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[Objectives] This study was conducted to explore the relationship between neutrophil percentage-to-albumin ratio (NPAR) and coronary heart disease complicated with diabetes. [Methods] A total of 603 patients with coronary heart disease who underwent coronary angiography in Pingquan County Hospital from January, 2023 to December, 2023 and met the inclusion criteria were included as the research object. All the patients were divided into a coronary heart disease complicated with diabetes group (CAD +T2DM group) (n=298 cases) and a control group (CAD group) (n=305 cases), according to patients' medical history, heart color ultrasound and biochemical test results. The clinical data, biochemical test results and coronary artery imaging data of patients were recorded, and the Gensini score was calculated. The neutrophil percentage (NEUT% ) and albumin count were determined to calculate NPAR. [Results] The NPAR value of the coronary heart disease complicated with diabetes mellitus group was (1. 6 ± 0. 42), which was significantly higher than that of the control group (1.47 ±0.49), and the difference was statistically significant (P<0.05). The area under the ROC curve was 0.619 (95% CI: 0.591-0.675, P < 0. 05), and the prediction of coronary heart disease complicated with diabetes using NPAR showed a Youden index of 0. 31, a sensitivity of 60.4%, a specificity of 40.3%, and a best cut-off score of 1.450 6. [Conclusions] The neutrophil percentage-to-albumin ratio (NPAR) is closely related to coronary heart disease complicated with diabetes mellitus, and NPAR has clinical application value in the diagnosis of coro-nary heart disease complicated with diabetes mellitus. [ABSTRACT FROM AUTHOR]