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Your search keyword '"Anna J Ciesielski Jones"' showing total 2 results
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1. Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development.

Author

Mandy Goldberg, Anna J Ciesielski Jones, John A McGrath, Christie Barker-Cummings, Deborah S Cousins, Lauren M Kipling, Juliana W Meadows, James S Kesner, Michele Marcus, Carolyn Monteilh, and Dale P Sandler

Subjects
Medicine, Science
Abstract

BackgroundMany studies investigating pubertal development use Tanner staging to assess maturation. Endocrine markers in urine and saliva may provide an objective, sensitive, and non-invasive method for assessing development.ObjectiveOur objective was to examine whether changes in endocrine levels can indicate the onset of pubertal development prior to changes in self-rated Tanner stage.MethodsThirty-five girls and 42 boys aged 7 to 15 years were enrolled in the Growth and Puberty (GAP) study, a longitudinal pilot study conducted from 2007-2009 involving children of women enrolled in the Agricultural Health Study (AHS) in Iowa. We collected saliva and urine samples and assessed pubertal development by self-rated Tanner staging (pubic hair, breast development (girls), genital development (boys)) at three visits over six months. We measured dehydroepiandrosterone (DHEA) in saliva and creatinine-adjusted luteinizing hormone (LH), testosterone, follicle stimulating hormone (FSH), estrone 3-glucuronide (E13G) and pregnanediol 3-glucuronide (Pd3G) concentrations in first morning urine. We evaluated the relationships over time between Tanner stage and each biomarker using repeated measures analysis.ResultsAmong girls still reporting Tanner breast stage 1 at the final visit, FSH levels increased over the 6-month follow-up period and were no longer lower than higher stage girls at the end of follow-up. We observed a similar pattern for testosterone in boys. By visit 3, boys still reporting Tanner genital stage 1 or pubic hair stage 1 had attained DHEA levels that were comparable to those among boys reporting Tanner stages 2 or 3.ConclusionsIncreasing concentrations of FSH in girls and DHEA and testosterone in boys over a 6-month period revealed the start of the pubertal process prior to changes in self-rated Tanner stage. Repeated, non-invasive endocrine measures may complement the more subjective assessment of physical markers in studies determining pubertal onset.

Published
2021
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2. Meta-analyses on prevalence of selected Parkinson’s nonmotor symptoms before and after diagnosis

Author

Honglei Chen, Anna J Ciesielski-Jones, Edward Zhao, Wen Zhang, Xuemei Huang, Michele A Justice, Rui Liu, Shyamal D. Peddada, Yi Lu, and Deborah S Cousins

Subjects
medicine.medical_specialty, Nonmotor symptoms, Neurology, Parkinson's disease, Cognitive Neuroscience, Natural history, Excessive daytime sleepiness, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Hyposmia, Internal medicine, Prevalence, Medicine, 10. No inequality, Depression (differential diagnoses), 030304 developmental biology, 0303 health sciences, business.industry, Research, medicine.disease, 3. Good health, Meta-analysis, Parkinson’s disease, Etiology, Anxiety, Neurology (clinical), medicine.symptom, business, Neuroscience, 030217 neurology & neurosurgery
Abstract

Background Nonmotor symptoms are common among patients with Parkinson’s disease (PD) and some may precede disease diagnosis. Methods We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis, using random-effect models. We searched PubMed (1965 through October/November 2012) for the following symptoms: hyposmia, constipation, rapid eye movement sleep behavior disorder, excessive daytime sleepiness, depression, and anxiety. Eligible studies were publications in English with original data on one or more of these symptoms. Results The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria, mostly (n = 320) on symptoms after PD diagnosis. For all symptoms, the prevalence was substantially higher in PD cases than in controls, each affecting over a third of the patients. Hyposmia was the most prevalent (75.5% in cases vs. 19.1% in controls), followed by constipation (50% vs. 17.7%), anxiety (39.9% vs. 19.1%), rapid eye movement sleep behavior disorder (37.0% vs. 7.0%), depression (36.6% vs. 14.9%), and excessive daytime sleepiness (33.9% vs. 10.5%). We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to this. However, the prevalence estimates were fairly robust in several sensitivity analyses. Only 20 studies had data on any symptoms prior to PD diagnosis, but still the analyses revealed higher prevalence in future PD cases than in controls. Conclusion These symptoms are common among PD patients both before and after diagnosis. Further studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications. Electronic supplementary material The online version of this article (doi:10.1186/2047-9158-4-1) contains supplementary material, which is available to authorized users.

Published
2015
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