35,428 results on '"Anker A"'
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2. Modeling and In-flight Torso Attitude Stabilization of a Jumping Quadruped
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Papadakis, Michail, Olsen, Jørgen Anker, Poulakakis, Ioannis, and Alexis, Kostas
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Computer Science - Robotics - Abstract
This paper addresses the modeling and attitude control of jumping quadrupeds in low-gravity environments. First, a convex decomposition procedure is presented to generate high-accuracy and low-cost collision geometries for quadrupeds performing agile maneuvers. A hierarchical control architecture is then investigated, separating torso orientation tracking from the generation of suitable, collision-free, corresponding leg motions. Nonlinear Model Predictive Controllers (NMPCs) are utilized in both layers of the controller. To compute the necessary leg motions, a torque allocation strategy is employed that leverages the symmetries of the system to avoid self-collisions and simplify the respective NMPC. To plan periodic trajectories online, a Finite State Machine (FSM)-based weight switching strategy is also used. The proposed controller is first evaluated in simulation, where 90 degree rotations in roll, pitch, and yaw are stabilized in 6.3, 2.4, and 5.5 seconds, respectively. The performance of the controller is further experimentally demonstrated by stabilizing constant and changing orientation references. Overall, this work provides a framework for the development of advanced model-based attitude controllers for jumping legged systems., Comment: 16 pages, 10 figures, to appear at the International Symposium of Robotics Research (ISRR) 2024. Paper site: https://michalispapadakis.github.io/mpc_olympus/
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- 2024
3. Hysteresis Behind A Bottleneck With Location-Dependent Capacity
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Hammerl, Alexander, Seshadri, Ravi, Rasmussen, Thomas Kjær, and Nielsen, Otto Anker
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Condensed Matter - Statistical Mechanics - Abstract
Macroscopic fundamental diagrams (MFDs) and related network traffic dynamics models have received both theoretical support and empirical validation with the emergence of new data collection technologies. However, the existence of well-defined MFD curves can only be expected for traffic networks with specific topologies and is subject to various disturbances, most importantly hysteresis phenomena. This study aims to improve the understanding of hysteresis in Macroscopic Fundamental Diagrams and Network Exit Functions (NEFs) during rush hour conditions. We apply the LWR theory to a highway corridor featuring a location-dependent downstream bottleneck to identify a figure-eight hysteresis pattern, clockwise on the top and counter-clockwise on the bottom. We discuss why this general pattern is rare in practical scenarios, where a single clockwise loop is more typical. The paper discusses the impact of the road topology and demand parameters on the formation and intensity of hysteresis loops analytically. To substantiate these findings, we employ numerical simulations using the Cell Transmission Model (CTM). Our simulations show that even a slight reduction in the capacity of the homogeneous section can significantly decrease MFD hysteresis while maintaining outflow at the corridor's downstream end. These reductions can be achieved with minimal intervention through standard traffic control measures, such as dynamic speed limits or ramp metering.
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- 2024
4. Imaging of single barium atoms in a second matrix site in solid xenon for barium tagging in a $^{136}$Xe double beta decay experiment
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Yvaine, M., Fairbank, D., Soderstrom, J., Taylor, C., Stanley, J., Walton, T., Chambers, C., Iverson, A., Fairbank, W., Kharusi, S. Al, Amy, A., Angelico, E., Anker, A., Arnquist, I. J., Atencio, A., Bane, J., Belov, V., Bernard, E. P., Bhatta, T., Bolotnikov, A., Breslin, J., Breur, P. A., Brodsky, J. P., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cesmecioglu, D., Chambers, E., Chana, B., Chernyak, D., Chiu, M., Collister, R., Cvitan, M., Daniels, T., Darroch, L., DeVoe, R., di Vacri, M. L., Dolinski, M. J., Eckert, B., Elbeltagi, M., Elmansali, R., Fatemighomi, N., Foust, B., Fu, Y. S., Gallacher, D., Gallice, N., Giacomini, G., Gillis, W., Gingras, C., Gornea, R., Gratta, G., Hardy, C. A., Hedges, S., Hein, E., Holt, J. D., Hoppe, E. W., Karelin, A., Keblbeck, D., Kotov, I., Kuchenkov, A., Kumar, K. S., Kwiatkowski, A. A., Larson, A., Latif, M. B., Leach, K. G., Lennarz, A., Leonard, D. S., Lewis, H., Li, G., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Majidi, S., Malbrunot, C., Masbou, J., McMichael, K., Peregrina, M. Medina, Moe, M., Mong, B., Moore, D. C., Natzke, C. R., Ngwadla, X. E., Ni, K., Nolan, A., Nowicki, S. C., Ondze, J. C. Nzobadila, Odian, A., Orrell, J. L., Ortega, G. S., Overman, C. T., Pagani, L., Smalley, H. Peltz, Perna, A., Pocar, A., Radeka, V., Raguzin, E., Rasiwala, H., Ray, D., Rescia, S., Richardson, G., Ross, R., Rowson, P. C., Saldanha, R., Sangiorgio, S., Schwartz, S., Sekula, S., Si, L., Soma, A. K., Spadoni, F., Stekhanov, V., Sun, X. L., Thibado, S., Tidball, A., Totev, T., Triambak, S., Tsang, T., Tyuka, O. A., van Bruggen, E., Vidal, M., Walent, M., Wamba, K., Wang, H. W., Wang, Q. D., Wang, W., Wang, Y. G., Watts, M., Wehrfritz, M., Wen, L. J., Wichoski, U., Wilde, S., Worcester, M., Xu, H., Yang, L., Yu, M., and Zeldovich, O.
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Physics - Atomic Physics ,High Energy Physics - Experiment ,Nuclear Experiment - Abstract
Neutrinoless double beta decay is one of the most sensitive probes for new physics beyond the Standard Model of particle physics. One of the isotopes under investigation is $^{136}$Xe, which would double beta decay into $^{136}$Ba. Detecting the single $^{136}$Ba daughter provides a sort of ultimate tool in the discrimination against backgrounds. Previous work demonstrated the ability to perform single atom imaging of Ba atoms in a single-vacancy site of a solid xenon matrix. In this paper, the effort to identify signal from individual barium atoms is extended to Ba atoms in a hexa-vacancy site in the matrix and is achieved despite increased photobleaching in this site. Abrupt fluorescence turn-off of a single Ba atom is also observed. Significant recovery of fluorescence signal lost through photobleaching is demonstrated upon annealing of Ba deposits in the Xe ice. Following annealing, it is observed that Ba atoms in the hexa-vacancy site exhibit antibleaching while Ba atoms in the tetra-vacancy site exhibit bleaching. This may be evidence for a matrix site transfer upon laser excitation. Our findings offer a path of continued research toward tagging of Ba daughters in all significant sites in solid xenon., Comment: 9 pages, 8 figures
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- 2024
5. Supernova electron-neutrino interactions with xenon in the nEXO detector
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nEXO Collaboration, Hedges, S., Kharusi, S. Al, Angelico, E., Brodsky, J. P., Richardson, G., Wilde, S., Amy, A., Anker, A., Arnquist, I. J., Arsenault, P., Atencio, A., Badhrees, I., Bane, J., Belov, V., Bernard, E. P., Bhatta, T., Bolotnikov, A., Breslin, J., Breur, P. A., Brown, E., Brunner, T., Caden, E., Cao, G. F., Cao, L. Q., Cesmecioglu, D., Chambers, E., Chana, B., Charlebois, S. A., Chernyak, D., Chiu, M., Collister, R., Cvitan, M., Dalmasson, J., Daniels, T., Darroch, L., DeVoe, R., di Vacri, M. L., Ding, Y. Y., Dolinski, M. J., Eckert, B., Elbeltagi, M., Elmansali, R., Fabris, L., Fairbank, W., Farine, J., Fatemighomi, N., Foust, B., Fu, Y. S., Gallacher, D., Gallice, N., Gillis, W., Goeldi, D., Gorham, A., Gornea, R., Gratta, G., Guan, Y. D., Hardy, C. A., Heffner, M., Hein, E., Holt, J. D., Hoppe, E. W., House, A., Hunt, W., Iverson, A., Kachru, P., Karelin, A., Keblbeck, D., Kuchenkov, A., Kumar, K. S., Larson, A., Latif, M. B., Leach, K. G., Lenardo, B. G., Leonard, D. S., Lewis, H., Li, G., Li, Z., Licciardi, C., Lindsay, R., MacLellan, R., Majidi, S., Malbrunot, C., Martel-Dion, P., Masbou, J., McMichael, K., Medina-Peregrina, M., Mong, B., Moore, D. C., Nattress, J., Natzke, C. R., Ngwadla, X. E., Ni, K., Nolan, A., Nowicki, S. C., Ondze, J. C. Nzobadila, Orrell, J. L., Ortega, G. S., Overman, C. T., Pagani, L., Smalley, H. Peltz, Peña-Perez, A., Perna, A., Piepke, A., Franco, T. Pinto, Pocar, A., Pratte, J. -F., Rasiwala, H., Ray, D., Raymond, K., Rescia, S., Riot, V., Ross, R., Saldanha, R., Sangiorgio, S., Schwartz, S., Sekula, S., Soderstrom, J., Soma, A. K., Spadoni, F., Sun, X. L., Thibado, S., Tidball, A., Totev, T., Triambak, S., Tsang, R. H. M., Tyuka, O. A., van Bruggen, E., Vidal, M., Viel, S., Walent, M., Wang, Q. D., Wang, W., Wang, Y. G., Watts, M., Wehrfritz, M., Wei, W., Wen, L. J., Wichoski, U., Wu, X. M., Xu, H., Yang, H. B., Yang, L., Yu, M., Yvaine, M., Zeldovich, O., and Zhao, J.
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment ,Nuclear Theory - Abstract
Electron-neutrino charged-current interactions with xenon nuclei were modeled in the nEXO neutrinoless double-$\beta$ decay detector (~5 metric ton, 90% ${}^{136}$Xe, 10% ${}^{134}$Xe) to evaluate its sensitivity to supernova neutrinos. Predictions for event rates and detectable signatures were modeled using the Model of Argon Reaction Low Energy Yields (MARLEY) event generator. We find good agreement between MARLEY's predictions and existing theoretical calculations of the inclusive cross sections at supernova neutrino energies. The interactions modeled by MARLEY were simulated within the nEXO simulation framework and were run through an example reconstruction algorithm to determine the detector's efficiency for reconstructing these events. The simulated data, incorporating the detector response, were used to study the ability of nEXO to reconstruct the incident electron-neutrino spectrum and these results were extended to a larger xenon detector of the same isotope enrichment. We estimate that nEXO will be able to observe electron-neutrino interactions with xenon from supernovae as far as 5-8 kpc from Earth, while the ability to reconstruct incident electron-neutrino spectrum parameters from observed interactions in nEXO is limited to closer supernovae., Comment: 17 pages, 16 figures
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- 2024
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6. Report from the Workshop on Xenon Detector $0\nu\beta\beta$ Searches: Steps Towards the Kilotonne Scale
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Anker, A., Avasthi, A., Brodeur, M., Brunner, T., Byrnes, N. K., Catarineu, N. R., Cottle, A., Englezos, P., Fairbank, W., Díaz, D. González, Guenette, R., Haselschwardt, S. J., Hedges, S., Heffner, M., Holt, J. D., Jamil, A., Jones, B. J. P., Kawada, N., Leardini, S., Lenardo, B. G., Marc, A., Masbou, J., Mistry, K., Mong, B., Monreal, B., Moore, D. C., Nygren, D. R., Olcina, I., Orrell, J. L., Pocar, A., Richardson, G., Rogers, L., Saldanha, R., Sangiorgio, S., Wittweg, C., Xia, Q., Yang, L., and Zennamo, J.
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Nuclear Experiment - Abstract
These proceedings summarize the program and discussions of the ``Workshop on Xenon Detector $0\nu\beta\beta$ Searches: Steps Towards the Kilotonne Scale'' held on October 25-27 2023 at SLAC National Accelerator Laboratory. This workshop brought together experts from the communities of neutrinoless double-beta decay and dark matter detection, to discuss paths forward for the realization of monolithic experiments with xenon approaching the kilotonne scale., Comment: 7 pages, 2 figures. Proceedings
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- 2024
7. Waveguide and cavity quantum electrodynamics with topological bowtie modes
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Vladimirova, Anastasiia, Arregui, Guillermo, Lepeshov, Sergei, Rosiek, Christian Anker, Lahijani, Babak Vosoughi, and Stobbe, Søren
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Physics - Optics - Abstract
We present a theoretical study on photonic topological crystals whose symmetry is governed by quantum valley-Hall topological insulators and whose propagating edge modes are strongly confined due to bowtie geometries. Dielectric bowtie structures exploit the field discontinuities at boundaries between materials with different refractive indices, and here bowties emerge at the topological interface due to the close proximity of two triangular features in the underlying crystal. The topological bowtie mode features a unit-cell mode volume down to $8\times10^{-4}$ cubic wavelengths at the center of the bowtie bridge of width $10~\text{nm}$, and we show that it is possible to use perturbed versions of the unit cells as building blocks for topological heterostructure bowtie cavities with quality factors exceeding $10^7$. Due to the tightly confined bowtie mode, this implies a strongly enhanced light-matter interaction as quantified by a Purcell factor of $3 \times 10^6$.
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- 2024
8. Cephalopod-inspired jetting devices for gastrointestinal drug delivery
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Arrick, G., Sticker, D., Ghazal, A., Lu, Y., Duncombe, T., Gwynne, D., Mouridsen, B., Wainer, J., Jepsen, J. P. H., Last, T. S., Schultz, D., Hess, K., Medina De Alba, E., Min, S., Poulsen, M., Anker, C., Karandikar, P., Pedersen, H. D., Collins, J., Egecioglu, N. E., Tamang, S., Cleveland, C., Ishida, K., Uhrenfeldt, A. H., Kuosmanen, J., Pereverzina, M., Hayward, A., Kirk, R. K., You, S., Dalsgaard, C. M., Gunnarsson, S. B., Patsi, I., Bohr, A., Azzarello, A., Frederiksen, M. R., Herskind, P., Li, J., Roxhed, N., Rahbek, U. L., Water, J. J., Buckley, S. T., and Traverso, G.
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- 2024
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9. Evaluation of the Biological Effect of a Nicotinamide-Containing Broad-Spectrum Sunscreen on Photodamaged Skin
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Torres-Moral, Teresa, Tell-Martí, Gemma, Bague, Jaume, Rosés-Gibert, Pau, Calbet-Llopart, Neus, Mateu, Judit, Pérez-Anker, Javiera, Potrony, Míriam, Alejo, Beatriz, Iglesias, Pablo, Espinosa, Natalia, Orte Cano, Carmen, Cinotti, Elisa, Del Marmol, Véronique, Fontaine, Margot, Miyamoto, Makiko, Monnier, Jilliana, Perrot, Jean Luc, Rubegni, Pietro, Tognetti, Linda, Suppa, Mariano, Demessant-Flavigny, Anne Laure, Le Floc’h, Caroline, Prieto, Leonor, Malvehy, Josep, and Puig, Susana
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- 2024
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10. Finerenone in heart failure and chronic kidney disease with type 2 diabetes: FINE-HEART pooled analysis of cardiovascular, kidney and mortality outcomes
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Vaduganathan, Muthiah, Filippatos, Gerasimos, Claggett, Brian L., Desai, Akshay S., Jhund, Pardeep S., Henderson, Alasdair, Brinker, Meike, Kolkhof, Peter, Schloemer, Patrick, Lay-Flurrie, James, Viswanathan, Prabhakar, Lam, Carolyn S. P., Senni, Michele, Shah, Sanjiv J., Voors, Adriaan A., Zannad, Faiez, Rossing, Peter, Ruilope, Luis M., Anker, Stefan D., Pitt, Bertram, Agarwal, Rajiv, McMurray, John J. V., and Solomon, Scott D.
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- 2024
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11. The Impact of CO, C3H6, and SO2 on Cu-CHA and V2O5-WO3/TiO2 Catalysts for NH3-SCR for Close-Coupled Operation
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Hansen, Brian B., Hammershøi, Peter S., Fagerberg, Freja H., Hansen, Simon I., Sjøgren, Xenia B., Vennestrøm, Peter N. R., Jensen, Anker D., and Janssens, Ton V. W.
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- 2024
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12. Population Pharmacokinetics and Dose Optimization of Piperacillin in Infants and Children with Pneumonia
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Jirasomprasert, Totsapol, Tian, Li-Yuan, You, Dian-Ping, Wang, Ya-Kun, Dong, Lei, Zhang, Ya-Hui, Hao, Guo-Xiang, van den Anker, John, Wu, Yue-E, Tang, Bo-Hao, Zhao, Wei, and Zheng, Yi
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- 2024
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13. Prognostic value of post-operative iron biomarkers in colorectal cancer: population-based patient cohort
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Gwenzi, Tafirenyika, Schrotz-King, Petra, Anker, Sophie C., Schöttker, Ben, Hoffmeister, Michael, and Brenner, Hermann
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- 2024
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14. Hard Rock Absorption Measurements in the W-Band
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Shteinman, Alex, Anker, Yaakov, and Einat, Moshe
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- 2024
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15. CHILI: Chemically-Informed Large-scale Inorganic Nanomaterials Dataset for Advancing Graph Machine Learning
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Friis-Jensen, Ulrik, Johansen, Frederik L., Anker, Andy S., Dam, Erik B., Jensen, Kirsten M. Ø., and Selvan, Raghavendra
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Computer Science - Machine Learning ,Statistics - Machine Learning - Abstract
Advances in graph machine learning (ML) have been driven by applications in chemistry as graphs have remained the most expressive representations of molecules. While early graph ML methods focused primarily on small organic molecules, recently, the scope of graph ML has expanded to include inorganic materials. Modelling the periodicity and symmetry of inorganic crystalline materials poses unique challenges, which existing graph ML methods are unable to address. Moving to inorganic nanomaterials increases complexity as the scale of number of nodes within each graph can be broad ($10$ to $10^5$). The bulk of existing graph ML focuses on characterising molecules and materials by predicting target properties with graphs as input. However, the most exciting applications of graph ML will be in their generative capabilities, which is currently not at par with other domains such as images or text. We invite the graph ML community to address these open challenges by presenting two new chemically-informed large-scale inorganic (CHILI) nanomaterials datasets: A medium-scale dataset (with overall >6M nodes, >49M edges) of mono-metallic oxide nanomaterials generated from 12 selected crystal types (CHILI-3K) and a large-scale dataset (with overall >183M nodes, >1.2B edges) of nanomaterials generated from experimentally determined crystal structures (CHILI-100K). We define 11 property prediction tasks and 6 structure prediction tasks, which are of special interest for nanomaterial research. We benchmark the performance of a wide array of baseline methods and use these benchmarking results to highlight areas which need future work. To the best of our knowledge, CHILI-3K and CHILI-100K are the first open-source nanomaterial datasets of this scale -- both on the individual graph level and of the dataset as a whole -- and the only nanomaterials datasets with high structural and elemental diversity., Comment: 16 pages, 15 figures, 8 tables. Dataset is available at https://github.com/UlrikFriisJensen/CHILI
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- 2024
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16. The Blue Rose
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Anker, Suzanne, primary
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- 2024
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17. Pyrexia
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Anker, Suzanne, primary
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- 2024
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18. The Cultures of Entanglement: On Nonhuman Life Forms in Contemporary Art
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Anker, Suzanne, primary and Flach, Sabine, additional
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- 2024
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19. Cardiac wasting in patients with cancer
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Anker, Markus S., Rashid, Ahmed Mustafa, Butler, Javed, and Khan, Muhammad Shahzeb
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- 2024
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20. Assessing the potential impacts of public transport-based crowdshipping: A case study in a central district of Copenhagen
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Cheng, Rong, Fessler, Andreas, Nielsen, Otto Anker, Larsen, Allan, and Jiang, Yu
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- 2024
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21. Machine Learning Approach in Dosage Individualization of Isoniazid for Tuberculosis
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Tang, Bo-Hao, Zhang, Xin-Fang, Fu, Shu-Meng, Yao, Bu-Fan, Zhang, Wei, Wu, Yue-E., Zheng, Yi, Zhou, Yue, van den Anker, John, Huang, Hai-Rong, Hao, Guo-Xiang, and Zhao, Wei
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- 2024
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22. Machine Learning: A Potential Therapeutic Tool to Facilitate Neonatal Therapeutic Decision Making
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Tang, Bo-Hao, Li, Qiu-Yue, Liu, Hui-Xin, Zheng, Yi, Wu, Yue-E., van den Anker, John, Hao, Guo-Xiang, and Zhao, Wei
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- 2024
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23. Construction of Brooks-Lindenstrauss kernels on affine buildings of arbitrary reduced type, with applications
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Anker, Jean-Philippe, Rémy, Bertrand, and Trojan, Bartosz
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Mathematics - Classical Analysis and ODEs ,Mathematics - Dynamical Systems ,Mathematics - Group Theory ,Mathematics - Number Theory ,Mathematics - Representation Theory ,81Q50, 11F85, 37A44, 37D40, 22E45, 35P20 - Abstract
This article deals with harmonic analysis on affine buildings. Its main goal is to construct suitable kernels associated to a discrete multitemporal wave equations on the latter spaces, the long-standing motivation being to contribute to progress in arithmetic quantum unique ergodicity (AQUE) on certain Riemannian manifolds.
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- 2023
24. Sharp estimates for distinguished random walks on affine buildings of type Ar
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Anker, Jean-Philippe, Schapira, Bruno, and Trojan, Bartosz
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Mathematics - Classical Analysis and ODEs - Abstract
We study a distinguished random walk on affine buildings of type Ar , which was already considered by Cartwright, Saloff-Coste and Woess. In rank r=2, it is the simple random walk and we obtain optimal global bounds for its transition density (same upper and lower bound, up to multiplicative constants). In the higher rank case, we obtain sharp uniform bounds in fairly large space-time regions which are sufficient for most applications.
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- 2023
25. Terrain Recognition and Contact Force Estimation through a Sensorized Paw for Legged Robots
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Vangen, Aleksander, Barnwal, Tejal, Olsen, Jørgen Anker, and Alexis, Kostas
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Computer Science - Robotics - Abstract
This paper introduces the Terrain Recognition And Contact Force Estimation Paw, a compact and sensorized shoe designed for legged robots. The paw end-effector is made of silicon that deforms upon the application of contact forces, while an embedded micro camera is utilized to capture images of the deformed inner surface inside the shoe, and a microphone picks up audio signals. Processed through machine learning techniques, the images are mapped to compute an accurate estimate of the cumulative 3D force vector, while the audio signals are analyzed to identify the terrain class (e.g., gravel, snow). By leveraging its on-edge computation ability, the paw enhances the capabilities of legged robots by providing key information in real-time that can be used to adapt locomotion control strategies. To assess the performance of this novel sensorized paw, we conducted experiments on the data collected through a specially-designed testbed for force estimation, as well as data from recordings of the audio signatures of different terrains interacting with the paw. The results demonstrate the accuracy and effectiveness of the system, highlighting its potential for improving legged robot performance., Comment: 21st International Conference on Advanced Robotics (ICAR 2023)
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- 2023
26. Design and Experimental Verification of a Jumping Legged Robot for Martian Lava Tube Exploration
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Olsen, Jørgen Anker and Alexis, Kostas
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Computer Science - Robotics - Abstract
The potential of Martian lava tubes for resource extraction and habitat sheltering highlights the need for robots capable to undertake the grueling task of their exploration. Driven by this motivation, in this work we introduce a legged robot system optimized for jumping in the low gravity of Mars, designed with leg configurations adaptable to both bipedal and quadrupedal systems. This design utilizes torque-controlled actuators coupled with springs for high-power jumping, robust locomotion, and an energy-efficient resting pose. Key design features include a 5-bar mechanism as leg concept, combined with springs connected by a high-strength cord. The selected 5-bar link lengths and spring stiffness were optimized for maximizing the jump height in Martian gravity and realized as a robot leg. Two such legs combined with a compact body allowed jump testing of a bipedal prototype. The robot is 0.472 m tall and weighs 7.9 kg. Jump testing with significant safety margins resulted in a measured jump height of 1.141 m in Earth's gravity, while a total of 4 jumping experiments are presented. Simulations utilizing the full motor torque and kinematic limits of the design resulted in a maximum possible jump height of 1.52 m in Earth's gravity and 3.63 m in Mars' gravity, highlighting the versatility of jumping as a form of locomotion and overcoming obstacles in lower gravity., Comment: 21st International Conference on Advanced Robotics (ICAR 2023)
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- 2023
27. Martian Lava Tube Exploration Using Jumping Legged Robots: A Concept Study
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Olsen, Jørgen Anker and Alexis, Kostas
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Computer Science - Robotics - Abstract
In recent years, robotic exploration has become increasingly important in planetary exploration. One area of particular interest for exploration is Martian lava tubes, which have several distinct features of interest. First, it is theorized that they contain more easily accessible resources such as water ice, needed for in-situ utilization on Mars. Second, lava tubes of significant size can provide radiation and impact shelter for possible future human missions to Mars. Third, lava tubes may offer a protected and preserved view into Mars' geological and possible biological past. However, exploration of these lava tubes poses significant challenges due to their sheer size, geometric complexity, uneven terrain, steep slopes, collapsed sections, significant obstacles, and unstable surfaces. Such challenges may hinder traditional wheeled rover exploration. To overcome these challenges, legged robots and particularly jumping systems have been proposed as potential solutions. Jumping legged robots utilize legs to both walk and jump. This allows them to traverse uneven terrain and steep slopes more easily compared to wheeled or tracked systems. In the context of Martian lava tube exploration, jumping legged robots would be particularly useful due to their ability to jump over big boulders, gaps, and obstacles, as well as to descend and climb steep slopes. This would allow them to explore and map such caves, and possibly collect samples from areas that may otherwise be inaccessible. This paper presents the specifications, design, capabilities, and possible mission profiles for state-of-the-art legged robots tailored to space exploration. Additionally, it presents the design, capabilities, and possible mission profiles of a new jumping legged robot for Martian lava tube exploration that is being developed at the Norwegian University of Science and Technology., Comment: 74rd International Astronautical Congress (IAC)
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- 2023
28. Optimal bounds for the Dunkl kernel in the dihedral case
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Anker, Jean-Philippe and Trojan, Bartosz
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Mathematics - Classical Analysis and ODEs ,Mathematics - Representation Theory ,Primary 33E30, Secondary 17B22, 20F55 - Abstract
We establish sharp upper and lower estimates of the Dunkl kernel in the case of dihedral groups.
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- 2023
29. Efficacy and Safety of Vamorolone Over 48 Weeks in Boys With Duchenne Muscular Dystrophy: A Randomized Controlled Trial.
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Dang, Utkarsh, Damsker, Jesse, Guglieri, Michela, Clemens, Paula, Perlman, Seth, Smith, Edward, Horrocks, Iain, Finkel, Richard, Mah, Jean, Deconinck, Nicolas, Goemans, Nathalie, Haberlová, Jana, Straub, Volker, Mengle-Gaw, Laurel, Schwartz, Benjamin, Harper, Amy, Shieh, Perry, De Waele, Liesbeth, Castro, Diana, Yang, Michele, Ryan, Monique, Tulinius, Mar, Webster, Richard, Mcmillan, Hugh, Kuntz, Nancy, Rao, Vamshi, Baranello, Giovanni, Spinty, Stefan, Childs, Anne-Marie, Sbrocchi, Annie, Selby, Kathryn, Monduy, Migvis, Nevo, Yoram, Vilchez, Juan, Nascimento-Osorio, Andres, Niks, Erik, De Groot, Imelda, Katsalouli, Marina, Van Den Anker, John, Ward, Leanne, Leinonen, Mika, DAlessandro, Andrea, Hoffman, Eric, and McDonald, Craig
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Humans ,Male ,Biomarkers ,Muscular Dystrophy ,Duchenne ,Prednisone ,Pregnadienediols ,Child ,Preschool ,Child - Abstract
BACKGROUND AND OBJECTIVES: Vamorolone is a dissociative agonist of the glucocorticoid receptor that has shown similar efficacy and reduced safety concerns in comparison with prednisone in Duchenne muscular dystrophy (DMD). This study was conducted to determine the efficacy and safety of vamorolone over 48 weeks and to study crossover participants (prednisone to vamorolone; placebo to vamorolone). METHODS: A randomized, double-blind, placebo-controlled and prednisone-controlled clinical trial of 2 doses of vamorolone was conducted in participants with DMD, in the ages from 4 years to younger than 7 years at baseline. The interventions were 2 mg/kg/d of vamorolone and 6 mg/kg/d of vamorolone for 48 weeks (period 1: 24 weeks + period 2: 24 weeks) and 0.75 mg/kg/d of prednisone and placebo for the first 24 weeks (before crossover). Efficacy was evaluated through gross motor outcomes and safety through adverse events, growth velocity, body mass index (BMI), and bone turnover biomarkers. This analysis focused on period 2. RESULTS: A total of 121 participants with DMD were randomized. Vamorolone at a dose of 6 mg/kg/d showed maintenance of improvement for all motor outcomes to week 48 (e.g., for primary outcome, time to stand from supine [TTSTAND] velocity, week 24 least squares mean [LSM] [SE] 0.052 [0.0130] rises/s vs week 48 LSM [SE] 0.0446 [0.0138]). After 48 weeks, vamorolone at a dose of 2 mg/kg/d showed similar improvements as 6 mg/kg/d for North Star Ambulatory Assessment (NSAA) (vamorolone 6 mg/kg/d-vamorolone 2 mg/kg/d LSM [SE] 0.49 [1.14]; 95% CI -1.80 to 2.78, p = 0.67), but less improvement for other motor outcomes. The placebo to vamorolone 6 mg/kg/d group showed rapid improvements after 20 weeks of treatment approaching benefit seen with 48-week 6 mg/kg/d of vamorolone treatment for TTSTAND, time to run/walk 10 m, and NSAA. There was significant improvement in linear growth after crossover in the prednisone to vamorolone 6 mg/kg/d group, and rapid reversal of prednisone-induced decline in bone turnover biomarkers in both crossover groups. There was an increase in BMI after 24 weeks of treatment that then stabilized for both vamorolone groups. DISCUSSION: Improvements of motor outcomes seen with 6 mg/kg/d of vamorolone at 24 weeks of treatment were maintained to 48 weeks of treatment. Vamorolone at a dose of 6 mg/kg/d showed better maintenance of effect compared with vamorolone at a dose of 2 mg/kg/d for most (3/5) motor outcomes. Bone morbidities of prednisone (stunting of growth and declines in serum bone biomarkers) were reversed when treatment transitioned to vamorolone. TRIAL REGISTRATION INFORMATION: ClinicalTrials.gov Identifier: NCT03439670. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that for boys with DMD, the efficacy of vamorolone at a dose of 6 mg/kg/d was maintained over 48 weeks.
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- 2024
30. 100 ancient genomes show repeated population turnovers in Neolithic Denmark
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Allentoft, Morten E, Sikora, Martin, Fischer, Anders, Sjögren, Karl-Göran, Ingason, Andrés, Macleod, Ruairidh, Rosengren, Anders, Schulz Paulsson, Bettina, Jørkov, Marie Louise Schjellerup, Novosolov, Maria, Stenderup, Jesper, Price, T Douglas, Fischer Mortensen, Morten, Nielsen, Anne Birgitte, Ulfeldt Hede, Mikkel, Sørensen, Lasse, Nielsen, Poul Otto, Rasmussen, Peter, Jensen, Theis Zetner Trolle, Refoyo-Martínez, Alba, Irving-Pease, Evan K, Barrie, William, Pearson, Alice, Sousa da Mota, Bárbara, Demeter, Fabrice, Henriksen, Rasmus A, Vimala, Tharsika, McColl, Hugh, Vaughn, Andrew, Vinner, Lasse, Renaud, Gabriel, Stern, Aaron, Johannsen, Niels Nørkjær, Ramsøe, Abigail Daisy, Schork, Andrew Joseph, Ruter, Anthony, Gotfredsen, Anne Birgitte, Henning Nielsen, Bjarne, Brinch Petersen, Erik, Kannegaard, Esben, Hansen, Jesper, Buck Pedersen, Kristoffer, Pedersen, Lisbeth, Klassen, Lutz, Meldgaard, Morten, Johansen, Morten, Uldum, Otto Christian, Lotz, Per, Lysdahl, Per, Bangsgaard, Pernille, Petersen, Peter Vang, Maring, Rikke, Iversen, Rune, Wåhlin, Sidsel, Anker Sørensen, Søren, Andersen, Søren H, Jørgensen, Thomas, Lynnerup, Niels, Lawson, Daniel J, Rasmussen, Simon, Korneliussen, Thorfinn Sand, Kjær, Kurt H, Durbin, Richard, Nielsen, Rasmus, Delaneau, Olivier, Werge, Thomas, Kristiansen, Kristian, and Willerslev, Eske
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Biological Sciences ,Genetics ,History ,Heritage and Archaeology ,Human Society ,Archaeology ,Historical Studies ,Anthropology ,Humans ,Genomics ,Genotype ,Denmark ,Emigrants and Immigrants ,Scandinavians and Nordic People ,General Science & Technology - Abstract
Major migration events in Holocene Eurasia have been characterized genetically at broad regional scales1-4. However, insights into the population dynamics in the contact zones are hampered by a lack of ancient genomic data sampled at high spatiotemporal resolution5-7. Here, to address this, we analysed shotgun-sequenced genomes from 100 skeletons spanning 7,300 years of the Mesolithic period, Neolithic period and Early Bronze Age in Denmark and integrated these with proxies for diet (13C and 15N content), mobility (87Sr/86Sr ratio) and vegetation cover (pollen). We observe that Danish Mesolithic individuals of the Maglemose, Kongemose and Ertebølle cultures form a distinct genetic cluster related to other Western European hunter-gatherers. Despite shifts in material culture they displayed genetic homogeneity from around 10,500 to 5,900 calibrated years before present, when Neolithic farmers with Anatolian-derived ancestry arrived. Although the Neolithic transition was delayed by more than a millennium relative to Central Europe, it was very abrupt and resulted in a population turnover with limited genetic contribution from local hunter-gatherers. The succeeding Neolithic population, associated with the Funnel Beaker culture, persisted for only about 1,000 years before immigrants with eastern Steppe-derived ancestry arrived. This second and equally rapid population replacement gave rise to the Single Grave culture with an ancestry profile more similar to present-day Danes. In our multiproxy dataset, these major demographic events are manifested as parallel shifts in genotype, phenotype, diet and land use.
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- 2024
31. Association of an impaired GH-IGF-I axis with cardiac wasting in patients with advanced cancer
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Fröhlich, Ann-Kathrin, Porthun, Jan, Talha, Khawaja M., Lena, Alessia, Hadzibegovic, Sara, Wilkenshoff, Ursula, Sonntag, Frederike, Nikolski, Anja, Ramer, Luisa Valentina, Zeller, Tanja, Keller, Ulrich, Bullinger, Lars, Anker, Stefan D., Haverkamp, Wilhelm, von Haehling, Stephan, Doehner, Wolfram, Rauch, Ursula, Skurk, Carsten, Cleland, John G. F., Butler, Javed, Coats, Andrew J. S., Landmesser, Ulf, Karakas, Mahir, and Anker, Markus S.
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- 2024
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32. The PopHEAD study: a population-based, cross-sectional study on headache burden in Norway: methods and validation of questionnaire-based diagnoses
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Argren, Maria Bengtson, Engstrand, Helene, Husøy, Andreas Kattem, Zwart, John-Anker, and Winsvold, Bendik Slagsvold
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- 2024
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33. Regional ice flow piracy following the collapse of Midgaard Glacier in Southeast Greenland
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Huiban, Flora, Millan, Romain, Kjeldsen, Kristian Kjellerup, Andresen, Camilla S., Dømgaard, Mads, Dehecq, Amaury, Brunt, Stephen, Khan, Shfaqat Abbas, Mouginot, Jérémie, and Bjørk, Anders Anker
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- 2024
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34. Overweight and obesity as risk factors for chronic low back pain: a new follow-up in the HUNT Study
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Heuch, Ingrid, Heuch, Ivar, Hagen, Knut, and Zwart, John-Anker
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- 2024
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35. “What if the patient has a severe reaction, and it is my fault?” A qualitative study exploring factors for sustainable implementation of penicillin allergy delabelling
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Bjørbak Alnæs, Marie, Skodvin, Brita, Anker Jahnsen, Jan, Kalleklev Velure, Grete, Oppegaard, Oddvar, Reiakvam Kittang, Bård, Storaas, Torgeir, and Aase Schaufel, Margrethe
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- 2024
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36. Biomarker-guided acute kidney injury risk assessment under liberal versus restrictive fluid therapy - the prospective-randomized MAYDAY-trial
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Anker, Alexandra M., Ruewe, Marc, Prantl, Lukas, Baringer, Magnus, Pawlik, Michael T., Zeman, Florian, Goecze, Ivan, and Klein, Silvan M.
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- 2024
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37. Effect of empagliflozin on total myocardial infarction events by type and additional coronary outcomes: insights from the randomized EMPA-REG OUTCOME trial
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Fitchett, David, Zinman, Bernard, Inzucchi, Silvio E., Wanner, Christoph, Anker, Stefan D., Pocock, Stuart, Mattheus, Michaela, Vedin, Ola, and Lund, Søren S.
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- 2024
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38. Correction to: Anterior surgical treatment for cervical degenerative radiculopathy: a prediction model for non‑success
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Mjåset, Christer, Solberg, Tore K., Zwart, John‑Anker, Småstuen, Milada C., Kolstad, Frode, and Grotle, Margreth
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- 2024
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39. Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding
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Wenzel, Eva Maria, Pedersen, Nina Marie, Elfmark, Liv Anker, Wang, Ling, Kjos, Ingrid, Stang, Espen, Malerød, Lene, Brech, Andreas, Stenmark, Harald, and Raiborg, Camilla
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- 2024
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40. Prospective study to characterize adalimumab exposure in pediatric patients with rheumatic diseases
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Welzel, Tatjana, Golhen, Klervi, Atkinson, Andrew, Gotta, Verena, Ternant, David, Kuemmerle-Deschner, Jasmin B., Michler, Christine, Koch, Gilbert, van den Anker, Johannes N., Pfister, Marc, and Woerner, Andreas
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- 2024
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41. Evaluation of the Biological Effect of a Nicotinamide-Containing Broad-Spectrum Sunscreen on Photodamaged Skin
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Teresa Torres-Moral, Gemma Tell-Martí, Jaume Bague, Pau Rosés-Gibert, Neus Calbet-Llopart, Judit Mateu, Javiera Pérez-Anker, Míriam Potrony, Beatriz Alejo, Pablo Iglesias, Natalia Espinosa, Carmen Orte Cano, Elisa Cinotti, Véronique Del Marmol, Margot Fontaine, Makiko Miyamoto, Jilliana Monnier, Jean Luc Perrot, Pietro Rubegni, Linda Tognetti, Mariano Suppa, Anne Laure Demessant-Flavigny, Caroline Le Floc’h, Leonor Prieto, Josep Malvehy, and Susana Puig
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Collagen ,Nicotinamide ,Photodamage ,Dermatology ,RL1-803 - Abstract
Abstract Introduction UVA-UVB increases skin matrix metalloproteinases and breaks down extracellular proteins and fibrillar type 1 collagen, leading to photodamage. Topical application of nicotinamide prevents UV-induced immunosuppression. Several studies have demonstrated the importance of protection against UV. This study aims to determine the biological effect of a high broad-spectrum UVB-UVA sunscreen containing nicotinamide and panthenol (SSNP) on photodamaged skin using linear confocal optical coherence tomography (LC-OCT), immunohistochemistry, and RNA profiling. Methods Two areas of severely photodamaged forearm skin (L01 and L02) and one less sun-damaged (naturally protected) area on the inner part of the forearm (L03) were identified in 14 subjects. These areas were imaged using LC-OCT and L01 and L03 were biopsied at baseline. After 4 weeks of treatment with SSNP, L02 was reimaged using LC-OCT, and biopsied. Histology, immunostaining with p21, p53, PCNA, and CPD, and RNA sequencing were performed in all samples. Results LC-OCT analysis showed that epidermis thickness and the number of keratinocytes is higher in the sun-exposed areas than in the non-exposed areas. Comparing before and after treatment, even though there is a trend towards normalization, the differences were not statistically significant. The expression of p21, PCNA, p53, and CPD increased in severely photodamaged skin compared to less-damaged skin. When comparing before and after treatment, only p21 showed a trend to decrease expression. RNA sequencing analysis identified 1552 significant genes correlating with the progression from non-visibly photodamaged skin to post-treatment and pre-treatment samples; in the analysis comparing pre- and post-treatment samples, 5429 genes were found to be significantly associated. A total of 1115 genes are common in these two analyses. Additionally, nine significant genes from the first analysis and eight from the second are related to collagen. Six of these collagen genes are common in the two analyses. MAPK and cGMP-PKG signalling pathways are upregulated in the progression to photodamage analysis. In the pre- and post-treatment analysis, 32 pathways are downregulated after treatment, the most statistically significant being the ErbB, Hippo, NOD-like receptor, TNF, and NF-kB signalling pathways. Conclusion This study demonstrates the role of SSNP in collagen generation, highlights the relevance of the cGMP-PKG and MAPK signalling pathways in photodamage, and shows the ability of SSNP to downregulate pathways activated by UV exposure. Additionally, it deepens our understanding of the effect of SSNP on immune-related pathways.
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- 2024
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42. Regional ice flow piracy following the collapse of Midgaard Glacier in Southeast Greenland
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Flora Huiban, Romain Millan, Kristian Kjellerup Kjeldsen, Camilla S. Andresen, Mads Dømgaard, Amaury Dehecq, Stephen Brunt, Shfaqat Abbas Khan, Jérémie Mouginot, and Anders Anker Bjørk
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Science - Abstract
Abstract Southeast Greenland contributes significantly to global sea level rise, with mass loss having increased by about 600% over the past 30 years due to enhanced melt and dynamic instabilities of marine-terminating glaciers. Accurate modelling of glacier dynamics is crucial to minimise uncertainties in predictions of future sea level rise, necessitating detailed reconstructions of long-term glacial histories. One key complexity in these models that is not well understood or documented is ice flow piracy, where ice is redirected between catchment basins, significantly influencing regional glacier dynamics and mass balance. Here, we document and characterise the collapse of Midgaard Glacier in Southeast Greenland using a multi-data approach, providing a 90-year record of the area’s complex glacial history. Initiated over 80 years ago, this collapse triggered catchment-scale dynamic changes in several neighbouring glaciers, impacting local glacial stability throughout the 20th century and into the present. Our analysis reveals that catchment-scale ice flow piracy can cause substantial disturbances in mass balance evolution and catchment reconfigurations, independent of climatic conditions. These findings underscore the importance of understanding long-term changes in complex glacier systems to make accurate predictions of future glacial mass loss and associated sea-level rise.
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- 2024
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43. The PopHEAD study: a population-based, cross-sectional study on headache burden in Norway: methods and validation of questionnaire-based diagnoses
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Maria Bengtson Argren, Helene Engstrand, Andreas Kattem Husøy, John-Anker Zwart, and Bendik Slagsvold Winsvold
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Headache burden ,Epidemiology ,Methodology ,Migraine ,Tension type headache ,Medication overuse headache ,Medicine - Abstract
Abstract Background There is a lack of up-to-date information on the prevalence and burden of headache in Norway. Here we describe the methods and validation of the diagnostic tool of the PopHEAD study, a study designed to determine the prevalence and burden of migraine, tension-type headache, and medication-overuse headache. Method PopHEAD is a Norwegian population-based cross-sectional study conducted in Vestfold and Telemark County in 2023. A random sample of 28,753 individuals aged 18 to 70 was invited to participate. The study used a digital version of the Headache-Attributed Restriction, Disability, Social Handicap and Impaired Participation (HARDSHIP) questionnaire, translated into Norwegian using the Lifting The Burden translation protocol. A subsample of participants was contacted by telephone within four weeks for an interview with a headache neurologist blinded to the questionnaire responses. Headache disorders were diagnosed according to the criteria of the International Classification of Headache Disorders version 3. Validity was expressed by sensitivity, specificity and Cohen’s kappa (κ). Results In total, 8,265 (3,344 men and 4,921 women) responded. Most men (75.0%) and women (89.7%) reported having had a headache in the past year. Of 667 participants contacted for a telephone interview, 505 responded. The sensitivity and specificity of the questionnaire-based diagnoses were 97% and 72% for self-reported headache in the previous year (Cohen’s kappa κ = 0.72), 77% and 85% for migraine (κ = 0.61), 77% and 74% for tension-type headache (κ = 0.51), and 58% and 99% for medication-overuse headache (κ = 0.63), respectively. Conclusion The PopHEAD questionnaire is a valid tool for identifying individuals with lifetime headache, migraine, tension-type headache, and medication overuse headache.
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- 2024
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44. Survey on the knowledge and practices in anorexia of aging diagnosis and management in Japan
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Sahoko Takagi, Shosuke Satake, Ken Sugimoto, Masafumi Kuzuya, Masahiro Akishita, Hidenori Arai, Ivan Aprahamian, Andrew J. Coats, Tatiana Klompenhouwer, Stefan D. Anker, and Hidetaka Wakabayashi
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Anorexia of aging ,Continuing education ,Geriatric anorexia ,Healthcare professionals ,Older patients ,Diseases of the musculoskeletal system ,RC925-935 ,Human anatomy ,QM1-695 - Abstract
Abstract Background Anorexia of aging (AA) is a condition in older adults that includes loss of appetite and reduced food intake. There is a lack of detailed analysis of the potential influence of educational initiatives in addressing AA. This study aimed to clarify the current state of knowledge and practice regarding AA and its relationship with the availability of continuing education opportunities among Japanese healthcare professionals involved in treating older patients. Methods The Japan Geriatrics Society and the Japanese Association on Sarcopenia and Frailty, in collaboration with the Society on Sarcopenia, Cachexia, and Wasting Disorders, conducted an online questionnaire survey on the knowledge and practices in AA detection and management. Questions were asked in the areas of demographics, screening, definition/diagnosis, treatment, referral, and awareness, with those who ‘participate’ in continuing education and professional development programmes in nutrition for their patients were classified as the ‘education group’ and those who ‘do not participate’ were classified as the ‘non‐education group’. The results for each question were compared. Results The analysis included 870 participants (physicians, 48%; registered dietitians, 16%; rehabilitation therapists, 14%; pharmacists, 12%; nurses, 6%; and other professionals, 5%). The education group (45%) was more likely than the non‐education group (55%) to use the Mini‐Nutritional Assessment Short Form (MNA‐SF) to screen for AA (49% vs. 27%) and less likely not to use a validated tool (33% vs. 47%). More participants used evidence‐based tools and materials for AA care (38% vs. 12%), and fewer used their clinical judgement (23% vs. 35%) or were unaware of the tools and materials (9% vs. 23%). The proportion using a team of professionals experienced in AA care were 47% and 24% of the education and non‐education groups, respectively. By profession, few physicians used specific validated tools and resources for AA screening and treatment. More than half of the dietitians used the MNA‐SF regardless of training opportunity availability. Regarding professional availability and team use, differences in educational opportunities were particularly large among physicians. Conclusions Participation in continuing education programmes on nutrition is associated with responsiveness to AA screening and treatment and the availability of a team of professionals, which may influence the quality of AA treatment. Nutrition education may support the confidence of healthcare professionals working with older adults in AA with complex clinical signs and encourage them to conduct evidence‐based practice.
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- 2024
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45. In vivo fluid dynamics of the Ventura interatrial shunt device in patients with heart failure
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Michael Pfeiffer, John Boehmer, John Gorcsan, Shunsuke Eguchi, Yoshiyuki Orihara, Michal Laufer Perl, Neal Eigler, William T. Abraham, Julio Nuñez Villota, Elizabeth Lee, Antoni Bayés‐Genís, Gil Moravsky, Saibal Kar, Michael R. Zile, Richard Holcomb, Stefan D. Anker, Gregg W. Stone, Josep Rodés‐Cabau, JoAnn Lindenfeld, and Jeroen J. Bax
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Flow dynamics ,Heart failure ,Interatrial shunt ,Transesophageal echocardiography ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims Interatrial shunts are under evaluation as a treatment for heart failure (HF); however, their in vivo flow performance has not been quantitatively studied. We aimed to investigate the fluid dynamics properties of the 0.51 cm orifice diameter Ventura shunt and assess its lumen integrity with serial transesophageal echocardiography (TEE). Methods and results Computational fluid dynamics (CFD) and bench flow tests were used to establish the flow‐pressure relationship of the shunt. Open‐label patients from the RELIEVE‐HF trial underwent TEE at shunt implant and at 6 and 12 month follow‐up. Shunt effective diameter (Deff) was derived from the vena contracta, and flow was determined by the continuity equation. CFD and bench studies independently validated that the shunt's discharge coefficient was 0.88 to 0.89. The device was successfully implanted in all 97 enrolled patients; mean age was 70 ± 11 years, 97% were NYHA class III, and 51% had LVEF ≤40%. Patency was confirmed in all instances, except for one stenotic shunt at 6 months. Deff remained unchanged from baseline at 12 months (0.47 ± 0.01 cm, P = 0.376), as did the trans‐shunt mean pressure gradient (5.1 ± 3.9 mmHg, P = 0.316) and flow (1137 ± 463 mL/min, P = 0.384). TEE measured flow versus pressure closely correlated (R2 ≥ 0.98) with a fluid dynamics model. At 12 months, the pulmonary/systemic flow Qp/Qs ratio was 1.22 ± 0.12. Conclusions When implanted in patients with advanced HF, this small interatrial shunt demonstrated predictable and durable patency and performance.
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- 2024
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46. Wave equation on general noncompact symmetric spaces
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Anker, Jean-Philippe and Zhang, Hong-Wei
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- 2024
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47. Developing New Analysis Tools for Near Surface Radio-based Neutrino Detectors
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ARIANNA Collaboration, Anker, A., Baldi, P., Barwick, S. W., Beise, J., Besson, D. Z., Chen, P., Gaswint, G., Glaser, C., Hallgren, A., Hanson, J. C., Klein, S. R., Kleinfelder, S. A., Lahmann, R., Liu, J., Nam, J., Nelles, A., Paul, M. P., Persichilli, C., Plaisier, I., Rice-Smith, R., Tatar, J., Terveer, K., Wang, S. -H, and Zhao, L.
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Astrophysics - High Energy Astrophysical Phenomena ,Physics - Data Analysis, Statistics and Probability - Abstract
The ARIANNA experiment is an Askaryan radio detector designed to measure high-energy neutrino induced cascades within the Antarctic ice. Ultra-high-energy neutrinos above $10^{16}$ eV have an extremely low flux, so experimental data captured at trigger level need to be classified correctly to retain more neutrino signal. We first describe two new physics-based neutrino selection methods, (the updown and dipole cut) that extend the previously published analysis to a specialized ARIANNA station with 8 antenna channels, which is double the number used in the prior analysis. For a standard trigger with a threshold signal to noise ratio at 4.4, the new cuts produce a neutrino efficiency of > 95% per station-year, while rejecting 99.93% of the background (corresponding to 53 remaining experimental background events). When the new cuts are combined with a previously developed cut using neutrino waveform templates, all background is removed at no change of efficiency. In addition, the neutrino efficiency is extrapolated to 1,000 station-years, obtaining 91%. This work then introduces a new selection method (deep learning (DL) cut) to augment the identification of neutrino events by using DL methods and compares the efficiency to the physics-based analysis. The DL cut gives 99% signal efficiency per station-year of operation while rejecting 99.997% of the background (corresponding to 2 remaining experimental background events), which are then removed by the waveform template cut at no significant change in efficiency. The results of the DL cut were verified using measured cosmic rays which shows the simulations do not introduce artifacts with respect to experimental data. The paper demonstrates the background rejection and signal efficiency of near surface antennas meets the requirements of a large scale future array, as considered in baseline design of the radio component of IceCube-Gen2., Comment: 29 pages, 16 figures, 3 tables
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- 2023
48. Degradation of tetracycline, oxytetracycline & ampicillin by purified multiple copper oxidase like laccase from Stentrophomonas sp. YBX1
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Xu, Yanbin, Anker, Yaakov, and Talawar, Manjunatha P.
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- 2024
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49. Breast Lipofilling: Is the Bra Really Full? Clinical Bra Pressure Measurement and In Vitro Testing of Processed and Unprocessed Fat Cells
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Biermann, Niklas, Eigenberger, Andreas, Felthaus, Oliver, Brébant, Vanessa, Heine, Norbert, Brix, Eva, Spoerl, Steffen, Prantl, Lukas, Gurtner, Geoffrey, and Anker, Alexandra M.
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- 2024
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50. Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
- Author
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Nievergelt, Caroline M., Maihofer, Adam X., Atkinson, Elizabeth G., Chen, Chia-Yen, Choi, Karmel W., Coleman, Jonathan R. I., Daskalakis, Nikolaos P., Duncan, Laramie E., Polimanti, Renato, Aaronson, Cindy, Amstadter, Ananda B., Andersen, Soren B., Andreassen, Ole A., Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegoviç, Esmina, Babić, Dragan, Bacanu, Silviu-Alin, Baker, Dewleen G., Batzler, Anthony, Beckham, Jean C., Belangero, Sintia, Benjet, Corina, Bergner, Carisa, Bierer, Linda M., Biernacka, Joanna M., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Brandolino, Amber, Breen, Gerome, Bressan, Rodrigo Affonseca, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Børglum, Anders D., Børte, Sigrid, Cahn, Leah, Calabrese, Joseph R., Caldas-de-Almeida, Jose Miguel, Chatzinakos, Chris, Cheema, Sheraz, Clouston, Sean A. P., Colodro-Conde, Lucía, Coombes, Brandon J., Cruz-Fuentes, Carlos S., Dale, Anders M., Dalvie, Shareefa, Davis, Lea K., Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Desarnaud, Frank, DiPietro, Christopher P., Disner, Seth G., Docherty, Anna R., Domschke, Katharina, Dyb, Grete, Kulenović, Alma Džubur, Edenberg, Howard J., Evans, Alexandra, Fabbri, Chiara, Fani, Negar, Farrer, Lindsay A., Feder, Adriana, Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gelaye, Bizu, Gelernter, Joel, Geuze, Elbert, Gillespie, Charles F., Goleva, Slavina B., Gordon, Scott D., Goçi, Aferdita, Grasser, Lana Ruvolo, Guindalini, Camila, Haas, Magali, Hagenaars, Saskia, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M. J., Hesselbrock, Victor, Hickie, Ian B., Hogan, Kelleigh, Hougaard, David Michael, Huang, Hailiang, Huckins, Laura M., Hveem, Kristian, Jakovljević, Miro, Javanbakht, Arash, Jenkins, Gregory D., Johnson, Jessica, Jones, Ian, Jovanovic, Tanja, Karstoft, Karen-Inge, Kaufman, Milissa L., Kennedy, James L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kotov, Roman, Kranzler, Henry R., Krebs, Kristi, Kremen, William S., Kuan, Pei-Fen, Lawford, Bruce R., Lebois, Lauren A. M., Lehto, Kelli, Levey, Daniel F., Lewis, Catrin, Liberzon, Israel, Linnstaedt, Sarah D., Logue, Mark W., Lori, Adriana, Lu, Yi, Luft, Benjamin J., Lupton, Michelle K., Luykx, Jurjen J., Makotkine, Iouri, Maples-Keller, Jessica L., Marchese, Shelby, Marmar, Charles, Martin, Nicholas G., Martínez-Levy, Gabriela A., McAloney, Kerrie, McFarlane, Alexander, McLaughlin, Katie A., McLean, Samuel A., Medland, Sarah E., Mehta, Divya, Meyers, Jacquelyn, Michopoulos, Vasiliki, Mikita, Elizabeth A., Milani, Lili, Milberg, William, Miller, Mark W., Morey, Rajendra A., Morris, Charles Phillip, Mors, Ole, Mortensen, Preben Bo, Mufford, Mary S., Nelson, Elliot C., Nordentoft, Merete, Norman, Sonya B., Nugent, Nicole R., O’Donnell, Meaghan, Orcutt, Holly K., Pan, Pedro M., Panizzon, Matthew S., Pathak, Gita A., Peters, Edward S., Peterson, Alan L., Peverill, Matthew, Pietrzak, Robert H., Polusny, Melissa A., Porjesz, Bernice, Powers, Abigail, Qin, Xue-Jun, Ratanatharathorn, Andrew, Risbrough, Victoria B., Roberts, Andrea L., Rothbaum, Alex O., Rothbaum, Barbara O., Roy-Byrne, Peter, Ruggiero, Kenneth J., Rung, Ariane, Runz, Heiko, Rutten, Bart P. F., de Viteri, Stacey Saenz, Salum, Giovanni Abrahão, Sampson, Laura, Sanchez, Sixto E., Santoro, Marcos, Seah, Carina, Seedat, Soraya, Seng, Julia S., Shabalin, Andrey, Sheerin, Christina M., Silove, Derrick, Smith, Alicia K., Smoller, Jordan W., Sponheim, Scott R., Stein, Dan J., Stensland, Synne, Stevens, Jennifer S., Sumner, Jennifer A., Teicher, Martin H., Thompson, Wesley K., Tiwari, Arun K., Trapido, Edward, Uddin, Monica, Ursano, Robert J., Valdimarsdóttir, Unnur, Van Hooff, Miranda, Vermetten, Eric, Vinkers, Christiaan H., Voisey, Joanne, Wang, Yunpeng, Wang, Zhewu, Waszczuk, Monika, Weber, Heike, Wendt, Frank R., Werge, Thomas, Williams, Michelle A., Williamson, Douglas E., Winsvold, Bendik S., Winternitz, Sherry, Wolf, Christiane, Wolf, Erika J., Xia, Yan, Xiong, Ying, Yehuda, Rachel, Young, Keith A., Young, Ross McD, Zai, Clement C., Zai, Gwyneth C., Zervas, Mark, Zhao, Hongyu, Zoellner, Lori A., Zwart, John-Anker, deRoon-Cassini, Terri, van Rooij, Sanne J. H., van den Heuvel, Leigh L., Stein, Murray B., Ressler, Kerry J., and Koenen, Karestan C.
- Published
- 2024
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