Search

Allogeneic hematopoietic cell transplantation (allo-HCT) is potentially curative for patients with malignant and benign hematologic conditions. Graft-versus-host disease (GVHD) is a known complication of allo-HCT that results in significant morbidity and mortality. A common GVHD prophylaxis strategy combines a calcineurin inhibitor with methotrexate. When mucositis and organ toxicity develop, the day +11 dose is frequently omitted to limit further organ damage. The potential impact of this practice on allo-HCT outcomes is unclear as published data show conflicting results. Thus, we performed a systematic review/meta-analysis of the available literature to assess the impact of omitting day +11 methotrexate on allo-HCT recipients. Data were extracted in relation to benefits (overall survival [OS], progression-free survival [PFS]) and harms (acute and chronic GVHD, non-relapse mortality [NRM], and relapse). Pooled OS rate favored those who received day +11 methotrexate vs. those who did not (HR = 1.21; 95% CI = 1.02-1.43; p = 0.03). There was no significant difference in pooled rates of PFS (HR = 0.96; 95% CI = 0.60-1.52; p = 0.85), acute GVHD (HR = 1.03; 95% CI = 0.35-2.98; p = 0.96), chronic GVHD (HR = 0.83; 95% CI = 0.44-1.57; p = 0.57), NRM (HR = 0.86; 95% CI = 0.67-1.11; p = 0.25), and relapse (HR = 0.97; 95% CI = 0.75-1.26; p = 0.83) between the two groups. Large prospective multicenter studies are needed to better define the significance of day +11 methotrexate omission.

In 2009, 9108 vulnerable road users (VRUs; pedestrians and bicyclists) died in the EU and 4722 in the US. Active safety systems, that is intelligent systems able to predict and prevent crashes, may significantly help to reduce VRU fatalities and injuries; however, current active safety systems for VRUs are only found on high-end vehicles, only support the host vehicle driver, and do not make use of wireless communication. The scope of this study is to describe the set-up and real-world verification of a platform to enable active safety systems for VRU. This platform is carried by VRUs and may support multiple road users using wireless communication. A simple conceptual application, addressing pedestrian safety at crossings, was developed to test the platform. This application was not cooperative (i.e. did not support multiple road users with wireless communication). The results presented in this study suggest that such a platform can be employed (i) as a logger for naturalistic studies on VRUs, (ii) to better understand VRU behaviour and accident causation and (iii) as a basis for the development of novel active safety applications, running on portable devices, such as future generation smart phones, and possibly enabled by wireless communication.

Hal yang sangat mendasar pada Bank Syariah adalah penerapan konsep bagi hasil, tata cara perhitungan bagi hasil serta pengaruhnya terhadap laporan 2 keuangan. Hasil usaha yang telah diperhitungkan dapat dibagikan sesuai nisbah (perbandingan pembagian keuntungan) yang telah disepakati bersama secara awal. Konsep bagi hasil ini dapat diterapkan dalam penghimpunan dana bank syariah. Salah satunya dengan menggunakan prinsip mudharabah muthlaqah, yang dapat diaplikasikan dalam kegiatan usaha perbankan untuk produk tabungan mudharabah dan deposito muthlaqah.