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1. CHARACTERIZATION OF COMPOSITES OF BERYLLIA AND LITHIUM-TITANATE PRODUCED BY SOL-GEL ROUTE

Author

B. N. Rath, S. J. Ghanwai, Mishra R., Bhattacharya S., Kaity S., Danani C., Kumar S., Alur V. D., Kumawat N., Sathiyamoorthy D., and Anantharaman S.

Subjects
Beryllium oxide, Lithium titanate, ITER, Tritium breeding ratio, Neutron multiplier, Neutron breeder, Clay industries. Ceramics. Glass, TP785-869
Abstract

Beryllium oxide (BeO) can be used as a constituent for lithium titanate (Li2TiO3) based composite material for neutron multiplication and breeding in International Thermonuclear Experimental Reactor (ITER) having tritium breeding ratio (TBR) more than 1.1. In the present investigation, we report the synthesis of various volume ratios of BeO-Li2TiO3 composites. The characterization showed that the coefficient of thermal expansion values for the composites are half of that of the Lithium titanate. The novel composites showed improved thermal conductivity compared to Li2TiO3. The thermal conductivity at 672 K which is close to the operating temperature is 47 W/mK which is ~17 times that of Li2TiO3. So there is a large improvement in thermal conductivity by use of this composite instead of use of Li2TiO3 and metallic Be separately. The impedance measurement showed that with the addition of BeO, there is reduction in electrical conductivity which is better to be used in the fusion reactor. The composites are found to have better modulus properties in comparison to Li2TiO3. So, from the present investigation, it could be concluded that it is possible to achieve tritium breeding ratio (TBR) more than 1.1 by optimizing the BeO and Li2TiO3 ratio with better properties.

Published
2014

3. Beyond the Imitation Game: Quantifying and extrapolating the capabilities of language models

Author

Srivastava, Aarohi, Rastogi, Abhinav, Rao, Abhishek, Shoeb, Abu Awal Md, Abid, Abubakar, Fisch, Adam, Brown, Adam R., Santoro, Adam, Gupta, Aditya, Garriga-Alonso, Adrià, Kluska, Agnieszka, Lewkowycz, Aitor, Agarwal, Akshat, Power, Alethea, Ray, Alex, Warstadt, Alex, Kocurek, Alexander W., Safaya, Ali, Tazarv, Ali, Xiang, Alice, Parrish, Alicia, Nie, Allen, Hussain, Aman, Askell, Amanda, Dsouza, Amanda, Slone, Ambrose, Rahane, Ameet, Iyer, Anantharaman S., Andreassen, Anders, Madotto, Andrea, Santilli, Andrea, Stuhlmüller, Andreas, Dai, Andrew, La, Andrew, Lampinen, Andrew, Zou, Andy, Jiang, Angela, Chen, Angelica, Vuong, Anh, Gupta, Animesh, Gottardi, Anna, Norelli, Antonio, Venkatesh, Anu, Gholamidavoodi, Arash, Tabassum, Arfa, Menezes, Arul, Kirubarajan, Arun, Mullokandov, Asher, Sabharwal, Ashish, Herrick, Austin, Efrat, Avia, Erdem, Aykut, Karakaş, Ayla, Roberts, B. Ryan, Loe, Bao Sheng, Zoph, Barret, Bojanowski, Bartłomiej, Özyurt, Batuhan, Hedayatnia, Behnam, Neyshabur, Behnam, Inden, Benjamin, Stein, Benno, Ekmekci, Berk, Lin, Bill Yuchen, Howald, Blake, Orinion, Bryan, Diao, Cameron, Dour, Cameron, Stinson, Catherine, Argueta, Cedrick, Ramírez, César Ferri, Singh, Chandan, Rathkopf, Charles, Meng, Chenlin, Baral, Chitta, Wu, Chiyu, Callison-Burch, Chris, Waites, Chris, Voigt, Christian, Manning, Christopher D., Potts, Christopher, Ramirez, Cindy, Rivera, Clara E., Siro, Clemencia, Raffel, Colin, Ashcraft, Courtney, Garbacea, Cristina, Sileo, Damien, Garrette, Dan, Hendrycks, Dan, Kilman, Dan, Roth, Dan, Freeman, Daniel, Khashabi, Daniel, Levy, Daniel, González, Daniel Moseguí, Perszyk, Danielle, Hernandez, Danny, Chen, Danqi, Ippolito, Daphne, Gilboa, Dar, Dohan, David, Drakard, David, Jurgens, David, Datta, Debajyoti, Ganguli, Deep, Emelin, Denis, Kleyko, Denis, Yuret, Deniz, Chen, Derek, Tam, Derek, Hupkes, Dieuwke, Misra, Diganta, Buzan, Dilyar, Mollo, Dimitri Coelho, Yang, Diyi, Lee, Dong-Ho, Schrader, Dylan, Shutova, Ekaterina, Cubuk, Ekin Dogus, Segal, Elad, Hagerman, Eleanor, Barnes, Elizabeth, Donoway, Elizabeth, Pavlick, Ellie, Rodola, Emanuele, Lam, Emma, Chu, Eric, Tang, Eric, Erdem, Erkut, Chang, Ernie, Chi, Ethan A., Dyer, Ethan, Jerzak, Ethan, Kim, Ethan, Manyasi, Eunice Engefu, Zheltonozhskii, Evgenii, Xia, Fanyue, Siar, Fatemeh, Martínez-Plumed, Fernando, Happé, Francesca, Chollet, Francois, Rong, Frieda, Mishra, Gaurav, Winata, Genta Indra, de Melo, Gerard, Kruszewski, Germán, Parascandolo, Giambattista, Mariani, Giorgio, Wang, Gloria, Jaimovitch-López, Gonzalo, Betz, Gregor, Gur-Ari, Guy, Galijasevic, Hana, Kim, Hannah, Rashkin, Hannah, Hajishirzi, Hannaneh, Mehta, Harsh, Bogar, Hayden, Shevlin, Henry, Schütze, Hinrich, Yakura, Hiromu, Zhang, Hongming, Wong, Hugh Mee, Ng, Ian, Noble, Isaac, Jumelet, Jaap, Geissinger, Jack, Kernion, Jackson, Hilton, Jacob, Lee, Jaehoon, Fisac, Jaime Fernández, Simon, James B., Koppel, James, Zheng, James, Zou, James, Kocoń, Jan, Thompson, Jana, Wingfield, Janelle, Kaplan, Jared, Radom, Jarema, Sohl-Dickstein, Jascha, Phang, Jason, Wei, Jason, Yosinski, Jason, Novikova, Jekaterina, Bosscher, Jelle, Marsh, Jennifer, Kim, Jeremy, Taal, Jeroen, Engel, Jesse, Alabi, Jesujoba, Xu, Jiacheng, Song, Jiaming, Tang, Jillian, Waweru, Joan, Burden, John, Miller, John, Balis, John U., Batchelder, Jonathan, Berant, Jonathan, Frohberg, Jörg, Rozen, Jos, Hernandez-Orallo, Jose, Boudeman, Joseph, Guerr, Joseph, Jones, Joseph, Tenenbaum, Joshua B., Rule, Joshua S., Chua, Joyce, Kanclerz, Kamil, Livescu, Karen, Krauth, Karl, Gopalakrishnan, Karthik, Ignatyeva, Katerina, Markert, Katja, Dhole, Kaustubh D., Gimpel, Kevin, Omondi, Kevin, Mathewson, Kory, Chiafullo, Kristen, Shkaruta, Ksenia, Shridhar, Kumar, McDonell, Kyle, Richardson, Kyle, Reynolds, Laria, Gao, Leo, Zhang, Li, Dugan, Liam, Qin, Lianhui, Contreras-Ochando, Lidia, Morency, Louis-Philippe, Moschella, Luca, Lam, Lucas, Noble, Lucy, Schmidt, Ludwig, He, Luheng, Colón, Luis Oliveros, Metz, Luke, Şenel, Lütfi Kerem, Bosma, Maarten, Sap, Maarten, ter Hoeve, Maartje, Farooqi, Maheen, Faruqui, Manaal, Mazeika, Mantas, Baturan, Marco, Marelli, Marco, Maru, Marco, Quintana, Maria Jose Ramírez, Tolkiehn, Marie, Giulianelli, Mario, Lewis, Martha, Potthast, Martin, Leavitt, Matthew L., Hagen, Matthias, Schubert, Mátyás, Baitemirova, Medina Orduna, Arnaud, Melody, McElrath, Melvin, Yee, Michael A., Cohen, Michael, Gu, Michael, Ivanitskiy, Michael, Starritt, Michael, Strube, Michael, Swędrowski, Michał, Bevilacqua, Michele, Yasunaga, Michihiro, Kale, Mihir, Cain, Mike, Xu, Mimee, Suzgun, Mirac, Walker, Mitch, Tiwari, Mo, Bansal, Mohit, Aminnaseri, Moin, Geva, Mor, Gheini, Mozhdeh, T, Mukund Varma, Peng, Nanyun, Chi, Nathan A., Lee, Nayeon, Krakover, Neta Gur-Ari, Cameron, Nicholas, Roberts, Nicholas, Doiron, Nick, Martinez, Nicole, Nangia, Nikita, Deckers, Niklas, Muennighoff, Niklas, Keskar, Nitish Shirish, Iyer, Niveditha S., Constant, Noah, Fiedel, Noah, Wen, Nuan, Zhang, Oliver, Agha, Omar, Elbaghdadi, Omar, Levy, Omer, Evans, Owain, Casares, Pablo Antonio Moreno, Doshi, Parth, Fung, Pascale, Liang, Paul Pu, Vicol, Paul, Alipoormolabashi, Pegah, Liao, Peiyuan, Liang, Percy, Chang, Peter, Eckersley, Peter, Htut, Phu Mon, Hwang, Pinyu, Miłkowski, Piotr, Patil, Piyush, Pezeshkpour, Pouya, Oli, Priti, Mei, Qiaozhu, Lyu, Qing, Chen, Qinlang, Banjade, Rabin, Rudolph, Rachel Etta, Gabriel, Raefer, Habacker, Rahel, Risco, Ramon, Millière, Raphaël, Garg, Rhythm, Barnes, Richard, Saurous, Rif A., Arakawa, Riku, Raymaekers, Robbe, Frank, Robert, Sikand, Rohan, Novak, Roman, Sitelew, Roman, LeBras, Ronan, Liu, Rosanne, Jacobs, Rowan, Zhang, Rui, Salakhutdinov, Ruslan, Chi, Ryan, Lee, Ryan, Stovall, Ryan, Teehan, Ryan, Yang, Rylan, Singh, Sahib, Mohammad, Saif M., Anand, Sajant, Dillavou, Sam, Shleifer, Sam, Wiseman, Sam, Gruetter, Samuel, Bowman, Samuel R., Schoenholz, Samuel S., Han, Sanghyun, Kwatra, Sanjeev, Rous, Sarah A., Ghazarian, Sarik, Ghosh, Sayan, Casey, Sean, Bischoff, Sebastian, Gehrmann, Sebastian, Schuster, Sebastian, Sadeghi, Sepideh, Hamdan, Shadi, Zhou, Sharon, Srivastava, Shashank, Shi, Sherry, Singh, Shikhar, Asaadi, Shima, Gu, Shixiang Shane, Pachchigar, Shubh, Toshniwal, Shubham, Upadhyay, Shyam, Shyamolima, Debnath, Shakeri, Siamak, Thormeyer, Simon, Melzi, Simone, Reddy, Siva, Makini, Sneha Priscilla, Lee, Soo-Hwan, Torene, Spencer, Hatwar, Sriharsha, Dehaene, Stanislas, Divic, Stefan, Ermon, Stefano, Biderman, Stella, Lin, Stephanie, Prasad, Stephen, Piantadosi, Steven T., Shieber, Stuart M., Misherghi, Summer, Kiritchenko, Svetlana, Mishra, Swaroop, Linzen, Tal, Schuster, Tal, Li, Tao, Yu, Tao, Ali, Tariq, Hashimoto, Tatsu, Wu, Te-Lin, Desbordes, Théo, Rothschild, Theodore, Phan, Thomas, Wang, Tianle, Nkinyili, Tiberius, Schick, Timo, Kornev, Timofei, Tunduny, Titus, Gerstenberg, Tobias, Chang, Trenton, Neeraj, Trishala, Khot, Tushar, Shultz, Tyler, Shaham, Uri, Misra, Vedant, Demberg, Vera, Nyamai, Victoria, Raunak, Vikas, Ramasesh, Vinay, Prabhu, Vinay Uday, Padmakumar, Vishakh, Srikumar, Vivek, Fedus, William, Saunders, William, Zhang, William, Vossen, Wout, Ren, Xiang, Tong, Xiaoyu, Zhao, Xinran, Wu, Xinyi, Shen, Xudong, Yaghoobzadeh, Yadollah, Lakretz, Yair, Song, Yangqiu, Bahri, Yasaman, Choi, Yejin, Yang, Yichi, Hao, Yiding, Chen, Yifu, Belinkov, Yonatan, Hou, Yu, Hou, Yufang, Bai, Yuntao, Seid, Zachary, Zhao, Zhuoye, Wang, Zijian, Wang, Zijie J., Wang, Zirui, and Wu, Ziyi

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence, Computer Science - Computers and Society, Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

Language models demonstrate both quantitative improvement and new qualitative capabilities with increasing scale. Despite their potentially transformative impact, these new capabilities are as yet poorly characterized. In order to inform future research, prepare for disruptive new model capabilities, and ameliorate socially harmful effects, it is vital that we understand the present and near-future capabilities and limitations of language models. To address this challenge, we introduce the Beyond the Imitation Game benchmark (BIG-bench). BIG-bench currently consists of 204 tasks, contributed by 450 authors across 132 institutions. Task topics are diverse, drawing problems from linguistics, childhood development, math, common-sense reasoning, biology, physics, social bias, software development, and beyond. BIG-bench focuses on tasks that are believed to be beyond the capabilities of current language models. We evaluate the behavior of OpenAI's GPT models, Google-internal dense transformer architectures, and Switch-style sparse transformers on BIG-bench, across model sizes spanning millions to hundreds of billions of parameters. In addition, a team of human expert raters performed all tasks in order to provide a strong baseline. Findings include: model performance and calibration both improve with scale, but are poor in absolute terms (and when compared with rater performance); performance is remarkably similar across model classes, though with benefits from sparsity; tasks that improve gradually and predictably commonly involve a large knowledge or memorization component, whereas tasks that exhibit "breakthrough" behavior at a critical scale often involve multiple steps or components, or brittle metrics; social bias typically increases with scale in settings with ambiguous context, but this can be improved with prompting., Comment: 27 pages, 17 figures + references and appendices, repo: https://github.com/google/BIG-bench

Published
2022

6. Beyond the Imitation Game: Quantifying and extrapolating the capabilities of language models.

Author

Aarohi Srivastava, Abhinav Rastogi, Abhishek Rao, Abu Awal Md Shoeb, Abubakar Abid, Adam Fisch, Adam R. Brown, Adam Santoro, Aditya Gupta, Adrià Garriga-Alonso, Agnieszka Kluska, Aitor Lewkowycz, Akshat Agarwal, Alethea Power, Alex Ray, Alex Warstadt, Alexander W. Kocurek, Ali Safaya, Ali Tazarv, Alice Xiang, Alicia Parrish, Allen Nie, Aman Hussain, Amanda Askell, Amanda Dsouza, Ambrose Slone, Ameet Rahane, Anantharaman S. Iyer, Anders Andreassen, Andrea Madotto, Andrea Santilli, Andreas Stuhlmüller, Andrew M. Dai, Andrew La, Andrew K. Lampinen, Andy Zou, Angela Jiang, Angelica Chen, Anh Vuong, Animesh Gupta, Anna Gottardi, Antonio Norelli, Anu Venkatesh, Arash Gholamidavoodi, Arfa Tabassum, Arul Menezes, Arun Kirubarajan, Asher Mullokandov, Ashish Sabharwal, Austin Herrick, Avia Efrat, Aykut Erdem, Ayla Karakas, B. Ryan Roberts, Bao Sheng Loe, Barret Zoph, Bartlomiej Bojanowski, Batuhan özyurt, Behnam Hedayatnia, Behnam Neyshabur, Benjamin Inden, Benno Stein 0001, Berk Ekmekci, Bill Yuchen Lin, Blake Howald, Bryan Orinion, Cameron Diao, Cameron Dour, Catherine Stinson, Cedrick Argueta, Cèsar Ferri Ramírez, Chandan Singh, Charles Rathkopf, Chenlin Meng, Chitta Baral, Chiyu Wu, Chris Callison-Burch, Chris Waites, Christian Voigt, Christopher D. Manning, Christopher Potts, Cindy Ramirez, Clara E. Rivera, Clemencia Siro, Colin Raffel, Courtney Ashcraft, Cristina Garbacea, Damien Sileo, Dan Garrette, Dan Hendrycks, Dan Kilman, Dan Roth, Daniel Freeman, Daniel Khashabi, Daniel Levy, Daniel Moseguí González, Danielle Perszyk, Danny Hernandez, Danqi Chen 0001, Daphne Ippolito, Dar Gilboa, David Dohan, David Drakard, David Jurgens, Debajyoti Datta, Deep Ganguli, Denis Emelin, Denis Kleyko, Deniz Yuret, Derek Chen, Derek Tam, Dieuwke Hupkes, Diganta Misra, Dilyar Buzan, Dimitri Coelho Mollo, Diyi Yang, Dong-Ho Lee, Dylan Schrader, Ekaterina Shutova, Ekin Dogus Cubuk, Elad Segal, Eleanor Hagerman, Elizabeth Barnes, Elizabeth Donoway, Ellie Pavlick, Emanuele Rodolà, Emma Lam, Eric Chu, Eric Tang, Erkut Erdem, Ernie Chang, Ethan A. Chi, Ethan Dyer, Ethan J. Jerzak, Ethan Kim, Eunice Engefu Manyasi, Evgenii Zheltonozhskii, Fanyue Xia, Fatemeh Siar, Fernando Martínez-Plumed, Francesca Happé, François Chollet, Frieda Rong, Gaurav Mishra, Genta Indra Winata, Gerard de Melo, Germán Kruszewski, Giambattista Parascandolo, Giorgio Mariani, Gloria Wang, Gonzalo Jaimovitch-López, Gregor Betz, Guy Gur-Ari, Hana Galijasevic, Hannah Kim 0010, Hannah Rashkin, Hannaneh Hajishirzi, Harsh Mehta, Hayden Bogar, Henry Shevlin, Hinrich Schütze, Hiromu Yakura, Hongming Zhang 0009, Hugh Mee Wong, Ian Ng, Isaac Noble, Jaap Jumelet, Jack Geissinger, Jackson Kernion, Jacob Hilton, Jaehoon Lee 0001, Jaime Fernández Fisac, James B. Simon, James Koppel, James Zheng, James Zou 0001, Jan Kocon, Jana Thompson, Janelle Wingfield, Jared Kaplan, Jarema Radom, Jascha Sohl-Dickstein, Jason Phang, Jason Wei, Jason Yosinski, Jekaterina Novikova, Jelle Bosscher, Jennifer Marsh, Jeremy Kim, Jeroen Taal, Jesse H. Engel, Jesujoba Alabi, Jiacheng Xu, Jiaming Song, Jillian Tang, Joan Waweru, John Burden, John Miller 0001, John U. Balis, Jonathan Batchelder, Jonathan Berant, Jörg Frohberg, Jos Rozen, José Hernández-Orallo, Joseph Boudeman, Joseph Guerr, Joseph Jones, Joshua B. Tenenbaum, Joshua S. Rule, Joyce Chua, Kamil Kanclerz, Karen Livescu, Karl Krauth, Karthik Gopalakrishnan 0001, Katerina Ignatyeva, Katja Markert, Kaustubh D. Dhole, Kevin Gimpel, Kevin Omondi, Kory W. Mathewson, Kristen Chiafullo, Ksenia Shkaruta, Kumar Shridhar, Kyle McDonell, Kyle Richardson 0001, Laria Reynolds, Leo Gao, Li Zhang 0039, Liam Dugan, Lianhui Qin, Lidia Contreras Ochando, Louis-Philippe Morency, Luca Moschella, Lucas Lam, Lucy Noble, Ludwig Schmidt, Luheng He, Luis Oliveros Colón, Luke Metz, Lütfi Kerem Senel, Maarten Bosma, Maarten Sap, Maartje ter Hoeve, Maheen Farooqi, Manaal Faruqui, Mantas Mazeika, Marco Baturan, Marco Marelli, Marco Maru, María José Ramírez-Quintana, Marie Tolkiehn, Mario Giulianelli, Martha Lewis, Martin Potthast, Matthew L. Leavitt, Matthias Hagen, Mátyás Schubert, Medina Baitemirova, Melody Arnaud, Melvin McElrath, Michael A. Yee, Michael Cohen, Michael Gu, Michael I. Ivanitskiy, Michael Starritt, Michael Strube 0001, Michal Swedrowski, Michele Bevilacqua, Michihiro Yasunaga, Mihir Kale, Mike Cain, Mimee Xu, Mirac Suzgun, Mitch Walker, Mo Tiwari, Mohit Bansal, Moin Aminnaseri, Mor Geva, Mozhdeh Gheini, Mukund Varma T., Nanyun Peng 0001, Nathan A. Chi, Nayeon Lee, Neta Gur-Ari Krakover, Nicholas Cameron 0001, Nicholas Roberts, Nick Doiron, Nicole Martinez, Nikita Nangia, Niklas Deckers, Niklas Muennighoff, Nitish Shirish Keskar, Niveditha Iyer, Noah Constant, Noah Fiedel, Nuan Wen, Oliver Zhang, Omar Agha, Omar Elbaghdadi, Omer Levy, Owain Evans, Pablo Antonio Moreno Casares, Parth Doshi, Pascale Fung, Paul Pu Liang, Paul Vicol, Pegah Alipoormolabashi, Peiyuan Liao, Percy Liang, Peter Chang, Peter Eckersley, Phu Mon Htut, Pinyu Hwang, Piotr Milkowski, Piyush Patil, Pouya Pezeshkpour, Priti Oli, Qiaozhu Mei, Qing Lyu 0001, Qinlang Chen 0001, Rabin Banjade, Rachel Etta Rudolph, Raefer Gabriel, Rahel Habacker, Ramon Risco, Raphaël Millière, Rhythm Garg, Richard Barnes 0002, Rif A. Saurous, Riku Arakawa, Robbe Raymaekers, Robert Frank 0001, Rohan Sikand, Roman Novak, Roman Sitelew, Ronan LeBras, Rosanne Liu, Rowan Jacobs, Rui Zhang 0037, Ruslan Salakhutdinov, Ryan Chi, Ryan Lee, Ryan Stovall, Ryan Teehan, Rylan Yang, Sahib Singh, Saif M. Mohammad, Sajant Anand, Sam Dillavou, Sam Shleifer, Sam Wiseman, Samuel Gruetter, Samuel R. Bowman, Samuel S. Schoenholz, Sanghyun Han, Sanjeev Kwatra, Sarah A. Rous, Sarik Ghazarian, Sayan Ghosh 0004, Sean Casey, Sebastian Bischoff 0001, Sebastian Gehrmann, Sebastian Schuster, Sepideh Sadeghi, Shadi Hamdan, Sharon Zhou, Shashank Srivastava, Sherry Shi, Shikhar Singh, Shima Asaadi, Shixiang Shane Gu, Shubh Pachchigar, Shubham Toshniwal, Shyam Upadhyay, Shyamolima (Shammie) Debnath, Siamak Shakeri, Simon Thormeyer, Simone Melzi, Siva Reddy, Sneha Priscilla Makini, Soo-Hwan Lee, Spencer Torene, Sriharsha Hatwar, Stanislas Dehaene, Stefan Divic, Stefano Ermon, Stella Biderman, Stephanie Lin, Stephen Prasad, Steven T. Piantadosi, Stuart M. Shieber, Summer Misherghi, Svetlana Kiritchenko, Swaroop Mishra, Tal Linzen, Tal Schuster, Tao Li 0039, Tao Yu 0009, Tariq Ali, Tatsu Hashimoto, Te-Lin Wu, Théo Desbordes, Theodore Rothschild, Thomas Phan, Tianle Wang 0009, Tiberius Nkinyili, Timo Schick, Timofei Kornev, Titus Tunduny, Tobias Gerstenberg, Trenton Chang, Trishala Neeraj, Tushar Khot, Tyler Shultz, Uri Shaham 0002, Vedant Misra, Vera Demberg, Victoria Nyamai, Vikas Raunak, Vinay V. Ramasesh, Vinay Uday Prabhu, Vishakh Padmakumar, Vivek Srikumar, William Fedus, William Saunders, William Zhang, Wout Vossen, Xiang Ren 0001, Xiaoyu Tong, Xinran Zhao, Xinyi Wu, Xudong Shen, Yadollah Yaghoobzadeh, Yair Lakretz, Yangqiu Song, Yasaman Bahri, Yejin Choi 0001, Yichi Yang, Yiding Hao, Yifu Chen, Yonatan Belinkov, Yu Hou, Yufang Hou 0001, Yuntao Bai, Zachary Seid, Zhuoye Zhao, Zijian Wang 0002, Zijie J. Wang, Zirui Wang, and Ziyi Wu

Published
2023

7. Beyond the Imitation Game: Quantifying and extrapolating the capabilities of language models.

Author

Aarohi Srivastava, Abhinav Rastogi, Abhishek Rao, Abu Awal Md Shoeb, Abubakar Abid, Adam Fisch, Adam R. Brown, Adam Santoro, Aditya Gupta, Adrià Garriga-Alonso, Agnieszka Kluska, Aitor Lewkowycz, Akshat Agarwal, Alethea Power, Alex Ray, Alex Warstadt, Alexander W. Kocurek, Ali Safaya, Ali Tazarv, Alice Xiang, Alicia Parrish, Allen Nie, Aman Hussain, Amanda Askell, Amanda Dsouza, Ambrose Slone, Ameet Rahane, Anantharaman S. Iyer, Anders Andreassen, Andrea Madotto, Andrea Santilli, Andreas Stuhlmüller, Andrew M. Dai, Andrew La, Andrew K. Lampinen, Andy Zou, Angela Jiang, Angelica Chen, Anh Vuong, Animesh Gupta, Anna Gottardi, Antonio Norelli, Anu Venkatesh, Arash Gholamidavoodi, Arfa Tabassum, Arul Menezes, Arun Kirubarajan, Asher Mullokandov, Ashish Sabharwal, Austin Herrick, Avia Efrat, Aykut Erdem, Ayla Karakas, B. Ryan Roberts, Bao Sheng Loe, Barret Zoph, Bartlomiej Bojanowski, Batuhan özyurt, Behnam Hedayatnia, Behnam Neyshabur, Benjamin Inden, Benno Stein 0001, Berk Ekmekci, Bill Yuchen Lin, Blake Howald, Bryan Orinion, Cameron Diao, Cameron Dour, Catherine Stinson, Cedrick Argueta, Cèsar Ferri Ramírez, Chandan Singh, Charles Rathkopf, Chenlin Meng, Chitta Baral, Chiyu Wu, Chris Callison-Burch, Chris Waites, Christian Voigt, Christopher D. Manning, Christopher Potts, Cindy Ramirez, Clara E. Rivera, Clemencia Siro, Colin Raffel, Courtney Ashcraft, Cristina Garbacea, Damien Sileo, Dan Garrette, Dan Hendrycks, Dan Kilman, Dan Roth, Daniel Freeman, Daniel Khashabi, Daniel Levy, Daniel Moseguí González, Danielle Perszyk, Danny Hernandez, Danqi Chen 0001, Daphne Ippolito, Dar Gilboa, David Dohan, David Drakard, David Jurgens, Debajyoti Datta, Deep Ganguli, Denis Emelin, Denis Kleyko, Deniz Yuret, Derek Chen, Derek Tam, Dieuwke Hupkes, Diganta Misra, Dilyar Buzan, Dimitri Coelho Mollo, Diyi Yang, Dong-Ho Lee, Dylan Schrader, Ekaterina Shutova, Ekin Dogus Cubuk, Elad Segal, Eleanor Hagerman, Elizabeth Barnes, Elizabeth Donoway, Ellie Pavlick, Emanuele Rodolà, Emma Lam, Eric Chu, Eric Tang, Erkut Erdem, Ernie Chang, Ethan A. Chi, Ethan Dyer, Ethan J. Jerzak, Ethan Kim, Eunice Engefu Manyasi, Evgenii Zheltonozhskii, Fanyue Xia, Fatemeh Siar, Fernando Martínez-Plumed, Francesca Happé, François Chollet, Frieda Rong, Gaurav Mishra, Genta Indra Winata, Gerard de Melo, Germán Kruszewski, Giambattista Parascandolo, Giorgio Mariani, Gloria Wang, Gonzalo Jaimovitch-López, Gregor Betz, Guy Gur-Ari, Hana Galijasevic, Hannah Kim 0010, Hannah Rashkin, Hannaneh Hajishirzi, Harsh Mehta, Hayden Bogar, Henry Shevlin, Hinrich Schütze, Hiromu Yakura, Hongming Zhang 0009, Hugh Mee Wong, Ian Ng, Isaac Noble, Jaap Jumelet, Jack Geissinger, Jackson Kernion, Jacob Hilton, Jaehoon Lee 0001, Jaime Fernández Fisac, James B. Simon, James Koppel, James Zheng, James Zou 0001, Jan Kocon, Jana Thompson, Janelle Wingfield, Jared Kaplan, Jarema Radom, Jascha Sohl-Dickstein, Jason Phang, Jason Wei, Jason Yosinski, Jekaterina Novikova, Jelle Bosscher, Jennifer Marsh, Jeremy Kim, Jeroen Taal, Jesse H. Engel, Jesujoba Alabi, Jiacheng Xu, Jiaming Song, Jillian Tang, Joan Waweru, John Burden, John Miller 0001, John U. Balis, Jonathan Batchelder, Jonathan Berant, Jörg Frohberg, Jos Rozen, José Hernández-Orallo, Joseph Boudeman, Joseph Guerr, Joseph Jones, Joshua B. Tenenbaum, Joshua S. Rule, Joyce Chua, Kamil Kanclerz, Karen Livescu, Karl Krauth, Karthik Gopalakrishnan 0001, Katerina Ignatyeva, Katja Markert, Kaustubh D. Dhole, Kevin Gimpel, Kevin Omondi, Kory W. Mathewson, Kristen Chiafullo, Ksenia Shkaruta, Kumar Shridhar, Kyle McDonell, Kyle Richardson 0001, Laria Reynolds, Leo Gao, Li Zhang 0039, Liam Dugan, Lianhui Qin, Lidia Contreras Ochando, Louis-Philippe Morency, Luca Moschella, Lucas Lam, Lucy Noble, Ludwig Schmidt, Luheng He, Luis Oliveros Colón, Luke Metz, Lütfi Kerem Senel, Maarten Bosma, Maarten Sap, Maartje ter Hoeve, Maheen Farooqi, Manaal Faruqui, Mantas Mazeika, Marco Baturan, Marco Marelli, Marco Maru, María José Ramírez-Quintana, Marie Tolkiehn, Mario Giulianelli, Martha Lewis, Martin Potthast, Matthew L. Leavitt, Matthias Hagen, Mátyás Schubert, Medina Baitemirova, Melody Arnaud, Melvin McElrath, Michael A. Yee, Michael Cohen, Michael Gu, Michael I. Ivanitskiy, Michael Starritt, Michael Strube 0001, Michal Swedrowski, Michele Bevilacqua, Michihiro Yasunaga, Mihir Kale, Mike Cain, Mimee Xu, Mirac Suzgun, Mitch Walker, Mo Tiwari, Mohit Bansal, Moin Aminnaseri, Mor Geva, Mozhdeh Gheini, Mukund Varma T., Nanyun Peng 0001, Nathan A. Chi, Nayeon Lee, Neta Gur-Ari Krakover, Nicholas Cameron 0001, Nicholas Roberts, Nick Doiron, Nicole Martinez, Nikita Nangia, Niklas Deckers, Niklas Muennighoff, Nitish Shirish Keskar, Niveditha Iyer, Noah Constant, Noah Fiedel, Nuan Wen, Oliver Zhang, Omar Agha, Omar Elbaghdadi, Omer Levy, Owain Evans, Pablo Antonio Moreno Casares, Parth Doshi, Pascale Fung, Paul Pu Liang, Paul Vicol, Pegah Alipoormolabashi, Peiyuan Liao, Percy Liang, Peter Chang, Peter Eckersley, Phu Mon Htut, Pinyu Hwang, Piotr Milkowski, Piyush Patil, Pouya Pezeshkpour, Priti Oli, Qiaozhu Mei, Qing Lyu 0001, Qinlang Chen 0001, Rabin Banjade, Rachel Etta Rudolph, Raefer Gabriel, Rahel Habacker, Ramon Risco, Raphaël Millière, Rhythm Garg, Richard Barnes 0002, Rif A. Saurous, Riku Arakawa, Robbe Raymaekers, Robert Frank 0001, Rohan Sikand, Roman Novak, Roman Sitelew, Ronan LeBras, Rosanne Liu, Rowan Jacobs, Rui Zhang 0037, Ruslan Salakhutdinov, Ryan Chi, Ryan Lee, Ryan Stovall, Ryan Teehan, Rylan Yang, Sahib Singh, Saif M. Mohammad, Sajant Anand, Sam Dillavou, Sam Shleifer, Sam Wiseman, Samuel Gruetter, Samuel R. Bowman, Samuel S. Schoenholz, Sanghyun Han, Sanjeev Kwatra, Sarah A. Rous, Sarik Ghazarian, Sayan Ghosh 0004, Sean Casey, Sebastian Bischoff 0001, Sebastian Gehrmann, Sebastian Schuster, Sepideh Sadeghi, Shadi Hamdan, Sharon Zhou, Shashank Srivastava, Sherry Shi, Shikhar Singh, Shima Asaadi, Shixiang Shane Gu, Shubh Pachchigar, Shubham Toshniwal, Shyam Upadhyay, Shyamolima (Shammie) Debnath, Siamak Shakeri, Simon Thormeyer, Simone Melzi, Siva Reddy, Sneha Priscilla Makini, Soo-Hwan Lee, Spencer Torene, Sriharsha Hatwar, Stanislas Dehaene, Stefan Divic, Stefano Ermon, Stella Biderman, Stephanie Lin, Stephen Prasad, Steven T. Piantadosi, Stuart M. Shieber, Summer Misherghi, Svetlana Kiritchenko, Swaroop Mishra, Tal Linzen, Tal Schuster, Tao Li 0039, Tao Yu 0009, Tariq Ali, Tatsu Hashimoto, Te-Lin Wu, Théo Desbordes, Theodore Rothschild, Thomas Phan, Tianle Wang 0009, Tiberius Nkinyili, Timo Schick, Timofei Kornev, Titus Tunduny, Tobias Gerstenberg, Trenton Chang, Trishala Neeraj, Tushar Khot, Tyler Shultz, Uri Shaham 0002, Vedant Misra, Vera Demberg, Victoria Nyamai, Vikas Raunak, Vinay V. Ramasesh, Vinay Uday Prabhu, Vishakh Padmakumar, Vivek Srikumar, William Fedus, William Saunders, William Zhang, Wout Vossen, Xiang Ren 0001, Xiaoyu Tong, Xinran Zhao, Xinyi Wu, Xudong Shen, Yadollah Yaghoobzadeh, Yair Lakretz, Yangqiu Song, Yasaman Bahri, Yejin Choi 0001, Yichi Yang, Yiding Hao, Yifu Chen, Yonatan Belinkov, Yu Hou, Yufang Hou 0001, Yuntao Bai, Zachary Seid, Zhuoye Zhao, Zijian Wang 0002, Zijie J. Wang, Zirui Wang, and Ziyi Wu

Published
2022
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14. Heparin-enriched plasma proteome is significantly altered in Alzheimer’s disease

Author

Qi Guo, Lingyan Ping, Eric B. Dammer, Duc M. Duong, Luming Yin, Kaiming Xu, Anantharaman Shantaraman, Edward J. Fox, Todd E Golde, Erik C.B. Johnson, Blaine R. Roberts, James J. Lah, Allan I. Levey, and Nicholas T. Seyfried

Subjects
Alzheimer’s disease, Amyloid, Biomarkers, Cerebrospinal fluid, Heparin, Heparan sulfate proteoglycans, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6
Abstract

Abstract Introduction Heparin binding proteins (HBPs) with roles in extracellular matrix assembly are strongly correlated to β-amyloid (Aβ) and tau pathology in Alzheimer’s disease (AD) brain and cerebrospinal fluid (CSF). However, it remains challenging to detect these proteins in plasma using standard mass spectrometry-based proteomic approaches. Methods We employed heparin-affinity chromatography, followed by off-line fractionation and tandem mass tag mass spectrometry (TMT-MS), to enrich HBPs from plasma obtained from AD (n = 62) and control (n = 47) samples. These profiles were then correlated to Aβ, tau and phosphorylated tau (pTau) CSF biomarkers and plasma pTau181 from the same individuals, as well as a consensus brain proteome network to assess the overlap with AD brain pathophysiology. Results Heparin enrichment from plasma was highly reproducible, enriched well-known HBPs like APOE and thrombin, and depleted high-abundant proteins such as albumin. A total of 2865 proteins, spanning 10 orders of magnitude in abundance, were measured across 109 samples. Compared to the consensus AD brain protein co-expression network, we observed that specific plasma proteins exhibited consistent direction of change in both brain and plasma, whereas others displayed divergent changes, highlighting the complex interplay between the two compartments. Elevated proteins in AD plasma, when compared to controls, included members of the matrisome module in brain that accumulate with Aβ deposits, such as SMOC1, SMOC2, SPON1, MDK, OLFML3, FRZB, GPNMB, and the APOE4 proteoform. Additionally, heparin-enriched proteins in plasma demonstrated significant correlations with conventional AD CSF biomarkers, including Aβ, total tau, pTau, and plasma pTau181. A panel of five plasma proteins classified AD from control individuals with an area under the curve (AUC) of 0.85. When combined with plasma pTau181, the panel significantly improved the classification performance of pTau181 alone, increasing the AUC from 0.93 to 0.98. This suggests that the heparin-enriched plasma proteome captures additional variance in cognitive dementia beyond what is explained by pTau181. Conclusion These findings support the utility of a heparin-affinity approach coupled with TMT-MS for enriching amyloid-associated proteins, as well as a wide spectrum of plasma biomarkers that reflect pathological changes in the AD brain.

Published
2024
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24. Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease

Author

Anantharaman Shantaraman, Eric B. Dammer, Obiadada Ugochukwu, Duc M. Duong, Luming Yin, E. Kathleen Carter, Marla Gearing, Alice Chen-Plotkin, Edward B. Lee, John Q. Trojanowski, David A. Bennett, James J. Lah, Allan I. Levey, Nicholas T. Seyfried, and Lenora Higginbotham

Subjects
Lewy body dementia, Biomarkers, Proteomics, Mass spectrometry, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6
Abstract

Abstract Lewy body dementia (LBD), a class of disorders comprising Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), features substantial clinical and pathological overlap with Alzheimer’s disease (AD). The identification of biomarkers unique to LBD pathophysiology could meaningfully advance its diagnosis, monitoring, and treatment. Using quantitative mass spectrometry (MS), we measured over 9,000 proteins across 138 dorsolateral prefrontal cortex (DLPFC) tissues from a University of Pennsylvania autopsy collection comprising control, Parkinson’s disease (PD), PDD, and DLB diagnoses. We then analyzed co-expression network protein alterations in those with LBD, validated these disease signatures in two independent LBD datasets, and compared these findings to those observed in network analyses of AD cases. The LBD network revealed numerous groups or “modules” of co-expressed proteins significantly altered in PDD and DLB, representing synaptic, metabolic, and inflammatory pathophysiology. A comparison of validated LBD signatures to those of AD identified distinct differences between the two diseases. Notably, synuclein-associated presynaptic modules were elevated in LBD but decreased in AD relative to controls. We also found that glial-associated matrisome signatures consistently elevated in AD were more variably altered in LBD, ultimately stratifying those LBD cases with low versus high burdens of concurrent beta-amyloid deposition. In conclusion, unbiased network proteomic analysis revealed diverse pathophysiological changes in the LBD frontal cortex distinct from alterations in AD. These results highlight the LBD brain network proteome as a promising source of biomarkers that could enhance clinical recognition and management.

Published
2024
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32. Microstructural Studies of Heat Treated Zr-2.5Nb Alloy for Pressure Tube Applications

Author

Saibaba, N., primary, Jha, S. K., additional, Tonpe, S., additional, Vaibhaw, Kumar, additional, Deshmukh, V., additional, Ramana Rao, S. V., additional, Mani Krishna, K. V., additional, Neogy, S., additional, Srivastava, D., additional, Dey, G. K., additional, Kulkarni, R. V., additional, Rath, B. B., additional, Ramadasan, E., additional, and Anantharaman, S. A., additional

Published
2011
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33. ON PROPER HAMILTONIAN-CONNECTION NUMBER OF GRAPHS.

Author

SAMPATHKUMAR, R. and ANANTHARAMAN, S.

Subjects
HAMILTONIAN graph theory, BIPARTITE graphs
Abstract

A graph G is Hamiltonian-connected if every two vertices of G are connected by a Hamilton path. A bipartite graph H is Hamiltonian-laceable if any two vertices from different partite sets of H are connected by a Hamilton path. An edge-coloring (adjacent edges may receive the same color) of a Hamiltonian-connected (respectively, Hamiltonian-laceable) graph G (resp. H) is a proper Hamilton path coloring if every two vertices u and v of G (resp. H) are connected by a Hamilton path Puv such that no two adjacent edges of Puv are colored the same. The minimum number of colors in a proper Hamilton path coloring of G (resp. H) is the proper Hamiltonian-connection number of G (resp. H). In this paper, proper Hamiltonian-connection numbers are determined for some classes of Hamiltonian-connected graphs and that of Hamiltonian-laceable graphs. [ABSTRACT FROM AUTHOR]

Published
2022

35. Correction: Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease

Author

Anantharaman Shantaraman, Eric B. Dammer, Obiadada Ugochukwu, Duc M. Duong, Luming Yin, E. Kathleen Carter, Marla Gearing, Alice Chen-Plotkin, Edward B. Lee, John Q. Trojanowski, David A. Bennett, James J. Lah, Allan I. Levey, Nicholas T. Seyfried, and Lenora Higginbotham

Subjects
Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6
Published
2024
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37. Twin edge coloring of total graph and graphs with twin chromatic index Δ + 2.

Author

Anantharaman, S.

Subjects
*GRAPH coloring, *EDGES (Geometry), *REGULAR graphs
Abstract

A twin edge coloring of a graph G is meant a proper edge coloring of G whose colors come from the integers modulo k that induce a proper vertex coloring in which the color of a vertex is the sum of the colors of its incident edges. The minimum k for which G has a twin edge coloring is the twin chromatic index of G. In this paper, I compute twin chromatic index of total graph of path and cycle also construct some special graphs with twin chromatic index is maximum degree plus two. [ABSTRACT FROM AUTHOR]

Published
2020

40. Adjacent vertex-distinguishing proper edge-coloring of strong product of graphs.

Author

Anantharaman, S.

Subjects
*GRAPH connectivity, *UNDIRECTED graphs, *MANUFACTURED products
Abstract

Let G be a finite, simple, undirected and connected graph. The adjacent vertex-distinguishing proper edge-coloring is the minimum number of colors required for a proper edge-coloring of G, in which no two adjacent vertices are incident to edges colored with the same set of colors. The minimum number of colors required for an adjacent vertex-distinguishing proper edgecoloring of G is called the adjacent vertex-distinguishing proper edge-chromatic index. In this paper, I compute adjacent vertex-distinguishing proper edge-chromatic index of strong product of graphs. [ABSTRACT FROM AUTHOR]

Published
2019

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