple segmentation heads or shared weights with compound labels can also be made use of. This work proposes a novel label sharing framework where a shared common label space is constructed and each of the individual label sets are systematically mapped to the common labels. This transforms multiple datasets with disparate label sets into a single large dataset with shared labels, and therefore all the segmentation tasks can be addressed by learning a single model. This eliminates the need for task specific adaptations in network architectures and also results in parameter and data efficient models. Furthermore, label sharing framework is naturally amenable for incremental learning where segmentations for new datasets can be easily learnt. We experimentally validate our method on various medical image segmentation datasets, each involving multi-label segmentation. Furthermore, we demonstrate the efficacy of the proposed method in terms of performance and incremental learning ability vis-a-vis alternative methods.
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- 2024
39. Helly Number, Radon Number and Rank in $\Delta$-Convexity on Graphs
- Author
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Anand, Bijo S, Anil, Arun, Changat, Manoj, Nair, Revathy S., and Narasimha-Shenoi, Prasanth G.
- Subjects
Mathematics - Combinatorics ,52A35, 05C38, 05C69 - Abstract
This article discusses $\Delta$-convexity on simple connected graphs. We establish general bounds for the Helly number, Radon number, and rank with respect to $\Delta$-convexity on graphs. Additionally, we give the exact values for the Helly number and Radon number for chordal graphs, as well as the rank for block graphs., Comment: 14 pages , 2 figures
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- 2024
40. Multi-agent Path Finding for Timed Tasks using Evolutionary Games
- Author
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Paul, Sheryl, Balakrishnan, Anand, Qin, Xin, and Deshmukh, Jyotirmoy V.
- Subjects
Computer Science - Multiagent Systems ,Computer Science - Computer Science and Game Theory ,Computer Science - Neural and Evolutionary Computing - Abstract
Autonomous multi-agent systems such as hospital robots and package delivery drones often operate in highly uncertain environments and are expected to achieve complex temporal task objectives while ensuring safety. While learning-based methods such as reinforcement learning are popular methods to train single and multi-agent autonomous systems under user-specified and state-based reward functions, applying these methods to satisfy trajectory-level task objectives is a challenging problem. Our first contribution is the use of weighted automata to specify trajectory-level objectives, such that, maximal paths induced in the weighted automaton correspond to desired trajectory-level behaviors. We show how weighted automata-based specifications go beyond timeliness properties focused on deadlines to performance properties such as expeditiousness. Our second contribution is the use of evolutionary game theory (EGT) principles to train homogeneous multi-agent teams targeting homogeneous task objectives. We show how shared experiences of agents and EGT-based policy updates allow us to outperform state-of-the-art reinforcement learning (RL) methods in minimizing path length by nearly 30\% in large spaces. We also show that our algorithm is computationally faster than deep RL methods by at least an order of magnitude. Additionally our results indicate that it scales better with an increase in the number of agents as compared to other methods.
- Published
- 2024
- Full Text
- View/download PDF
41. Reliability, Resilience and Human Factors Engineering for Trustworthy AI Systems
- Author
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Mishra, Saurabh, Rao, Anand, Krishnan, Ramayya, Ayyub, Bilal, Aria, Amin, and Zio, Enrico
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Computer Science - Artificial Intelligence ,Electrical Engineering and Systems Science - Systems and Control - Abstract
As AI systems become integral to critical operations across industries and services, ensuring their reliability and safety is essential. We offer a framework that integrates established reliability and resilience engineering principles into AI systems. By applying traditional metrics such as failure rate and Mean Time Between Failures (MTBF) along with resilience engineering and human reliability analysis, we propose an integrate framework to manage AI system performance, and prevent or efficiently recover from failures. Our work adapts classical engineering methods to AI systems and outlines a research agenda for future technical studies. We apply our framework to a real-world AI system, using system status data from platforms such as openAI, to demonstrate its practical applicability. This framework aligns with emerging global standards and regulatory frameworks, providing a methodology to enhance the trustworthiness of AI systems. Our aim is to guide policy, regulation, and the development of reliable, safe, and adaptable AI technologies capable of consistent performance in real-world environments.
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- 2024
42. Lynx: Enabling Efficient MoE Inference through Dynamic Batch-Aware Expert Selection
- Author
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Gupta, Vima, Sinha, Kartik, Gavrilovska, Ada, and Iyer, Anand Padmanabha
- Subjects
Computer Science - Machine Learning ,Computer Science - Distributed, Parallel, and Cluster Computing - Abstract
Mixture-of-Experts (MoE) architectures have recently gained popularity in enabling efficient scaling of large language models. However, we uncover a fundamental tension: while MoEs are designed for selective expert activation, production serving requires request batching, which forces the activation of all experts and negates MoE's efficiency benefits during the decode phase. We present Lynx, a system that enables efficient MoE inference through dynamic, batch-aware expert selection. Our key insight is that expert importance varies significantly across tokens and inference phases, creating opportunities for runtime optimization. Lynx leverages this insight through a lightweight framework that dynamically reduces active experts while preserving model accuracy. Our evaluations show that Lynx achieves up to 1.55x reduction in inference latency while maintaining negligible accuracy loss from baseline model across complex code generation and mathematical reasoning tasks.
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- 2024
43. A Comprehensive Survey of AI-Driven Advancements and Techniques in Automated Program Repair and Code Generation
- Author
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Anand, Avinash, Gupta, Akshit, Yadav, Nishchay, and Bajaj, Shaurya
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Computer Science - Artificial Intelligence - Abstract
Bug fixing and code generation have been core research topics in software development for many years. The recent explosive growth in Large Language Models has completely transformed these spaces, putting in reach incredibly powerful tools for both. In this survey, 27 recent papers have been reviewed and split into two groups: one dedicated to Automated Program Repair (APR) and LLM integration and the other to code generation using LLMs. The first group consists of new methods for bug detection and repair, which include locating semantic errors, security vulnerabilities, and runtime failure bugs. The place of LLMs in reducing manual debugging efforts is emphasized in this work by APR toward context-aware fixes, with innovations that boost accuracy and efficiency in automatic debugging. The second group dwells on code generation, providing an overview of both general-purpose LLMs fine-tuned for programming and task-specific models. It also presents methods to improve code generation, such as identifier-aware training, fine-tuning at the instruction level, and incorporating semantic code structures. This survey work contrasts the methodologies in APR and code generation to identify trends such as using LLMs, feedback loops to enable iterative code improvement and open-source models. It also discusses the challenges of achieving functional correctness and security and outlines future directions for research in LLM-based software development., Comment: A survey of recent developments in AI-assisted automated program repair
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- 2024
44. Exploring the Role of LLMs for Supporting Older Adults: Opportunities and Concerns
- Author
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Kaliappan, Sidharth, Anand, Abhay Sheel, Saha, Koustuv, and Karkar, Ravi
- Subjects
Computer Science - Human-Computer Interaction - Abstract
We explore some of the existing research in HCI around technology for older adults and examine the role of LLMs in enhancing it. We also discuss the digital divide and emphasize the need for inclusive technology design. At the same time, we also surface concerns regarding privacy, security, and the accuracy of information provided by LLMs, alongside the importance of user-centered design to make technology accessible and effective for the elderly. We show the transformative possibilities of LLM-supported interactions at the intersection of aging, technology, and human-computer interaction, advocating for further research and development in this area., Comment: This short paper was accepted at CHI 2024 Workshop on HCI and Aging: New Directions, New Principles
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- 2024
45. Feynman's Entangled Paths to Optimized Circuit Design
- Author
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Anand, Kartik
- Subjects
Quantum Physics - Abstract
We motivate an intuitive way to think about quantum circuit optimization problem inspired by Feynman's path formalism. While the use of path integrals in quantum circuits remains largely underdeveloped due to the lack of definition of the action functional for such systems. However this feynman's path perspective leads us to consider about how entanglement evolution throughout the circuit can serve as a guiding principle for optimizing circuit design. We conjecture that an optimal state-path is highly likely to belong to a family of paths with the minimum possible path-entanglement sum. This could enhance the efficiency of circuit optimization problems by narrowing the state-path search space, leading to faster convergence and reliable output. Further, we discuss that for some special target states this conjecture may not provide significant insights to the circuit optimization problem and argue that such cases constitute only a small subset of the target sets encountered by a circuit optimization algorithm., Comment: 9 pages, 4 figures
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- 2024
46. The Hubble constant anchor galaxy NGC 4258: metallicity and distance from blue supergiants
- Author
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Kudritzki, Rolf-Peter, Urbaneja, Miguel A., Bresolin, Fabio, Macri, Lucas M., Yuan, Wenlong, Li, Siyang, Anand, Gagandeep S., and Riess, Adam G.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
A quantitative spectroscopic study of blue supergiant stars in the Hubble constant anchor galaxy NGC 4258 is presented. The non-LTE analysis of Keck I telescope LRIS spectra yields a central logarithmic metallicity (in units of the solar value) of [Z] = -0.05\pm0.05 and a very shallow gradient of -(0.09\pm0.11)r/r25 with respect to galactocentric distance in units of the isophotal radius. Good agreement with the mass-metallicity relationship of star forming galaxies based on stellar absorption line studies is found. A comparison with HII region oxygen abundances obtained from the analysis of strong emission lines shows reasonable agreement when the Pettini & Pagel (2004) calibration is used, while the Zaritsky et al. (1994) calibration yields values that are 0.2 to 0.3 dex larger. These results allow to put the metallicity calibration of the Cepheid Period--Luminosity relation in this anchor galaxy on a purely stellar basis. Interstellar reddening and extinction are determined using HST and JWST photometry. Based on extinction-corrected magnitudes, combined with the stellar effective temperatures and gravities we determine, we use the Flux-weighted Gravity--Luminosity Relationship (FGLR) to estimate an independent spectroscopic distance. We obtain a distance modulus m-M = 29.38\pm0.12 mag, in agreement with the geometrical distance derived from the analysis of the water maser orbits in the galaxy's central circumnuclear disk., Comment: accepted for publication in the Astrophysical Journal
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- 2024
47. Reduced Sample Complexity in Scenario-Based Control System Design via Constraint Scaling
- Author
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Choi, Jaeseok, Deo, Anand, Lagoa, Constantino, and Subramanyam, Anirudh
- Subjects
Mathematics - Optimization and Control ,Mathematics - Probability ,90C15 (Primary) 60F10, 93D09 (Secondary) - Abstract
The scenario approach is widely used in robust control system design and chance-constrained optimization, maintaining convexity without requiring assumptions about the probability distribution of uncertain parameters. However, the approach can demand large sample sizes, making it intractable for safety-critical applications that require very low levels of constraint violation. To address this challenge, we propose a novel yet simple constraint scaling method, inspired by large deviations theory. Under mild nonparametric conditions on the underlying probability distribution, we show that our method yields an exponential reduction in sample size requirements for bilinear constraints with low violation levels compared to the classical approach, thereby significantly improving computational tractability. Numerical experiments on robust pole assignment problems support our theoretical findings.
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- 2024
48. Azurin-Based Peptide p28 Arrests the p53-HDM2 Interactions: A Novel Anti-Cancer Pathway
- Author
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Joy, Albin, Srivastava, Anand, and Biswas, Rajib
- Subjects
Condensed Matter - Soft Condensed Matter - Abstract
Azurin and its derived peptides, notably p28, exhibit significant anticancer properties, primarily by stabilizing the tumor suppressor protein p53 and preventing its degradation. Previous studies have shown that p28 binds to p53's DNA-binding domain, protecting it from degradation mechanisms. Expanding on these findings, our research explored whether p28 acts on additional cancer pathways beyond p53 stabilization. Specifically, we examined the interactions between p28 and Human Double Minute 2 (HDM2), a protein that downregulates p53's tumor-suppressive activity by binding to its transactivation domain (TAD). HDM2 is crucial in diminishing p53's function, and our study aimed to determine if p28 disrupts this HDM2-p53 interaction. Using HADDOCK docking and molecular dynamics simulations, we identified three stable conformations of the HDM2-p28 complex. These conformations effectively block HDM2's hydrophobic pocket, allowing for sustained inter-chain interactions and showing favorable binding energies. Further analysis pinpointed essential residues in these interactions, and we calculated interaction energies using the Molecular Mechanics Poisson-Boltzmann Surface Area (MMPBSA) method. Our findings reveal that by blocking HDM2's binding sites, p28 helps maintain p53's transcriptional activity, thus enhancing its tumor-suppressive functions, including apoptosis and cell cycle arrest in cancer cells. This study enhances understanding of azurin-derived peptides' anticancer mechanisms and highlights p28's potential as a peptide-based anticancer agent. These findings also suggest the possibility of designing additional peptide therapies targeting HDM2 and other cancer-related pathways, opening new directions in anticancer therapeutics.
- Published
- 2024
49. Focused ion beam polishing based optimization of high-Q silica microdisk resonators
- Author
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Eswaramoorthy, Lekshmi, Sharma, Parul, Kumar, Brijesh, S, Abhay Anand V, Singh, Anuj Kumar, Mandal, Kishor Kumar, Mokkapati, Sudha, and Kumar, Anshuman
- Subjects
Physics - Optics ,Condensed Matter - Materials Science - Abstract
Whispering gallery mode (WGM) microdisk resonators are promising optical devices that confine light efficiently and enable enhanced nonlinear optical effects. This work presents a novel approach to reduce sidewall roughness in SiO\textsubscript{2} microdisk resonators using focused ion beam (FIB) polishing. The microdisks, with varying diameter ranging from 5 to 20 $\mu$m are fabricated using a multi-step fabrication scheme. However, the etching process introduces significant sidewall roughness, which increases with decreasing microdisk radius, degrading the resonators' quality. To address this issue, a FIB system is employed to polish the sidewalls, using optimized process parameters to minimize Ga ion implantation. White light interferometry measurements reveal a significant reduction in surface roughness from 7 nm to 20 nm for a 5 $\mu$m diameter microdisk, leading to a substantial enhancement in the scattering quality factor (Qss) from $3\times 10^2$ to $2\times 10^6$. These findings demonstrate the effectiveness of FIB polishing in improving the quality of microdisk resonators and open up new possibilities for the fabrication of advanced photonic devices.
- Published
- 2024
50. Phases of decodability in the surface code with unitary errors
- Author
-
Bao, Yimu and Anand, Sajant
- Subjects
Quantum Physics ,Condensed Matter - Disordered Systems and Neural Networks ,Condensed Matter - Statistical Mechanics - Abstract
The maximum likelihood (ML) decoder in the two-dimensional surface code with generic unitary errors is governed by a statistical mechanics model with complex weights, which can be simulated via (1+1)D transfer matrix contraction. Information loss with an increasing error rate manifests as a ferromagnetic-to-paramagnetic transition in the contraction dynamics. In this work, we establish entanglement as a separate obstruction to decoding; it can undergo a transition from area- to volume-law scaling in the transfer matrix contraction with increasing unitary error rate. In particular, the volume-law entanglement can coexist with ferromagnetic order, giving rise to a phase in which the encoded information is retained yet is effectively undecodable. We numerically simulate the ML decoding in the surface code subject to both single- and two-qubit Pauli-X rotations and obtain a phase diagram that contains a ferromagnetic area-law, a paramagnetic volume-law, and a potential ferromagnetic volume-law phase. We further show that, starting from the paramagnetic volume-law phase, tilting the single-qubit rotation away from the X-axis couples the stat-mech models for X and Z errors and can lead to a ferromagnetic volume-law phase in which, although Z errors remain correctable, the encoded classical information is hard to recover. To perform numerical simulations, we develop an algorithm for syndrome sampling based on the isometric tensor network representation of the surface code., Comment: 5 + 13 pages
- Published
- 2024
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