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Background: The anal symptoms occurring pregnancy and post-partum, mainly related to Haemorrhoidal Disease (HD), have been reported with a wide range of incidence in the Literature. Although in many cases the course of the disease is mild and self-limiting, sometimes it is severe enough to give a bad quality of life. Methods: Our study has been conducted by means of a questionnaire administered via of a social media with the aim of obtaining an epidemiologic data on incidence of symptoms of HD in an unselected population of pregnant women. In addition, we investigated for the presence of those factors notoriously predisposing or associated to haemorrhoidal disease (constipation, straining on the toilet, low dietary fibers and fluid intake). Results: Out of 133 patients 51% reported Symptoms of HD during pregnancy, mainly in the second and third trimester. Constipation, straining on the toilet, low dietary fiber and fluid intake were not significantly related to incidence of haemorrhoids. Only a previous history of haemorrhoidal disease correlated to onset of hemorrhoids in pregnancy and reached a statistical significance (odds ratio = 5.2, pConclusion: Although with the limitations posed by the nature of our retrospective study via a self-assessment interview, our results suggest that the occurrence of HD in pregnancy seems not sustained by the classical risk factors observed in the general population. At the moment, specific therapeutic measuresare lacking and treatment relies on empiric suggestions concerning diet, fluid intake, bowel care, local ointment. Further studies are needed in order to identify a targeted etiologic treatment, taking in mind however, that surgery can be an option in selected cases.

The term "perinatal mental illness" refers to the set of psychiatric disorders that occur during pregnancy and up to one year after childbirth. The disorders that occurred before pregnancy along with the disorders that emerge during pregnancy or in the postpartum period are all considered perinatal mental illnesses. The causes of prenatal mental illness are still unknown. However, recent studies have shown a major risk in patients with autoimmune diseases.We performed a comprehensive search of relevant studies from february 2000 to dicember 2021 to ensure all possible studies were captured. A systematic search of Pubmed databases was conducted. We selected 'autoimmune disease' as the search term, combining with 'perinatal mental illness', 'perinatal depression' or 'postpartum anxiety' or 'postpartum psychosis' or 'bipolar disorder' or 'postpartum blues'.The results of our review show that patients with perinatal mental illness have higher risks of subsequent autoimmune diseases. In fact, when a woman develop perinatal mental illness, accurate counseling can be employed: on the one hand, the woman should be send to the psychiatrist, on the other hand she has to be informed about the increased risk of a future developement of autoimmune disease.As described in the literature, correlation between perinatal mental illness and autoimmune disease could bring new diagnostic opportunities, relevant for practical decisions. Further studies need to confirm the correlation between perinatal mental illness and autoimmune disease.

Placental site trophoblastic tumor (PSTT) is a very rare form of gestational trophoblastic disease (GTD) that occurs mainly in women who have a history of termination of pregnancy. It has different characteristics from other gestational trophoblastic tumors: it grows slowly, secretes low levels of beta-human chorionic gonadotropin (β-hCG), with low metastatic potential. We report a case of PSTT of a 32-year-old patient. Seven months after delivery, the patient presented at our Center with persistence of menorrhagia for at least 1 month. A slightly high level of beta-human chorionic gonadotropin (β-hCG) was observed. TVUS and MRI, an operative hysteroscopy and a laparoscopy were performed. The histological and immunohistochemical findings demonstrated PSTT. Diagnosis of juvenile cystic adenomyoma (JCA) was also added. A total body CT scan was negative for metastases. A total hysterectomy with salpingectomy was performed. We performed a search of relevant studies about PSTT of the last years. A systematic search of Pubmed databases was conducted. Appropriate search terms were constructed by reviewing abstracts, titles and keywords relating to PSTT known to the authors. All articles known to the authors useful to the review were included, comparing with our clinical case. Stages and treatment are related to survival rates, with long term survival expected for stage I low-risk disease after hysterectomy. Our case is a stage I disease with good prognostic factors (patient's age and absence of metastases) and, as described in the literature, a total hysterectomy with salpingectomy was performed.

Pericentric inversion of chromosome 19 has been found in several members of three unrelated families from a restricted geographical region. In one of the families, an additional pericentric inversion of chromosome 9 was observed. Reproductive problems, multiple abortions in two families and a neonatal death in the third, were present. A review of previously described cases is included, and the genetic risk connected with this type of rearrangement is also discussed.

62 hojas La computación distribuida para el procesamiento en paralelo sobre un clúster de computadores ofrece un rendimiento computacional mayor con tiempos de respuesta mucho menores que si se realizara el mismo procesamiento en una sola máquina. Si se toma en cuenta que cada computador por sí solo implica una serie de recursos y costos para su funcionamiento (económicos, humanos, etc.), y además se considera que cuanto más computadores se incluyan al clúster representará un aumento en tiempos de transmisión de información entre ellos, no es difícil inferir que habrá un punto en el cual se deberá hacer un balance entre las ventajas que ofrecen la inclusión de más computadores (en términos de capacidad de cómputo) y el costo que representan (en energía, dinero y transferencia de datos). Pregrado Ingeniería de Sistemas