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154 results on '"Andrade, Silvia P."'

1. COVID-19 Vaccination and New Onset Glomerular Disease: Results from the IRocGN2 International Registry.

Author

Waldman, Meryl, Sinaii, Ninet, Lerma, Edgar, Kurien, Anila, Jhaveri, Kenar, Uppal, Nupur, Wanchoo, Rimda, Avasare, Rupali, Zuckerman, Jonathan, Liew, Adrian, Gallan, Alexander, El-Meanawy, Ashraf, Yagil, Yoram, Lebedev, Larissa, Baskaran, Krishoban, Vilayur, Eswari, Cohen, Adrienne, Weerasinghe, Nethmi, Petrakis, Ioannis, Stylianou, Kostas, Gakiopoulou, Hariklia, Hamilton, Alexander, Edney, Naomi, Millner, Rachel, Marinaki, Smaragdi, Rein, Joshua, Killen, John, Rodríguez Chagolla, Jose, Bassil, Claude, Lopez Del Valle, Ramon, Evans, Jordan, Zawaideh, Mona, Baxi, Pravir, Rodby, Roger, Vankalakunti, Mahesha, Mejia Vilet, Juan, Ramirez Andrade, Silvia, Homan, Mal, Vásquez Jiménez, Enzo, Perinpanayagam, Natasha, Velez, Juan, Mohamed, Muner, Mohammed, Khalid, Sekar, Arjun, Ollila, Laura, Aron, Abraham, Arellano Arteaga, Kevin, Islam, Mahmud, Berrio, Esperanza, Maoujoud, Omar, Morales, Rebecca, Seipp, Regan, Schulze, Carl, Yenchek, Robert, Vancea, Irina, Muneeb, Muhammad, Howard, Lilian, Caza, Tiffany, and Urisman, Anatoly

Subjects
Humans, COVID-19, COVID-19 Vaccines, Vaccination
Abstract

KEY POINTS: IgAN and MCD are the most common de novo glomerular diseases reported after COVID-19 vaccination, particularly after mRNA vaccination. Membranous nephropathy, pauci-immune GN, and collapsing GN have also been attributed to COVID-19 vaccination, some with dual histologies. Recovery of kidney function and proteinuria remission is more likely in IgAN and MCD by 4–6 months compared with the other glomerular diseases. BACKGROUND: Patients with de novo glomerular disease (GD) with various renal histologies have been reported after vaccination against SARS-CoV-2. Causality has not been established, and the long-term outcomes are not known. To better characterize the GDs and clinical courses/outcomes, we created the International Registry of COVID-19 vaccination and Glomerulonephritis to study in aggregate patients with de novo GN suspected after COVID-19 vaccine exposure. METHODS: A REDCap survey was used for anonymized data collection. Detailed information on vaccination type and timing and GD histology were recorded in the registry. We collected serial information on laboratory values (before and after vaccination and during follow-up), treatments, and kidney-related outcomes. RESULTS: Ninety-eight patients with GD were entered into the registry over 11 months from 44 centers throughout the world. Median follow-up was 89 days after diagnosis. IgA nephropathy (IgAN) and minimal change disease (MCD) were the most common kidney diseases reported. Recovery of kidney function and remission of proteinuria were more likely in IgAN and MCD at 4–6 months than with pauci-immune GN/vasculitis and membranous nephropathy. CONCLUSIONS: The development of GD after vaccination against SARS-CoV-2 may be a very rare adverse event. Temporal association is present for IgAN and MCD, but causality is not firmly established. Kidney outcomes for IgAN and MCD are favorable. No changes in vaccination risk-benefit assessment are recommended based on these findings.

Published
2023

2. Oral formulation of Wnt inhibitor complex reduces inflammation and fibrosis in intraperitoneal implants in vivo

Author

de Castro Santos, Ana Luíza, da Silva, Natália Jordana Alves, Viana, Celso Tarso Rodrigues, dos Santos, Letícia Cristine Cardoso, da Silva, Gabriel Henrique Costa, Scalzo Júnior, Sérgio Ricardo Aluotto, Costa, Pedro Augusto Carvalho, da Silva, Walison Nunes, de Jesus, Itamar Couto Guedes, Birbrair, Alexander, de Magalhães, Mariana T. Q., Frézard, Frédéric, Guatimosim, Silvia, Haley, Rebecca M., Mitchell, Michael J., Andrade, Silvia Passos, Campos, Paula Peixoto, and Guimaraes, Pedro Pires Goulart

Published
2023
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9. Comparison of strip meniscometry and Schirmer tear test results and tear film breakup time between healthy dogs and dogs with dry eye disease.

Author

Franco Nascimento, Felipe, Goulart Consoni Passareli, João Victor, Felipe da Costa Zulim, Luís, Alves Silva, Danielle, Giuffrida, Rogerio, Garcia Estanho, Giovana José, Claudino Villa, Mayra, and Franco Andrade, Silvia

Subjects
LABORATORY dogs, EYE diseases, DOGS, KERATOCONJUNCTIVITIS, SENSITIVITY & specificity (Statistics), RANK correlation (Statistics), STANDARD deviations, TIME measurements
Abstract

Copyright of Arquivos Brasileiros de Oftalmologia is the property of Arquivos Brasileiros de Oftalmologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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13. The increase of philanthropic entities in the SUS: what does this scenario reveal?

Author

Marques da Silva, João Felipe, Gimenez Carvalho, Brígida, Mendes Pereira, Adelyne Maria, Almeida Nunes, Elisabete de Fátima, de Freitas Mendonça, Fernanda, Lopes Santini, Stela Maris, Vieira Andrade, Silvia Karla Azevedo, and de Moura Ferraz, Edinalva

Abstract

The article analyzes aspects of the change in the legal nature of private healthcare from "for-profit" to "non-profit" entities. It is an exploratory research, supported by the policy analysis framework, focusing on secondary data from the Cadastro Nacional de Estabelecimentos de Saúde (National Registry of Health Facilities - CNES) from 2012 to 2020 and a case study. The results show an increase in these entities in all regions of the country and evidence that they behave like profit-oriented entities. The change in legal nature hides a broader process of implicit commodification of healthcare services, encouraged by state policies and related to exemptions provided by law. DESCRIPTORS: Voluntary Health Agencies, legislation & jurisprudence. Fund Raising. Health Management. Unified Health System. Public Policy. [ABSTRACT FROM AUTHOR]

Published
2023
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31. The intensity of the foreign body response to polyether‐polyurethane implant in diabetic mice is strain‐dependent.

Author

de Almeida, Simone A., Orellano, Laura A. A., Pereira, Luciana X., Viana, Celso T. R., Andrade, Silvia P., Campos, Paula P., and Ferreira, Mônica A. N. D.

Subjects
FOREIGN bodies, LABORATORY mice, POLYURETHANE elastomers, FOREIGN body reaction, ARTIFICIAL implants, BLOOD sugar, GLYCEMIC index
Abstract

A number of genetic factors have been linked to the development of diabetes, a condition that often requires implantable devices such as glucose sensors. In normoglycaemic individuals, this procedure induces a foreign body reaction (FBR) that is detrimental to bioimplant functionality. However, the influence of the genetic background on this reaction in diabetes has not been investigated. We examined the components of FBR (capsule thickness, collagen deposition, mast cell and foreign body giant cell number) in subcutaneous implants of polyether polyurethane (SIPP) in streptozotocin (STZ)‐induced diabetes in Swiss, C57BL/6 and Balb/c mice. The fasting blood glucose levels before STZ injections were 133.5 ± 5.1 mg/dL, after the treatment increased 68.4% in Swiss mice, 62.4% in C57BL/6 and 30.9% in Balb/c mice. All FBR features were higher in implants of Swiss and C57BL/6 mice compared with those in implants of Balb/c. Likewise, the apoptotic index was higher in implants of diabetic Swiss and C57BL/6 mice whose glycaemic levels were the highest. Our findings show an association between the severity of hyperglycaemic levels and the intensity of the FBR to SIPP. These important strain‐related differences in susceptibility to diabetes and the intensity of the FBR must be considered in management using implantable devices in diabetic individuals. [ABSTRACT FROM AUTHOR]

Published
2021
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32. Sulfonamide-Functionalized Polymeric Nanoparticles for Enhanced InVivo Colorectal Cancer Therapy

Author

Guimarães, Pedro Pires Goulart, Viana, Celso Tarso Rodrigues, Pereira, Luciana, Gontijo, Savio Morato Lacerda, Campos, Paula Peixoto, Andrade, Silvia Passos, Santos, Robson A.S., and Sinisterra, Rubén D.

Abstract

Background: Colorectal cancer (CRC) is the third most common cancer in the world. 5-Fluorouracil (5-FU) is a conventional and most effective drug used in the clinic for the treatment ofCRC. However, the clinical use of 5-FU is limited due to the acquired resistance and systemictoxicity, such as hepatotoxicity and gastrointestinal toxicity. Objective: Recent advances in nanomedicine are being exploited to develop nanoparticle platformsto overcome resistance and therapeutic delivery of active molecules. Here, we developed 5-FUloaded sulfadiazine-poly(lactide-co-glycolide) nanoparticles (SUL-PLGA NPs) to be applied in thecolorectal cancer model. Methods: We assessed the in vivo efficacy of the SUL-PLGA NPs to enhance the antitumor effectof 5-FU. Results: In vivo treatment with 5-FU-SUL-PLGA NPs significantly reduced tumor growth in acolon cancer xenograft model compared to free 5-FU and 5-FU loaded non-targeted NPs. Treatmentwith 5-FU-SUL-PLGA NPs also increased blood vessel diameters within tumors, whichcould act in conjunction to enhance antitumor efficacy. In addition, 5-FU-SUL-PLGA NPs significantlyreduced liver mass and lung mass, which are the most common metastasis sites of CRC, anddecreased liver hepatotoxicity compared to free 5-FU drug and 5-FU loaded non-targeted NPs. Conclusion: Our findings suggest that the use of 5-FU-SUL-PLGA NPs is a promising strategy toenhance 5-FU efficacy against CRC.

Published
2022
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38. Crystalcryoglobulinemia as a manifestation of monoclonal gammopathy of renal significance in a patient with renal cell carcinoma

Author

Comunidad-Bonilla, Roque A, Navarro-Gerrard, Megan A, Uribe-Uribe, Norma, Ramírez-Andrade, Silvia E, Cohen-Bucay, Abraham, and Mejia-Vilet, Juan M

Abstract

Crystalcryoglobulinemia refers to the extracellular deposition of crystals in the systemic vasculature, leading to vascular injury, thrombosis, and occlusion. This entity is usually described as a complication of multiple myeloma, although it can also occur in the setting of a monoclonal gammopathy of renal significance. Synchronous presentation of a monoclonal gammopathy and renal cell carcinoma is rare. Hypothetically, as both neoplasms’ growth depends on certain cytokines such as interleukin-6, it is possible that cytokine production from one neoplasm may stimulate the growth of the other. In this report, we describe a case of crystalcryoglobulinemia in a patient with a monoclonal gammopathy of renal significance and concomitant renal cell carcinoma. Additionally, we performed a systematic review of the literature and analyzed data of 61 reported cases of crystalcryoglobulinemia and of 40 reported cases describing the association between multiple myeloma and renal cell carcinoma.

Published
2021
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39. Sesquiterpene Polygodial from Drimys brasiliensis(Winteraceae) Down-Regulates Implant-Induced Inflammation and Fibrogenesis in Mice

Author

Ferreira, Bruno Antonio, Norton Filho, Anderson Ferraz, Deconte, Simone Ramos, Tomiosso, Tatiana Carla, Thevenard, Fernanda, Andrade, Silvia Passos, Lago, João Henrique Ghilardi, and Araújo, Fernanda de Assis

Abstract

Drimys brasiliensis(Winteraceae) has been investigated in traditional medicine for its anti-inflammatory properties to treat gastric ulcers and allergic and respiratory system diseases as well as for cancer treatment. In this work, we investigate the ability of the sesquiterpene polygodial, isolated from D. brasiliensisstem barks, to modulate the chronic inflammatory response induced by polyester-polyurethane sponge implants in C57BL/6J mice. Daily treatment with polygodial inhibited the macrophage content in the implants as determined by the activity of the N-acetyl-β-d-glucosaminidase enzyme as well as decreased the levels of CXCL1/KC and CCL2/JE/MCP-1 pro-inflammatory chemokines and the presence of mast cells along the formed fibrovascular tissue. Similarly, the deposition of a new extracellular matrix (total collagen and type I and III collagen fibers) as well as the production of the TGF-β1 cytokine were attenuated in implants treated with polygodial, showing for the first time its antifibrogenic capacity. The hemoglobin content, the number of newly formed vessels, and the levels of VEGF cytokine, which were used as parameters for the assessment of the neovascularization of the implants, did not change after treatment with polygodial. The anti-inflammatory and antifibrogenic effects of polygodial over the components of the granulation tissue induced by the sponge implant indicate a therapeutic potential for the treatment of inflammatory diseases associated with the development of fibrovascular tissue.

Published
2020
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41. Oral omega 3 in different proportions of EPA, DHA, and antioxidants as adjuvant in treatment of keratoconjunctivitis sicca in dogs.

Author

Silva, Danielle Alves, Nai, Gisele Alborgetti, Giuffrida, Rogério, Sgrignoli, Marcos Rógério, dos Santos, Daniela Rodrigues, Donadão, Isabela Vasconcelos, Nascimento, Felipe Franco, Dinallo, Heloise Rangel, and Andrade, Silvia Franco

Subjects
OMEGA-3 fatty acids, KERATOCONJUNCTIVITIS, DOCOSAHEXAENOIC acid, TACROLIMUS, ANTINEOPLASTIC agents
Abstract

Copyright of Arquivos Brasileiros de Oftalmologia is the property of Arquivos Brasileiros de Oftalmologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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42. Comparison of the efficacy of 0.03% tacrolimus eye drops diluted in olive oil and linseed oil for the treatment of keratoconjunctivitis sicca in dogs.

Author

da Costa Zulim, Luís Felipe, Alborgetti Nai, Gisele, Giuffrida, Rogério, Guimarães Pereira, Carolina Silva, Benguella, Hugo, Gutierrez Cruz, Aline, Duran Foglia, Bruna Toledo, da Silveira Batista, Aline, and Franco Andrade, Silvia

Subjects
KERATOCONJUNCTIVITIS sicca, TACROLIMUS, OLIVE oil, LINSEED oil, OPHTHALMOLOGY, ANIMAL models in research
Abstract

Copyright of Arquivos Brasileiros de Oftalmologia is the property of Arquivos Brasileiros de Oftalmologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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43. Alterations in the dynamics of inflammation, proliferation and apoptosis in subcutaneous implants of lupus-prone mice

Author

Campos, Paula P., Vasconcelos, Anilton C., Ferreira, Mônica A.N.D., and Andrade, Silvia P.

Subjects
Mast cells, Collagen deposition, 612 - Fisiología
Abstract

Wound repair is a complex process that involves inflammation, proliferation, extracellular matrix deposition/remodeling and apoptosis. Autoimmune diseases profoundly affect the healing process. We have used histological parameters to characterize the recruitment of mast cells and the proliferative activity and apoptosis in the fibrovascular tissue induced by subcutaneous polyether-polyurethane sponge implants in lupus-prone New Zealand White (NZW) and in control Balb/c mouse strains at days 10 and 21 post implantation. Fibrovascular tissue infiltration (hematoxylin and eosin staining), mast cell number (Dominici staining) and cellular proliferation (AgNOR staining) peaked early (day 10) but collagen deposition (picrosirius red staining) and apoptosis remained high in implants of NZW mice during the experimental period. In contrast, implants of Balb/c animals showed a progressive increase in mast cell recruitment and cellular proliferation but apoptosis fell from day 10 to 21 postimplantation. This divergent response early mast cells recruitment, excessive collagen deposition and disturbed removal of apoptotic cells from the site of injury in NZW mice implies that the genotype trait of NZW mice is a determining factor in abnormal healing response.

Published
2011

45. Cellular proliferation, differentiation and apoptosis in polyether-polyurethane sponge implant model in mice

Author

Campos, Paula P., Andrade, Silvia P., Moro, L., Ferreira, M.A.N.D., and Vasconcelos, A.C.

Subjects
Sponge implants, 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], Collagen
Abstract

The integration of implanted material to host organism requires spatial and temporal organization of several cellular processes, such as proliferation, differentiation and apoptosis. Despite the clinical relevance of these processes, there is little information regarding the sequence of such events in synthetic matrices. Here, we present a combination of techniques used to characterize the fibrovascular response in subcutaneous polyether-polyurethane sponge implants in mice at days 4, 7, 10 and 14 postimplantation. The AgNOR technique was modified and used as a surrogate marker for proliferating and activated cells invading the implant. The number of AgNOR-stained cells increased progressively from day 4 (606±76) to day 14 (2146±71) postimplantation. The number of TUNEL-positive (apoptotic index) cells also increased progressively from day 4 (459±40) to day 14 (1157±119) postimplantation. However, the ratio of TUNEL-labeled/proliferating cells had its highest peak in the early phase of the process remaining stable until day 14. Using Picrosirius staining it was shown that thin collagen increased from day 4, peaking at day 10 and falling markedly at day 14, whereas dense collagen increased progressively during the whole period. These experiments hold potential to investigate not only distinct phases of tissue repair induced by synthetic matrices but also to study underlying mechanisms involved

Published
2006

46. Role of Cannabinoid Receptors in an Experimental Model of Inflammatory Angiogenesis

Author

Guabiraba, Rodrigo, Coelho, Amanda M., Russo, Remo Castro, Barcelos, Lucíola S., Andrade, Silvia P., Teixeira, Mauro M., Universidade Federal de Minas Gerais, and University of Bristol [Bristol]

Subjects
[SDV]Life Sciences [q-bio], lipids (amino acids, peptides, and proteins)
Abstract

Introduction: Angiogenesis depends on a complex network of cells and mediators. The activation or blockade of annabinoid receptors showed to be an interesting pharmacological strategy to attenuate the angiogenic and/or inflammatory response in many experimental models. Here we investigated how this strategy may interfere in inflammatory angiogenesis. Methods: Polyester-polyurethane sponges were implanted in C57BL/6 mice. Animals received daily doses (10 mg/kg, s.c.) of the cannabinoid antagonists SR141716A (CB1) and SR144528 (CB2), separately, or 3 mg/Kg (s.c.) of the cannabinoid CB1/CB2 agonist WIN 55212-2, for 7 or 14 days. The implants were then collected for ELISA, hemoglobin, myeloperoxidase and N-acetylglucosaminidase measurements, used as indexes for angiogenesis, neutrophil and macrophage accumulation, respectively. Results: CB1 or CB2 receptor antagonist treatment was able to reduce cellular influx to the sponge at 7 and 14 days, with distinctive pattern for macrophages and neutrophils. The CB1/CB2 agonist also reduced cellular influx. Both treatments affected angiogenesis. These alterations were accompanied by changes in the levels of TNF-a, VEGF, CXCL1-3/KC, CCL2/JE and RANTES in all treatments. Discussion: The blockade or activation of cannabinoid receptors showed to be effective in reducing inflammatory and angiogenic responses. Altough acting in a similar way, different levels of cytokines and chemokines may help explain this paradoxal response.

Published
2006

47. Sponge-induced angiogenesis and inflammation in PAF receptor-deficient mice (PAFR-KO)

Author

Ferreira, Mônica A N D, Barcelos, Lucíola S, Campos, Paula P, Vasconcelos, Anilton C, Teixeira, Mauro M, and Andrade, Silvia P

Subjects
Dihydropyridines, Neutrophils, Administration, Topical, Polyurethanes, Neovascularization, Physiologic, Platelet Membrane Glycoproteins, Receptors, G-Protein-Coupled, Hemoglobins, Mice, Implants, Experimental, Acetylglucosaminidase, Humans, Animals, Platelet Activating Factor, Peroxidase, Skin, Inflammation, Mice, Knockout, Mice, Inbred BALB C, Granuloma, Neovascularization, Pathologic, Macrophages, Imidazoles, Fibroblasts, Mice, Mutant Strains, Porifera, Papers, Granulation Tissue, Commentary, Blood Vessels, Chemokines
Abstract

1. To determine biological functions of platelet-activating factor (PAF) in chronic inflammation, we have investigated the kinetics of angiogenesis, inflammatory cells recruitment and cytokine production in sponge-induced granuloma in wild type and PAF receptor-deficient mice (PAFR-KO). 2. Angiogenesis as determined by morphometric analysis and hemoglobin content was significantly higher in the implants of PAFR-KO mice at all time points. Treatment with PAF receptor antagonist UK74505 (30 mg kg(-1)) also increased angiogenesis in sponge implants. 3. Neutrophils and macrophages accumulation, as determined by myeloperoxidase and N-acetylglucosaminidase activities in the supernatant of implanted sponges were markedly decreased in PAFR-KO mice. Surprisingly, the levels of the proinflammatory chemokines, keratinocyte-derived chemokine and chemokine monocyte chemoattractant protein 1 were higher in the implants of the transgenic animals. 4. We have shown that angiogenesis was stimulated in PAFR-KO mice whereas inflammation was decreased, indicating that PAF is an endogenous regulator of new blood vessels formation in the inflammatory microenvironment induced by the sponge implant.

Published
2004

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