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2. Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for generous support, and Dr. Anne Butlin (AZ) and Dr. Nick Bampos (Cambridge) for valuable assistance

Author

Ian, Paterson, David Y.-K., Chen, Mark J., Coster, Jose L., Aceña, Jordi, Bach, Karl R., Gibson, Linda E., Keown, Renata M., Oballa, Thomas, Trieselmann, Debra J., Wallace, Andrew P., Hodgson, and Roger D., Norcross

Published
2002

3. Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1

Author

Ian, Paterson, David Y-K, Chen, Mark J, Coster, Jose L, Aceña, Jordi, Bach, Karl R, Gibson, Linda E, Keown, Renata M, Oballa, Thomas, Trieselmann, Debra J, Wallace, Andrew P, Hodgson, and Roger D, Norcross

Abstract

As an exceptionally potent antimitotic macrolide, altohyrtin A/spongistatin 1 shows great promise in cancer chemotherapy but its extreme scarcity in the natural sponges has halted its further preclinical development. A highly stereocontrolled total synthesis, which exploits boron-mediated aldol bond constructions, has been realized to provide, for the first time, a useful amount of synthetic material.

Published
2001

4. Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for generous support, and Dr. Anne Butlin (AZ) and Dr. Nick Bampos (Cambridge) for valuable assistance

Author

Debra J. Wallace, Thomas Trieselmann, Jordi Bach, Mark J. Coster, Ian Paterson, David Y.-K. Chen, Renata M. Oballa, Karl Richard Gibson, Roger D. Norcross, Andrew P. Hodgson, Linda E. Keown, and Jose Luis Acena

Subjects
Cancer chemotherapy, Aldol reaction, Chemistry, Stereochemistry, Total synthesis, General Chemistry, Altohyrtin A, Spongistatin, Combinatorial chemistry, Catalysis, Spongistatin 1
Abstract

As an exceptionally potent antimitotic macrolide, altohyrtin A/spongistatin 1 shows great promise in cancer chemotherapy but its extreme scarcity in the natural sponges has halted its further preclinical development. A highly stereocontrolled total synthesis, which exploits boron-mediated aldol bond constructions, has been realized to provide, for the first time, a useful amount of synthetic material.

Published
2001
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