Search

Your search keyword '"Anna J. V. C. Brilhante"' showing total 2 results
Start Over Author "Anna J. V. C. Brilhante"
2 results on '"Anna J. V. C. Brilhante"'

1. Resolving the metabolism of monolignols and other lignin-related aromatic compounds in Xanthomonas citri

Author

Damaris B. Martim, Anna J. V. C. Brilhante, Augusto R. Lima, Douglas A. A. Paixão, Joaquim Martins-Junior, Fernanda M. Kashiwagi, Lucia D. Wolf, Mariany S. Costa, Fabrícia F. Menezes, Rafaela Prata, Matheus C. Gazolla, Juliana A. Aricetti, Gabriela F. Persinoti, George J. M. Rocha, and Priscila O. Giuseppe

Subjects
Science
Abstract

Abstract Lignin, a major plant cell wall component, has an important role in plant-defense mechanisms against pathogens and is a promising renewable carbon source to produce bio-based chemicals. However, our understanding of microbial metabolism is incomplete regarding certain lignin-related compounds like p-coumaryl and sinapyl alcohols. Here, we reveal peripheral pathways for the catabolism of the three main lignin precursors (p-coumaryl, coniferyl, and sinapyl alcohols) in the plant pathogen Xanthomonas citri. Our study demonstrates all the necessary enzymatic steps for funneling these monolignols into the tricarboxylic acid cycle, concurrently uncovering aryl aldehyde reductases that likely protect the pathogen from aldehydes toxicity. It also shows that lignin-related aromatic compounds activate transcriptional responses related to chemotaxis and flagellar-dependent motility, which might play an important role during plant infection. Together our findings provide foundational knowledge to support biotechnological advances for both plant diseases treatments and conversion of lignin-derived compounds into bio-based chemicals.

Published
2024
Full Text
View/download PDF

2. Multifactorial Basis and Therapeutic Strategies in Metabolism-Related Diseases

Author

Ana Carolina Migliorini Figueira, Maiara F. Terra, Anna J. V. C. Brilhante, Marta García-Arévalo, João Victor da Silva Guerra, and Marieli Mariano Gonçalves Dias

Subjects
medicine.medical_specialty, obesity, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Population, MAFLD, Review, Disease, Severity of Illness Index, Metabolic Diseases, Risk Factors, Diabetes mellitus, Severity of illness, Prevalence, medicine, Animals, Humans, TX341-641, NCDs, Noncommunicable Diseases, Intensive care medicine, education, education.field_of_study, Nutrition and Dietetics, diabetes, SARS-CoV-2, business.industry, Nutrition. Foods and food supply, Fatty liver, COVID-19, medicine.disease, Obesity, cardiovascular diseases, Chronic Disease, business, metabolism, Food Science
Abstract

Throughout the 20th and 21st centuries, the incidence of non-communicable diseases (NCDs), also known as chronic diseases, has been increasing worldwide. Changes in dietary and physical activity patterns, along with genetic conditions, are the main factors that modulate the metabolism of individuals, leading to the development of NCDs. Obesity, diabetes, metabolic associated fatty liver disease (MAFLD), and cardiovascular diseases (CVDs) are classified in this group of chronic diseases. Therefore, understanding the underlying molecular mechanisms of these diseases leads us to develop more accurate and effective treatments to reduce or mitigate their prevalence in the population. Given the global relevance of NCDs and ongoing research progress, this article reviews the current understanding about NCDs and their related risk factors, with a focus on obesity, diabetes, MAFLD, and CVDs, summarizing the knowledge about their pathophysiology and highlighting the currently available and emerging therapeutic strategies, especially pharmacological interventions. All of these diseases play an important role in the contamination by the SARS-CoV-2 virus, as well as in the progression and severity of the symptoms of the coronavirus disease 2019 (COVID-19). Therefore, we briefly explore the relationship between NCDs and COVID-19.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results