Search

Your search keyword '"Andrea Bolomo"' showing total 5 results
Start Over Author "Andrea Bolomo"
5 results on '"Andrea Bolomo"'

1. OP-13 CHOLANGIOCARCINOMA IN LATIN AMERICA: A MULTICENTER OBSERVATIONAL STUDY ALERTS ON ETHNICAL DISPARITIES IN TUMOR PRESENTATION AND OUTCOME

Author

Leonardo G Da Fonseca, Laura Izquierdo Sanchez, Pedro H Hashizume, Yanina Carlino, Estefanía Liza Baca, Cristina Zambrano, Santiago Sepulveda, Andrea Bolomo, Pedro M Rodrigues, Ioana Riaño, Andre Boonstra, Jose D Debes, Luis Bujanda, Flair J Carrilho, Marco Arrese, Juan C Roa, Enrique Carrera, Javier Díaz Ferrer, Domingo Balderramo, Claudia P Oliveira, and Jesus M Banales

Subjects
Specialties of internal medicine, RC581-951
Abstract

Conflict of interest: No Introduction and Objectives: Cholangiocarcinoma (CCA) represents a global health challenge, with rising incidence and mortality rates. This study aimed to elucidate the clinical course and practices of CCA in Latin America. Patients / Materials and Methods: This observational cohort study investigated individuals diagnosed with CCA between 2010-2023 in five referral centers across Latin America. Demographic, biochemical, and clinical data were analyzed. Results and Discussion: A total of 309 patients were enrolled, demonstrating a balanced distribution of CCA subtypes (intrahepatic, perihilar, and distal), with Hispanics and Caucasians as the predominant ethnic groups, followed by Africans. Major risk factors identified included age, diabetes, obesity, MASLD, bile duct stones, and cholecystitis. Disparities in overweight/obesity prevalence were noted among CCA subtypes and ethnicities, with higher rates in extrahepatic CCAs and among Hispanics and Caucasians. At diagnosis, 72% of patients had ECOG-PS scores of 0-1, with disease presentations ranging from localized (47%) to locally advanced (19%) and metastatic (34%). Patients who did not receive any anti-cancer therapy exhibited a median survival of 2.3 months. Survival rates significantly improved across treatment modalities, with surgery yielding the longest (34 months), followed by chemotherapy (8 months). Notably, Africans presented with worse ECOG-PS scores and more advanced disease, while Hispanics were less frequently treated with chemotherapy, contributing to lower survival rates. Conclusions: The high prevalence of late-stage CCA diagnosis in Latin America, particularly among Africans, alongside a substantial proportion of Hispanic patients not receiving chemotherapy, underscores a dismal prognosis for patients. These findings highlight structural challenges in cancer screening and healthcare access among diverse ethnic backgrounds and lower socioeconomic statuses in the region. Urgent measures are warranted, including identifying preventable risk factors, increasing awareness among high-risk populations, and establishing equitable health coverage to address these disparities.

Published
2024
Full Text
View/download PDF

2. Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America

Author

Domingo Balderramo, Angelo Z. Mattos, Victoria Mulqui, Talita Chiesa, Zuly Plácido-Damián, Jaysoom Abarca, Andrea Bolomo, Yanina Carlino, Isadora Z. Bombassaro, Denusa Wiltgen, Laura Tenorio Castillo, Karina Díaz, Johana Acuña, Estela Manero, Jhon Prieto, Enrique Carrera, Javier Díaz-Ferrer, and Jose D. Debes

Subjects
Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background. The role of liver function tests (LFT) as prognostic factors in patients admitted with COVID-19 has not been fully investigated, particularly outside resource-rich countries. We aimed at evaluating the prognostic value of abnormal LFT on admission and during hospitalization of patients with COVID-19. Methods. We performed a retrospective study that included 298 adult patients hospitalized for COVID-19, between 05/2020 and 02/2021, in 6 hospitals from 5 countries in South America. We analyzed demographic and comorbid variables and laboratory tests on admission and during hospitalization. LFT over twice the upper limit of normal (ALEx2) were also evaluated in relation to a variety of factors on admission and during hospitalization. De novo-ALEx2 was defined as the presence of ALEx2 at one week of hospitalization in patients without ALEx2 on admission. Patients were followed until hospital discharge or death. Multivariable analysis was used to evaluate the association between ALEx2 on admission and during hospitalization and mortality. Results. Of the total of 298 patients, 60% were male, with a mean age of 60 years, and 74% of patients had at least one comorbidity. Of those, 137 (46%) patients were transferred to the intensive care unit and 66 (22.1%) patients died during hospitalization. ALEx2 on admission was present in 87 (29.2%) patients and was found to be independently associated with 1-week mortality (odds ratio (OR) = 3.55; 95% confidence interval (95%CI) 1.05–12.05). Moreover, 84 (39.8%) out of 211 patients without ALEx2 at admission developed de novo-ALEx2, which was independently associated with mortality during second week of hospitalization (OR = 6.09; 95%CI 1.28–29) and overall mortality (OR = 2.93, 95%CI 1.05–8.19). Conclusions. A moderate elevation of LFT during admission was associated with a poor short-term prognosis in patients hospitalized with COVID-19. In addition, moderate elevation of LFT at one week of hospitalization was an independent risk factor for overall mortality in these patients.

Published
2021
Full Text
View/download PDF

3. Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America

Author

Yanina Carlino, Isadora Z Bombassaro, Domingo Balderramo, Jhon Prieto, Javier Diaz-Ferrer, Denusa Wiltgen, Victoria Mulqui, Jose D. Debes, Laura Tenorio Castillo, Jaysoom Abarca, Zuly Plácido-Damián, Andrea Bolomo, Enrique Carrera, Talita Chiesa, Karina Díaz, Angelo Z. Mattos, Johana Acuña, and Estela Manero

Subjects
Adult, Male, medicine.medical_specialty, Article Subject, Coronavirus disease 2019 (COVID-19), RC799-869, Comorbidity, law.invention, Risk Factors, law, Internal medicine, medicine, Humans, Hospital Mortality, Risk factor, Retrospective Studies, Hepatology, medicine.diagnostic_test, SARS-CoV-2, business.industry, Gastroenterology, COVID-19, Retrospective cohort study, General Medicine, Odds ratio, Diseases of the digestive system. Gastroenterology, Middle Aged, medicine.disease, Intensive care unit, Confidence interval, Hospitalization, Intensive Care Units, Liver, business, Liver function tests, Research Article
Abstract

Background. The role of liver function tests (LFT) as prognostic factors in patients admitted with COVID-19 has not been fully investigated, particularly outside resource-rich countries. We aimed at evaluating the prognostic value of abnormal LFT on admission and during hospitalization of patients with COVID-19. Methods. We performed a retrospective study that included 298 adult patients hospitalized for COVID-19, between 05/2020 and 02/2021, in 6 hospitals from 5 countries in South America. We analyzed demographic and comorbid variables and laboratory tests on admission and during hospitalization. LFT over twice the upper limit of normal (ALEx2) were also evaluated in relation to a variety of factors on admission and during hospitalization. De novo-ALEx2 was defined as the presence of ALEx2 at one week of hospitalization in patients without ALEx2 on admission. Patients were followed until hospital discharge or death. Multivariable analysis was used to evaluate the association between ALEx2 on admission and during hospitalization and mortality. Results. Of the total of 298 patients, 60% were male, with a mean age of 60 years, and 74% of patients had at least one comorbidity. Of those, 137 (46%) patients were transferred to the intensive care unit and 66 (22.1%) patients died during hospitalization. ALEx2 on admission was present in 87 (29.2%) patients and was found to be independently associated with 1-week mortality (odds ratio (OR) = 3.55; 95% confidence interval (95%CI) 1.05–12.05). Moreover, 84 (39.8%) out of 211 patients without ALEx2 at admission developed de novo-ALEx2, which was independently associated with mortality during second week of hospitalization (OR = 6.09; 95%CI 1.28–29) and overall mortality (OR = 2.93, 95%CI 1.05–8.19). Conclusions. A moderate elevation of LFT during admission was associated with a poor short-term prognosis in patients hospitalized with COVID-19. In addition, moderate elevation of LFT at one week of hospitalization was an independent risk factor for overall mortality in these patients.

Published
2021
Full Text
View/download PDF

4. Hepatitis E virus infection in hemodialysis patients: A prospective analysis

Author

Carla Cristani, Guadalupe Di Cola, Jose D. Debes, Fernando Diehl, Andrea Bolomo, Domingo Balderramo, María Belén Pisano, Pehuén Fernández, Viviana Ré, James S. Leathers, Jorge de la Fuente, and Maribel G. Martinez‐Wassaf

Subjects
0301 basic medicine, medicine.medical_specialty, HEMODIALYSIS, CIENCIAS MÉDICAS Y DE LA SALUD, medicine.medical_treatment, MEDLINE, Argentina, Ciencias de la Salud, 03 medical and health sciences, Prospective analysis, 0302 clinical medicine, Renal Dialysis, Internal medicine, medicine, Hepatitis E virus, Humans, Prospective Studies, Prospective cohort study, ARGENTINA, business.industry, Incidence (epidemiology), Incidence, Hepatitis E, medicine.disease, Enfermedades Infecciosas, 030104 developmental biology, Nephrology, HEPATITIS E, Kidney Failure, Chronic, 030211 gastroenterology & hepatology, Hemodialysis, business, Hepatitis E virus infection
Abstract

This study highlights variations in HEV serological status inpatients with ESRD undergoing HD.To assess the dynamics of HEV infection in thispopulation, we prospectively evaluated individuals with end-stagerenal disease (ESRD) undergoing HD at a private hospital in Cordoba, Argentina, between November 2014 and November 2017. Fil: Pisano, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina Fil: Leathers, James. Vanderbilt University School Of Medicine; Estados Unidos Fil: Balderramo, Domingo. Hospital Privado Centro Médico de Córdoba; Argentina Fil: Diehl, Fernando. Hospital Privado Centro Médico de Córdoba; Argentina Fil: Bolomo, Andrea. Hospital Privado Centro Médico de Córdoba; Argentina Fil: Fernández, Pehuen. Hospital Privado Centro Médico de Córdoba; Argentina Fil: Martínez Wassaf, Maribel. Laboratorios Clínicos Especializados- Lace; Argentina Fil: Cristani, Carla. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina Fil: Di Cola Bucciarelli, Guadalupe. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina Fil: De la Fuente, Jorge. Hospital Privado Centro Médico de Córdoba; Argentina Fil: Debes, José D.. Universidad de Minnesota; Estados Unidos Fil: Ré, Viviana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina

Published
2018

5. Benefit of an electronic medical record-based alarm in the optimization of stress ulcer prophylaxis

Author

Marianela Patricia Bedini, Ana Florencia Becerra, Jacqueline Griselda Gonzalez, Emanuel José Saad, Gustavo Daniel Martini, Ricardo Arturo Albertini, Andrea Bolomo, Cristian Morales, Domingo Balderramo, James S. Leathers, Silvana Quiroga, and Luciana Castellani

Subjects
Risk, Icu patients, medicine.medical_specialty, Peptic Ulcer, Hospitalized patients, health care facilities, manpower, and services, Inappropriate Prescribing, Comorbidity, 030204 cardiovascular system & hematology, law.invention, Tertiary Care Centers, 03 medical and health sciences, ALARM, 0302 clinical medicine, law, medicine, Electronic Health Records, Humans, In patient, 030212 general & internal medicine, Medical prescription, Inpatients, Hepatology, business.industry, Stress ulcer, Gastroenterology, Electronic medical record, Proton Pump Inhibitors, medicine.disease, Anti-Ulcer Agents, Intensive care unit, Respiration, Artificial, Intensive Care Units, Peptic Ulcer Hemorrhage, Histamine H2 Antagonists, Clinical Alarms, Emergency medicine, Costs and Cost Analysis, business
Abstract

The use of stress ulcer prophylaxis (SUP) has risen in recent years, even in patients without a clear indication for therapy.To evaluate the efficacy of an electronic medical record (EMR)-based alarm to improve appropriate SUP use in hospitalized patients.We conducted an uncontrolled before-after study comparing SUP prescription in intensive care unit (ICU) patients and non-ICU patients, before and after the implementation of an EMR-based alarm that provided the correct indications for SUP.1627 patients in the pre-intervention and 1513 patients in the post-intervention cohorts were included. The EMR-based alarm improved appropriate (49.6% vs. 66.6%, p0.001) and reduced inappropriate SUP use (50.4% vs. 33.3%, p0.001) in ICU patients only. These differences were related to the optimization of SUP in low risk patients. There was no difference in overt gastrointestinal bleeding between the two cohorts. Unjustified costs related to SUP were reduced by a third after EMR-based alarm use.The use of an EMR-based alarm improved appropriate and reduced inappropriate use of SUP in ICU patients. This benefit was limited to optimization in low risk patients and associated with a decrease in SUP costs.

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results