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Neurosurgery is a highly specialized field: it often involves surgical manipulation of noble structures and cerebral retraction is frequently necessary to reach deep-seated brain lesions. There are still no reliable methods preventing possible retraction complications. The objective of this study was to design work chambers well suited for transcranial endoscopic surgery while providing safe retraction of the surrounding brain tissue. The chamber is designed to be inserted close to the intracranial point of interest; once it is best placed it can be opened. This should guarantee an appreciable workspace similar to that of current neurosurgical procedures. The experimental aspect of this study involved the use of a force sensor to evaluate the pressures exerted on the brain tissue during the retraction phase. Following pterional craniotomy, pressure measurements were made during retraction with the use of a conventional metal spatula with different inclinations. Note that, although the force values necessary for retraction and exerted on the spatula by the neurosurgeon are the same, the local pressure exerted on the parenchyma at the edge of the spatula at different inclinations varied greatly. A new method of cerebral retraction using a chamber retractor (CR) has been designed to avoid any type of complication due to spatula edge overpressures and to maintain acceptable pressure values exerted on the parenchyma.

Nowadays sustainability is a key topic and waste should be considered a resource. For this reason, a large body of literature is being developed on the management of the large quantity of post-cons...

Abstract This work shows an innovative application for electric arc furnace (EAF) slag: its use as a filler for nitrile butadiene rubber (NBR). Composites with various EAF slag contents were tested. It was found that the polymer matrix significantly reduces the leaching of slag (determined according to the standard CEN-EN 12457-2) incorporated in the NBR. The processability characteristics determined by the rheometric curves highlight that the EAF slag accelerates the crosslinking kinetics, reducing the production cycle time. Mechanical characterization demonstrated that EAF slag increases hardness and compression modulus. The ability to recover an imposed deformation quantified by the compression set is reduced as the EAF slag amount increases but remains below an acceptable value. It can be stated that in sealing systems, the EAF slag as a filler for NBR positively affects the compound properties. Moreover, NBR filled with EAF slag also has magnetic properties compared with standard rubber.

To date, discarded tires are reused in many applications, however, because of the enormous quantity decommissioned annually, it is essential to continue researching new recycling methods as well as applications to reduce waste and preserve new resources. In the present study, a simple recycling technology of end-of-life tire (ELT) powder is proposed, and the influence of steel slag as filler is assessed. Europe produces about 7 Mt of steel slag annually, and although most of it is reused as an artificial aggregate, about 15% is still landfilled. Also in the case of steel slag, the study of new applications is mandatory so that the combination of these two waste materials, in a 100% recycled composite fits across different industrial sectors facing the same environmental issue. It was found that the leaching of the slag incorporated in the rubber matrix is reduced and that the ELT powder recycled by this technology gives rise to a well-cohesive material. A good rubber-filler interaction was found by swelling test and differential scanning calorimetry (DSC) analysis. The slag reduces the friction coefficient and increases the thermal conductivity. The experimental results showed how some properties of recycled ELT can be improved by adding the steel slag.

The European steel industry produces about 70 million tons/year of steel by the electric arc furnace (EAF). The slag consists of about 15% by weight of the produced steel, thus from the perspective of the circular economy, it has a high potential as a co-product. This research aims to assess an innovative reuse of EAF slag as filler in different polymer matrixes: thermoplastic (polypropylene), thermosetting (epoxy resin), elastomeric (nitrile butadiene rubber), and recycled end of life rubber tire. A comparison between neat polymer and polymer filled with a certain amount of EAF slag has been carried out by tensile (or flexural), compression, and hardness tests. Experimental results show that slag as a filler increases the composites’ hardness and elastic modulus at the expense of toughness. For a safe reuse of the slag, the leaching of hazardous elements must comply with current legislation. It was found that, although the used EAF slag releases small amounts of Cr, Mo, and V, incorporating it into a polymer matrix reduces the leaching. The EAF slag particles distribution has been observed by scanning electron microscopy (SEM) images. The obtained results show good technical feasibility of this innovative slag application so that it could pave the way to a new industrial symbiosis between dissimilar sectors, bringing economic and environmental benefits.

This study focuses on the variations in the brain tissue dynamic behaviour pointing out new insight into the material nonlinear viscoelasticity. Shear dynamic response curves are obtained in different working conditions in terms of strain sweep and superimposed static compression offsets (SCO) applied in orthogonal direction to the shear. The strain sweep mode is used to study the storage and loss moduli dependence on the amplitude of the applied strain. It is found that the material exhibits linear viscoelastic behaviour up to about 0.1% strain amplitude. Above this critical threshold, the storage modulus G' decreases rapidly with increasing dynamic strain amplitude and this effect is gradually intensified as the SCO are increased. In addition, it is observed that the loss factor (G''/G') increases by increasing the SCO applied to the specimens. The dynamic strain amplitude results of the storage modulus reveal that the elastic component of the brain tissue's stiffness (G') evaluated at low strain strongly increases with increasing static superimposed compression strain while the loss factor in the same strain range appears to be SCO independent. Finally, dynamic stiffness recovery after a large strain deformation is considered. The reduction in low amplitude dynamic modulus and subsequent recovery kinetics due to a perturbation is found to be independent of the level of the SCO. The same assessments were carried out on 5 consecutive strain sweep cycle loading. It has been noticed that at the last cycle, the dissipation peak is reduced, and the non-linearity of the curve begins earlier. This could be explained by the effects of cerebral edema on cells and their surrounding environment.

In this study, electric arc furnace (EAF) slag as a filler in an epoxy matrix is investigated to validate its use instead of sand in construction applications, such as epoxy screeds. The slag chemical composition was determined and morphological and elemental analysis of its phases was analysed. The leaching of Cr, Mo, and V was evaluated both on EAF slag and on the composites materials, demonstrating that polymeric matrix inhibits the release of heavy metals. Epoxy composites with different percentages of slag were mechanically characterized by flexural test, compression test, and Vickers microhardness. The samples were compared to those of epoxy resin filled with sand in the same volume percentage. As a reference, a commercial product specifically formulated for laying epoxy screeds was also tested. The results demonstrated that EAF slag could substitute the sand in epoxy screeds, obtaining a composite material with equal and even superior mechanical properties.

Environmental stress cracking is a serious problem for polyethylene because it can cause failure without any visible warning due to the slow crack growth accelerated by aggressive agents. Tie molecules and entanglements are the main macromolecular characteristic increasing environmental stress cracking resistance, thus in this work mechanical and thermal properties governed by those macromolecular characteristics are determined by performing simple tests executable in the industrial laboratories for quality control on recycled high-density polyethylene. The mutual relation between the determined properties confirms their dependence on the investigated macromolecular characteristics and allows to predict in a comparative way the expected environmental stress cracking. The mechanical properties related to the environmental stress cracking resistance are the strain hardening modulus and the natural draw ratio. The strain hardening modulus is an intrinsic property that measure the disentanglement capability of the inter-lamellar links and the natural draw ratio is a highly sensitive parameter to the macromolecular network strength via the intercrystalline tie molecules. Since the measurement of these properties according to the standard ISO 18,488 requires a temperature chamber not often available in the industrial laboratories, the tensile test was performed also at room temperature and displacement rate 0.5 mm/min; a proportionality between the data obtained at different test condition emerged. The thermal property related to the environmental stress cracking resistance is the stepwise isothermal segregation ratio that state the chain fraction that generates a high rate of tie molecules responsible of environmental stress cracking resistance.

This work reports and analyzes the mechanical properties of some composites obtained using stabilized waste with epoxy resins E-227. For comparison, correspondent composite samples were realized using calcite as a filler. The recovered stabilized waste was obtained by means of a new method to stabilize municipal solid waste incineration (MSWI) fly ash (FA), based on the use of bottom ash (BA). The aim of this paper is to show that the stabilization process, which can be considered a zero&mdash, waste treatment, produces inert materials, that can be reused as a filler. The production of new filler was made on a pilot plant, designed to verify the transferability of the proposed stabilization technology. Mechanical analysis revealed that flexural modulus raises by increasing the filler content around 30% wt, independently of filler type, stabilized sample or calcium carbonate. Mechanical properties are lower in the samples with the high amount of filler due to the crowding effect. The morphology of composite materials showed a non-homogeneous dispersion of particles in stabilized sample filler, characterized by large particle agglomerates. Finally, according to the ESCAPE simplified method, the obtained composites result more sustainable in comparison with the corresponding ones produced by using natural resources (like calcite). These findings open new possibilities for the reuse of the stabilized material, in frame of circular economy principles, with environmental and economic advantages.

The administration of partially purified homologous follicular stimulating hormone to adult females of Rana esculenta hypophysectomized during the growth phase of the ovaries is followed by an increase of estrogens and progesterone in the blood. The luteinizing hormone seems to act by increasing only the progesterone level. These effects are eliminated by ovariectomy. In autumn and winter, hypophysectomy seems to affect only slightly the low levels of circulating hormones, probably because in that period the gonads are less sensitive to hormones from the pituitary.