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Background In post-coronavirus disease-19 (post-COVID-19) conditions (long COVID), systemic vascular dysfunction is implicated, but the mechanisms are uncertain, and the treatment is imprecise. Methods and results Patients convalescing after hospitalization for COVID-19 and risk factor matched controls underwent multisystem phenotyping using blood biomarkers, cardiorenal and pulmonary imaging, and gluteal subcutaneous biopsy (NCT04403607). Small resistance arteries were isolated and examined using wire myography, histopathology, immunohistochemistry, and spatial transcriptomics. Endothelium-independent (sodium nitroprusside) and -dependent (acetylcholine) vasorelaxation and vasoconstriction to the thromboxane A2 receptor agonist, U46619, and endothelin-1 (ET-1) in the presence or absence of a RhoA/Rho-kinase inhibitor (fasudil), were investigated. Thirty-seven patients, including 27 (mean age 57 years, 48% women, 41% cardiovascular disease) 3 months post-COVID-19 and 10 controls (mean age 57 years, 20% women, 30% cardiovascular disease), were included. Compared with control responses, U46619-induced constriction was increased (P = 0.002) and endothelium-independent vasorelaxation was reduced in arteries from COVID-19 patients (P Conclusion Patients with post-COVID-19 conditions have enhanced vascular fibrosis and myosin light change phosphorylation. Rho-kinase activation represents a novel therapeutic target for clinical trials.

The function of multi-leaf collimators (MLC) is to modulate and shape the intensity of a radiotherapy beam by either blocking or unblocking beamlets. A variation on this functionality is tested in this work wherein the MLC is split into layers, with each layer attenuating the beam by a different amount. In this design, full blocking of a beamlet occurs only if all layers are blocked. This work suggests that such a device, a multi-layer MLC (MLMLC), can deliver dose distributions like a single layer MLC can deliver while requiring less time and monitor units (MU) METHODS: Optimal fluences were made for prostate plans using the Eclipse v13.6. An algorithm was developed to create step-and-shoot MLMLC patterns to match these optimal fluences when using up to six layers of MLC. Twelve MLMLC plans were made in total. These patterns were imported back into Eclipse as equivalent tungsten compensators and doses were calculated. Dose-volume histogram (DVH) values, total monitor units (MU), and total time to deliver were compared between arc-style MLMLC plans and nine-field step and shoot IMRT plans created completely in Eclipse using a single layer MLC.When using three or more layers, specified DVH values between the two sets agreed to within 5% while requiring roughly half as much time to deliver and about 20% fewer MU.Demonstrated that having multi-layer MLC can deliver dose distributions like a single layer MLC with less time and monitor units.

Background Published data suggest worse outcomes in acute coronary syndrome (ACS) patients and concurrent coronavirus disease 2019 (COVID-19) infection. Mechanisms remain unclear. Objectives The purpose of this study was to report the demographics, angiographic findings, and in-hospital outcomes of COVID-19 ACS patients and compare these with pre–COVID-19 cohorts. Methods From March 1, 2020 to July 31, 2020, data from 55 international centers were entered into a prospective, COVID-ACS Registry. Patients were COVID-19 positive (or had a high index of clinical suspicion) and underwent invasive coronary angiography for suspected ACS. Outcomes were in-hospital major cardiovascular events (all-cause mortality, re–myocardial infarction, heart failure, stroke, unplanned revascularization, or stent thrombosis). Results were compared with national pre–COVID-19 databases (MINAP [Myocardial Ischaemia National Audit Project] 2019 and BCIS [British Cardiovascular Intervention Society] 2018 to 2019). Results In 144 ST-segment elevation myocardial infarction (STEMI) and 121 non–ST-segment elevation acute coronary syndrome (NSTE-ACS) patients, symptom-to-admission times were significantly prolonged (COVID-STEMI vs. BCIS: median 339.0 min vs. 173.0 min; p, Central Illustration

Coronary perforation is a potentially life-threatening complication of percutaneous coronary intervention (PCI). We studied incidence, outcomes and temporal trends following PCI-related coronary artery perforation (CAP).MethodsProspective systematic review and meta-analysis including meta-regression using MEDLINE and EMBASE to November 2020. We included ‘all-comer’ PCI cohorts including large PCI registries and randomised controlled trials and excluding registries or trials limited to PCI in high-risk populations such as chronic total occlusion PCI or cohorts treated only with atheroablative devices. Regression analysis and corresponding correlation coefficients were performed comparing perforation incidence, mortality rate, tamponade rate and the rate of Ellis III perforations against the midpoint (year) of data collection to determine if a significant temporal relationship was present.Results3997 studies were screened for inclusion. 67 studies met eligibility criteria with a total of 5 568 191 PCIs included over a 38-year period (1982–2020). The overall pooled incidence of perforation was 0.39% (95% CI 0.34% to 0.45%) and remained similar throughout the study period. Around 1 in 5 coronary perforations led to tamponade (21.1%). Ellis III perforations are increasing in frequency and account for 43% of all perforations. Perforation mortality has trended lower over the years (7.5%; 95% CI 6.7% to 8.4%). Perforation risk factors derived using meta-regression were female sex, hypertension, chronic kidney disease and previous coronary bypass grafting. Coronary perforation was most frequently caused by distal wire exit (37%) followed by balloon dilation catheters (28%). Covered stents were used to treat 25% of perforations, with emergency cardiac surgery needed in 17%.ConclusionCoronary perforation complicates approximately 1 in 250 PCIs. Ellis III perforations are increasing in incidence although it is unclear whether this is due to reporting bias. Despite this, the overall perforation mortality rate (7.5%) has trended lower in recent years. Limitations of our findings include bias that may be introduced through analysis of multidesign studies and registries without pre-specified standardised perforation reporting CMore research into coronary perforation management including the optimal use of covered stents seems warranted.PROSPERO registration numberCRD42020207881.

Background Microvascular angina is caused by cardiac small vessel disease, and dysregulation of the endothelin system is implicated. The minor G allele of the non-coding single nucleotide polymorphism (SNP) rs9349379 enhances expression of the endothelin 1 gene in human vascular cells, increasing circulating concentrations of ET-1. The prevalence of this allele is higher in patients with ischemic heart disease. Zibotentan is a potent, selective inhibitor of the ETA receptor. We have identified zibotentan as a potential disease-modifying therapy for patients with microvascular angina. Methods We will assess the efficacy and safety of adjunctive treatment with oral zibotentan (10 mg daily) in patients with microvascular angina and assess whether rs9349379 (minor G allele; population prevalence ~36%) acts as a theragnostic biomarker of the response to treatment with zibotentan. The PRIZE trial is a prospective, randomized, double-blind, placebo-controlled, sequential cross-over trial. The study population will be enriched to ensure a G-allele frequency of 50% for the rs9349379 SNP. The participants will receive a single-blind placebo run-in followed by treatment with either 10 mg of zibotentan daily for 12 weeks then placebo for 12 weeks, or vice versa, in random order. The primary outcome is treadmill exercise duration using the Bruce protocol. The primary analysis will assess the within-subject difference in exercise duration following treatment with zibotentan versus placebo. Conclusion PRIZE invokes precision medicine in microvascular angina. Should our hypotheses be confirmed, this developmental trial will inform the rationale and design for undertaking a larger multicenter trial.

Background Microvascular and/or vasospastic anginas are relevant causes of ischemia with no obstructive coronary artery disease (INOCA) in patients after computed tomography coronary angiography (CTCA). Objectives Our research has 2 objectives. The first is to undertake a diagnostic study, and the second is to undertake a nested, clinical trial of stratified medicine. Design A prospective, multicenter, randomized, blinded, sham-controlled trial of stratified medicine (NCT03477890) will be performed. All-comers referred for clinically indicated CTCA for investigation of suspected coronary artery disease (CAD) will be screened in 3 regional centers. Following informed consent, eligible patients with angina symptoms are enrolled before CTCA and remain eligible if CTCA excludes obstructive CAD. Diagnostic study: Invasive coronary angiography involving an interventional diagnostic procedure (IDP) to assess for disease endotypes: (1) angina due to obstructive CAD (fractional flow reserve ≤0.80); (2) microvascular angina (coronary flow reserve 25); (3) microvascular angina due to small vessel spasm (acetylcholine); (4) vasospastic angina due to epicardial coronary spasm (acetylcholine); and (5) noncoronary etiology (normal coronary function). The IDP involves direct invasive measurements using a diagnostic coronary guidewire followed by provocation testing with intracoronary acetylcholine. The primary outcome of the diagnostic study is the reclassification of the initial CTCA diagnosis based on the IDP. Stratified medicine trial: Participants are immediately randomized 1:1 in the catheter laboratory to therapy stratified by endotype (intervention group) or not (control group). The primary outcome of the trial is the mean within-subject change in Seattle Angina Questionnaire score at 6 months. Secondary outcomes include safety, feasibility, diagnostic utility (impact on diagnosis and certainty), and clinical utility (impact on treatment and investigations). Health status assessments include quality of life, illness perception, anxiety-depression score, treatment satisfaction, and physical activity. Participants who are not randomized will enter a follow-up registry. Health and economic outcomes in the longer term will be assessed using electronic patient record linkage. Value CorCTCA will prospectively characterize the prevalence of disease endotypes in INOCA and determine the clinical value of stratified medicine in this population., Graphical abstract Unlabelled Image

Objective Increased rates of insufficiency fractures are reported after radiation therapy without well-defined causality. Here, we conduct a cross-sectional study on the density change of a non-lesioned vertebral bone after irradiation relative to a control bone in patients with spinal metastases. Methods Patients were identified who received radiation therapy for spinal metastases to a region, including an adjacent vertebra without identifiable malignancy on pre-treatment CT. Every patient had an untreated vertebra of a similar type available as a control. A Hounsfield-density calibration curve was used to measure the vertebral body density before and after treatment. Analysis of covariance was used to model vertebral bone density changes with respect to treatment status. Significance was established as

Background: The pathophysiology and trajectory of multiorgan involvement in post-COVID-19 syndrome is uncertain. Methods: A prospective, multicenter, longitudinal, cohort study involving post-COVID-19 patients enrolled in-hospital or early post-discharge (visit 1) and re-evaluated 28-60 days post-discharge (visit 2). Multisystem investigations included chest computed tomography with pulmonary and coronary angiography, cardiovascular and renal magnetic resonance imaging, digital electrocardiography, and multisystem biomarkers. The primary outcome was the adjudicated likelihood of myocarditis.Results: 161 patients (mean age 55 years, 43% female) and 27 controls with similar age, sex, ethnicity, and vascular risk factors were enrolled from 22 May 2020 to 2 July 2021 and had a primary outcome evaluation. Compared to controls, at 28-60 days post-discharge, patients with COVID-19 had persisting evidence of cardio-renal involvement, systemic inflammation, and hemostasis pathway activation. Myocarditis was adjudicated as being not likely (n=17; 10%), unlikely (n=56; 35%), probable (n=67; 42%) or very likely (n=21; 13%). Acute kidney injury (odds ratio, 95% confidence interval: 3.40 (1.13, 11.84); p=0.038) and low hemoglobin A1c (0.26 (0.07, 0.87); p=0.035) were multivariable associates of adjudicated myocarditis. During convalescence, compared to controls, COVID-19 was associated with worse health-related quality of life (EQ5D-5L) (pConclusions: The illness trajectory of COVID-19 includes persisting cardio-renal inflammation, lung damage and hemostasis activation. Adjudicated myocarditis occurred in one in eight hospitalized patients and was associated with impairments in health status, physical and psychological wellbeing during community convalescence. Public registration: ClinicalTrials.gov identifier is NCT04403607.

This study examines a covenant of the Prophet, namely, a treaty, patent of protection or charter of privileges, that was copied by Fāris al-Shidyāq at some time before the middle of the nineteenth century. It provides a biographical sketch of the copyist. It reproduces the Arabic original as found in Majmū‘ fawā’id along with an English translation. This is followed by a commentary on the covenant and a series of conclusions, namely, that the “Shidyāq Covenant” from 1857 is a copy of the “Rylands Covenant,” which appears to be an Ottoman-issued document dating from the sixteenth or seventeenth century. This “Shidyāq/Rylands Covenant” could represent the missing link between the “Covenant of the Prophet Muḥammad with the Christians of Najrān,” found in the Chronicle of Seert, and the “Covenant of the Prophet Muḥammad with the Christians of the World,” namely, the Testamentum et Pactiones made famous by Gabriel Sionita in 1630. The significance of this study resides in the fact that it shares a previously unpublished and unstudied covenant of the Prophet Muḥammad, in both Arabic and English, with the scholarly community, while exploring the problems posed by transmission. The more covenants that are rediscovered, the better we will understand their origin, diffusion, and relationship, allowing us to better assess their authenticity. What is more, if these documents are accepted by Muslims as authentic, either in word or in spirit, they can help counter and prevent radicalization, promote moderation, and help protect minorities.

No abstract available.

Testicular germ cell tumours are the most common malignancy in men aged 20 to 40 years. They are subdivided into seminoma and non-seminomatous germ cell tumours (NSGCTs). Both seminoma and NSGCT occur at about the same rate, however some tumours contain a combination of both. Cisplatin-based chemotherapy is used adjuvantly in high-risk stage 1 mixed and NSGCT patients and contributes towards oncological cure in almost all metastatic cases, regardless of histology. However, cardiovascular toxicity is a major concern. In addition to acute endothelial toxicity and associated risk of arterial thrombosis, accelerated atherosclerosis may be the result of chemotherapy-associated latent cardio-metabolic dysfunction. A 45-year-old man began treatment with cisplatin-based chemotherapy for testicular cancer. On day 9, he suffered an anterior ST segment elevation myocardial infarction (STEMI). There was proximal occlusion of the left anterior descending (LAD) artery but otherwise normal coronary arteries. Ten months following chemotherapy, he had another STEMI. There was a fresh obstructive lesion in the previously angiographically normal mid LAD, new diffuse coronary atheroma elsewhere and a deterioration in lipid profile despite statin therapy. Acute and longer-term cardiovascular risks of cisplatin-based chemotherapy may have different underlying pathophysiological mechanisms. These issues are of growing relevance in a population of patients expected to have excellent cancer-related outcomes.

No abstract available.

MI with non-obstructive coronary arteries (MINOCA) is caused by a heterogeneous group of vascular or myocardial disorders. MINOCA occurs in 5–15% of patients presenting with acute ST-segment elevation MI or non-ST segment elevation MI and prognosis is impaired. The diagnosis of MINOCA is made during coronary angiography following acute MI, where there is no stenosis ≥50% present in an infarct-related epicardial artery and no overt systemic aetiology for the presentation. Accurate diagnosis and subsequent management require the appropriate utilisation of intravascular imaging, coronary function testing and subsequent imaging to assess for myocardial disorders without coronary involvement. Although plaque-related MINOCA is currently managed with empirical secondary prevention strategies, there remains an unmet therapeutic need for targeted and evidence-based therapy for MINOCA patients and increased awareness of the recommended diagnostic pathway.

Ischemic heart disease (IHD) is a leading global cause of ill-health and premature death. Clinical research into IHD is providing new insights into the pathophysiology, epidemiology and treatment of this condition. The major endotypes of IHD include coronary heart disease (CHD) and vasomotor disorders, including microvascular angina and vasospastic angina. Considering unselected patients presenting with stable chest pain, the pre-test probability of CHD is higher in men whereas the pre-test probability of a vasomotor disorder is higher in women. The diagnostic accuracy of diagnostic tests designed to assess coronary anatomy and disease and/or coronary vascular function (functional tests) differ for coronary endotypes. Clinical management should therefore be personalized and take account of sex-related factors. In this review, we consider the definitions of angina and myocardial ischemia. We then appraise the mechanistic links between myocardial ischemia and anginal symptoms and the relative merits of non-invasive and invasive diagnostic tests and related clinical management. Finally, we describe the rationale and importance of stratified medicine of IHD.

A man in his 60s presented to the emergency department with two hours of gradually worsening right-sided chest pain that occurred at rest. During the week before presentation he had also experienced a coryzal illness, including rhinorrhoea, non-productive cough, fever, and lethargy. He described shorter episodes of chest pain, lasting less than 15 minutes, for four weeks before this attendance, but he had not sought medical advice. His vital signs were stable, he was apyrexial, and had normal heart sounds and no pericardial rub. His right chest wall was tender to palpation, particularly at the costochondral margins. The patient was a smoker, had a history of hypertension and dyslipidaemia, and a family history of angina. …

Background Angina is associated with impaired quality of life and an adverse prognosis. Purpose Prospectively evaluate quality of life and clinical outcomes in patients with angina undergoing invasive coronary angiography according to endotype: symptoms and/or signs of ischaemia and no obstructive coronary artery disease (INOCA) compared to obstructive coronary artery disease subjects managed by medical therapy, revascularization with percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) surgery, respectively. Methods We conducted a prospective clinical evaluation of patients with angina undergoing clinically indicated invasive management (NCT03193294). Symptom severity and quality of life were assessed at baseline and repeated after 6 months. Comparisons between treatment groups were based on analysis of covariance general linear models adjusting for baseline score, sex, and cardiovascular risk. INOCA subjects were considered as one diagnostic group and not all subjects had invasive vasoreactivity testing. Results 391 patients (mean age 62±10 years, 52% female) were enrolled over 12 months and classified into one of four groups: INOCA (N=185; 47%), obstructive CAD treated by PCI (N=126; 32%), obstructive CAD treated by CABG (N=48; 12%) and obstructive CAD managed with medical therapy (N=32; 8%). After adjusting for between group differences and overall risk, INOCA subjects had worse angina and worse treatment response at follow up (21% and 27% reduction in angina score compared to CAD patients revascularized with PCI and CABG respectively). INOCA subjects had numerically lower treatment response than CAD patients managed with medications (6.4 units, −12%; P=0.181). Population baseline mean Seattle Angina Questionnaire (SAQ) frequency score (60±26) and SAQ summary score (52.5±19) were similar between groups. The absolute difference was 6.4 units versus medically managed CAD (95% CI: −3.0 to 15.9; P=0.181), 11.3 units versus the CAD group undergoing PCI (6.1 to 16.5; P Conclusion(s) Patients with INOCA had more severe angina symptoms reflecting worse quality of life and treatment response at 6 months with similar MACE as CAD subjects even after adjustment for confounding factors. This study highlights the need for evidence-based antianginal therapies and disease-modifying treatments for angina patients regardless of the presence of obstructive coronary disease. Figure 1 Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): This work was funded by the British Heart Foundation (PG/17/2532884; RE/13/5/30177; RE/18/6134217)

Background COVID-19 is typically a primary respiratory illness with multisystem involvement. The prevalence and clinical significance of cardiovascular and multisystem involvement in COVID-19 remain unclear. Methods This is a prospective, observational, multicentre, longitudinal, cohort study with minimal selection criteria and a near-consecutive approach to screening. Patients who have received hospital care for COVID-19 will be enrolled within 28 days of discharge. Myocardial injury will be diagnosed according to the peak troponin I in relation to the upper reference limit (URL, 99th centile) (Abbott Architect troponin I assay; sex-specific URL, male: >34 ng/L; female: >16 ng/L). Multisystem, multimodality imaging will be undertaken during the convalescent phase at 28 days post-discharge (Visit 2). Imaging of the heart, lung, and kidneys will include multiparametric, stress perfusion, cardiovascular magnetic resonance imaging, and computed tomography coronary angiography. Health and well-being will be assessed in the longer term. The primary outcome is the proportion of patients with a diagnosis of myocardial inflammation. Conclusion CISCO-19 will provide detailed insights into cardiovascular and multisystem involvement of COVID-19. Our study will inform the rationale and design of novel therapeutic and management strategies for affected patients. Clinical trial registration ClinicalTrials.gov identifier NCT04403607.

Background and aims Anti-platelet and anti-thrombotic therapy are well-established treatments in acute coronary syndromes. Highly sensitive assays have diminished the positive predictive value of troponin in acute coronary syndromes and increased the importance of the clinical assessment in interpreting positive results. This cohort study sought to investigate over-treatment of non-coronary troponin rises and associated adverse outcomes. Methods and results We reviewed 223 consecutive patients presenting to Queen Elizabeth University Hospital, Glasgow, with suspected acute coronary syndromes over a six-week period. Of these, 27 (12%) met our ‘inappropriate therapy’ criteria. This group had a low ischaemic risk (HEART score: 4.2 ± 1.4) (GRACE score: 117 ± 30.8) but an intermediate-high bleeding risk (CRUSADE score: 34 ± 14.5). Approximately half of the patients (14/27, 52%) reported chest pain, with only 4/27 (15%) having ischaemic ECG changes. There were three intracranial haemorrhages, each after the patient had received a single dose of aspirin, ticagrelor and fondaparinux. Conclusion The combination of injudicious high-sensitivity troponin testing with potent anti-platelet and anti-thrombotic therapy was associated with possible over-treatment of patients and associated harm. Emphasis on interpretation of troponin in the context of clinical presentation and improved awareness of type 2 myocardial infarction are essential to limit iatrogenic pharmacological harm.

Background Adenosine is frequently used during coronary angiography to induce hyperaemia and allow operators to perform quantitative measurements of lesion severity. Acute bronchospasm is a recognised side effect relating to the activation of ‘off target’ A2B receptors. The true incidence of severe bronchospasm relating to adenosine administration is not known. Methods Using an electronic patient database, we analysed 100,253 consecutive coronary angiograms over almost 19 years. Fractional flow reserve (FFR) was measured under systemic adenosine in 9,440 cases. Results Adenosine-related bronchospasm was reported in only five cases (0.05%). One case resulted in a life-threatening respiratory arrest. Conclusions This study reveals the incidence of acute bronchospasm during FFR testing to be extremely low. Although rare, these reactions can be severe and are not simply limited to patients with brittle airways disease. Physicians should be aware of the utility of bolus intravenous aminophylline providing targeted therapy to reverse and treat adenosine-related bronchospasm.

Black carbon (BC) contributes to both degraded air quality and Arctic warming, however sources of Arctic BC and their geographic contributions remain uncertain. We interpret a series of recent airborne and ground-based measurements with the GEOS-Chem global chemical transport model and its adjoint to attribute the sources of Arctic BC. The springtime airborne measurements performed by the NETCARE campaign in 2015 and the PAMARCMiP campaigns in 2009 and 2011 offer BC vertical profiles extending to > 6 km across the Arctic and include profiles above Arctic ground monitoring stations. Long-term ground-based measurements are examined from multiple methods (thermal, laser incandescence and light absorption) at Alert (2011–2013), Barrow (2009–2015) and Ny-Ålesund (2009–2014) stations. Our simulations with the addition of gas flaring emissions are consistent with ground-based measurements of BC concentrations at Alert and Barrow in winter and spring (rRMSE < 13 %), and with airborne measurements of BC vertical profile across the Arctic (rRMSE = 17 %). Sensitivity simulations suggest that anthropogenic emissions in eastern and southern Asia are the largest source of the Arctic BC column both in spring (56 %) and annually (37 %), with larger contributions aloft than near the surface (e.g. a contribution of 66 % between 400–700 hPa and of 46 % below 900 hPa in spring). Anthropogenic emissions from northern Asia contribute considerable BC to the lower troposphere (a contribution of 27 % in spring and of 43 % annually below 900 hPa). Biomass burning has a substantial contribution to Arctic BC below 400 hPa of 25 % annually, despite minor influence in spring ( 50 %) in winter and those from eastern and southern Asia are the largest in spring (~ 40 %). At Ny-Ålesund, anthropogenic emissions from Europe (~ 30 %) and northern Asia (~ 30 %) are major sources in winter and early spring. Biomass burning from North America is the most important contributor to surface BC at all stations in summer, especially at Barrow where North American biomass burning contributes more than 90 % of BC in July and August. Our adjoint simulations indicate pronounced spatial and seasonal heterogeneity in the contribution of emissions to the Arctic BC column concentrations with noteworthy contributions from emissions in eastern China (15 %) and western Siberia (6.5 %). Although uncertain, gas flaring emissions from oilfields in western Siberia could have a striking impact (13 %) on Arctic BC loadings in January, comparable to the total influence of continental Europe and North America (6.5 % each in January).

At 84-pages, Reimagining Malcolm X: Street Thinker Versus Homo Academicusby Seyed Javad Miri is more of a booklet than a book. In fact, like mostof the 40 books on sociology and religion published by this scholar, many ofwhich are self-published or released by subsidy publishers, it falls into thatawkward category between an essay that is too long and a book that is tooshort. Considering the fact that most university and independent academicpresses place profit and marketability before contribution to scholarship inthe field, the fact that ambitious and prolific academics seek to be proactiveand find alternate modes of sharing their scholarship should be commended.Consequently, scholars working in the field of sociology and religion shouldbe grateful to both Miri and the University Press of America for making thiswork on Malcolm X available to readers and researchers.Reimagining Malcolm X examines the significance of el-Hajj Malik el-Shabazz as a social theorist by analyzing his views on race, academia, philosophy,and politics. The work is divided into four chapters: “Novel Strategiesof Interpretation,” “Undisciplinary Fields of Knowledge,” “Violence, Religion,and Extremism,” and “The Epic of America.”In chapter 1, Miri points out that “Malcolm X has not been appropriatedwithin the body of academic social sciences as he should have been” (p. 9).This is both obvious and intentional. It is heartening, however, to see thatinterest in Malcolm’s thoughts has extended to certain segments of Iranianacademia. As the author reveals, however, some Iranian scholars are reticentto see the value of Malcolmian theories and concepts (p. xi). Despite all ofits revolutionary rhetoric, the Islamic Republic of Iran has shown little interestin el-Hajj Malik el-Shabazz. On the contrary, it has preferred to invitehis nemesis Louis Farrakhan, a man who admits that he created the conditionsthat lead to Malcolm’s assassination, to preach at the seminary in Qum.Considering that the Iranian regime considers itself the bastion of Shi‘iteorthodoxy and cracks down on both political critics and practitioners oftaṣawwuf (‘irfān or Sufism), it is ironic that its leaders have promoted a manwho believes that W. D. Fard was the incarnation of Allah and that ElijahMuhammad, as opposed to Muhammad ibn ‘Abd Allah, was Allah’s final ...

An investigation of how emergency vehicle lighting (EVL) can be improved is reported with reference to an analysis of police vehicle road traffic accidents (Study 1). In Study 2, 37 regular drivers were shown film clips of a marked police vehicle, in which flash rate (1 Hz, 4 Hz) and pattern (single, triple pulse) were varied on the blue Light Emitting Diode (LED) roofbar. Results indicate a 4 Hz flash rate conveys greater urgency than a 1 Hz rate, while a 1 Hz, single flash combination was ranked the least urgent of all combinations. Participants claimed they would leave significantly more space before pulling out in front of an approaching police car (gap acceptance) in the 4 Hz single pulse condition in comparison to other EVL combinations. The preliminary implications for which flash characteristics could prove most optimal for emergency service use are discussed with regard to effects on driver perception and expected driving behaviour.

Herbal Medicine in Yemen contains eleven studies on a wide range of virtually unrelated subjects. In their introduction, the editors mention that “religious and magical rituals are employed side by side with material medica” (p. 1) in Yemen. This should serve as warning for what is to come and send practitioners of phytotherapy into flight. They assert that Yemenites employ an enormous variety of plant-based medicines and allege that “[t]this is different in other Islamic countries, e.g. Morocco, where animal drugs are widely used” (p. 1). As an herbalist who has lived for extended periods in Morocco, who has also travelled widely therein and met many of its herbalists and healers, their latter assertion is not accurate. In all of the stalls and stores I visited in markets in cities nationwide, the only animal drugs I ever saw were small quantities of dried lizards and other such creatures; I found more animal drugs in the shops of sorcerers and witches who dabbled in the dark arts ...

According to accepted knowledge, Malcolm X left the Nation of Islam to embrace ‘orthodox’ Islam after his pilgrimage to Mecca. As a result of his contacts with Saudis and Egyptians, it was assumed that Malik Al-Shabazz had embraced Sunnism or Salafism. This study, however, suggests that Malcolm X was brought into mainstream Islam by Dr. Mohammad Taki Mehdi, an Iraqi Shi‘a. Not only did Dr. Mehdi make arrangements for Malcolm X’s pilgrimage, he appears to have acted as his spiritual and political mentor. On the basis of interviews with family and friends of the late Dr. Mehdi, it is suggested that the famous activist may have shared the story of Imam Husayn with his African American associate. If Malcolm X decided to follow in the footsteps of Imam Husayn, he could be considered a de-facto Shi‘a by some. At the very least, it would suggest that Malcolm was influenced by Shi‘ism.

Peripheral longitudinal growth strain (LGS) was measured on a total of 81, 22-year-old pruned Eucalyptus nitens trees from five thinning treatments in a plantation thinning trial in Tasmania. Growth strain data were gathered at breast height on each tree using the CIRAD-Foret method. The effects of thinning treatment and tree diameter on LGS and its relationships to solid-wood traits determined in a processing trial were examined. LGS was significantly higher in the direction of the prevailing wind and was not significantly affected by either thinning treatment or tree diameter. An index of log end splitting was positively related to tree diameter, sawlog position (upper/lower), and LGS, which explained up to an additional 20% of the variance after tree diameter and log position were accounted for in a linear regression model. High LGS and log end splitting were significant indicators of increased board end splitting.

Iran’s Intellectual Revolution, by Mehran Kamrava, offers an overview ofthe three major political orientations that have evolved in Iran since theIslamic revolution of 1979, especially since the death of Khomeini in 1989.The first chapter examines the silent, and often not-so-silent, revolution that has taken place in Iran over the past few decades; the second and third chapterscontextualize these emerging Iranian discourses; and the fourth, fifth,and sixth chapters focus on the religious conservative, religious reformist,and secular-modernist discourses.Chapter three surveys the religious conservative discourse of Khomeini,Khamenei, Montazeri, Mesbah Yazdi, Rafsanjani, and Amoli. The authorfocuses on issues of interpretation, emulation, and the rule of the jurist (bothconditional and absolute), all of which are essential if one wishes to understandthe country’s current internal conflict and the varying conceptions ofIslamic government that exist ...