9 results on '"Ananthi Anandhakrishnan"'
Search Results
2. Acute decompensated heart failure in a patient with longstanding uncontrolled Graves' thyrotoxicosis
- Author
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Ananthi Anandhakrishnan and Kirun Gunganah
- Subjects
General Medicine - Published
- 2023
3. Hypokalaemia: An unusual feature of pseudohypoprathyroidism Type 1b
- Author
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Ananthi Anandhakrishnan, Rachel Flynn, Jansher Khan, Kumbirai Dodzo, Gadintshware Gaoatswe, John P Monson, and Kirun Gunganah
- Subjects
General Medicine - Published
- 2023
4. How COVID-19 has changed the unselected medical take: an observational study
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Kai Man Alexander Ho, Laurence Lovat, Yiwen Soo, Arun Mahay, Ananthi Anandhakrishnan, and Andrew P Rochford
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Adult ,Male ,Healthcare use ,2019-20 coronavirus outbreak ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,030204 cardiovascular system & hematology ,03 medical and health sciences ,Patient Admission ,0302 clinical medicine ,Pandemic ,Health care ,medicine ,Humans ,030212 general & internal medicine ,Pandemics ,Aged ,Retrospective Studies ,Aged, 80 and over ,Health Services Needs and Demand ,business.industry ,COVID-19 rapid report ,COVID-19 ,General Medicine ,Middle Aged ,United Kingdom ,Treatment Outcome ,Emergency medicine ,Female ,Observational study ,Coronavirus Infections ,business - Abstract
INTRODUCTION: COVID-19 has had a profound effect on the NHS. Little information has been published as to how the unselected medical take has been affected. METHODS: We retrospectively reviewed patients who were referred to general medicine during March 2020. We compared clinical outcomes of patients with and without COVID-19. RESULTS: 814 patients were included, comprising 777 unique patients. On average, 26 patients were admitted per day. 38% of admitted patients were suspected of COVID-19, with greater numbers of COVID-19 patients in the second half compared to the first half of the month (p
- Published
- 2020
5. How to refer to people with disease in research outputs: The disconnection between academic practise and that preferred by people with multiple sclerosis
- Author
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Gavin Giovannoni, Christina Crowe, David Baker, Rodden M. Middleton, Ananthi Anandhakrishnan, Hazel Lockart–Jones, K. Tuite-Dalton, and David V. Ford
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Multiple Sclerosis ,media_common.quotation_subject ,Alternative medicine ,Writing style ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Terminology as Topic ,Reading (process) ,medicine ,Humans ,Social media ,Registries ,Public engagement ,Psychiatry ,media_common ,Publishing ,Government ,Research ,Patient Preference ,General Medicine ,United Kingdom ,030104 developmental biology ,Neurology ,Family medicine ,North America ,Neurology (clinical) ,Disconnection ,Psychology ,Social Media ,030217 neurology & neurosurgery ,Primary research - Abstract
Background Increasingly, Government and Charity funders require public engagement in research. Invariably these research outputs describe the condition of someone with the disease of interest. We therefore sought to identify the preferred descriptor of someone with a disease, such as multiple sclerosis (MS) and to determine what descriptors are currently used by academics. Methods Several surveys were undertaken: one from the Research Network of the MS Society (MSSRN), a major MS Charity within the United Kingdom, who are involved in reviewing grant applications, priority setting and research governance (n=146), and surveys from both the United Kingdom MS register (MSR; n=1713) and the North American Research Committee on Multiple Sclerosis (NARCOMS) registry (n=518). People were asked to rate descriptors of someone affected with MS. These were compared to that used by academic experimenters in basic science and clinical science research papers. Results Although the frequency of responses varied between surveys the overall findings showed many consistencies. This included use of person/people with MS (pwMS ) as the preferred descriptor for someone with MS for social media and scientific publications. This was the preferred choice in about 55–60% people from the MRS and in over 70% in the NARCOMS and the MSSRN, respectively. Although MSer was the second preferred–choice for use in social media, there was as a large range of preferences from the ‘most-preferred' to the ‘most-disliked.' This reflected an earlier survey by UK-based research blogs using the term MSer (n=173). In contrast, pwMS had few ‘dislikes' and results were skewed towards the ‘liked' and ‘most-preferred' choices. Client and sufferer were generally disliked terms, although there was some regional variation in levels of choice. Patient was generally seen as a neutral term that was neither strongly liked nor disliked. However, patient gained more public support for use within scientific publications (~20–25%) compared to social media (~10–15%). This descriptor was however most commonly used (98–99%) within both pre-clinical (searched in 6-month output of preclinical autoimmune MS models; n=161) and in clinical publications (specialist MS journals; n=220), whereas pwMS was not reported in over 75% of papers published in some specialised MS journals, and did not appear in the pre-clinical animal studies examined. Conclusion There is a clear disconnection between preferences by individuals living with MS and current academic practise. As pwMS are increasingly reading primary research publications and are involved in patient and public involvement in research and grant review activities, the sensitivities of lay readers should be considered when writing research outputs. This issue may affect other diseases and a change in writing style could be adopted to show that we respect the wishes of the people that we study and wish to help.
- Published
- 2016
6. List of Contributors
- Author
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Ian A. Aird, Nimantha M.W. de Alwis, Ananthi Anandhakrishnan, Stephen L. Atkin, Anindo Banerjee, Philippe Bareille, Jordan Barnard, Ayat Bashir, Frauke Becker, Helene Brandon, Matthew D. Campbell, K. Clément, Esther M. Cohen-Tovée, Piers L. Cornelissen, Caroline Day, B. Dubern, Pamela Dyson, Javier T. Gonzalez, Yitka Graham, Emily Heiden, Nicola Heslehurst, Lucy Hewitson, Sarah Hill, Charlotte Hilton, Ann L. Hunter, Lynne Johnston, Susan E. Jones, Marta Korbonits, Angelos Kyriacou, Claire Lane, Helen Long, Floriana S. Luppino, Cristina G. Matei, Ray Meleady, Yemi Oluboyede, C. Poitou, Unaiza Qamar, Zoe H. Rutherford, Thozhukat Sathyapalan, Emma Slack, Deborah Snowdon, Sarah Steven, Grace Stonebanks, Akheel A. Syed, Martin J. Tovée, Arutchelvam Vijayaraman, Jolanta U. Weaver, Manoj Wickramasinghe, Leonore M. de Wit, and Stephen Hyer
- Published
- 2018
7. Glucagon-Like Peptide 1 and Human Obesity
- Author
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Ananthi Anandhakrishnan and Márta Korbonits
- Subjects
0301 basic medicine ,endocrine system ,Liraglutide ,business.industry ,digestive, oral, and skin physiology ,Postmarketing surveillance ,030209 endocrinology & metabolism ,Pharmacology ,Overweight ,medicine.disease ,Bioinformatics ,Obesity ,Management of obesity ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Weight loss ,medicine ,medicine.symptom ,business ,Weight gain ,Glucagon-like peptide 1 receptor ,medicine.drug - Abstract
Numerous phase III studies of glucagon-like peptide 1 (GLP-1) analogue liraglutide, recently licensed by the Food and Drug Administration and European Medical Association for the medical management of obese and comorbidly overweight individuals, at a high dose (3 mg/day) have repeatedly demonstrated a superior achievement and maintained weight loss in obese individuals compared with placebo control and currently licensed antiobesity medications. Although the pathophysiology of human obesity is undoubtedly multifaceted, clinical evidence implicates a role for altered GLP-1 signaling; genetic studies suggest altered GLP-1 signaling to be a risk factor toward obesity, whereas observational and interventional studies of GLP-1 responses in lean and obese men suggest that weight gain may induce secondary deficits in GLP-1. Whatever the relationship, cause, or effect, functional GLP-1 signaling seems to play a role in obesity pathophysiology: pharmacologic replenishment of this deficit perhaps explains the superior weight loss profile of GLP-1 agonists as weight loss agents. Generally well tolerated, provided that longer-term postmarketing surveillance supports the currently available evidence of a low risk-benefit ratio, GLP-1 analogues provide promise toward achieving the as-yet unmet clinical need for a successful sustainable drug for the medical management of obesity.
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- 2018
8. Glucagon-like peptide 1 in the pathophysiology and pharmacotherapy of clinical obesity
- Author
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Ananthi Anandhakrishnan and Márta Korbonits
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endocrine system ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Review ,Pharmacology ,Placebo ,Bioinformatics ,Management of obesity ,Obesity pathophysiology ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,Weight loss ,Diabetes mellitus ,Internal Medicine ,Medicine ,030212 general & internal medicine ,Risk factor ,Glucagon-like peptide 1 ,business.industry ,Liraglutide ,medicine.disease ,Obesity ,Clinical obesity ,medicine.symptom ,business ,Glucagon-like peptide 1 analogues ,medicine.drug - Abstract
Though the pathophysiology of clinical obesity is undoubtedly multifaceted, several lines of clinical evidence implicate an important functional role for glucagon-like peptide 1 (GLP-1) signalling. Clinical studies assessing GLP-1 responses in normal weight and obese subjects suggest that weight gain may induce functional deficits in GLP-1 signalling that facilitates maintenance of the obesity phenotype. In addition, genetic studies implicate a possible role for altered GLP-1 signalling as a risk factor towards the development of obesity. As reductions in functional GLP-1 signalling seem to play a role in clinical obesity, the pharmacological replenishment seems a promising target for the medical management of obesity in clinical practice. GLP-1 analogue liraglutide at a high dose (3 mg/d) has shown promising results in achieving and maintaining greater weight loss in obese individuals compared to placebo control, and currently licensed anti-obesity medications. Generally well tolerated, provided that longer-term data in clinical practice supports the currently available evidence of superior short- and long-term weight loss efficacy, GLP-1 analogues provide promise towards achieving the successful, sustainable medical management of obesity that remains as yet, an unmet clinical need.
- Published
- 2016
9. Glucagon-like peptide 1 in the pathophysiology and pharmacotherapy of clinical obesity.
- Author
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Anandhakrishnan A and Korbonits M
- Abstract
Though the pathophysiology of clinical obesity is undoubtedly multifaceted, several lines of clinical evidence implicate an important functional role for glucagon-like peptide 1 (GLP-1) signalling. Clinical studies assessing GLP-1 responses in normal weight and obese subjects suggest that weight gain may induce functional deficits in GLP-1 signalling that facilitates maintenance of the obesity phenotype. In addition, genetic studies implicate a possible role for altered GLP-1 signalling as a risk factor towards the development of obesity. As reductions in functional GLP-1 signalling seem to play a role in clinical obesity, the pharmacological replenishment seems a promising target for the medical management of obesity in clinical practice. GLP-1 analogue liraglutide at a high dose (3 mg/d) has shown promising results in achieving and maintaining greater weight loss in obese individuals compared to placebo control, and currently licensed anti-obesity medications. Generally well tolerated, provided that longer-term data in clinical practice supports the currently available evidence of superior short- and long-term weight loss efficacy, GLP-1 analogues provide promise towards achieving the successful, sustainable medical management of obesity that remains as yet, an unmet clinical need., Competing Interests: Conflict-of-interest statement: Authors declare no conflict of interests for this article.
- Published
- 2016
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