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BARREL observed electron precipitation over wide range of energy and timescalesPrecipitating electron distribution is determined using spectroscopy for 19 January 2013 eventBARREL timing data has accuracy within sampling interval of 0.05 s.

Abstract Brainstem cerebral cavernous malformations (CCM) are clinically more aggressive compared to superficial CCMs. Due to their location, resection can be challenging, making stereotactic radiosurgery (SRS) an attractive alternative for symptomatic patient. Brainstem CCM patients (n = 170) were treated with Gamma Knife SRS at 11 radiosurgical centers. Hemorrhagic risk reduction, risk factors of post-SRS hemorrhage, and clinical outcomes were retrospectively analyzed. Most patients had a single (165/170 patients) brainstem CCMs treated; the majority of CCMs (165/181) presented with bleeding. Single-session SRS decreased the risk of repeat hemorrhage in patients with hemorrhagic brainstem CCM (HR: 0.17, p 13 Gy (HR = 2.57, p = 0.044). Adverse radiation effect (ARE) occurred in 9 patients (5.3%) and was symptomatic in four (2.4%). At a median follow-up of 3.4 years (Inter-quartile range: 5.4), 13 patients (8.0%) had a worsened clinical status, with the treated CCM being the cause in 5.6% (10) of the patients. Single-session SRS decreased the risk of repeat hemorrhage in patients with hemorrhagic brainstem CCM and conveyed this benefit with a low risk of advrse radiation effects (ARE) and worsening clinical status.

Introdução: A frequência descrita de infecções fúngicas invasivas (IFI) em receptores de transplante hepático (TH) varia de 0 a 15%. Fatores que modulam o risco de IFI após TH incluem a ocorrência de complicações técnicas, necessidade de diálise, gravidade clínica dos receptores no momento do transplante, intensidade da imunossupressão, distribuição geográfica dos fungos e exposição aos mesmos. O uso de profilaxia antifúngica e os avanços nas técnicas cirúrgicas e no manejo do paciente submetido a TH levaram a redução expressiva do risco de IFI após TH: na era pré-MELD, a incidência chegava a 43%. Nas séries disponíveis, as causas mais frequentes das IFI após TH são candidíase invasiva, aspergilose invasiva e criptococose, representando, respectivamente, 68%, 11% e 6% das IFI ocorridas após TH. Dados brasileiros são escassos. Materiais e métodos: Avaliação retrospectiva de coorte de pacientes submetidos a TH entre 2015 e 2020 quanto ao diagnóstico de IFI. Os métodos diagnósticos incluíram cultura, pesquisa de antígenos, sorologia e histopatologia. O diagnóstico de IFI foi definido conforme critérios previamente descritos pelo EORTC/MSG e atualizados em 2020. Resultados Durante o período de estudo, foram realizados 565 transplantes em 531 pacientes. A incidência de IFI foi de 4%. Entre os 21 episódios de IFI diagnosticados, houve 17 episódios comprovados (81%) e 4 prováveis (19%). As etiologias mais frequentes foram candidíase invasiva (14 casos, 67%) e criptococose (3 casos, 14%). 86% dos casos de candidíase foram causados por espécies não-albicans. Houve um caso diagnosticado de aspergilose, histoplasmose, pneumocistose e tricosporonose. O tempo transcorrido desde o transplante até o diagnóstico foi, em mediana, de 20 dias para candidíase invasiva e de 535 dias, para criptococose. A mortalidade em 30 dias foi de 29% para candidíase invasiva e 67% para criptococose. Conclusões: A incidência de IFI nessa coorte de receptores de TH foi de 4%, com elevada mortalidade. A etiologia mais frequente foi Candida spp., com predomínio de espécies não-albicans. Após o período pós transplante precoce, criptococose representou a principal etiologia. Palavras-chave: Transplante hepático, Infecções fúngicas invasivas, Candidíase invasiva, Criptococose, Epidemiologia. Conflitos de interesse: Não houve conflitos de interesse relacionados a esse trabalho. Ética e financiamentos: Não houve conflitos de interesse relacionados a esse trabalho.

ABSTRACT Lower urinary tract abnormalities are directly implicated in the etiology of renal dysfunction in 6 to 24% of dialytic patients. These patients require bladder capacity and compliance readjustment before being considered viable candidates for renal transplantation. Vesical augmentation surgeries often involve the use of intestinal segments. Although these procedures can effectively restore bladder capacity and compliance, they present various issues related to maintaining mucous absorption and secretion capacity. Acidosis, recurrent urinary tract infections, and stone formation are extremely common, leading to frequent hospitalizations and graft function loss. Urinary tissue is certainly ideal for these reconstructions; however, bladder augmentation using ureter and renal pelvis are feasible only in a minority of cases. Experimental studies have been conducted to establish the groundwork for vascularized bladder transplantation. Last year, for the first time, this procedure was performed on a brain-dead patient. During this intervention, cystectomy was performed with preservation the vascular pedicle, followed by organ reimplantation. The graft remained viable for a period of 12 hours post-transplant. However, this intervention utilized a robotic platform, making it less reproducible in a multi-organ procurement setting as well as for most transplant centers. Moreover, it is debatable whether the benefits of exclusive bladder transplantation outweigh the risks associated with immunosuppression. For patients needing renal transplantation and requiring lower urinary tract reconstruction, however, utilizing the donor’s bladder may offer an attractive alternative, avoiding the inherent complications of enterocystoplasty without increasing immunological risk. Combined kidney and bladder transplantation has the potential to emerge as the next frontier in abdominal organ transplants.

Tattoos can serve as an essential source of biometric information for public security, aiding in identifying suspects and victims. In order to automate tattoo classification, tasks like classification require more detailed image content analysis, such as semantic segmentation. However, a dataset with appropriate semantic segmentation annotations is currently lacking. Also, there are countless ways to categorize tattoo classes, and many are not directly categorizable, either because they belong to a specific artistic trait or characterize an object with previously undefined semantics. An effective way to overcome these limitations is to build recognition systems based on open-set assumptions. Nevertheless, state-of-the-art open set approaches are not directly applicable in tattoo semantic segmentation, mainly due to the significant class imbalance (predominant background). To the best of our knowledge, this paper is the first to explore semantic segmentation in closed and open-set scenarios for tattoos. In this sense, this paper presents two key contributions: (i) a novel large-margin loss function and generalized open-set classifier approach and (ii) an open-set tattoo semantic segmentation dataset with a publicly accessible test set, enabling comparisons and future research in this area. The proposed approach outperforms other methods, achieving 0.8013 of AUROC, 0.6318 of Macro F1, 0.4900 of mIoU, and notably 0.2753 of IoU for the unknown class, demonstrating the feasibility of this approach for automatic tattoo analysis. The paper also highlights key limitations and open research areas in this challenging field. Dataset and codes are available at https://github.com/Brilhador/tssd2023.

RESUMO O trabalho consistiu em verificar a ocorrência de Oncideres saga Dalman, 1823, em Prosopis juliflora (SW) D.C. utilizada na arborização do Campus da Universidade Federal Rural do Rio de Janeiro, no período de setembro a dezembro de 1996.

O objetivo deste trabalho é dimensionar sistemas fotovoltaicos com as estações de recargas, para atender à demanda de veículos elétricos e diminuir a quantidade de CO2 emitido para a atmosfera. Para isso, foram avaliados os benefícios ambientais e financeiros com a implantação desses sistemas. Os dados obtidos foram coletados do Instituto Brasileiro de Geografia e Estatística, do Instituto Nacional de Metrologia, Qualidade e Tecnologia e por pesquisas bibliográficas, que foram bases para o levantamento quantitativo, a fim de se traçar o perfil de consumo da frota de veículos e dimensionar os sistemas fotovoltaicos e as estações de recargas. Com a criação desses sistemas e das referidas estações para veículos elétricos, será possível ter um fluxo de caixa acumulado de R$ 7.808.226,92 em 25 anos de operação e evitar a emissão de 79.644 tCO2 para a atmosfera.

Introdução: As infecções da corrente sanguínea (ICS) são frequentes após transplante hepático, acometendo 19 a 41% dos receptores. Estão associadas a elevadas morbidade e mortalidade, sobretudo quando causadas por bactérias multidroga resistentes (MDR). Métodos: Avaliação retrospectiva de coorte de pacientes submetidos a transplantes de fígado no Hospital Adventista Silvestre entre 2015 e 2020. O diagnóstico de ICS nos primeiros 180 dias pós-transplante foi realizado através de sistemas automatizados de cultivo, com identificação e antibiograma realizados através de metodologia automatizada, com complementação diagnóstica com testes de bancada, conforme a necessidade. A comparação da mortalidade em 1 ano foi calculada por meio do teste de qui quadrado, utilizando o software OpenEpi. Resultados: No período de estudo, foram realizados 564 transplantes em 530 receptores. 53 receptores (10%) apresentaram 72 episódios de ICS nos primeiros 180 dias após o transplante hepático, com mediana de tempo desde o transplante até o diagnóstico de ICS igual a 14 dias. Houve isolamento de 77 microrganismos nos 72 episódios. Houve 5 casos (7%) de infecções polimicrobianas e 9 casos (13%) de bacteremia persistente, definida como isolamento do mesmo microrganismo em hemocultura dentro de 15 dias após a cultura inicial. Em 44 episódios (57%), foram isoladas enterobactérias, com predomínio de Klebsiella pneumoniae (30 episódios; 39%). Nos demais, foram isolados cocos Gram-positivos (n = 19; 25%), bacilos Gram-negativos não fermentadores (n = 11; 14%) e leveduras (n = 3; 4%). Em 27 episódios (38%), houve isolamento de bactéria MDR. A mortalidade em 7 e 30 dias entre pacientes acometidos por ICS, foi de 17% e 44%, respectivamente. Notavelmente, pacientes acometidos por ICS por enterobactérias resistentes aos carbapenêmicos tiveram mortalidade de 71% em 30 dias. Os receptores acometidos por ICS tiveram mortalidade de 62% em 1 ano, enquanto nos não acometidos a mortalidade foi de 20% em 1 ano (p < 0,001, Odds Ratio de 6,60, IC95%: 3,64-12,20). Conclusão: Nesta coorte recente de transplante hepático, a ICS continua sendo complicação frequente, com proporção expressiva causada por bactérias MDR. Sua ocorrência se deu predominantemente no período pós-transplante precoce e esteve associada com elevada mortalidade em 7 e 30 dias, além de ter sido associada com elevação significante de mortalidade em 1 ano, na comparação com pacientes sem diagnóstico de ICS.

Abstract Focal cortical dysplasia (FCD) is one of the most common malformations causing refractory epilepsy. Dysregulation of glutamatergic systems plays a critical role in the hyperexcitability of dysplastic neurons in FCD lesions. The pharmacoresistant nature of epilepsy associated with FCD may be due to a lack of well‐tolerated and precise antiepileptic drugs that can target glutamate receptors. Here, for the first time in human FCD brain slices, we show that the established, noncompetitive α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor antagonist, perampanel has potent antiepileptic action. Moreover, we demonstrate that this effect is due to a reduction in burst firing behavior in human FCD microcircuits. These data support a potential role for the treatment of refractory epilepsy associated with FCD in human patients.

The objective of this study was to understand the effect of the choice of backfill constitutive models on the numerical simulation of a geosynthetic reinforced soil-integrated bridge system (GRS-IBS). The #89 material, a crushed angular granite stone, characterized by maximum particle sizes of 9 mm, was used for the reinforced backfill for the retaining wall. Consolidated drained triaxial tests were conducted at confining stresses of 48 kPa, 83 kPa, and 117 kPa. The average friction angle was 42 degrees. Two soil models (the linear-elastic perfectly-plastic and the Hardening Soil) were calibrated using the laboratory test results. The calibrated soil models were then used to model the reinforced backfill material in finite element simulations of the abutment. Results of the calculated vertical stresses at the instrument position showed reasonable agreement with the field measurement. The non-linear model predicted about twice the deformation (lateral displacement and bridge seat settlement) compared to the linear-elastic perfectly plastic model. Settlement results showed maximum values corresponding to 0.22% and 0.45% of the abutment height for linear-elastic perfectly-plastic model and Hardening-Soil model, respectively, which are less than 0.5% limit recommended by US FHWA, while the lateral displacements were 0.22% and 0.44% of the abutment height for linear-elastic perfectly-plastic model and Hardening Soil model, respectively, both less than the 1% limit recommended by the US FHWA.

Neuroendocrine tumors are part of a heterogeneous group of tumors located in organs such as the gastrointestinal tract (GIT), lungs, thymus, thyroid, and adrenal glands. The most prevalent sites are the small intestine, cecal appendix, and pancreas. More than 50% of these tumors are associated with metastases at the time of diagnosis. Neuroendocrine tumors are classified according to the degree of cell differentiation and the histopathological proliferation index of the lesion. Neuroendocrine tumors can be well differentiated or poorly differentiated. G3 tumors are characterized by Ki-67 expression greater than 20% and can be either well differentiated (G3 NET) or poorly differentiated (G3 NEC). Neuroendocrine carcinoma (NEC G3) is subdivided into small-cell and large-cell types. When neuroendocrine tumors present clinical and compressive symptoms, carcinoid syndrome is evident. Carcinoid syndrome occurs when the tumor produces neuroendocrine mediators that cannot be metabolized by the liver due to either the size of the tumor or their secretion by the liver itself. Several therapeutic strategies have been described for the treatment of metastatic neuroendocrine tumors, including curative or palliative surgical approaches, peptide receptor radionuclide therapy, percutaneous therapy, systemic chemotherapy, and radiotherapy. Liver surgery is the only approach that can offer a cure for metastatic patients. Liver metastases must be completely resected, and in this context, orthotopic liver transplantation has gained prominence for yielding very promising outcomes in selected cases. The aim of this study is to review the literature on OLT as a form of treatment with curative intent for patients with gastroenteropancreatic neuroendocrine tumors with liver metastasis.

This essay aims to bring to light other ways of learning and teaching music, with the object of revisiting musical practices existing in different parts of Brazil, which are invisible in disparate music courses. In this reflective weaving, experiences and conceptual immersions acquired in diverse sociocultural contexts will be interposed. Through dialogues with fundamental theorists such as Brandão (1983) and Prudente (2019), the deconstruction of the hegemony of Western music in relation to the ancestral knowledge of traditional peoples will be the guardians and maintainers of emancipatory musical practices, which intersect in different dimensions of making and teaching music.

The social projects in music are a modern topic in the field of music education. Due to the importance of the point provided here, it is indicated the expansion of the object learning and teaching music beyond the aspects of social context in which these music social projects are inserted. Therefore, we seek to achieve an expanded look at the musical experiences offered in social projects not only in Brazil, but also in contexts with refugees originally from countries at war. In this article, we also illustrate experiences in social projects located in North Dakota, in the United States. Through dialogues with researchers of music education, we seek to reflect on the situation of refugees from countries at war, the sense of belonging, and the role of music education in communities in relation to the demands that permeate the musical aspects.

Summary: Background: Better understanding of the association between characteristics of patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management. Methods: Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective, observational study of 1164 patients from 20 hospitals across the United States. Disease severity was assessed using a 7-point ordinal scale based on degree of respiratory illness. Patients were prospectively surveyed for 1 year after discharge for post-acute sequalae of COVID-19 (PASC) through quarterly surveys. Demographics, comorbidities, radiographic findings, clinical laboratory values, SARS-CoV-2 PCR and serology were captured over a 28-day period. Multivariable logistic regression was performed. Findings: The median age was 59 years (interquartile range [IQR] 20); 711 (61%) were men; overall mortality was 14%, and 228 (20%) required invasive mechanical ventilation. Unsupervised clustering of ordinal score over time revealed distinct disease course trajectories. Risk factors associated with prolonged hospitalization or death by day 28 included age ≥ 65 years (odds ratio [OR], 2.01; 95% CI 1.28–3.17), Hispanic ethnicity (OR, 1.71; 95% CI 1.13–2.57), elevated baseline creatinine (OR 2.80; 95% CI 1.63– 4.80) or troponin (OR 1.89; 95% 1.03–3.47), baseline lymphopenia (OR 2.19; 95% CI 1.61–2.97), presence of infiltrate by chest imaging (OR 3.16; 95% CI 1.96–5.10), and high SARS-CoV2 viral load (OR 1.53; 95% CI 1.17–2.00). Fatal cases had the lowest ratio of SARS-CoV-2 antibody to viral load levels compared to other trajectories over time (p=0.001). 589 survivors (51%) completed at least one survey at follow-up with 305 (52%) having at least one symptom consistent with PASC, most commonly dyspnea (56% among symptomatic patients). Female sex was the only associated risk factor for PASC. Interpretation: Integration of PCR cycle threshold, and antibody values with demographics, comorbidities, and laboratory/radiographic findings identified risk factors for 28-day outcome severity, though only female sex was associated with PASC. Longitudinal clinical phenotyping offers important insights, and provides a framework for immunophenotyping for acute and long COVID-19. Funding: NIH.

A 37-year-old healthcare worker from the northeastern region of Brazil experienced 2 clinical episodes of coronavirus disease. Infection with severe acute respiratory syndrome coronavirus 2 was confirmed by reverse transcription PCR in samples collected 116 days apart. Whole-genome sequencing revealed that the 2 infections were caused by the most prevalent lineage in Brazil, B.1.1.33, and the emerging lineage P.2. The first infection occurred in June 2020; Bayesian analysis suggests reinfection at some point during September 14–October 11, 2020, a few days before the second episode of coronavirus disease. Of note, P.2 corresponds to an emergent viral lineage in Brazil that contains the mutation E484K in the spike protein. The P.2 lineage was initially detected in the state of Rio de Janeiro, and since then it has been found throughout the country. Our findings suggest not only a reinfection case but also geographic dissemination of the emerging Brazil clade P.2.

This study sought to understand how the sociocultural and socioeconomic contexts influences/ interferes/modifies the teacher development process of the music teachers who participated in this research, in the light of the perspective of gift, by Marcel Mauss. Following a qualitative methodology, we opted for the narrative interview, a dynamic method that is based on the pedagogical practice of educators. As a result of this study, we have reached the conclusion that there are diverse dimensions of musical education where the interviewees defend a sensitive listening to their own path, conceiving a pedagogical path guided by alterity and gift.

The die casting consists of the injection of a liquid metal into a mold cavity, submitting the mechanism to high pressures and subsequent cooling until its solidification. Understanding the operation of injection molding machines, as well as the factors that influence the good process development of these machines, it is important for the mechanical engineering area, in general. Thus, the purpose of this work was to evaluate the closing unit design of a mini-injection moulding machine, using CAD (computer-aided design) and CAE (computer-aided engineering) tools. Through an experimental research, it was possible to observe the behavior of the project, in terms of motion and static analysis. The results have shown an efficient project, regarding the modeling and analysis of movements, however, the tension static analysis points to needed improvements in the model, such as resizing of the articulation bars, in which the tensions were overloaded.

Janine Dahinden and Bridget Anderson discuss each other’s responses to the challenges of knowledge production in migration studies. Dahinden introduces the concept of the “migrant-citizen nexus” and Anderson argues for more attention to be paid to the racialisation of “the migrant” through the ways that nationality elides race and discuss the nationalistic policies adopted in reaction to the pandemic.

In this article, the most important publications on the subject are compiled to highlight the progress in biodiesel production from tropical cultivars, including energy and environmental potential, raw materials, and the advantages and disadvantages of this biofuel. A critical and objective review of biodiesel production as an alternative fuel for power generation systems and its importance in the energy matrix was conducted. A survey of real applications, new computational and experimental trends, and proposals in internal combustion engines employing organic biofuel was performed. The main findings were as follows: (i) there is the possibility of integration and support in the energy matrix of different countries, as well as the competing with and complementing, energetically, other renewable energy sources, such as solar and wind; (ii) Jatropha curcas, sunflowers, soybean, Moringa oleifera, palm, cottonseed, castor, rubber seed, and coconut are tropical cultivars used to obtained oils into biodiesel; (iii) the findings can be utilized as a theoretical basis for future policies influencing the energy sector through regulatory measures.

ABSTRACT Introduction: Surgical training models prepare the resident for a more ethical surgical practice as well as providing a less steep learning curve. In urology, there are well-known models of pyeloplasty simulation, urethro-vesical anastomosis and nephrectomy, which have helped in the training of urology residents (1–3). Learning laparoscopic prostatectomy is a difficult surgery and requires advanced surgical skill from the surgeon (4), requires operate without a direct view of the surgical field in a two-dimensional space and with longer instruments (5). Laparoscopic prostatectomy step by step makes the surgeon's learning curve less difficult, lead to less intraoperative complications, such as blood loss, while also enabling shorter operative time and less positive surgical margins (6). The objective of surgical models is to simulate surgical procedures in a reliable way thus preparing the surgeon for his daily practice, surgical simulations in animal models have been described to compensate for inadequate clinical exposure (7). The canine model of prostate cancer has many similarities with humans. Despite trying to develop a model that is as credible as possible, there are ethical issues in several countries, such as Brazil, that do not allow the use of live dogs for scientific experimentation and there is a difficulty in not standardizing the animals used (8, 9). The swine surgical training model is widely known, accepted and used as a valuable tool in the teaching of new surgeons (10). The porcine video laparoscopic prostatectomy model allows the urologist in training to exercise the skills required in a real surgical situation, practicing them in a single session (10). We will present an experimental model in pigs for training urology residents in laparoscopic radical prostatectomy with current techniques (11–13). The limitations found are that the prostate has no limits as well defined as in humans, the urethra is long and coiled, the fat surrounding the pelvic organs is scarce and there is no postoperative follow-up for evaluating functionality after the procedure, as well as the effectiveness of the surgery with surgical margins. However, it is similar in surgical model presented, it is reproducible and can provide a realistic simulation environment to the beginner surgeon. Material and Methods: In this paper, according to the institutional protocol approved by the institutional ethics and research committee FMUSP n° 964/2017 and protocol was in accordance with current international regulations for the use of animals in Research: Reporting In Vivo Experiments (ARRIVE) guide. Ten male pigs weighing 20 to 22kg were used. The animals were anesthetized with a combination of Telazol (5mg/kg), Xylazine (1.5mg/kg), Cetamine (22mg/kg) and Atropine (0.04mg/kg) for orotracheal intubation followed by Isoflurane (2%). Animals were euthanized at the end of the procedure with a lethal dose of KCl (2mEq/kg). The trocar insertion points were marked using the epigastric vessels and umbilical region as reference points. Initially, urethral catheterization was performed using a hydrophilic Nitinol guidewire, followed by a perineal incision to dissect the tortuous urethra of the porcine model. A malleable urethral catheter 8Fr was inserted into their bladder. The animal was placed in the Trendelenburg position inserted and 12mm trocars were inserted in its umbilical region, utilizing 10mm in the surgeon's dominant hand, 5mm in his non-dominant hand of the surgeon, and 5mm in the first assistant's trocar. The surgeon replicates the steps performed in a laparoscopic radical prostatectomy in humans, including the bladder catheterization, dissection of the anterior bladder plane, the vesicular and prostatic dissection, the suture of the dorsal venous plexus, a prostatectomy, an urethral vesical anast omosis, as well as the waterproof test, even including the performing of surgical steps using current concepts of anterior urethral suspension as the reconstruction of the posterior plane of the rhabdosphincter. Results: All steps of surgery could be reproduced in all ten porcine cases. No significant bleeding was observed and the surgical time was gradually reduced fifty percent from case one to last cases. Conclusions: The porcine model allowed the surgeon to replicate all the steps usually performed in a laparoscopic radical prostatectomy. The junior surgeons are better prepared to such difficult surgery. However, further studies will be necessary to prove the impact of the animal model presented in urological clinical practice.

Este dossiê internacional centralizado na temática Artes e Educação do Campo: Emancipação, Diversidade e Pedagogias Outras traz a reflexão da multidimensionalidade das Artes na dinâmica da Educação do Campo e da Educação Popular. É oportunizado à leitura um fórum de debate que reúne quinze reflexões feitas por pesquisadores, pesquisadoras e articulistas acadêmicos de dezenove universidades, sendo cinco instituições acadêmicas estrangeiras e vinte e nove universidades públicas brasileiras, as quais concorreram pela construção de um painel que ilustra acuidade científica na discussão da filotecnia, demandada por pedagogias outras. Com o viés da emancipação e da diversidade, indicam a emergência de novas epistemologias, que inscrevem a afirmação das minorias frente à crise da hegemonia eurocaucasiana. Esse quadro é reflexo do dinamismo universitário, que diante da crise sanitária mundial em decorrência da pandemia do Sars-Cov-2, com os cuidados da Organização Mundial da Saúde (OMS), não parou com a produção de conhecimento. Isso ocorrendo em decorrência da necessidade do tratamento remoto nos processos de ensino, de aprendizagem e de trabalho. De tal sorte que o imprescindível aparato da tecnologia de informação evidenciou, ainda mais, a desigualdade, cristalizando, em meio de tantas possibilidades de comunicação, o controle que as ferramentas da tecnologia da informação impõem. Na era do conhecimento, as minorias vulneráveis ganharam mais estofo para suas emergências afirmativas. Pois, nessa era, o preconceituoso encontra mais torturo para sua ação, que já é considerada anacrônica. Considerando o conhecimento, que é estrutural na tecnologia da informação, é também por natureza antitético ao preconceito. Isso evidenciou o anacronismo que é estruturante na exclusão, sendo uma patologia cuja enfermidade no tecido social configura a ignorância, travando a possibilidade de desenvolvimento, sobretudo no âmbito da multiplicidade dos saberes, que aprofunda as relações humanas. Caracterizando, assim, uma ação patológica que tem tentado desarticular as epistemologias emergentes, que têm encontrado na Música, no Teatro, no Cinema e nas Artes Visuais, um campo de resistência e de luta de afirmação de sua axiologia, a qual é contrária ao valor hegemônico do caucasianismo da europeidade ocidental. É necessário romper com a história única, que é o principal vírus na violenta doença da hegemonia ocidental. É nessa linha de abordagem, que se situa a discussão no viés do respeito à diversidade, e à biodiversidade, que já era consagrada na cosmovisão primogênita da ancestralidade dos diversos, tais como: ibéricos, asiáticos, africanos e ameríndios, que foram vítimas da colonização europeia, persistente ainda na atualidade. Nesse contexto, as Artes na Educação do Campo constituem uma possibilidade de oxigenação dialética de ensino dos ancestrais, que apontam para as pedagogias outras que são diferentes da verticalidade que caracterizam eurocentrismo caucasiano, que é persistente na pedagogia monocultural. Partindo dessas reflexões, a organizadora e os organizadores convidam a todos e a todas para a leitura prazerosa e construtiva deste dossiê.

Managers have discretion over the timing of accounting information disclosure; existing literature has investigated the potential determinants regarding this choice. Thus, this study aimed to evaluate whether the type of accounting information is a factor that influences the anticipation of its disclosure to external users. The dataset comprises information provided by Brazilian companies listed on the Brasil Bolsa Balcão (B3) between 2010 and 2016. The research employed linear regression and the logistic regression model to evaluate whether type of news is a determinant for the timing of financial disclosures. Empirical evidence indicates that the nature of information (i.e., good or bad news) is related to the time taken (i.e., postponement or anticipation) in disclosing quarterly accounting figures of companies. Overall, our results contribute to the disclosure literature in Brazil and indicate that postponements are associated with the disclosure of negative news.

Introduction: Management is essential for meeting the requirements of a project and the computational tools of Business Intelligence (BI) have great potential to contribution, providing management information about the business. Tools of this type are used in several sectors of the industry, but in civil construction, the focus of this work, the scenario is different, with much to aadvance. Therefore, a survey of BI tools applicable to the construction sector and its uses ar presented. Method: It conducts a systematic review of the literature, which analyzed 595 articles from six databases (ACM, Engineering Village, IEEE, Material Science Engineering, Science Direct, Scopus and Web of Science). Results: It identifies12 different applications, mainly in cost management, budget and job security. In the applications, uses of Data Warehouse and OLAP technologies were evidenced. In addition, it was found that most BI tools were developed for each company to the detriment of commercial software. Conclusion: There are several BI tools for civil construction, with different purposes. Most softwares were developed for each case studied due to the unique characteristics of the construction sector. It is believed that the large-scale adoption of the tools involves cooperation between companies, class entities and universities. Limitations were found in the research regarding the characterization of companies, due to the absence of this data in the analyzed articles. Finally, it is suggested that the challenges of implementing the technologies and the verified limitations can be addressed in future studies.

Aumento na incidência de infecções bacterianas nosocomiais e infecções fúngicas invasivas (IFI) já foi descrito em pacientes com COVID-19. A Criptococose é uma infecção oportunista relevante em pacientes imunossuprimidos, incluindo portadores de HIV, transplantes, câncer, doenças reumatológicas e hepatopatias crônicas. O espectro clínico inclui desde formas leves a meningoencefalite grave e doença disseminada. Paciente de 70 anos, submetido a transplante hepático de doador falecido em 29/03/20, em decorrência de cirrose por VHC e hepatocarcinoma, teve boa evolução em pós-operatório imediato. Recebeu imunossupressão inicial com micofenolato e metilprednisolona. Evoluiu, no 5º dia de pós-operatório, com insuficiência respiratória, necessidade de intubação orotraqueal e início de hemodiálise. Após o isolamento de Acinetobacter baumannii multirresistente em cultura de aspirado traqueal e diagnóstico de pneumonia, recebeu tratamento com meropenem e polimixina B. Evoluiu com melhora do quadro, tendo realizado a última hemodiálise e recebido alta da unidade de terapia intensiva em 18/04. Em 29/04, apresentou febre, hipoxemia e leucopenia com linfopenia. Tomografia de tórax não demonstrou alterações relevantes. Em 01/05, houve piora da hipoxemia e desconforto respiratório. Nova tomografia de tórax evidenciou padrão de vidro fosco difuso, com consolidações de permeio. Optou-se por reintrodução de antimicrobianos e transferência para CTI COVID-19. RT-PCR confirmou infecção por SARS-CoV-2. Evoluiu com piora progressiva da instabilidade hemodinâmica e ventilatória, além de disfunção hepática, refratários aos cuidados estabelecidos. Após o óbito, hemoculturas coletadas em 03/05 tiveram isolamento de Cryptococcus neoformans. IFI podem complicar o curso de pacientes com COVID-19, o que já foi demonstrado para Aspergilose Invasiva, Candidíase Invasiva e Mucormicose. A Criptococose é considerada a terceira causa mais frequente de IFI em receptores de TOS, já tendo sido descrita como a causa mais frequente de IFI em receptores de transplante renal brasileiros. Cirróticos representam 21 a 36% dos casos de Criptococose não associada ao HIV: a forma de apresentação mais comum é peritonite, seguida de meningite e doença pulmonar. Relatos de Criptococose em associação à COVID-19 são raros. A doença pode complicar a evolução de receptores de TOS com COVID-19: o reconhecimento do risco pode levar ao diagnóstico e tratamento específico mais precoces.

A toxoplasmose é uma zoonose endêmica no Brasil. Pacientes submetidos a transplantes de órgãos sólidos (TOS) podem ser acometidos pela doença por infecção primária, reativação de infecção latente ou transmissão pelo doador. A apresentação clínica pode incluir miocardite, linfonodomegalias, hepatoesplenomegalia, abscesso cerebral, meningite, coriorretinite, pneumonite, hepatite e pancitopenia. Paciente de 54 anos foi submetido a transplante de fígado de doador falecido por cirrose alcoólica em outubro de 2017, com boa evolução pós-operatória. Recebeu imunossupressão inicial com tacrolimus, micofenolato e prednisona, além de profilaxia com sulfametoxazol/trimetoprim, mantida nos primeiros 6 meses. Sorologias foram reagentes para CMV, HSV, EBV e não reagentes para Toxoplasmose, HIV, HTLV, HAV, HBV, HCV e Chagas. Iniciou, no nono mês após o transplante, quadro febril agudo associado a mialgias e exantema, evoluindo com cefaleia e confusão mental. Na admissão, apresentava rebaixamento da consciência, desorientação e sinais de meningismo, evoluindo com crises convulsivas. Tomografia de crânio não evidenciou alterações. Raquicentese revelou líquor límpido, com 14 leucócitos/mm3 (50% mononucleares) e hiperproteinorraquia; exames diretos, culturas e antígeno criptocócico foram negativos. PCR foi negativo para HSV 1 e 2, EBV, CMV, Tuberculose e Toxoplasmose. Houve detecção de IgM para Toxoplasmose e o pareamento de sorologias confirmou infecção aguda. A despeito do início do tratamento específico com sulfametoxazol/trimetoprim intravenoso, manteve febre diária e confusão mental. Nova análise do líquor, 8 dias após a primeira, evidenciou 9 leucócitos/mm3 (100% mononucleares) e redução da proteinorraquia. A repetição do PCR para Toxoplasma gondii teve resultado detectado. Com o tratamento específico por 6 semanas, seguido de profilaxia secundária, o paciente evoluiu com resolução do quadro clínico. Segue sob acompanhamento, com boa função do enxerto e sem intercorrências. Apesar de a encefalite por Toxoplasma gondii com lesões intracranianas produzindo efeito de massa ser uma apresentação relativamente frequente em pacientes imunossuprimidos, é incomum em pacientes submetidos a TOS. Relatos de meningite aguda por Toxoplasmose são escassos, estando, na maior parte das descrições, presente em associação com abscessos cerebrais. O caso descrito ressalta que a toxoplasmose aguda deve ser considerada no diagnóstico diferencial de meningite em pacientes imunossuprimidos.

Africa is rapidly urbanising, and transport systems often cannot keep pace, leading to disconnected cities that might entrench car dependency (and preference), along with gender and socioeconomic inequality. In Ghana, transport emissions have risen 75% between 2000 to 2016, along with congestion, pollution and traffic accidents – despite attempts to quell the problem via bans on aged vehicles or more recently, penalties. This paper builds on prior work and argues that putting accessibility at the centre of transport systems will foster sustainability in these cities, yet such data is difficult to find, especially gender-sensitive mobility data. This paper uses a novel approach, combining qualitative and quantitative methods, to study the accessibility across genders in Kumasi and Accra and identify future scenarios for sustainable and accessible systems. This working paper presents preliminary findings.

Objective: The aim of the current study is to investigate the chemical composition, cytotoxic effect, and leishmanicidal activity of propolis collected in the semi-arid region of Bahia, Brazil.Methods: EtOH extract, hexane, EtOAc and MeOH fractions from propolis were analyzed by ultra-performance liquid chromatography coupled with diode array detector and quadrupole time-of-flight mass spectrometry. The identification was based on the exact mass, general fragmentation behaviors and UV absorption of the flavonoids. The in vitro cytotoxic effect and leishmanicidal activity of ethanolic extract, hexane, ethyl acetate, and methanolic fractions of propolis were evaluated.Results: Five triterpenes and twenty-four flavonoids were identified. The propolis did not present toxicity to the host cell up to the maximum concentration tested. In addition, all tested samples showed statistically significant activity against promastigotes of Leishmania chagasi and Leishmania amazonensis. Regarding the activity against amastigote forms of L. amazonensis, the hexane fraction, presented statistically significant activity with IC50 of 1.3 ± 0.1 μg/ml.Conclusion: The results support the idea that propolis can be used for future antileishmania studies.

Objetivo: Conhecer a adesão dos idosos às formas de administração do tratamento da tuberculose. Métodos: Estudo exploratório-descritivo, transversal e quantitativo, desenvolvido no Distrito Sanitário Oeste de Natal, com os idosos que fizeram tratamento entre janeiro de 2010 a dezembro de 2015. Resultados: Observou-se que os idosos utilizam tanto o regime autoadministrado (51,1%) quanto o diretamente observado (48,9%). Em ambos os grupos prevaleceu a faixa etária de 60 a 69 anos (29,8%; 35,1%), a forma pulmonar da doença (41,5%; 44,7%) e o caso novo como tipo de entrada para o tratamento (31,9%; 27,7%). Quanto ao encerramento, destacou-se a conclusão do tratamento (33,0%; 25,5%). Conclusão: A tuberculose ainda é prevalente no Brasil, destacando-se a importância do diagnóstico e tratamento adequados, além da adoção de medidas de controle e capacitação dos profissionais de saúde frente ao cuidado desses pacientes.

Viral metagenomics is increasingly being used for the identification of emerging and re-emerging viral pathogens in clinical samples with unknown etiology. The objective of this study was to shield light on the metavirome composition in clinical samples obtained from patients with clinical history compatible with an arboviral infection, but that presented inconclusive results when tested using RT-qPCR. The inconclusive amplification results might be an indication of the presence of an emerging arboviral agent that is inefficiently amplified by conventional PCR techniques. A total of eight serum samples with inconclusive amplification results for the routinely tested arboviruses—dengue (DENV), Zika (ZIKV), and Chikungunya (CHIKV) obtained during DENV and CHIKV outbreaks registered in the state of Alagoas, Northeast Brazil between July and August 2021—were submitted to metagenomic next-generation sequencing assay using NextSeq 2000 and bioinformatic pipeline for viral discovery. The performed bioinformatic analysis revealed the presence of two arboviruses: DENV type 2 (DENV-2) and CHIKV with a high genome coverage. Further, the metavirome of those samples revealed the presence of multiple commensal viruses apparently without clinical significance. The phylogenetic analysis demonstrated that the DENV-2 genome belonged to the Asian/American genotype and clustered with other Brazilian strains. The identified CHIKV genome was taxonomically assigned as ECSA genotype, which is circulating in Brazil. Together, our results reinforce the utility of metagenomics as a valuable tool for viral identification in samples with inconclusive arboviral amplification. Viral metagenomics is one of the most potent methods for the identification of emerging arboviruses.

Este estudo busca compreender de que modo o carnaval pode educar as relações étnico-raciais, ao expor, por meio de dados bibliográficos e documentais, alguns acontecimentos históricos que perpetram o carnaval como um fenômeno que consente a ruptura de barreiras socioculturais e socioeconômicas. A abordagem qualitativa desta pesquisa assinala-se e conecta-se com questões subjetivas ao campo e aos sujeitos da pesquisa. Os dados permitem concluir que há um processo pedagógico por vezes invisibilizado, mas que reverbera por ser gerido dentro da maior atividade festiva do planeta, permitindo o enlace de aspectos ímpares a partir dos blocos afro de samba- -reggae da primeira capital do Brasil, a cidade de Salvador, no Estado da Bahia.

This paper aims to discuss the access of the Apinayé indigenous people to the Rural Education Degree: Codes and Languages - Arts and Music, at the Federal University of Tocantins (UFT), Tocantinópolis campus, state of Tocantins, Brazil, as well as to dialogue with some contemporary theorists (Brandão, 1983; Haesbaert, 2016; Lévi-Strauss, 1973; Nimuendajú, 1956; Santos, 1999) about socio-cultural diversity in the State of Tocantins. For that, the research addresses aspects of selection processes, didactic-pedagogical practices, language and affirmative policy programs that (do not) favor the access and inclusion/permanence of these students in the University. The research is of a bibliographical and exploratory nature, with a qualitative-interpretative approach. Since its first selection process in 2014, this graduation course annually welcomes incoming Apinayé indigenous students. The research results show that, although UFT uses different affirmative actions such as specific programs to welcome and support indigenous students and the didactic-pedagogical activities implemented in the classroom in the Degree in Rural Education have their specificities focused on the formation of the people of the countryside, all this has not been enough to guarantee the inclusion/permanence of the indigenous people in this undergraduate course. The largest barriers faced by Apinayé students have been the Portuguese language and the epistemology of academia.

Abstract The high prevalence of anxiety disorders associated with pharmacotherapy side effects have motivated the search for new pharmacological agents. Species from Citrus genus, such as Citrus limon (sicilian lemon), have been used in folk medicine as a potential therapy to minimize emotional disorders. In order to searching for new effective treatments with fewer side effects, the present study evaluated the anxiolytic mechanism of action and the hypnotic-sedative activity from the Citrus limon fruit's peels essential oil (CLEO). Adults male Swiss mice were submitted to barbiturate-induced sleep test; elevated plus-maze (EPM) and light-dark box (LDB) (evaluation of the mechanism of action); rotarod; and catalepsy tests. CLEO oral treatment decreased latency and increased the sleep total time; moreover it induced in animals an increased the number of entries and percentage of time spent into open arms of the EPM; an increased the number of transitions and the percentage of time into light compartment in the LDB; which were only antagonized by flumazenil pretreatment, with no injury at motor function. Thus, results suggest that CLEO treatment induced an anxiolytic behavior suggestively modulated by the benzodiazepine binding site of the GABAA receptor or by an increase of GABAergic neurotransmission, without cause impairment in the motor coordination.

Gestores de companhias possuem discricionariedade sobre o momento de divulgação dos resultados contábeis das companhias, levando a literatura a investigar potenciais determinantes da tempestividade da evidenciação. Nesse sentido, o objetivo deste estudo foi o de avaliar se o tipo de notícia a ser divulgada é fator que influencia a antecipação ou postergação da divulgação de informações ao mercado. Com base em dados de companhias abertas brasileiras listadas na B3, entre 2010 e 2016, foi implementada uma estratégia de se avaliar, por meio de regressão linear e logística, se o tipo de notícia está relacionado com a decisão do momento da publicação das demonstrações contábeis. As evidências encontradas indicam que as más (boas) estão relacionadas com a postergação (antecipação) da divulgação dos resultados contábeis trimestrais das companhias. Os resultados, portanto, contribuem com a literatura de evidenciação no Brasil e indicam que postergações estão associadas à divulgação de notícias negativas.

As intoxicações por agrotóxicos resultam da exposição ocupacional dos trabalhadores rurais, principalmente nas áreas agrícolas. Para reduzir esses problemas é necessário o uso de estratégias de monitoramento e controle do manejo racional dos produtos químicos utilizados. O objetivou-se com o trabalho avaliar o perfil ocupacional dos trabalhadores rurais por meio de entrevistas e exames toxicológicos. O estudo caracteriza-se por uma pesquisa aplicada, de característica exploratória, com procedimento de levantamento a partir de uma amostra com 50 agricultores. Observou-se maioria dos fatores de riscos aos trabalhadores está intrinsecamente relacionada, pois quando são verificadas as correlações causais da exposição e intoxicação dos agricultores, verificamos que a baixa escolaridade associada à carência técnica de instrução do uso racional dos agrotóxicos, o tempo prolongado de exposição e o não uso de EPIs, contribuem para o perfil toxicológico dos trabalhadores rurais. Em relação às análises laboratoriais foi possível observar que parte dos trabalhadores apresentava intoxicação aguda, verificada através da análise da colinesterase, porém, não foi suficiente para causar danos as funções renais e hepáticas. Contudo, podendo ocorrer com o uso crônico e recorrente dessas substâncias químicas. Portanto, é necessário uma maior fiscalização na aplicação dos agrotóxicos no campo, treinamento dos trabalhadores rurais sobre uso correto dos insumos agrícolas e estratégias de intervenção pelos órgãos de saúde e meio ambiente.

The solar thermal power generation usually takes the water-medium heat absorption as the first generation, the molten salt heat absorption as the second generation, and the Braden circulation system using air, supercritical carbon dioxide or solid particles as the medium is called the third generation of solar heat power system. Through the use of air or ceramic particles as a heat-absorbing medium, the use of dry heat storage media such as refractory bricks and ceramic materials for large-scale heat storage, can improve system efficiency and reduce costs, the system's thermal storage capacity to ensure that the power station at any time according to power grid requirements for scheduling; the system uses standardized module design, through the factory production, power plant design, equipment production, installation, commissioning and operation are simple, the system stored heat can be used for food processing, drying, agricultural applications; according to the United States DOE research, modules with heat storage capability Equipped with a small gas turbine for quick start-up and shutdown, could improve grid voltage and frequency.

Abstract One of the hallmarks of acute inflammation is neutrophil infiltration of tissues. We investigated molecular mechanisms implicated in acute neutrophilic inflammation induced by the venom of a freshwater stingray (Potamotrygon cf. henlei) in mice. Ray venom induced early mobilization of neutrophil in the microvasculature of cremaster mice and infiltration of the peritoneal cavity 2 hours after injury, in a dose-response manner. IL-1β, IL-6, TNF-α, and KC were produced. The neutrophilic infiltration did not occur in mice with ST2 receptor and MyD88 adapters neutralized, or in those with PI3K and p38 MAPK signaling blocked. Drastic reduction of neutrophil infiltration to peritoneal cavities was observed in ST2−/−, TLR2/TLR4−/−, MyD88−/−, TRIF−/− and IL-17A−/− mice, and a partial reduction was observed in IL-18R−/− mice. Mast cell Kit W(sh)/W(sh)-, AHR-, NLRP3-, ICE-, IL-1β-, P2RX7-, CD39-, IL-17RA-, and TBX21 KO mice retain the ability to induce neutrophilia in peritoneal cavity after ray venom injection. IL-6 and TNF-α alone were insufficient for promote neutrophilia in the absence of ST2 signaling. Finally, abundant production of IL-33 by cardiomyocytes was observed. These results refine our understanding of the importance of the IL-33/ST2 axis and IL-33-producing cardiomyocytes in the early acute neutrophilia induced by freshwater stingray venoms.

Objective: to characterize the Brazilian production of nursing theses and dissertations on women’s health in the prison system. Methods: bibliometric study based on the panorama of scientific production in the context of Nursing post-graduations in Brazil. Data were collected in the Directory of Theses and Dissertations of the Coordination for Improvement of Higher Education Personnel. Results: eleven documents were included in the sample. Most of them were carried out during masters courses (63.6%), with predominance of studies conducted in the Northeast (63.6%), Southeast (18.1%) and Midwest (18.1%). Regarding the most explored themes, the relationship of women/mothers with their children presented a higher proportion (54.5%). Qualitative studies (45.4%), with descriptive designs (36.3%) predominated. Conclusion: Brazilian nursing theses and dissertations on women’s health in the prison system consisted of qualitative studies developed in the Northeast, Southeast and Midwest, and presented a gap in the production of nursing knowledge.

A apicultura é uma atividade que depende de diversos fatores dentre eles o ambiental. Em épocas onde o alimento para as abelhas é escasso faz-se necessário optar pela alimentação artificial, tornando-se necessário conhecer os alimentos que serão oferecidos as abelhas. Objetivou-se com essa pesquisa avaliar a influência de combinações de fontes de alimentações energéticas e proteicas sobre a longevidade das abelhas operárias (Apis mellifera L.) in vitro. As fontes avaliadas foram a mistura de pólen (10%) e açúcar de confeiteiro (90%), apenas o açúcar de confeiteiro (100%), uma mistura de pólen (10%) e mel (90%) e açúcar de confeiteiro (90%) e mel (10%). Foram coletadas abelhas recém-emergidas de favos de crias e colocadas em grupos de 20 abelhas em gaiolas de madeiras, com ambiente controlado, onde foram servidas as devidas alimentações e registrado o levantamento da quantidade de abelhas mortas diariamente. O trabalho foi conduzido em delineamento experimental inteiramente casualizado, com quatro tratamentos e seis repetições. Na análise de sobrevivência das abelhas notou-se que a alimentação da mistura de pólen (10%) e açúcar (90%) foi a que proporcionou os melhores resultados em relação a longevidade das abelhas, ao contrário da alimentação de apenas o açúcar que apresentou menor longevidade.

Objective: to understand the experience of fathers with the kangaroo mother care method. Methods: an integrative literature review in the following databases: Scientific Electronic Library Online, Medical Literature Analysis and Retrieval System Online, Latin American and Caribbean Health Sciences, Web of Science, Current Nursing and Allied Health Literature. Results: a total of 732 articles were obtained and seven were selected. It was identified that fathers experienced the kangaroo method with fulfillment and pleasure. They presented difficulties, fears and insecurities that may be associated with the functioning and life support devices used to ensure the survival of premature infants, related to the distancing between father and newborn. Conclusion: the father is currently more participative and aware of his role in the family environment and in the care inherent to the premature child. However, despite feeling unprepared, fathers are proud and hopeful with the clinical evolution when experiencing the kangaroo method.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Brazil was dominated by two lineages designated as B.1.1.28 and B.1.1.33. The two SARS-CoV-2 variants harboring mutations at the receptor-binding domain of the Spike (S) protein, designated as lineages P.1 and P.2, evolved from lineage B.1.1.28 and are rapidly spreading in Brazil. Lineage P.1 is considered a Variant of Concern (VOC) because of the presence of multiple mutations in the S protein (including K417T, E484K, N501Y), while lineage P.2 only harbors mutation S:E484K and is considered a Variant of Interest (VOI). On the other hand, epidemiologically relevant B.1.1.33 deriving lineages have not been described so far. Here we report the identification of a new SARS-CoV-2 VOI within lineage B.1.1.33 that also harbors mutation S:E484K and was detected in Brazil between November 2020 and February 2021. This VOI displayed four non-synonymous lineage-defining mutations (NSP3:A1711V, NSP6:F36L, S:E484K, and NS7b:E33A) and was designated as lineage N.9. The VOI N.9 probably emerged in August 2020 and has spread across different Brazilian states from the Southeast, South, North, and Northeast regions.

The aim of this study is to understand and analyze the processes involved in the production of humour and new lexical units and verify the constitution and the witty functioning of the senses in entries that make up the book Le dictionnaire des mots qui n’existent pas (1992). To carry out this research, we consider Freud (1905), Possenti (2010), Bergson (2007) and Raskin (1944). So, we explore some questions which allowed us to understand how the lexicon, presented as a comic creativity, reveals an offensive reality.

Run-time profiling of software applications is key to energy efficiency. Even the most optimized hardware combined to an optimally designed software may become inefficient if operated poorly. Moreover, the diversification of modern computing platforms and broadening of their run-time configuration space make the task of optimally operating software ever more complex. With the growing financial and environmental impact of data center operation and cloud-based applications, optimal software operation becomes increasingly more relevant to existing and next-generation workloads. In order to guide software operation towards energy savings, energy and performance data must be gathered to provide a meaningful assessment of the application behavior under different system configurations, which is not appropriately addressed in existing tools. In this work we present Containergy, a new performance evaluation and profiling tool that uses software containers to perform application run-time assessment, providing energy and performance profiling data with negligible overhead (below 2%). It is focused on energy efficiency for next generation workloads. Practical experiments with emerging workloads, such as video transcoding and machine-learning image classification, are presented. The profiling results are analyzed in terms of performance and energy savings under a Quality-of-Service (QoS) perspective. For video transcoding, we verified that wrong choices in the configuration space can lead to an increase above 300% in energy consumption for the same task and operational levels. Considering the image classification case study, the results show that the choice of the machine-learning algorithm and model affect significantly the energy efficiency. Profiling datasets of AlexNet and SqueezeNet, which present similar accuracy, indicate that the latter represents 55.8% in energy saving compared to the former.

Tuberculosis is an infectious-contagious disease, whose etiological agent is Mycobacterium tuberculosis, and currently stands as the second leading cause of death from infectious diseases in the world. This study aims to describe its clinical, diagnostic and therapeutic aspects in the elderly. This is an exploratory-descriptive cross-sectional study with a quantitative approach, developed in a Sanitary District in Natal/RN, from January 2010 to December 2015. Among the 94 participants, the majority were males (51.1%) aged between 60 and 69. The pulmonary form of the disease was predominant (86.2%) in the studied group and most of the cases were new (59.6%). The treatment was self-administered (52.1%) and completed within the appropriate period (57.4%). The tuberculin test was not undergone by the majority of the elderly (76.6%), neither was histopathology (86.2%), while chest X-ray was suggestive of tuberculosis (72.3%). It was observed that the elderly did not undergo the first bacilloscopy (59.5%) and, out of those who were subjected to the second, it was positive for most (54.2%). It is worth mentioning that the Human Immunodeficiency Virus serology was not carried out in 54.2% of the senior patients with tuberculosis. Older individuals make up a risk population group and should be given special attention from health professionals.

O gerenciamento inadequado dos resíduos sólidos urbanos acarreta inúmeros impactos no meio ambiente, alterando suas características físicas, químicas e biológicas. A ausência de tratamentos adequados para resíduos sólidos urbanos aliados a disposição incorreta torna-se um grande problema de ordem estética e uma alarmante ameaça à saúde pública. Assim, para que o gerenciamento adequado dos resíduos sólidos urbanos seja executado de acordo a legislação vigente é necessários mecanismo e estratégias para o manejo dos resíduos desde sua origem até sua disposição ambientalmente adequada. Este trabalho tem por objetivo diagnosticar o atual processo de gerenciamento dos resíduos sólidos urbanos do município de São Bentinho-PB, e propor o gerenciamento dos mesmos de maneira mais adequada diante das condições locais. A metodologia de diagnóstico fundamentou-se num levantamento bibliográfico, entrevista ao órgão competente e a aplicação de questionários a população do município. Com o resultado deste estudo foi notório que a maioria da população necessita ser informada sobre as questões ambientais, para que exerçam sua responsabilidade no gerenciamento do lixo. O poder público municipal não tem tomado nenhuma providência para minimizar os impactos relacionados ao gerenciamento impróprio de seus resíduos, é necessário incentivos e ações para conscientização da população em relação à educação ambiental.Management of municipal solid waste in the city of São Bentinho-PB – Brazil Inadequate management of municipal solid waste entails numerous impacts on the environment by changing its physical, chemical and biological characteristics. The absence of appropriate treatments for solid urban waste coupled with incorrect disposal becomes a problem of aesthetic and an alarming threat public health. So for the proper management of municipal solid waste is implemented in accordance with current legislation is needed mechanism and strategies for the management of waste from its origin to its environmentally sound disposal. This study aims to diagnose the current management process of municipal solid waste in the municipality of São Bento-PB, and propose the management of these more adequately on the local conditions. The diagnostic methodology was based on a literature review, interview with the competent body and the application of questionnaires to municipal population. With the result of this study it was noticeable that most of the population needs to be informed about environmental issues, to exercise their responsibility in managing waste. The municipal government has not taken any steps to minimize impacts related to improper management of their waste, we need incentives and actions for public awareness on environmental education.

No semiárido a ocorrência de longos períodos de estiagem vem tornado a irrigação uma pratica indispensável para exploração agrícola. Desta forma objetivou-se, com esta pesquisa, avaliar o crescimento e a produção de do algodoeiro cv. BRS Jady irrigado com águas de distintos níveis de salinidades e doses de matéria orgânica. O experimento foi conduzido utilizando-se um Neossolo Regolítico Eutrófico de textura franco arenosa no município de Campina Grande-PB. Adotou-se o delineamento experimental de blocos ao acaso, em esquema fatorial 4 x 4, com três repetições, cujos os tratamentos resultaram da combinação de quatro níveis de condutividade elétrica da água (CEa) (1,7; 3,4; 5,1 e 6,8 dS m-1) e quatro doses de matéria orgânica (0; 2,5; 3,5 e 4,5% em base do volume do solo). A irrigação com água salina de CE a partir 1,7 dS m-1 afetou negativamente o crescimento e a produção do algodoeiro cv. BRS Jady, provocando reduções no diâmetro de caule, altura de planta, área foliar, fitomassa seca total, massa de algodão em pluma, massa total de sementes e rendimento de fibra. A adubação orgânica com doses crescentes promoveu aumento na altura de plantas, área foliar e massa total de sementes do algodoeiro cv. BRS Jady. Houve interação entre os fatores aguas salinas e doses de matéria orgânica para diâmetro caulinar, fitomassa seca total e massa de algodão em pluma, sendo os maiores valores obtidos na das doses de 3,5 e 4,5% de matéria orgânica. Organic fertilization and waters of different salin levels in the cultivation of colored fiber cotton Abstract: In the semiarid the occurrence of long periods of drought has made irrigation an indispensable practice for agricultural exploration. The objective of this research was to evaluate the growth and yield of cotton cv. BRS Jady irrigated with waters of different levels of salinities and doses of organic matter. The experiment was conducted using a sandy loam texture Eutrophic Neolithic in the municipality of Campina Grande-PB. A randomized complete block design was used in a 4 x 4 factorial scheme with three replications, the treatments of which were the result of the combination of four levels of electrical conductivity (ECw, 1.7, 3.4, 5.1 And 6.8 dS m-1) and four doses of organic matter (0, 2.5, 3.5 and 4.5% on the basis of soil volume). Irrigation with EC saline water from 1.7 dS m-1 negatively affected the growth and yield of cotton cv. BRS Jady, causing reductions in stem diameter, plant height, leaf area, total dry matter, feathered cotton mass, total seed mass and fiber yield. Organic fertilization with increasing doses promoted increase in plant height, leaf area and total seed mass of cotton cv. BRS Jady. There was interaction between saltwater factors and organic matter doses for shoot diameter, total dry matter and cotton mass in feathers, the highest values being obtained in the 3.5 and 4.5% organic matter doses.

A series of eight substituted bis-2-hydroxy-1,4-naphthoquinone derivatives was synthesized through lawsone condensation with various aromatic and aliphatic aldehydes under mild acidic conditions. The title compounds were evaluated for antileishmanial activity in vitro against Leishmania amazonensis and Leishmania braziliensis promastigotes; six compounds showed good activity without significant toxic effects. The compound with the highest activity was used for an in vivo assay with Leishmania amazonensis.