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20 results on '"Ang, Jann C."'

1. Immunomodulatory drugs have divergent effects on humoral and cellular immune responses to SARS-CoV-2 vaccination in people living with rheumatoid arthritis

Author

Benoit, Jenna M., Breznik, Jessica A., Ang, Jann C., Bhakta, Hina, Huynh, Angela, Cowbrough, Braeden, Baker, Barbara, Heessels, Lauren, Lodhi, Sumiya, Yan, Elizabeth, Ewusie, Joycelyne, Nazy, Ishac, Bramson, Jonathan, Miller, Matthew S., Bernatsky, Sasha, Larché, Maggie J., and Bowdish, Dawn M. E.

Published
2023
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2. IgA potentiates NETosis in response to viral infection

Author

Stacey, Hannah D., Golubeva, Diana, Posca, Alyssa, Ang, Jann C., Novakowski, Kyle E., Zahoor, Muhammad Atif, Kaushic, Charu, Cairns, Ewa, Bowdish, Dawn M. E., Mullarkey, Caitlin E., and Miller, Matthew S.

Published
2021

4. Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

Author

Afkhami, Sam, D’Agostino, Michael R., Zhang, Ali, Stacey, Hannah D., Marzok, Art, Kang, Alisha, Singh, Ramandeep, Bavananthasivam, Jegarubee, Ye, Gluke, Luo, Xiangqian, Wang, Fuan, Ang, Jann C., Zganiacz, Anna, Sankar, Uma, Kazhdan, Natallia, Koenig, Joshua F.E., Phelps, Allyssa, Gameiro, Steven F., Tang, Shangguo, Jordana, Manel, Wan, Yonghong, Mossman, Karen L., Jeyanathan, Mangalakumari, Gillgrass, Amy, Medina, Maria Fe C., Smaill, Fiona, Lichty, Brian D., Miller, Matthew S., and Xing, Zhou

Published
2022
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5. High‐Precision Viral Detection Using Electrochemical Kinetic Profiling of Aptamer‐Antigen Recognition in Clinical Samples and Machine Learning.

Author

Sen, Payel, Zhang, Zijie, Sakib, Sadman, Gu, Jimmy, Li, Wantong, Adhikari, Bal Ram, Motsenyat, Ariel, L'Heureux‐Hache, Jonathan, Ang, Jann C., Panesar, Gurpreet, Salena, Bruno J., Yamamura, Debora, Miller, Matthew S., Li, Yingfu, and Soleymani, Leyla

Subjects
MACHINE learning, VIRAL antigens, SARS-CoV-2, COMMUNICABLE diseases, CELL surface antigens
Abstract

High‐precision viral detection at point of need with clinical samples plays a pivotal role in the diagnosis of infectious diseases and the control of a global pandemic. However, the complexity of clinical samples that often contain very low viral concentrations makes it a huge challenge to develop simple diagnostic devices that do not require any sample processing and yet are capable of meeting performance metrics such as very high sensitivity and specificity. Herein we describe a new single‐pot and single‐step electrochemical method that uses real‐time kinetic profiling of the interaction between a high‐affinity aptamer and an antigen on a viral surface. This method generates many data points per sample, which when combined with machine learning, can deliver highly accurate test results in a short testing time. We demonstrate this concept using both SARS‐CoV‐2 and Influenza A viruses as model viruses with specifically engineered high‐affinity aptamers. Utilizing this technique to diagnose COVID‐19 with 37 real human saliva samples results in a sensitivity and specificity of both 100 % (27 true negatives and 10 true positives, with 0 false negative and 0 false positive), which showcases the superb diagnostic precision of this method. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination

Author

Breznik, Jessica A., Huynh, Angela, Zhang, Ali, Bilaver, Lucas, Bhakta, Hina, Stacey, Hannah D., Ang, Jann C., Bramson, Jonathan L., Nazy, Ishac, Miller, Matthew S., Denburg, Judah, Costa, Andrew P., and Bowdish, Dawn M. E.

Subjects
COVID-19 Vaccines, SARS-CoV-2, Vaccination, Cytomegalovirus Infections, Immunology, Humans, Cytomegalovirus, COVID-19, Immunology and Allergy, Clinical and Human Immunology, Antibodies, Aged
Abstract

Chronic infection with human CMV may contribute to poor vaccine efficacy in older adults. We assessed the effects of CMV serostatus on Ab quantity and quality, as well as cellular memory recall responses, after two and three SARS-CoV-2 mRNA vaccine doses, in older adults in assisted living facilities. CMV serostatus did not affect anti-Spike and anti–receptor-binding domain IgG Ab levels, nor neutralization capacity against wild-type or β variants of SARS-CoV-2 several months after vaccination. CMV seropositivity altered T cell expression of senescence-associated markers and increased effector memory re-expressing CD45RA T cell numbers, as has been previously reported; however, this did not impact Spike-specific CD4+ T cell memory recall responses. CMV-seropositive individuals did not have a higher incidence of COVID-19, although prior infection influenced humoral immunity. Therefore, CMV seropositivity may alter T cell composition but does not impede the durability of humoral protection or cellular memory responses after SARS-CoV-2 mRNA vaccination in older adults.

Published
2022

7. Three on Three: Universal and High-Affinity Molecular Recognition of the Symmetric Homotrimeric Spike Protein of SARS-CoV-2 with a Symmetric Homotrimeric Aptamer

Author

Li, Jiuxing, primary, Zhang, Zijie, additional, Gu, Jimmy, additional, Amini, Ryan, additional, Mansfield, Alexandria G., additional, Xia, Jianrun, additional, White, Dawn, additional, Stacey, Hannah D., additional, Ang, Jann C., additional, Panesar, Gurpreet, additional, Capretta, Alfredo, additional, Filipe, Carlos D. M., additional, Mossman, Karen, additional, Salena, Bruno J., additional, Gubbay, Jonathan B., additional, Balion, Cynthia, additional, Soleymani, Leyla, additional, Miller, Matthew S., additional, Yamamura, Deborah, additional, Brennan, John D., additional, and Li, Yingfu, additional

Published
2022
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9. A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern

Author

Zhang, Zijie, primary, Li, Jiuxing, additional, Gu, Jimmy, additional, Amini, Ryan, additional, Stacey, Hannah D., additional, Ang, Jann C., additional, White, Dawn, additional, Filipe, Carlos D. M., additional, Mossman, Karen, additional, Miller, Matthew S., additional, Salena, Bruno J., additional, Yamamura, Deborah, additional, Sen, Payel, additional, Soleymani, Leyla, additional, Brennan, John D., additional, and Li, Yingfu, additional

Published
2022
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10. Front Cover: A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern (Chem. Eur. J. 15/2022)

Author

Zhang, Zijie, primary, Li, Jiuxing, additional, Gu, Jimmy, additional, Amini, Ryan, additional, Stacey, Hannah D., additional, Ang, Jann C., additional, White, Dawn, additional, Filipe, Carlos D. M., additional, Mossman, Karen, additional, Miller, Matthew S., additional, Salena, Bruno J., additional, Yamamura, Deborah, additional, Sen, Payel, additional, Soleymani, Leyla, additional, Brennan, John D., additional, and Li, Yingfu, additional

Published
2022
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12. High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva

Author

Zhang, Zijie, primary, Pandey, Richa, additional, Li, Jiuxing, additional, Gu, Jimmy, additional, White, Dawn, additional, Stacey, Hannah D., additional, Ang, Jann C., additional, Steinberg, Catherine‐Jean, additional, Capretta, Alfredo, additional, Filipe, Carlos D. M., additional, Mossman, Karen, additional, Balion, Cynthia, additional, Miller, Matthew S., additional, Salena, Bruno J., additional, Yamamura, Deborah, additional, Soleymani, Leyla, additional, Brennan, John D., additional, and Li, Yingfu, additional

Published
2021
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14. Single-dose respiratory mucosal delivery of next-generation viral-vectored COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

Author

Afkhami, Sam, primary, D’Agostino, Michael R., additional, Zhang, Ali, additional, Stacey, Hannah D., additional, Marzok, Art, additional, Kang, Alisha, additional, Singh, Ramandeep, additional, Bavananthasivam, Jegarubee, additional, Ye, Gluke, additional, Luo, Xiangqian, additional, Wang, Fuan, additional, Ang, Jann C., additional, Zganiacz, Anna, additional, Sankar, Uma, additional, Kazhdan, Natallia, additional, Koenig, Joshua F. E., additional, Phelps, Allyssa, additional, Jordana, Manel, additional, Wan, Yonghong, additional, Mossman, Karen L., additional, Jeyanathan, Mangalakumari, additional, Gillgrass, Amy, additional, Medina, Maria Fe C., additional, Smaill, Fiona, additional, Lichty, Brian D., additional, Miller, Matthew S., additional, and Xing, Zhou, additional

Published
2021
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15. Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library

Author

Li, Jiuxing, primary, Zhang, Zijie, additional, Gu, Jimmy, additional, Stacey, Hannah D, additional, Ang, Jann C, additional, Capretta, Alfredo, additional, Filipe, Carlos D M, additional, Mossman, Karen L, additional, Balion, Cynthia, additional, Salena, Bruno J, additional, Yamamura, Deborah, additional, Soleymani, Leyla, additional, Miller, Matthew S, additional, Brennan, John D, additional, and Li, Yingfu, additional

Published
2021
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16. Characteristics of Anti-SARS-CoV-2 Antibodies in Recovered COVID-19 Subjects

Author

Huynh, Angela, primary, Arnold, Donald M., additional, Smith, James W., additional, Moore, Jane C., additional, Zhang, Ali, additional, Chagla, Zain, additional, Harvey, Bart J., additional, Stacey, Hannah D., additional, Ang, Jann C., additional, Clare, Rumi, additional, Ivetic, Nikola, additional, Chetty, Vasudhevan T., additional, Bowdish, Dawn M. E., additional, Miller, Matthew S., additional, Kelton, John G., additional, and Nazy, Ishac, additional

Published
2021
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17. IgA Potentiates NETosis in Response to Viral Infection

Author

Stacey, Hannah D., primary, Golubeva, Diana, additional, Posca, Alyssa, additional, Ang, Jann C., additional, Novakowski, Kyle E., additional, Zahoor, Muhammad Atif, additional, Kaushic, Charu, additional, Cairns, Ewa, additional, Bowdish, Dawn M. E., additional, Mullarkey, Caitlin E., additional, and Miller, Matthew S., additional

Published
2021
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18. Characteristics of anti-SARS-CoV-2 antibodies in recovered COVID-19 subjects

Author

Huynh, Angela, primary, Arnold, Donald M., additional, Smith, James W., additional, Moore, Jane C., additional, Zhang, Ali, additional, Chagla, Zain, additional, Harvey, Bart J., additional, Stacey, Hannah D., additional, Ang, Jann C., additional, Clare, Rumi, additional, Ivetic, Nikola, additional, Chetty, Vasudhevan T., additional, Bowdish, Dawn ME, additional, Miller, Matthew S., additional, Kelton, John G., additional, and Nazy, Ishac, additional

Published
2020
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19. Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination.

Author

Breznik JA, Huynh A, Zhang A, Bilaver L, Bhakta H, Stacey HD, Ang JC, Bramson JL, Nazy I, Miller MS, Denburg J, Costa AP, and Bowdish DME

Subjects
Humans, Aged, COVID-19 Vaccines, Cytomegalovirus, SARS-CoV-2, Antibodies, Vaccination, mRNA Vaccines, COVID-19 prevention & control, Cytomegalovirus Infections
Abstract

Chronic infection with human CMV may contribute to poor vaccine efficacy in older adults. We assessed the effects of CMV serostatus on Ab quantity and quality, as well as cellular memory recall responses, after two and three SARS-CoV-2 mRNA vaccine doses, in older adults in assisted living facilities. CMV serostatus did not affect anti-Spike and anti-receptor-binding domain IgG Ab levels, nor neutralization capacity against wild-type or β variants of SARS-CoV-2 several months after vaccination. CMV seropositivity altered T cell expression of senescence-associated markers and increased effector memory re-expressing CD45RA T cell numbers, as has been previously reported; however, this did not impact Spike-specific CD4+ T cell memory recall responses. CMV-seropositive individuals did not have a higher incidence of COVID-19, although prior infection influenced humoral immunity. Therefore, CMV seropositivity may alter T cell composition but does not impede the durability of humoral protection or cellular memory responses after SARS-CoV-2 mRNA vaccination in older adults., (Copyright © 2022 by The American Association of Immunologists, Inc.)

Published
2022
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20. A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS-CoV-2 Variants of Concern.

Author

Zhang Z, Li J, Gu J, Amini R, Stacey HD, Ang JC, White D, Filipe CDM, Mossman K, Miller MS, Salena BJ, Yamamura D, Sen P, Soleymani L, Brennan JD, and Li Y

Abstract

Invited for the cover of this issue are John Brennan, Yingfu Li, and co-workers at McMaster University. The image depicts MSA52 as a universal DNA aptamer that recognizes spike proteins of diverse SARS-CoV-2 variants of concern. Read the full text of the article at 10.1002/chem.202200078., (© 2022 Wiley-VCH GmbH.)

Published
2022
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