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3 results on '"Andre Manfred, Willasch"'

1. Supportive Care During Pediatric Hematopoietic Stem Cell Transplantation: Prevention of Infections. A Report From Workshops on Supportive Care of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Author

Marianne Ifversen, Roland Meisel, Petr Sedlacek, Krzysztof Kalwak, Luisa Sisinni, Daphna Hutt, Thomas Lehrnbecher, Adriana Balduzzi, Tamara Diesch, Andrea Jarisch, Tayfun Güngör, Jerry Stein, Isaac Yaniv, Halvard Bonig, Michaela Kuhlen, Marc Ansari, Tiago Nava, Jean-Hugues Dalle, Cristina Diaz-de-Heredia, Eugenia Trigoso, Ulrike Falkenberg, Mihaela Hartmann, Marco Deiana, Marta Canesi, Chiara Broggi, Alice Bertaina, Brenda Gibson, Gergely Krivan, Kim Vettenranta, Toni Matic, Jochen Buechner, Anita Lawitschka, Christina Peters, Akif Yesilipek, Koray Yalçin, Giovanna Lucchini, Shahrzad Bakhtiar, Dominik Turkiewicz, Riitta Niinimäki, Jacek Wachowiak, Simone Cesaro, Arnaud Dalissier, Selim Corbacioglu, Andre Manfred Willasch, and Peter Bader

Subjects
infection precaution, allogeneic hematological stem cell transplantation, children, antibiotic prophylactic therapy, vaccination, Pediatrics, RJ1-570
Abstract

Specific protocols define eligibility, conditioning, donor selection, graft composition and prophylaxis of graft vs. host disease for children and young adults undergoing hematopoietic stem cell transplant (HSCT). However, international protocols rarely, if ever, detail supportive care, including pharmaceutical infection prophylaxis, physical protection with face masks and cohort isolation or food restrictions. Supportive care suffers from a lack of scientific evidence and implementation of practices in the transplant centers brings extensive restrictions to the child's and family's daily life after HSCT. Therefore, the Board of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) held a series of dedicated workshops since 2017 with the aim of initiating the production of a set of minimal recommendations. The present paper describes the consensus reached within the field of infection prophylaxis.

Published
2021
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2. Prediction model for the incidence and prevalence of type 1 diabetes in childhood and adolescence: evidence for a cohort-dependent increase within the next two decades in Germany

Author

Stefan, Ehehalt, Klaus, Dietz, Andre Manfred, Willasch, Andreas, Neu, and J, Wissert

Subjects
Male, Pediatrics, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Cohort Studies, Age Distribution, Sex Factors, Germany, Epidemiology, Cohort Effect, Internal Medicine, medicine, Prevalence, Humans, Age of Onset, Child, Type 1 diabetes, Models, Statistical, business.industry, Incidence (epidemiology), Incidence, Lexis diagram, Infant, Newborn, Infant, medicine.disease, Diabetes Mellitus, Type 1, Cohort effect, Child, Preschool, Pediatrics, Perinatology and Child Health, Cohort, Female, Age of onset, business, Cohort study, Forecasting
Abstract

Ehehalt S, Dietz K, Willasch AM, Neu A; for the DIARY-Group Baden-Wuerttemberg. Prediction model for the incidence and prevalence of type 1 diabetes in childhood and adolescence: evidence for a cohort-dependent increase within the next two decades in Germany. Objective: To provide data on type 1 diabetes (T1D) epidemiology in childhood over a period of 20 years and to predict prevalence and cohort-age-specific incidence rates (IRs) for the next two decades in Germany. Methods: The Baden-Wuerttemberg Diabetes Incidence Registry (DIARY) includes children and adolescents below 15 years of age with new onset of T1D (period 1987–2006, n = 5108 cases). Results: The mean age- and sex-standardized IR was 15.3/100 000/year (95% CI 14.8–15.7) and the average increase in the IR was 4.4% per year (95% CI 3.9–4.9). Within the next 20 years (2007–2026), the risk for developing diabetes will increase like the square of a linear function with calendar year for all age ranges. There is a strong correlation between the predicted IRs of the cohorts and the observed IRs (n = 300; root mean square error = 0.56; r2 = 0.71) and a negative correlation between mean age at onset and T1D IR (p = 0.02). On 31 December 2006, the prevalence of T1D was 0.126% (95% CI 0.121–0.132). The predicted prevalence (end of 2026) is estimated to be 0.265% (95% CI 0.25–0.28; predicted cases: n = 2950; 95% CI 2900–3000). Conclusions: In comparison to observations made in the past, the risk of disease rises even faster than expected: The younger the child, the quicker the increase of the cohort-age-specific IR and the higher the risk for T1D during lifetime.

Published
2011

3. Myeloablative conditioning for first allogeneic HSCT in pediatric all: FTBI or chemotherapy? - An update of the retrospective multicenter EBMT-PDWP study

Author

Andre Manfred Willasch, Christina Peters, Petr Sedlacek, Jean-Hughes Dalle, Vassiliki Kitra-Roussou, Akif Yesilipek, Jacek Wachowiak, Arjan Lankester, Arcangelo Prete, Amir Ali Hamidieh, Marianne Ifversen, Jochen Buechner, Gergely Krivan, Rose-Marie Hamladji, Cristina Diaz de Heredia, Elena Skorobogatova, Gerard Michel, Franco Locatelli, Alice Bertaina, Paul Veys, Sophie Dupont, Reuven Or, Tayfun Gungor, Olga Aleinikova, Sabina Sufliarska, Mikael Sundin, Jelena Rascon, Ain Kaare, Damir Nemet, Franca Fagioli, Thomas Erich Klingebiel, Jan Styczyński, Marc Bierings, Thomas Nagy, Manuel Abecasis, Boris Afanasyev, Marc Ansari, Kim Venntenranta, Amal AlSeraihy, Alicja Chybicka, Stephen Robinson, Yves Bertrand, Alphan Kupesiz, Ardeshir Ghavamzadeh, Antonio Campos, Arnaud Dalissier, Myriam Labopin, Selim Corbacioglu, Jaques Emmanuel Galimard, and Peter Bader

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