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1. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.

Author

Schijven, Dick, Postema, Merel C, Fukunaga, Masaki, Matsumoto, Junya, Miura, Kenichiro, de Zwarte, Sonja MC, van Haren, Neeltje EM, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa, Ortiz-García de la Foz, Víctor, Tordesillas-Gutierrez, Diana, Vázquez-Bourgon, Javier, Crespo-Facorro, Benedicto, Alnæs, Dag, Dahl, Andreas, Westlye, Lars T, Agartz, Ingrid, Andreassen, Ole A, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E, Schall, Ulrich, Scott, Rodney J, Carr, Vaughan J, Green, Melissa J, Henskens, Frans A, Loughland, Carmel M, Pantelis, Christos, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo TJ, Nenadić, Igor, Krämer, Bernd, Gruber, Oliver, Satterthwaite, Theodore D, Bustillo, Juan, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D, Ford, Judith M, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan, Fuentes-Claramonte, Paola, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond, Sarró, Salvador, Pomarol-Clotet, Edith, Ciullo, Valentina, Piras, Fabrizio, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N, Sim, Kang, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André, Borgwardt, Stefan, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, and Antonucci, Linda A

Subjects
Brain, Cerebral Cortex, Humans, Magnetic Resonance Imaging, Case-Control Studies, Schizophrenia, Female, Male, Functional Laterality, asymmetry, brain imaging, cortical, subcortical, Clinical Research, Mental Health, Neurosciences, Brain Disorders, Mental health
Abstract

Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.

Published
2023

2. Brain texture as a marker of transdiagnostic clinical profiles in patients with recent-onset psychosis and depression

Author

Korda, Alexandra I., Andreou, Christina, Ruef, Anne, Hahn, Lisa, Schmidt, André, Dannlowski, Udo, Kambeitz-Ilankovic, Lana, Dwyer, Dominic B., Kambeitz, Joseph, Wenzel, Julian, Ruhrmann, Stephan, Wood, Stephen J., Salokangas, Raimo K. R., Pantelis, Christos, Schultze-Lutter, Frauke, Meisenzahl, Eva, Brambilla, Paolo, Selvaggi, Pierluigi, Bertolino, Alessandro, Hietala, Jarmo, Upthegrove, Rachel, Lalousis, Paris Alexandros, Riecher-Rössler, Anita, Davatzikos, Christos, Lencer, Rebekka, Koutsouleris, Nikolaos, and Borgwardt, Stefan

Published
2024
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3. Alterations of Functional Connectivity Dynamics in Affective and Psychotic Disorders

Author

Betz, Linda, Erkens, Anne, Gussmann, Eva, Haas, Shalaila, Hasan, Alkomiet, Hoff, Claudius, Khanyaree, Ifrah, Melo, Aylin, Muckenhuber-Sternbauer, Susanna, Köhler, Janis, Öztürk, Ömer, Penzel, Nora, Popovic, David, Rangnick, Adrian, von Saldern, Sebastian, Sanfelici, Rachele, Spangemacher, Moritz, Tupac, Ana, Urquijo, Maria Fernanda, Weiske, Johanna, Wosgien, Antonia, Blume, Karsten, Gebhardt, Dominika, Kaiser, Nathalie, Milz, Ruth, Nikolaides, Alexandra, Seves, Mauro, Vent, Silke, Wassen, Martina, Andreou, Christina, Egloff, Laura, Harrisberger, Fabienne, Lenz, Claudia, Leanza, Letizia, Mackintosh, Amatya, Smieskova, Renata, Studerus, Erich, Walter, Anna, Widmayer, Sonja, Day, Chris, Iqbal, Mariam, Pelton, Mirabel, Mallikarjun, Pavan, Stainton, Alexandra, Lin, Ashleigh, Denissoff, Alexander, Ellilä, Anu, From, Tiina, Heinimaa, Markus, Ilonen, Tuula, Jalo, Päivi, Laurikainen, Heikki, Luutonen, Antti, Mäkela, Akseli, Paju, Janina, Pesonen, Henri, Säilä, Reetta-Liina, Toivonen, Anna, Turtonen, Otto, Solana, Ana Beatriz, Abraham, Manuela, Hehn, Nicolas, Schirmer, Timo, Altamura, Carlo, Belleri, Marika, Bottinelli, Francesca, Ferro, Adele, Re, Marta, Monzani, Emiliano, Sberna, Maurizio, D’Agostino, Armando, Del Fabro, Lorenzo, Perna, Giampaolo, Nobile, Maria, Alciati, Alessandra, Balestrieri, Matteo, Bonivento, Carolina, Cabras, Giuseppe, Fabbro, Franco, Garzitto, Marco, Piccin, Sara, Hoheisel, Linnea, Kambeitz-Ilankovic, Lana, Wenzel, Julian, Haas, Shalaila S., Antonucci, Linda A., Ruef, Anne, Schultze-Lutter, Frauke, Lichtenstein, Theresa, Rosen, Marlene, Dwyer, Dominic B., Salokangas, Raimo K.R., Lencer, Rebekka, Brambilla, Paolo, Borgwardt, Stephan, Wood, Stephen J., Upthegrove, Rachel, Bertolino, Alessandro, Ruhrmann, Stephan, Meisenzahl, Eva, Koutsouleris, Nikolaos, Fink, Gereon R., Daun, Silvia, and Kambeitz, Joseph

Published
2024
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7. Individualized pretest risk estimates to guide treatment decisions in patients with clinical high risk for psychotic disorders

Author

Sprüngli-Toffel, Elodie, Studerus, Erich, Curtis, Logos, Conchon, Caroline, Alameda, Luis, Bailey, Barbara, Caron, Camille, Haase, Carmina, Gros, Julia, Herbrecht, Evelyn, Huber, Christian G., Riecher-Rössler, Anita, Conus, Philippe, Solida, Alessandra, Armando, Marco, Kapsaridi, Afroditi, Ducommun, Mathieu Mercapide, Klauser, Paul, Plessen, Kerstin Jessica, Urben, Sébastien, Edan, Anne, Nanzer, Nathalie, Navarro, Ana Liso, Schneider, Maude, Genoud, Davina, Michel, Chantal, Kindler, Jochen, Kaess, Michael, Oliver, Dominic, Fusar-Poli, Paolo, Borgwardt, Stefan, and Andreou, Christina

Published
2024
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8. Chaos analysis of the cortical boundary for the recognition of psychosis

Author

Korda, Alexandra I., Andreou, Christina, Avram, Mihai, Frisman, Marina, Aliqadri, Mariya, Riecher-Rossler, Anita, Handels, Heinz, Martinetz, Thomas, and Borgwardt, Stefan

Subjects
Health, Psychology and mental health
Abstract

Background: Structural MRI studies in people with first-episode psychosis (FEP) and those in the clinical high-risk (CHR) state have consistently shown volumetric abnormalities that depict changes in the structural complexity of the cortical boundary. The aim of the present study was to employ chaos analysis in the identification of people with psychosis based on the structural complexity of the cortical boundary and subcortical areas. Methods: We performed chaos analysis of the grey matter distribution on structural MRIs. First, the outer boundary points for each slice in the axial, coronal and sagittal view were calculated for grey matter maps. Next, the distance of each boundary point from the centre of mass in the grey matter was calculated and stored as spatial series, which was further analyzed by extracting the Largest Lyapunov Exponent (lambda [[lambda]]), a feature depicting the structural complexity of the cortical boundary. Results: Structural MRIs were acquired from 77 FEP, 73 CHR and 44 healthy controls. We compared X brain maps between groups, which resulted in statistically significant differences in all comparisons. By matching the [lambda] values extracted in axial view with the Morlet wavelet, differences on the surface relief are observed between groups. Limitations: Parameters were selected after experimentation on the examined sample. Investigation of the effectiveness of the method in a larger data set is needed. Conclusion: The proposed framework using spatial series verifies diagnosis-relevant features and may contribute to the identification of structural biomarkers for psychosis., Introduction Abnormalities in cortical surface areas and cortical thickness have been observed consistently in schizophrenia; these appear to be present during first-episode psychosis (FEP) and in the clinical high-risk state [...]

Published
2023
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11. Neurobiologically Based Stratification of Recent-Onset Depression and Psychosis: Identification of Two Distinct Transdiagnostic Phenotypes

Author

Lalousis, Paris Alexandros, Schmaal, Lianne, Wood, Stephen J., Reniers, Renate L.E.P., Barnes, Nicholas M., Chisholm, Katharine, Griffiths, Sian Lowri, Stainton, Alexandra, Wen, Junhao, Hwang, Gyujoon, Davatzikos, Christos, Wenzel, Julian, Kambeitz-Ilankovic, Lana, Andreou, Christina, Bonivento, Carolina, Dannlowski, Udo, Ferro, Adele, Lichtenstein, Theresa, Riecher-Rössler, Anita, Romer, Georg, Rosen, Marlene, Bertolino, Alessandro, Borgwardt, Stefan, Brambilla, Paolo, Kambeitz, Joseph, Lencer, Rebekka, Pantelis, Christos, Ruhrmann, Stephan, Salokangas, Raimo K.R., Schultze-Lutter, Frauke, Schmidt, André, Meisenzahl, Eva, Koutsouleris, Nikolaos, Dwyer, Dominic, and Upthegrove, Rachel

Published
2022
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15. Test-retest reliability of behavioral and computational measures of advice taking under volatility.

Author

Karvelis, Povilas, Hauke, Daniel J., Wobmann, Michelle, Andreou, Christina, Mackintosh, Amatya, de Bock, Renate, Borgwardt, Stefan, and Diaconescu, Andreea O.

Abstract

The development of computational models for studying mental disorders is on the rise. However, their psychometric properties remain understudied, posing a risk of undermining their use in empirical research and clinical translation. Here we investigated test-retest reliability (with a 2-week interval) of a computational assay probing advice-taking under volatility with a Hierarchical Gaussian Filter (HGF) model. In a sample of 39 healthy participants, we found the computational measures to have largely poor reliability (intra-class correlation coefficient or ICC < 0.5), on par with the behavioral measures of task performance. Further analysis revealed that reliability was substantially impacted by intrinsic measurement noise (indicated by parameter recovery analysis) and to a smaller extent by practice effects. However, a large portion of within-subject variance remained unexplained and may be attributable to state-like fluctuations. Despite the poor test-retest reliability, we found the assay to have face validity at the group level. Overall, our work highlights that the different sources of variance affecting test-retest reliability need to be studied in greater detail. A better understanding of these sources would facilitate the design of more psychometrically sound assays, which would improve the quality of future research and increase the probability of clinical translation. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Pathways to care in youth and young adults at clinical high risk for psychosis in Switzerland: Current situation and clinical implementation of the PsyYoung project.

Author

Bailey, Barbara, Solida, Alessandra, Andreou, Christina, Plessen, Kerstin Jessica, Conus, Philippe, Mercapide, Mathieu, Kasparidi, Afrodite, Conchon, Caroline, Sprüngli‐Toffel, Elodie, Genoud, Davina, Caron, Camille, Golay, Philippe, Curtis, Logos, Herbrecht, Evelyn, Huber, Christian G., Alameda, Luis, and Armando, Marco

Subjects
YOUNG adults, CARE of people, PSYCHOSES, AT-risk people, MENTAL health
Abstract

Aim: We aim to give an insight into the current situation in Switzerland concerning the pathways to care of young people with clinical high risk of psychosis. In a second step we propose a procedure of optimizing pathways to care developed within the project PsyYoung. Methods: A qualitative survey derived and adapted from Kotlicka‐Antczak et al. (2020) was conducted in large early detection services of three Swiss cantons (Geneva, Basel‐Stadt, Vaud) focusing on pathways to care. More specifically, using questionnaires delivered to the heads of participating services, information was collected on referral sources, on activities to implement outreach campaigns and on the use of a pre‐screening tool. Results: Main results on referral source indicated that sources were variable but seemed to come primarily from the medical sector and more so from the psychiatric sector. Very few referrals came from non‐medical sectors. Outreach activities included the contact to other clinics as well as through brochures and posters. All services but one used the Prodromal Questionnaire – 16 as pre‐screening tool. Conclusions: All in all, the results indicate a referral and care pathway system implemented mostly within the medical and particularly mental health sector. Accordingly, the PsyYoung project proposes a procedure for pathways to care which could help overcome the obstacle of referrals being restrained to a narrow field of mental health and to harmonize the referral process within services dedicated to the same aim of helping young people at high risk of developing a psychosis. [ABSTRACT FROM AUTHOR]

Published
2024
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19. High‐Resolution Profiling of Human Vocal Fold Cellular Landscapes With Single‐Nuclei RNA Sequencing.

Author

Laitman, Benjamin M., Charytonowicz, Daniel, Zhu, Ashley J., Lynch, Katie, Varelas, Eleni A., Burton, Madeline, Andreou, Christina, Kore, Pragati, Kirke, Diana N., Chen, Ya‐Wen, Beaumont, Kristin G., Sebra, Robert, Genden, Eric M., and Courey, Mark S.

Abstract

Introduction: The function of the vocal folds (VFs) is determined by the phenotype, abundance, and distribution of differentiated cells within specific microenvironments. Identifying this histologic framework is crucial in understanding laryngeal disease. A paucity of studies investigating VF cellular heterogeneity has been undertaken. Here, we examined the cellular landscape of human VFs by utilizing single‐nuclei RNA‐sequencing. Methods: Normal true VF tissue was excised from five patients undergoing pitch elevation surgery. Tissue was snap frozen in liquid nitrogen and subjected to cellular digestion and nuclear extraction. Nuclei were processed for single‐nucleus sequencing using the 10X Genomics Chromium platform. Sequencing reads were assembled using cellranger and analyzed with the scanpy package in python. Results: RNA sequencing revealed 18 global cell clusters. While many were of epithelial origin, expected cell types, such as fibroblasts, immune cells, muscle cells, and endothelial cells were present. Subcluster analysis defined unique epithelial, immune, and fibroblast subpopulations. Conclusion: This study evaluated the cellular heterogeneity of normal human VFs by utilizing single‐nuclei RNA‐sequencing. With further confirmation through additional spatial sequencing and microscopic imaging, a novel cellular map of the VFs may provide insight into new cellular targets for VF disease. Level of Evidence: NA Laryngoscope, 134:3193–3200, 2024 [ABSTRACT FROM AUTHOR]

Published
2024
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20. Validation of the Bullying Scale for Adults - Results of the PRONIA-study

Author

Betz, Linda, Erkens, Anne, Gussmann, Eva, Haas, Shalaila, Hasan, Alkomiet, Hoff, Claudius, Khanya-ree, Ifrah, Melo, Aylin, Muckenhuber-Sternbauer, Susanna, Köhler, Janis, Öztürk, Ömer, Penzel, Nora, Popovic, David, Rangnick, Adrian, von Saldern, Sebastian, Sanfelici, Rachele, Spangemacher, Moritz, Tupac, Ana, Urquijo, Maria Fernanda, Weiske, Johanna, Wosgien, Antonia, Hedderich, Dennis, Blume, Karsten, Woopen, Christiane, Andreou, Christina, Egloff, Laura, Harrisberger, Fabienne, Lenz, Claudia, Leanza, Letizia, Mackin-tosh, Amatya, Smieskova, Renata, Studerus, Erich, Walter, Anna, Widmayer, Sonja, Day, Chris, Griffiths, Sian Lowri, Iqbal, Mariam, Pelton, Mirabel, Mallikarjun, Pavan, Stainton, Alexandra, Lin, Ashleigh, Denissoff, Alexander, Ellilä, Anu, From, Tiina, Heinimaa, Markus, Ilonen, Tuula, Jalo, Päivi, Lauri-kainen, Heikki, Luutonen, Antti, Mäkela, Akseli, Paju, Janina, Pesonen, Henri, Armio, Reetta-Liina, Toivonen, Anna, Turtonen, Otto, Solana, Ana Beatriz, Abraham, Manuela, Hehn, Nicolas, Schirmer, Timo, Altamura, Carlo, Belleri, Marika, Bottinelli, Francesca, Ferro, Adele, Re, Marta, Monzani, Emiliano, Percudani, Mauro, Sberna, Maurizio, D'Agostino, Armando, Del Fabro, Lorenzo, Perna, Giampaolo, Nobile, Maria, Alciati, Alessandra, Balestrieri, Matteo, Bonivento, Carolina, Cabras, Giuseppe, Fabbro, Franco, Garzitto, Marco, Piccin, Sara, Haidl, Theresa Katharina, Schneider, Nicole, Dickmann, Kim, Ruhrmann, Stephan, Kaiser, Nathalie, Rosen, Marlene, Seves, Mauro, Lichtenstein, Thorsten, Upthegrove, Rachel, Salokangas, Raimo K.R., Pantelis, Christos, Meisenzahl, Eva, Wood, Stephen J., Brambilla, Paolo, Borgwardt, Stefan, Rebekka, Lencer, Kambeitz, Joseph, Koutsouleris, Nikolaos, and Schultze-Lutter, Frauke

Published
2020
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30. Alterations of Functional Connectivity Dynamics in Affective and Psychotic Disorders

Author

Hoheisel, Linnea, Kambeitz-Ilankovic, Lana, Wenzel, Julian, Haas, Shalaila S., Antonucci, Linda A., Ruef, Anne, Penzel, Nora, Schultze-Lutter, Frauke, Lichtenstein, Theresa, Rosen, Marlene, Dwyer, Dominic B., Salokangas, Raimo K.R., Lencer, Rebekka, Brambilla, Paolo, Borgwardt, Stephan, Wood, Stephen J., Upthegrove, Rachel, Bertolino, Alessandro, Ruhrmann, Stephan, Meisenzahl, Eva, Koutsouleris, Nikolaos, Fink, Gereon R., Daun, Silvia, Kambeitz, Joseph, Betz, Linda, Erkens, Anne, Gussmann, Eva, Haas, Shalaila, Hasan, Alkomiet, Hoff, Claudius, Khanyaree, Ifrah, Melo, Aylin, Muckenhuber-Sternbauer, Susanna, Köhler, Janis, Öztürk, Ömer, Penzel, Nora, Popovic, David, Rangnick, Adrian, von Saldern, Sebastian, Sanfelici, Rachele, Spangemacher, Moritz, Tupac, Ana, Urquijo, Maria Fernanda, Weiske, Johanna, Wosgien, Antonia, Blume, Karsten, Gebhardt, Dominika, Kaiser, Nathalie, Milz, Ruth, Nikolaides, Alexandra, Seves, Mauro, Vent, Silke, Wassen, Martina, Andreou, Christina, Egloff, Laura, Harrisberger, Fabienne, Lenz, Claudia, Leanza, Letizia, Mackintosh, Amatya, Smieskova, Renata, Studerus, Erich, Walter, Anna, Widmayer, Sonja, Day, Chris, Iqbal, Mariam, Pelton, Mirabel, Mallikarjun, Pavan, Stainton, Alexandra, Lin, Ashleigh, Denissoff, Alexander, Ellilä, Anu, From, Tiina, Heinimaa, Markus, Ilonen, Tuula, Jalo, Päivi, Laurikainen, Heikki, Luutonen, Antti, Mäkela, Akseli, Paju, Janina, Pesonen, Henri, Säilä, Reetta-Liina, Toivonen, Anna, Turtonen, Otto, Solana, Ana Beatriz, Abraham, Manuela, Hehn, Nicolas, Schirmer, Timo, Altamura, Carlo, Belleri, Marika, Bottinelli, Francesca, Ferro, Adele, Re, Marta, Monzani, Emiliano, Sberna, Maurizio, D’Agostino, Armando, Del Fabro, Lorenzo, Perna, Giampaolo, Nobile, Maria, Alciati, Alessandra, Balestrieri, Matteo, Bonivento, Carolina, Cabras, Giuseppe, Fabbro, Franco, Garzitto, Marco, and Piccin, Sara

Abstract

Patients with psychosis and patients with depression exhibit widespread neurobiological abnormalities. The analysis of dynamic functional connectivity (dFC) allows for the detection of changes in complex brain activity patterns, providing insights into common and unique processes underlying these disorders.

Published
2024
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39. The heterogeneity of attenuated and brief limited psychotic symptoms: association of contents with age, sex, country, religion, comorbidities, and functioning

Author

Theisen, Christian, primary, Rosen, Marlene, additional, Meisenzahl, Eva, additional, Koutsouleris, Nikolaos, additional, Lichtenstein, Theresa, additional, Ruhrmann, Stephan, additional, Kambeitz, Joseph, additional, Kambeitz-Ilankovic, Lana, additional, Riecher-Rössler, Anita, additional, Chisholm, Katharine, additional, Upthegrove, Rachel, additional, Antonucci, Linda A., additional, Bertolino, Alessandro, additional, Pigoni, Alessandro, additional, Salokangas, Raimo K. R., additional, Pantelis, Christos, additional, Wood, Stephen J., additional, Lencer, Rebekka, additional, Falkai, Peter, additional, Hietala, Jarmo, additional, Brambilla, Paolo, additional, Schmidt, André, additional, Andreou, Christina, additional, Borgwardt, Stefan, additional, Osman, Naweed, additional, and Schultze-Lutter, Frauke, additional

Published
2023
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44. Prevalence of cognitive impairments and strengths in the early course of psychosis and depression

Author

Stainton, Alexandra, Chisholm, Katharine, Griffiths, Siân Lowri, Kambeitz-Ilankovic, Lana, Wenzel, Julian, Bonivento, Carolina, Brambilla, Paolo, Iqbal, Mariam, Lichtenstein, Theresa K, Rosen, Marlene, Antonucci, Linda A, Maggioni, Eleonora, Kambeitz, Joseph, Borgwardt, Stefan, Riecher-Rössler, Anita, Andreou, Christina, Schmidt, André, Schultze-Lutter, Frauke, Meisenzahl, Eva, Ruhrmann, Stephan, Salokangas, Raimo K R, Pantelis, Christos, Lencer, Rebekka, Romer, Georg, Bertolino, Alessandro, Upthegrove, Rachel, Koutsouleris, Nikolaos, Allott, Kelly, and Wood, Stephen J

Subjects
610 Medicine & health
Abstract

BACKGROUND Studies investigating cognitive impairments in psychosis and depression have typically compared the average performance of the clinical group against healthy controls (HC), and do not report on the actual prevalence of cognitive impairments or strengths within these clinical groups. This information is essential so that clinical services can provide adequate resources to supporting cognitive functioning. Thus, we investigated this prevalence in individuals in the early course of psychosis or depression. METHODS A comprehensive cognitive test battery comprising 12 tests was completed by 1286 individuals aged 15-41 (mean age 25.07, s.d. 5.88) from the PRONIA study at baseline: HC (N = 454), clinical high risk for psychosis (CHR; N = 270), recent-onset depression (ROD; N = 267), and recent-onset psychosis (ROP; N = 295). Z-scores were calculated to estimate the prevalence of moderate or severe deficits or strengths (>2 s.d. or 1-2 s.d. below or above HC, respectively) for each cognitive test. RESULTS Impairment in at least two cognitive tests was as follows: ROP (88.3% moderately, 45.1% severely impaired), CHR (71.2% moderately, 22.4% severely impaired), ROD (61.6% moderately, 16.2% severely impaired). Across clinical groups, impairments were most prevalent in tests of working memory, processing speed, and verbal learning. Above average performance (>1 s.d.) in at least two tests was present for 40.5% ROD, 36.1% CHR, 16.1% ROP, and was >2 SDs in 1.8% ROD, 1.4% CHR, and 0% ROP. CONCLUSIONS These findings suggest that interventions should be tailored to the individual, with working memory, processing speed, and verbal learning likely to be important transdiagnostic targets.

Published
2023
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46. Brain texture as a marker of transdiagnostic clinical profiles in patients with recent-onset psychosis and depression

Author

Korda, Alexandra, primary, Andreou, Christina, additional, Ruef, Anne, additional, Hahn, Lisa, additional, Schmidt, André, additional, Dannlowski, Udo, additional, Kambeitz-Ilankovic, Lana, additional, Dwyer, Dominic, additional, Kambeitz, Joseph, additional, Wenzel, Julian, additional, Ruhrmann, Stephan, additional, Salokangas, Raimo, additional, Pantelis, Christos, additional, Schultze-Lutter, Frauke, additional, Meisenzahl, Eva, additional, Brambilla, Paolo, additional, Selvaggi, Pierluigi, additional, Upthegrove, Rachel, additional, Lalousis, Paris Alexandros, additional, Riecher-Rössler, Anita, additional, Davatzikos, Christos, additional, Lencer, Rebekka, additional, Koutsouleris, Nikolaos, additional, and Borgwardt, Stefan, additional

Published
2023
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47. The heterogeneity of attenuated and brief limited psychotic symptoms::association of contents with age, sex, country, religion, comorbidities, and functioning

Author

Theisen, Christian, Rosen, Marlene, Meisenzahl, Eva, Koutsouleris, Nikolaos, Lichtenstein, Theresa, Ruhrmann, Stephan, Kambeitz, Joseph, Kambeitz-Ilankovic, Lana, Riecher-Rössler, Anita, Chisholm, Katharine, Upthegrove, Rachel, Antonucci, Linda A., Bertolino, Alessandro, Pigoni, Alessandro, Salokangas, Raimo K. R., Pantelis, Christos, Wood, Stephen J., Lencer, Rebekka, Falkai, Peter, Hietala, Jarmo, Brambilla, Paolo, Schmidt, André, Andreou, Christina, Borgwardt, Stefan, Osman, Naweed, Schultze-Lutter, Frauke, Theisen, Christian, Rosen, Marlene, Meisenzahl, Eva, Koutsouleris, Nikolaos, Lichtenstein, Theresa, Ruhrmann, Stephan, Kambeitz, Joseph, Kambeitz-Ilankovic, Lana, Riecher-Rössler, Anita, Chisholm, Katharine, Upthegrove, Rachel, Antonucci, Linda A., Bertolino, Alessandro, Pigoni, Alessandro, Salokangas, Raimo K. R., Pantelis, Christos, Wood, Stephen J., Lencer, Rebekka, Falkai, Peter, Hietala, Jarmo, Brambilla, Paolo, Schmidt, André, Andreou, Christina, Borgwardt, Stefan, Osman, Naweed, and Schultze-Lutter, Frauke

Abstract

Introduction: The Attenuated Psychosis Symptoms (APS) syndrome mostly represents the ultra-high-risk state of psychosis but, as does the Brief Intermittent Psychotic Symptoms (BIPS) syndrome, shows a large variance in conversion rates. This may be due to the heterogeneity of APS/BIPS that may be related to the effects of culture, sex, age, and other psychiatric morbidities. Thus, we investigated the different thematic contents of APS and their association with sex, age, country, religion, comorbidity, and functioning to gain a better understanding of the psychosis-risk syndrome. Method: A sample of 232 clinical high-risk subjects according to the ultra-high risk and basic symptom criteria was recruited as part of a European study conducted in Germany, Italy, Switzerland, and Finland. Case vignettes, originally used for supervision of inclusion criteria, were investigated for APS/BIPS contents, which were compared for sex, age, country, religion, functioning, and comorbidities using chi-squared tests and regression analyses. Result: We extracted 109 different contents, mainly of APS (96.8%): 63 delusional, 29 hallucinatory, and 17 speech-disorganized contents. Only 20 contents (18.3%) were present in at least 5% of the sample, with paranoid and referential ideas being the most frequent. Thirty-one (28.5%) contents, in particular, bizarre ideas and perceptual abnormalities, demonstrated an association with age, country, comorbidity, or functioning, with regression models of country and obsessive-compulsive disorders explaining most of the variance: 55.8 and 38.3%, respectively. Contents did not differ between religious groups. Conclusion: Psychosis-risk patients report a wide range of different contents of APS/BIPS, underlining the psychopathological heterogeneity of this group but also revealing a potential core set of contents. Compared to earlier reports on North-American samples, our maximum prevalence rates of contents were considerably lower; this likely being r

Published
2023

48. Improving pathways to care for patients at high psychosis risk in Switzerland : PsyYoung study protocol

Author

Conchon, Caroline, Sprüngli-Toffel, Elodie, Alameda, Luis, Edan, Anne, Bailey, Barbara, Solida, Alessandra, Plessen, Kerstin Jessica, Conus, Philippe, Kapsaridi, Afroditi, Genoud, Davina, Crameri, Aureliano, Jouabli, Sondes, Caron, Camille, Grob, Carmina, Gros, Julia, Senn, Smeralda, Curtis, Logos, Liso Navarro, Ana, Barbe, Remy, Nanzer, Nathalie, Herbrecht, Evelyn, Huber, Christian G., Micali, Nadia, Armando, Marco, Borgwardt, Stefan, Andreou, Christina, Conchon, Caroline, Sprüngli-Toffel, Elodie, Alameda, Luis, Edan, Anne, Bailey, Barbara, Solida, Alessandra, Plessen, Kerstin Jessica, Conus, Philippe, Kapsaridi, Afroditi, Genoud, Davina, Crameri, Aureliano, Jouabli, Sondes, Caron, Camille, Grob, Carmina, Gros, Julia, Senn, Smeralda, Curtis, Logos, Liso Navarro, Ana, Barbe, Remy, Nanzer, Nathalie, Herbrecht, Evelyn, Huber, Christian G., Micali, Nadia, Armando, Marco, Borgwardt, Stefan, and Andreou, Christina

Abstract

Aims: Psychotic disorders are one of the main causes of chronic disability in young people. An at-risk mental state (ARMS) is represented by subclinical symptoms that precede the first episode of psychosis (FEP). The PsyYoung project aims to optimize the detection of an ARMS while reducing unnecessary psychiatric treatments. It investigates the effects of service changes on the referrals and outcomes of young people with ARMS or a FEP. Methods: Six psychiatric outpatient clinics in three cantons (Basel-Stadt, Vaud, and Geneva) participated in the project. They passed through an implementation phase including service changes and the adaptation of a standardized stepped care model for diagnosis and assessment, in addition to measures for increasing the awareness, networking and training of local professionals. Preliminary results: All participating cantons had entered the implementation phase. By March 2023, there were 619 referrals to participating sites. A total of 163 patients (37% FEP and 31% ARMS) and 15 close relatives had participated in individual longitudinal assessments, and 26 patients participated in qualitative interviews. Conclusion: This national collaborative project addresses the issue of early intervention for emerging psychoses, and creates spaces for fruitful reflections and collaboration in Switzerland. The ultimate aim of PsyYoung is to harmonize clinical practices in early intervention of psychosis on a national level.

Published
2023

49. Improving Pathways to Care for Patients at High Psychosis Risk in Switzerland: PsyYoung Study Protocol

Author

Promotion Santé Suisse, Conchon, Caroline, Sprüngli-Toffel, Elodie, Alameda, Luis, Edan, Anne, Bailey, Barbara, Solida, Alessandra, Plessen, Kerstin J., Conus, Philippe, Kapsaridi, Afroditi, Genoud, Davina, Crameri, Aureliano, Jouabli, Sondes, Caron, Camille, Grob, Carmina, Gros, Julia, Senn, Smeralda, Curtis, Logos, Liso Navarro, Ana, Barbe, Remy, Nanzer, Nathalie, Herbrecht, Evelyn, Huber, Christian G., Micali, Nadia, Armando, Marco, Borgwardt, Stefan, Andreou, Christina, Promotion Santé Suisse, Conchon, Caroline, Sprüngli-Toffel, Elodie, Alameda, Luis, Edan, Anne, Bailey, Barbara, Solida, Alessandra, Plessen, Kerstin J., Conus, Philippe, Kapsaridi, Afroditi, Genoud, Davina, Crameri, Aureliano, Jouabli, Sondes, Caron, Camille, Grob, Carmina, Gros, Julia, Senn, Smeralda, Curtis, Logos, Liso Navarro, Ana, Barbe, Remy, Nanzer, Nathalie, Herbrecht, Evelyn, Huber, Christian G., Micali, Nadia, Armando, Marco, Borgwardt, Stefan, and Andreou, Christina

Abstract

Aims: Psychotic disorders are one of the main causes of chronic disability in young people. An at-risk mental state (ARMS) is represented by subclinical symptoms that precede the first episode of psychosis (FEP). The PsyYoung project aims to optimize the detection of an ARMS while reducing unnecessary psychiatric treatments. It investigates the effects of service changes on the referrals and outcomes of young people with ARMS or a FEP. Methods: Six psychiatric outpatient clinics in three cantons (Basel-Stadt, Vaud, and Geneva) participated in the project. They passed through an implementation phase including service changes and the adaptation of a standardized stepped care model for diagnosis and assessment, in addition to measures for increasing the awareness, networking and training of local professionals. Preliminary results: All participating cantons had entered the implementation phase. By March 2023, there were 619 referrals to participating sites. A total of 163 patients (37% FEP and 31% ARMS) and 15 close relatives had participated in individual longitudinal assessments, and 26 patients participated in qualitative interviews. Conclusion: This national collaborative project addresses the issue of early intervention for emerging psychoses, and creates spaces for fruitful reflections and collaboration in Switzerland. The ultimate aim of PsyYoung is to harmonize clinical practices in early intervention of psychosis on a national level.

Published
2023

50. Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

Author

Schijven, Dick; https://orcid.org/0000-0001-5190-7241, Postema, Merel C; https://orcid.org/0000-0002-1536-7062, Fukunaga, Masaki; https://orcid.org/0000-0003-1010-2644, Matsumoto, Junya; https://orcid.org/0000-0003-4228-3208, Miura, Kenichiro, de Zwarte, Sonja M C, van Haren, Neeltje E M, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa; https://orcid.org/0000-0003-0570-5352, de la Foz, Víctor Ortiz-García; https://orcid.org/0000-0002-0627-1827, Tordesillas-Gutierrez, Diana; https://orcid.org/0000-0003-1458-3932, Vázquez-Bourgon, Javier; https://orcid.org/0000-0002-5478-3376, Crespo-Facorro, Benedicto, Alnæs, Dag; https://orcid.org/0000-0001-7361-5418, Dahl, Andreas; https://orcid.org/0000-0002-2668-8371, Westlye, Lars T; https://orcid.org/0000-0001-8644-956X, Agartz, Ingrid, Andreassen, Ole A; https://orcid.org/0000-0002-4461-3568, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E; https://orcid.org/0000-0003-3482-721X, Schall, Ulrich; https://orcid.org/0000-0001-9041-4562, Scott, Rodney J; https://orcid.org/0000-0001-7724-3404, Carr, Vaughan J; https://orcid.org/0000-0002-8907-5804, Green, Melissa J; https://orcid.org/0000-0002-9361-4874, Henskens, Frans A; https://orcid.org/0000-0003-2358-5630, Loughland, Carmel M, Pantelis, Christos; https://orcid.org/0000-0002-9565-0238, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina; https://orcid.org/0000-0002-0526-8095, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo T J, Nenadić, Igor, Krämer, Bernd; https://orcid.org/0000-0002-1145-9103, Gruber, Oliver; https://orcid.org/0000-0003-1841-7413, Satterthwaite, Theodore D; https://orcid.org/0000-0001-7072-9399, Bustillo, Juan; https://orcid.org/0000-0001-8730-8152, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D; https://orcid.org/0000-0001-9058-0747, Ford, Judith M; https://orcid.org/0000-0002-6500-6548, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong; https://orcid.org/0000-0002-3522-3912, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan; https://orcid.org/0000-0003-2132-4445, Fuentes-Claramonte, Paola; https://orcid.org/0000-0002-1428-7976, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond; https://orcid.org/0000-0001-5557-1562, Sarró, Salvador; https://orcid.org/0000-0003-1835-2189, Pomarol-Clotet, Edith, Ciullo, Valentina; https://orcid.org/0000-0002-6870-6259, Piras, Fabrizio; https://orcid.org/0000-0003-3566-5494, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco; https://orcid.org/0000-0002-7432-4249, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N; https://orcid.org/0000-0003-0156-0395, Sim, Kang; https://orcid.org/0000-0003-3209-9626, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M; https://orcid.org/0000-0003-0829-0519, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André; https://orcid.org/0000-0001-6055-8397, Borgwardt, Stefan; https://orcid.org/0000-0002-5792-3987, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M; https://orcid.org/0000-0002-2444-5675, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda; https://orcid.org/0000-0002-8898-8599, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo; https://orcid.org/0000-0002-0623-3759, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, Antonucci, Linda A, Fazio, Leonardo; https://orcid.org/0000-0003-4000-974X, Pergola, Giulio; https://orcid.org/0000-0002-9193-1841, Bertolino, Alessandro, Díaz-Caneja, Covadonga M; https://orcid.org/0000-0001-8538-3175, Janssen, Joost, Lois, Noemi G; https://orcid.org/0000-0002-6600-072X, Arango, Celso; https://orcid.org/0000-0003-3382-4754, Tomyshev, Alexander S, Lebedeva, Irina, Cervenka, Simon, Sellgren, Carl M, Georgiadis, Foivos, Kirschner, Matthias; https://orcid.org/0000-0002-9486-1439, Kaiser, Stefan, Hajek, Tomas, Skoch, Antonin; https://orcid.org/0000-0002-1739-3256, Spaniel, Filip, Kim, Minah; https://orcid.org/0000-0001-8668-0817, Kwak, Yoo Bin, Oh, Sanghoon; https://orcid.org/0000-0002-7394-5211, Kwon, Jun Soo; https://orcid.org/0000-0002-1060-1462, James, Anthony; https://orcid.org/0000-0002-2742-8328, Bakker, Geor, Knöchel, Christian, Stäblein, Michael, Oertel, Viola, Uhlmann, Anne; https://orcid.org/0000-0002-1753-7811, Howells, Fleur M, Stein, Dan J; https://orcid.org/0000-0001-7218-7810, Temmingh, Henk S; https://orcid.org/0000-0002-7688-0759, Diaz-Zuluaga, Ana M, Pineda-Zapata, Julian A, López-Jaramillo, Carlos, Homan, Stephanie; https://orcid.org/0000-0003-1449-7508, Ji, Ellen; https://orcid.org/0000-0003-1527-8868, Surbeck, Werner; https://orcid.org/0000-0002-4733-795X, Homan, Philipp; https://orcid.org/0000-0001-9034-148X, Fisher, Simon E; https://orcid.org/0000-0002-3132-1996, Franke, Barbara; https://orcid.org/0000-0003-4375-6572, Glahn, David C; https://orcid.org/0000-0002-4749-6977, Gur, Ruben C; https://orcid.org/0000-0002-9657-1996, Hashimoto, Ryota, Jahanshad, Neda, Luders, Eileen; https://orcid.org/0000-0001-5659-992X, Medland, Sarah E, Thompson, Paul M; https://orcid.org/0000-0002-4720-8867, Turner, Jessica A, van Erp, Theo G M, Francks, Clyde; https://orcid.org/0000-0002-9098-890X, Schijven, Dick; https://orcid.org/0000-0001-5190-7241, Postema, Merel C; https://orcid.org/0000-0002-1536-7062, Fukunaga, Masaki; https://orcid.org/0000-0003-1010-2644, Matsumoto, Junya; https://orcid.org/0000-0003-4228-3208, Miura, Kenichiro, de Zwarte, Sonja M C, van Haren, Neeltje E M, Cahn, Wiepke, Hulshoff Pol, Hilleke E, Kahn, René S, Ayesa-Arriola, Rosa; https://orcid.org/0000-0003-0570-5352, de la Foz, Víctor Ortiz-García; https://orcid.org/0000-0002-0627-1827, Tordesillas-Gutierrez, Diana; https://orcid.org/0000-0003-1458-3932, Vázquez-Bourgon, Javier; https://orcid.org/0000-0002-5478-3376, Crespo-Facorro, Benedicto, Alnæs, Dag; https://orcid.org/0000-0001-7361-5418, Dahl, Andreas; https://orcid.org/0000-0002-2668-8371, Westlye, Lars T; https://orcid.org/0000-0001-8644-956X, Agartz, Ingrid, Andreassen, Ole A; https://orcid.org/0000-0002-4461-3568, Jönsson, Erik G, Kochunov, Peter, Bruggemann, Jason M, Catts, Stanley V, Michie, Patricia T, Mowry, Bryan J, Quidé, Yann, Rasser, Paul E; https://orcid.org/0000-0003-3482-721X, Schall, Ulrich; https://orcid.org/0000-0001-9041-4562, Scott, Rodney J; https://orcid.org/0000-0001-7724-3404, Carr, Vaughan J; https://orcid.org/0000-0002-8907-5804, Green, Melissa J; https://orcid.org/0000-0002-9361-4874, Henskens, Frans A; https://orcid.org/0000-0003-2358-5630, Loughland, Carmel M, Pantelis, Christos; https://orcid.org/0000-0002-9565-0238, Weickert, Cynthia Shannon, Weickert, Thomas W, de Haan, Lieuwe, Brosch, Katharina; https://orcid.org/0000-0002-0526-8095, Pfarr, Julia-Katharina, Ringwald, Kai G, Stein, Frederike, Jansen, Andreas, Kircher, Tilo T J, Nenadić, Igor, Krämer, Bernd; https://orcid.org/0000-0002-1145-9103, Gruber, Oliver; https://orcid.org/0000-0003-1841-7413, Satterthwaite, Theodore D; https://orcid.org/0000-0001-7072-9399, Bustillo, Juan; https://orcid.org/0000-0001-8730-8152, Mathalon, Daniel H, Preda, Adrian, Calhoun, Vince D; https://orcid.org/0000-0001-9058-0747, Ford, Judith M; https://orcid.org/0000-0002-6500-6548, Potkin, Steven G, Chen, Jingxu, Tan, Yunlong; https://orcid.org/0000-0002-3522-3912, Wang, Zhiren, Xiang, Hong, Fan, Fengmei, Bernardoni, Fabio, Ehrlich, Stefan; https://orcid.org/0000-0003-2132-4445, Fuentes-Claramonte, Paola; https://orcid.org/0000-0002-1428-7976, Garcia-Leon, Maria Angeles, Guerrero-Pedraza, Amalia, Salvador, Raymond; https://orcid.org/0000-0001-5557-1562, Sarró, Salvador; https://orcid.org/0000-0003-1835-2189, Pomarol-Clotet, Edith, Ciullo, Valentina; https://orcid.org/0000-0002-6870-6259, Piras, Fabrizio; https://orcid.org/0000-0003-3566-5494, Vecchio, Daniela, Banaj, Nerisa, Spalletta, Gianfranco; https://orcid.org/0000-0002-7432-4249, Michielse, Stijn, van Amelsvoort, Therese, Dickie, Erin W, Voineskos, Aristotle N; https://orcid.org/0000-0003-0156-0395, Sim, Kang; https://orcid.org/0000-0003-3209-9626, Ciufolini, Simone, Dazzan, Paola, Murray, Robin M; https://orcid.org/0000-0003-0829-0519, Kim, Woo-Sung, Chung, Young-Chul, Andreou, Christina, Schmidt, André; https://orcid.org/0000-0001-6055-8397, Borgwardt, Stefan; https://orcid.org/0000-0002-5792-3987, McIntosh, Andrew M, Whalley, Heather C, Lawrie, Stephen M; https://orcid.org/0000-0002-2444-5675, du Plessis, Stefan, Luckhoff, Hilmar K, Scheffler, Freda; https://orcid.org/0000-0002-8898-8599, Emsley, Robin, Grotegerd, Dominik, Lencer, Rebekka, Dannlowski, Udo; https://orcid.org/0000-0002-0623-3759, Edmond, Jesse T, Rootes-Murdy, Kelly, Stephen, Julia M, Mayer, Andrew R, Antonucci, Linda A, Fazio, Leonardo; https://orcid.org/0000-0003-4000-974X, Pergola, Giulio; https://orcid.org/0000-0002-9193-1841, Bertolino, Alessandro, Díaz-Caneja, Covadonga M; https://orcid.org/0000-0001-8538-3175, Janssen, Joost, Lois, Noemi G; https://orcid.org/0000-0002-6600-072X, Arango, Celso; https://orcid.org/0000-0003-3382-4754, Tomyshev, Alexander S, Lebedeva, Irina, Cervenka, Simon, Sellgren, Carl M, Georgiadis, Foivos, Kirschner, Matthias; https://orcid.org/0000-0002-9486-1439, Kaiser, Stefan, Hajek, Tomas, Skoch, Antonin; https://orcid.org/0000-0002-1739-3256, Spaniel, Filip, Kim, Minah; https://orcid.org/0000-0001-8668-0817, Kwak, Yoo Bin, Oh, Sanghoon; https://orcid.org/0000-0002-7394-5211, Kwon, Jun Soo; https://orcid.org/0000-0002-1060-1462, James, Anthony; https://orcid.org/0000-0002-2742-8328, Bakker, Geor, Knöchel, Christian, Stäblein, Michael, Oertel, Viola, Uhlmann, Anne; https://orcid.org/0000-0002-1753-7811, Howells, Fleur M, Stein, Dan J; https://orcid.org/0000-0001-7218-7810, Temmingh, Henk S; https://orcid.org/0000-0002-7688-0759, Diaz-Zuluaga, Ana M, Pineda-Zapata, Julian A, López-Jaramillo, Carlos, Homan, Stephanie; https://orcid.org/0000-0003-1449-7508, Ji, Ellen; https://orcid.org/0000-0003-1527-8868, Surbeck, Werner; https://orcid.org/0000-0002-4733-795X, Homan, Philipp; https://orcid.org/0000-0001-9034-148X, Fisher, Simon E; https://orcid.org/0000-0002-3132-1996, Franke, Barbara; https://orcid.org/0000-0003-4375-6572, Glahn, David C; https://orcid.org/0000-0002-4749-6977, Gur, Ruben C; https://orcid.org/0000-0002-9657-1996, Hashimoto, Ryota, Jahanshad, Neda, Luders, Eileen; https://orcid.org/0000-0001-5659-992X, Medland, Sarah E, Thompson, Paul M; https://orcid.org/0000-0002-4720-8867, Turner, Jessica A, van Erp, Theo G M, and Francks, Clyde; https://orcid.org/0000-0002-9098-890X

Abstract

Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, using MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets in the ENIGMA consortium, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macro-structural asymmetry may reflect differences at the molecular, cytoarchitectonic or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.

Published
2023

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