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Four new compounds, suaedamas A-D (1-4), and seven known ones (5-11) were isolated from the aerial parts of Suaeda maritima. Their chemical structures were evaluated by the IR, HR-ESI-MS, 1D-, and 2D-NMR, experimental and calculated ECD spectra. Compounds 1-6 inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC 50 values ranging from 29.3 to 85.5 μM, compared to that of the positive control compound, dexamethasone, which showed IC 50 value of 13.4 μM., (© 2024 Wiley-VHCA AG, Zurich, Switzerland.)

A phytochemical investigation of the methanolic extract of aerial parts of the Acanthus ilicifolius led to the isolation of two new lignan glycosides, acaniliciosides A and B ( 1 and 2 ), together with ten known compounds ( 3 - 12 ). The structures of isolated compounds were elucidated based on HR-ESI-MS, 1D and 2D NMR spectroscopic data. The absolute configurations of two new compounds were established by CD spectra. With the exception of compound 12 , other compounds inhibited NO production in LPS activated RAW264.7 cells with IC 50 values of 2.14-28.18 µM, as potent as that of the positive control of N G -monomethyl-L-arginine acetate (L-NMMA, IC 50 of 32.50 µM). In addition, compounds 5 - 8 showed cytotoxic effects against SK-LU-1 and HepG2 cell lines with the IC 50 values ranging from 16.48 to 76.40 μM compared to the positive control (ellipticine) with the IC 50 values ranging from 1.23 to 1.46 μM.

Three new oleanane-type triterpene saponins, named camphanosides A-C (1-3), along with five known compounds, chikusetsusaponin IVa (4), spinasaponin A 28-O-glucoside (5), (-)-epicatechin (6), (-)-epicatechin 3-O-gallate (7), and (-)-epigallocatechin 3-O-gallate (8) were isolated from the leaves Camellia phanii Hakoda & Ninh. Their structures were established by 1D and 2D-NMR and mass spectral analysis and chemical methods. Moreover, compounds 1-5 were also evaluated for α-glucosidase inhibitory activity. Compounds 1-3 exhibited moderate α-glucosidase inhibitory activity with IC 50 values of 230.7±18.0, 251.4±22.7, and 421.4±25.6 μM, respectively., (© 2024 Wiley-VHCA AG, Zurich, Switzerland.)

Phytochemical study on the roots of Achyranthes bidentata Blume led to the isolation of sixteen compounds including three new ones ( 1-3 ). Their chemical structures were determined as oleanolic acid 28- O - β -D-glucopyranoside-3- O -[ β -D-glucopyranosyl-(1→3)- β -D-galactopyranoside) ( 1 ), methyl (8 Z ,11 Z )-5,6,7-trihydroxytetradeca-8,11-dienoate ( 2 ), methyl (6 E ,11 Z )-5,8,9-trihydroxytetradeca-6,11-dienoate ( 3 ), fulgidic acid ( 4 ), (9 E ,11 E )-13-oxooctadeca-9,11-dienoic acid ( 5 ), (9 Z ,11 E ,15 Z )-13-hydroxyoctadeca-9,11,15-trienoic acid ( 6 ), oleanolic acid 28- O - β -D-glucopyranoside-3- O - α -L-rhamnopyranosyl-(1→4)- β -D-glucuronopyranoside ( 7 ), oleanolic acid 28- O - β -D-glucopyranoside-3- O - β -D - glucopyranosyl-(1→2)-[ α -L-rhamnopyranosyl-(1→3)]- β -D-glucuronopyranoside ( 8 ), oleanolic acid 3- O - β -D - glucopyranosyl-(1→2)-[ α -L-rhamnopyranosyl-(1→3)]- β -D-glucuronopyranoside ( 9 ), oleanolic acid 3- O - α -L-rhamnopyranosyl-(1→3)- β -D-glucuronopyranoside ( 10 ), blumenol C glucoside ( 11 ), citroside A ( 12 ), 6 S ,9 S -roseoside ( 13 ), ginsenoside Rg1 ( 14 ), 20-hydroxyecdysone ( 15 ), and benzyl α -L-rhamnopyranosyl-(1→6)]- β -D-glucopyranoside ( 16 ) by spectroscopic analysis. Compounds 1 , 7 and 11-16 inhibited NO production in LPS-activated RAW264.7 cells with IC 50 values in the range from 28.03 to 54.23 µM (positive control, L-NMMA: IC 50 = 35.52 µM). Compounds 14 and 15 showed anti α -glucosidase activity with IC 50 values of 176.24 and 156.92 µM, respectively, compared with the positive control, acarbose, IC 50 = 160.99 μM.

Background and Aims: Job satisfaction of healthcare workers from conventional and university hospitals (or teaching hospitals) might be different due to several factors, for example medical staff required to carry out multiple clinical and teaching tasks simultaneously. Our study aimed to determine how the job satisfaction among healthcare workers in university hospitals is different from those in conventional hospitals., Methods: A cross-sectional study was conducted by using the validated and contextualized job satisfaction tool for the Vietnamese context to survey 216 healthcare workers at a university hospital in Vietnam from January to March 2020 with online Google forms., Results: The results indicated low overall job satisfaction (43.1%) in our study university hospital with the score cutoff of 80%. However, healthcare workers still reported high job satisfaction rates in certain aspects, such as personal empathy (70.8%), discipline, and reward (67.6%), co-worker collaboration (65.3%), training and promotion (63%), workplace environment (57.4%), and salary and allowance (44.9%). Subgroup analysis revealed statistically significant differences in job satisfaction ( p  < 0.01) related to age (31 to 40-year-old), and job position with ORs 3.9, and 8.6 respectively., Conclusion: University hospitals need to improve the healthcare workers' job satisfaction. It is recommended that special human resource strategies should be developed focusing on keeping satisfying older healthcare staff by recognizing their contributions and providing appropriate benefits based on their positions in the hospital., Competing Interests: The authors declare no conflict of interest., (© 2024 The Authors. Health Science Reports published by Wiley Periodicals LLC.)

Introduction: Patient safety is a global challenge of preventing and mitigating medical errors which might harm patients during their course of treatment and care. This study was employed to contribute to the existing literature aimed to assess patient safety culture among health staff and to determine predictors of health staff perceptions of patient safety in hospitals in Vietnam., Methods: A cross-sectional study was conducted in three hospitals of Vietnam with a total of 763 participants. This study used the Hospital Patient Safety Scale developed by the American Health and Quality Research Organization., Results: In general, 8 of 12 patient safety dimensions in two hospital; and 10 of 12 dimensions in a third hospital had average scores of 60% and above positive responses. The communication openness and organizational learning dimensions were found to be significant different when comparing hospitals. Regarding sample characteristics, department (subclinical department) and health staff positions (nurses/technicians, pharmacists) were significant predictors in the total model including three hospitals ( R 2  = 0.07)., Conclusion: This study reported that communication openness and organization learning are two aspects that need to be improved they are strongly related to patient safety culture and to knowledge exchange among health staff. It has been suggested that hospitals should deliver patient safety training courses and establish a supportive learning environment to improve these challenges., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Thu, Anh, Ha, Tien, Giang, Nga, Nam and Hung.)

One new phenylpropanoid glycoside, tinosinen A ( 1 ) and 13 known compounds, tinosinen ( 2 ), citrusin B ( 3 ), picraquassioside C ( 4 ), erythro -guaiacylglycerol- β - O -4'-coniferyl alcohol ( 5 ), erythro -guaiacylglycerol-8- O -4'-(sinapyl alcohol) ether ( 6 ), erythro -syringylglycerol-8- O -4'-(sinapyl alcohol) ether ( 7 ), seco -isolariciresinol 9- O -D- β -glucopyranoside ( 8 ), tinosposide A ( 9 ), pinoresinol-4'- O-β -D-glucopyranoside ( 10 ), syringaresinol-4'- O - β -D-glucopyranoside ( 11 ), pinoresinol ( 12 ), syringaresinol ( 13 ), and lirioresino- β -dimethyl ether ( 14 ) were isolated from the stems of Tinospora sinensis (Lour.) Merr. Their structures were established by detailed spectroscopic studies and comparisons with those reported in the literature. Compound 13 showed significant inhibitory NO production (IC 50 value of 38.53 ± 1.90 μM) in RAW264.7 macrophages, LPS-stimulated. Compounds 3 - 7 , 11 , 12 , and 14 inhibited NO production with IC 50 values ranging from 38.53 to 99.07 μM.

A new furostane saponin, ramosaponin ( 1 ), and four known furostane saponins, protodioscin ( 2 ), dehydrotomatoside ( 3 ), (25  R )-26- O -( β -D-glucopyranosyl)-furost-5-ene-3 β ,22 α ,26-triol 3- O - β -D-glucopyranosyl-(1→4)- β -D-galactopyranoside ( 4 ), and anguivioside A ( 5 ) were isolated from the methanol extract of Allium ramosum seeds. Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for reduction of lipid accumulation in HepG2 cell line. As a result, compound 1 showed significant lipid accumulation inhibitory activity with an IC 50 value of 64.32 ± 3.87 µM.

Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids ( 1-6 ) and five lignans ( 7-11 ) including a new pre-schisanartane-type, schisandrathera A ( 1 ), a new dibenzocyclooctadiene glycoside, schisandrathera B ( 7 ) and two new lignans, schisandrathera C ( 8 ) and schisandrathera D ( 9 ). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (prostate cancer) and MCF7 (breast cancer) cell lines. Among these compounds, schirubrisin B ( 3 ) showed strong cytotoxic effect on both PC3 and MCF7 cell lines with IC 50 values of 3.21 ± 0.68, 13.30 ± 0.68 μM, respectively, whereas ten remaining compounds were found to be less effective in the investigated models.

Background: Previous studies have observed lower utilization of maternal healthcare services by ethnic minority groups in Vietnam compared with the majority Kinh community. This study sought to assess the utilization of maternal healthcare service-associated factors within 12 ethnic minority groups., Method: The cross-sectional study enrolled 996 women from 12 ethnic minority groups in Vietnam in 2019. Women had pregnancy outcomes in the last 5 years. The two variables for maternal healthcare utilization were [1] a minimum of four antenatal contacts and [2] health facility-based delivery. We examined the association of individual characteristics of maternal healthcare services using multilevel modeling. Odds ratios (ORs) and 95% confidence intervals (CIs) were reported., Results: This nationally representative study found that 34.1% of women from ethnic minority backgrounds had four or more antenatal contacts during pregnancy, ranging from 8.3% in Mong community to 80.2% in Cham An Giang. Most of the women (94.4%) delivered at health facilities. Factors independently correlated with having fewer than four antenatal contacts included being illiterate, early marriage, unemployment, religious affiliation, household economy, and distance to the nearest health facility. Factors significantly associated with home delivery were living in the most disadvantaged areas and having fewer than four antenatal contacts., Conclusion: Substantial inequity exists in antenatal coverage both within ethnic minority groups and between socio-economic groups. The low coverage of having at least four antenatal contacts and its' correlates with facility-based delivery suggests that the government should focus efforts on increasing the number of antenatal contacts for ethnic minority women.

Out-of-pocket payment is one of the indicators measuring the achievement of Universal Health Coverage. According to the World Health Organization, for countries from the Asia Pacific Region, out-of-pocket payments should not exceed 30%-40% of total health expenditure. This study aimed to identify factors influencing out-of-pocket payment for the near-poor for outpatient healthcare services as well as across health facilities at different levels. The data of 1143 individuals using outpatient care were used for analysis. Healthcare payments were analyzed for those who sought outpatient care in the past 6 months. The Heckman selection model was used to control any bias resulting from self-selection of the insurance scheme. The finding revealed that health insurance reduces average out-of-pocket payments by about 21% ( P  < .001). Using private health facilities incurred more out-of-pocket payments than public health facilities ( P  < .001). The study suggested that health insurance for the near-poor should be modified to promote universal health coverage in Vietnam., Competing Interests: Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2021.)

The aim of this study was to report the prevalence of self-reported non-communicable diseases among ethnic minority populations in Vietnam and related factors. A total of 5033 individuals aged 15 years and older who belonged to ethnic minority populations from 12 provinces in Vietnam completed a household survey. The overall prevalence of self-reported non-communicable diseases was 12.4% (95% CI: 11.5%-13.4%). Cardiovascular diseases were the most prevalent, followed by diabetes. Ethnicity was shown to have an independently significant correlation to having any non-communicable diseases. Older people, near-poor and non-poor people had significantly higher odds of having non-communicable diseases as compared to younger and poor people., Competing Interests: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2020.)

Out-of-pocket expenditure/payment (OOP) is one of the indicators measuring the achievement of Universal Health Coverage. This article aimed to compare OOP among the insured and uninsured for their outpatient and inpatient health care services. The data of 6710 individuals using outpatient care and 924 individuals using inpatient care at 78 district hospitals and 246 commune health centers in 6 provinces from the World Bank survey, "The 2015 Vietnam District and Commune Health Facility," were used for analysis. In the ordinary least square model, the estimated coefficient of the insurance status variable suggested that insurance reduced OOP by 31.1% for outpatient care and 31.5% for inpatient care of the insured as compared with the uninsured ( P <0.001). For outpatient care, insurance reduced OOP more for those enrollees using commune health centers than those using district health facilities, 42.3% and 20.2%, respectively. For inpatient care at district health facilities, insurance reduced OOP by 34.9% as compared with the uninsured ( P <0.001). The study suggested that more active solutions should be created to promote the universal health insurance in Vietnam.

Background : Injection is one of the most frequently used medical methods to introduce drugs or other substances into the body for purposes of treatment or prevention. Unsafe injection can cause adverse outcomes, such as abscess and anaphylactic shock, and increases the risk of blood-borne transmission of viruses to patients and health care workers, as well as the community. Recognizing the importance of injection safety, in 2000 the Vietnamese Ministry of Health (MOH) collaborated with the Vietnam Nurses Association to launch the "Safe injection" program throughout the country, including Hanoi. Methods : This cross-sectional study, combining quantitative and qualitative analysis, was conducted from February to August 2012 in Ha Dong General Hospital using a structured questionnaire and observation checklist. The target population of the study was 109 nurses working in clinical departments and 436 injections were observed. Results : The percentage of nurses who are familiar with injection safety standards was found to be 82.6%. The proportion of practical injections that met the 23 standards of injection safety set by the MOH amounted to 22.2%. The factors related to safe injection practice of nurses who are younger age group (OR=3.1; p<0.05) and lower amount of working years (OR=2.8; p<0.05). Conclusions : Despite the high level of knowledge about safety injection, a low proportion of nurses performed correct safety injection practice. Moreover, the results demonstrated that experience might not always guarantee better practice. The findings raise the need for further training about this issue, especially among older nurses., Competing Interests: Competing interests: No competing interests were disclosed.

Background : Injection is one of the most frequently used medical methods to introduce drugs or other substances into the body for purposes of treatment or prevention. Unsafe injection can cause adverse outcomes, such as abscess and anaphylactic shock, and increases the risk of blood-borne transmission of viruses to patients and health care workers, as well as the community. Recognizing the importance of injection safety, in 2000 the Vietnamese Ministry of Health (MOH) collaborated with the Vietnam Nurses Association to launch the "Safe injection" program throughout the country, including Hanoi. Methods : This cross-sectional study, combining quantitative and qualitative analysis, was conducted from February to August 2012 in Ha Dong General Hospital using a structured questionnaire and observation checklist. The target population of the study was 109 nurses working in clinical departments and 436 injections were observed. Results : The percentage of nurses who are familiar with injection safety standards was found to be 82.6%. The proportion of practical injections that met the 23 standards of injection safety set by the MOH amounted to 22.2%. The factors related to safe injection practice of nurses who are younger age group (OR=3.1; p<0.05) and lower amount of working years (OR=2.8; p<0.05). Conclusions : Despite the high level of knowledge about safety injection, a low proportion of nurses performed correct safety injection practice. Moreover, the results demonstrated that experience might not always guarantee better practice. The findings raise the need for further training about this issue, especially among older nurses., Competing Interests: Competing interests: No competing interests were disclosed.

Background : Injection is one of the most frequently used medical methods to introduce drugs or other substances into the body for purposes of treatment or prevention. Unsafe injection can cause adverse outcomes, such as abscess and anaphylactic shock, and increases the risk of blood-borne transmission of viruses to patients and health care workers, as well as the community. Recognizing the importance of injection safety, in 2000 the Vietnamese Ministry of Health (MOH) collaborated with the Vietnam Nurses Association to launch the "Safe injection" program throughout the country, including Hanoi. Methods : This cross-sectional study, combining quantitative and qualitative analysis, was conducted from February to August 2012 in Ha Dong General Hospital using a structured questionnaire and observation checklist. The target population of the study was 109 nurses working in clinical departments and 436 injections were observed. Results : The percentage of nurses who are familiar with injection safety standards was found to be 82.6%. The proportion of practical injections that met the 23 standards of injection safety set by the MOH amounted to 22.2%. The factors related to safe injection practice of nurses who were younger age group (OR=3.1; p<0.05) and fewer number of years working as a nurse (OR=2.8; p<0.05). Conclusions : While nurses have high level of knowledge about safe injections but a small proportion actually practiced. Experience may not always guarantee safe practices.  Injection safety training should be regularly imparted upon all categories of nurses., Competing Interests: No competing interests were disclosed.

Background: Injection is one of the most frequently used medical methods to introduce drugs or other substances into the body for purposes of treatment or prevention. Unsafe injection can cause adverse outcomes, such as abscess and anaphylactic shock, and increases the risk of blood-borne transmission of viruses to patients and health care workers, as well as the community. Recognizing the importance of injection safety, in 2000 the Vietnamese Ministry of Health (MOH) collaborated with the Vietnam Nurses Association to launch the "Safe injection" program throughout the country, including Hanoi. Methods: This cross-sectional study, combining quantitative and qualitative analysis, was conducted from February to August 2012 in Ha Dong General Hospital using a structured questionnaire and observation checklist. The target population of the study was 109 nurses working in clinical departments and 436 injections were observed. Results: The percentage of nurses who are familiar with injection safety standards was found to be 82.6%. The proportion of practical injections that met the 23 standards of injection safety set by the MOH amounted to 22.2%. The factors related to safe injection practice of nurses who are younger age group (OR=3.1; p<0.05) and lower amount of working years (OR=2.8; p<0.05). Conclusions: A low proportion of nurses performed correct safety injection practice, which raises the need for further training about this issue, especially among older nurses., Competing Interests: Competing interests: No competing interests were disclosed.

Stigma and discrimination experienced by nurses infected with human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV) potentially undermine their positions. The aim of this study was to determine the factors associated with nurses’ attitudes towards accepting co-workers with HIV, HBV, or HCV. The study design was descriptive and cross-sectional. Four hundred Vietnamese nurses participated in this study using stratified random sampling at two public hospitals in Hanoi, Vietnam. A self-administrated questionnaire was used to obtain data. Descriptive statistics and multivariable logistic regression was performed to analyze data. Nine percent of nurses had experienced a needle-stick or sharps injury (NSI) from a patient infected with HIV, and 15.8% of respondents reported having a previous NSI from a patient infected with HBV or HCV. Some nurses reported that they could not accept contact between patients and nurses infected with HIV (25.2%) and HBV or HCV (12.7%). Older age and a belief that colleagues should disclose their infection status were associated with positive attitudes towards HIV-, HBV-, or HCV-positive colleagues. Fear of transmission was associated with negative attitudes towards HIV-positive co-workers. Infected employees disclosure of their status may help their colleagues to be more accepting by providing appropriate workplace adjustments for infected employees. HIV is generally a more stigmatized infection, and therefore attitudes towards HIV-positive co-workers might be affected by fear of transmission. Providing education to recognize infectious risk may be effective in improving nurses’ attitudes in Vietnam, as elsewhere.