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Abstract This work studies domain walls between chirally-separated vacua in supersymmetric Yang-Mills theory (SYM) on ℝ3 × 𝕊1 in the semiclassical limit. For all gauge groups we explicitly find the electric fluxes of all BPS domain walls and fully characterize the representation that they form under the global symmetry of SYM. We compute the characters of these representations formed by the semiclassical domain walls. We also compute these characters for the worldvolume TQFTs appearing in the literature for SU(N) and Sp(N) gauge groups. We find complete agreement between the two computations, providing thus a dynamical test of the proposed worldvolume TQFTs. We also propose a new worldvolume TQFT for E 6 domain walls, subjecting it to the same tests. Finally, we study deconfinement of quarks on domain walls for all gauge groups. We show that for all gauge groups confining strings (stable in the abelianized regime) can end on domain walls, regardless of whether or not the group has a center.

Abstract We study four-dimensional gauge theories with arbitrary simple gauge group with 1-form global center symmetry and 0-form parity or discrete chiral symmetry. We canonically quantize on 𝕋3, in a fixed background field gauging the 1-form symmetry. We show that the mixed 0-form/1-form ’t Hooft anomaly results in a central extension of the global-symmetry operator algebra. We determine this algebra in each case and show that the anomaly implies degeneracies in the spectrum of the Hamiltonian at any finite- size torus. We discuss the consistency of these constraints with both older and recent semiclassical calculations in SU(N) theories, with or without adjoint fermions, as well as with their conjectured infrared phases.

Abstract We study the physics of quark deconfinement on domain walls in four-di- mensional supersymmetric SU(N) Yang-Mills theory, compactified on a small circle with supersymmetric boundary conditions. We numerically examine the properties of BPS domain walls connecting vacua k units apart. We also determine their electric fluxes and use the results to show that Wilson loops of any nonzero N -ality exhibit perimeter law on all k-walls. Our results confirm and extend, to all N and k, the validity of the semiclassical picture of deconfinement of Anber, Sulejmanpasic and one of us (EP), arXiv:1501.06773 , providing a microscopic explanation of mixed 0-form/1-form anomaly inflow.

The notion of universal quantum computation can be generalized to multilevel qudits, which offer advantages in resource usage and algorithmic efficiencies. Trapped ions, which are pristine and well-controlled quantum systems, offer an ideal platform to develop qudit-based quantum information processing. Previous work has not fully explored the practicality of implementing trapped-ion qudits accounting for known experimental error sources. Here, we describe a universal set of protocols for state preparation, single-qudit gates, a generalization of the Mølmer-Sørensen gate for two-qudit gates, and a measurement scheme which utilizes shelving to a metastable state. We numerically simulate known sources of error from previous trapped-ion experiments, and show that there are no fundamental limitations to achieving fidelities above 99% for three-level qudits encoded in ^{137}Ba^{+} ions. Our methods are extensible to higher-dimensional qudits, and our measurement and single-qudit gate protocols can achieve 99% fidelities for five-level qudits. We identify avenues to further decrease errors in future work. Our results suggest that three-level trapped-ion qudits will be a useful technology for quantum information processing.

Summary: Malignant tumors exhibit high degrees of genomic heterogeneity at the cellular level, leading to the view that subpopulations of tumor cells drive growth and treatment resistance. To examine the degree to which tumors also exhibit metabolic heterogeneity at the level of individual cells, we employed multi-isotope imaging mass spectrometry (MIMS) to quantify utilization of stable isotopes of glucose and glutamine along with a label for cell division. Mouse models of melanoma and malignant peripheral nerve sheath tumors (MPNSTs) exhibited striking heterogeneity of substrate utilization, evident in both proliferating and non-proliferating cells. We identified a correlation between metabolic heterogeneity, proliferation, and therapeutic resistance. Heterogeneity in metabolic substrate usage as revealed by incorporation of glucose and glutamine tracers is thus a marker for tumor proliferation. Collectively, our data demonstrate that MIMS provides a powerful tool with which to dissect metabolic functions of individual cells within the native tumor environment.

From grazing lands to meat packing, beef production systems in the United States are striving to meet global demands without compromising environmental quality or local profitability. These challenges and opportunities are manifest in four US regions connected ecologically and socially through beef production: the American Southwest, the Ogallala Aquifer region, the Northern Plains, and the Upper Midwestern Corn Belt. Most calves raised on extensive, arid Southwestern ranches are exported to the Ogallala Aquifer region for finishing on grains that are grown either locally on Ogallala Aquifer water or imported from the Upper Midwest. Changes in climate, vegetation, and human demographics threaten the sustainability of the regionally-interconnected system. Heritage cattle genetics, precision ranching, and alternative supply chain options are three strategies that show promise for addressing these sustainability threats, but major knowledge gaps exist. For instance, while environmentally-friendly landscape use by Raramuri Criollo, a heritage cattle type, has been identified in several arid rangeland settings, little is known about their performance in conventional feed yards. While precision agriculture is already prevalent in croplands, less is known about how such technologies can be cost effective in arid rangelands. Moreover, many perceive grass-finishing on rangeland as environmentally friendly and beneficial for local agricultural communities, but tradeoffs involving greenhouse gas emissions, increased rangeland use, and disruption of cattle feeding systems of the Ogallala Aquifer region must be assessed. Here we introduce a USDA-NIFA Coordinated Agricultural Project designed to fill these knowledge gaps and advance sustainability of beef production linked to the US Southwest. With a boundary-spanning approach of education, participatory research, and extension, the project is identifying tradeoffs of the three strategies with explicit attention to pericoupling (i.e., socioeconomic and environmental interactions) of regions connected by beef production and full consideration of the coupled ecological and social systems within those regions.

EF-hand Ca2+-binding protein family members, α- and β-parvalbumins have been studied for decades. Yet, considerable information is lacking distinguishing functional differences between mammalian α-parvalbumin (PVALB) and oncomodulin (OCM), a branded β-parvalbumin. Herein, we provide an overview detailing the current body of work centered around OCM as an EF-Hand Ca2+-binding protein and describe potential mechanisms of OCM function within the inner ear and immune cells. Additionally, we posit that OCM is evolutionarily distinct from PVALB and most other β-parvalbumins. This review summarizes recent studies pertaining to the function of OCM and emphasizes OCM as a parvalbumin possessing a unique cell and tissue distribution, Ca2+ buffering capacity and phylogenetic origin.

Lymphatic vascular development involves specification of lymphatic endothelial progenitors that subsequently undergo sprouting, proliferation and tissue growth to form a complex second vasculature. The Hippo pathway and effectors Yap and Taz control organ growth and regulate morphogenesis and cellular proliferation. Yap and Taz control angiogenesis but a role in lymphangiogenesis remains to be fully elucidated. Here we show that YAP displays dynamic changes in lymphatic progenitors and Yap1 is essential for lymphatic vascular development in zebrafish. Maternal and Zygotic (MZ) yap1 mutants show normal specification of lymphatic progenitors, abnormal cellular sprouting and reduced numbers of lymphatic progenitors emerging from the cardinal vein during lymphangiogenesis. Furthermore, Yap1 is indispensable for Vegfc-induced proliferation in a transgenic model of Vegfc overexpression. Paracrine Vegfc-signalling ultimately increases nuclear YAP in lymphatic progenitors to control lymphatic development. We thus identify a role for Yap in lymphangiogenesis, acting downstream of Vegfc to promote expansion of this vascular lineage.

During the last two decades, Haemophilus influenzae serotype a (Hia) emerged as an important cause of invasive disease in Canadian First Nations and Inuit, and Alaskan Native populations, with the highest rates reported in young children. Immunocompetent adults, in contrast to children, do not typically develop invasive Hia disease. To clarify factors responsible for an increased burden of invasive Hia disease in certain population groups we studied serum bactericidal activity (SBA) against Hia and quantified IgG and IgM specific to Hia capsular polysaccharide in healthy adult members of two First Nations communities: 1) with reported cases of invasive Hia disease (Northern Ontario, NO), and 2) without reported cases (Southern Ontario, SO), in comparison to non-First Nations living in proximity to the NO First Nations community, and non-First Nations elderly non-frail Canadians from across the country (total of 110 First Nations and 76 non-First Nations). To elucidate the specificity of bactericidal antibodies, sera were absorbed with various Hia antigens. Naturally acquired SBA against Hia was detected at higher rates in First Nations (NO, 80%; SO, 96%) than non-First Nations elderly Canadians (64%); the SBA titres in First Nations were higher than in non-First Nations elderly Canadians (P0.05). Among First Nations, SBA was mediated predominantly by IgM, and by both antibodies specific to Hia capsular polysaccharide and lipooligosaccharide. CONCLUSIONS:The SBA against Hia is frequently present in sera of First Nations adults regardless of the burden of Hia disease observed in their community; it may represent part of the natural antibody repertoire, which is potentially formed in this population under the influence of certain epigenetic factors. Although the nature of these antibodies deserves further studies to understand their origin, the data suggest that they may represent important protective mechanism against invasive Hia disease.

In the post-Haemophilus influenzae type b (Hib) vaccine era that began in the 1980's, H. influenzae type a (Hia) emerged as a prominent cause of invasive disease in North American Aboriginal populations. To test whether a lack of naturally acquired antibodies may underlie increased rates of invasive Hia disease, we compared serum bactericidal activity against Hia and Hib and IgG and IgM against capsular polysaccharide between Canadian Aboriginal and non-Aboriginal healthy and immunocompromised adults. Both healthy and immunocompromised Aboriginal adults exhibited significantly higher bactericidal antibody titers against Hia than did non-Aboriginal adults (p = 0.042 and 0.045 respectively), with no difference in functional antibody activity against Hib. IgM concentrations against Hia were higher than IgG in most study groups; the inverse was true for antibody concentrations against Hib. Our results indicate that Aboriginal adults possess substantial serum bactericidal activity against Hia that is mostly due to IgM antibodies. The presence of sustained IgM against Hia suggests recent Hia exposure.