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1. Frontal theta oscillations during emotion regulation in people with borderline personality disorder

Author

Moritz Haaf, Nenad Polomac, Ana Starcevic, Marvin Lack, Stefanie Kellner, Anna-Lena Dohrmann, Ulrike Fuger, Saskia Steinmann, Jonas Rauh, Guido Nolte, Christoph Mulert, and Gregor Leicht

Subjects
Borderline personality disorder, emotionally unstable personality disorder, EEG, cognitive reappraisal, prefrontal cortex, Psychiatry, RC435-571
Abstract

Background Borderline personality disorder (BPD) is a severe psychiatric disorder conceptualised as a disorder of emotion regulation. Emotion regulation has been linked to a frontolimbic network comprising the dorsolateral prefrontal cortex and the amygdala, which apparently synchronises its activity via oscillatory coupling in the theta frequency range. Aims To analyse whether there are distinct differences in theta oscillatory coupling in frontal brain regions between individuals with BPD and matched controls during emotion regulation by cognitive reappraisal. Method Electroencephalogram (EEG) recordings were performed in 25 women diagnosed with BPD and 25 matched controls during a cognitive reappraisal task in which participants were instructed to downregulate negative emotions evoked by aversive visual stimuli. Between- and within-group time–frequency analyses were conducted to analyse regulation-associated theta activity (3.5–8.5 Hz). Results Oscillatory theta activity differed between the participants with BPD and matched controls during cognitive reappraisal. Regulation-associated theta increases were lower in frontal regions in the BPD cohort compared with matched controls. Functional connectivity analysis for regulation-associated changes in the theta frequency band revealed a lower multivariate interaction measure (MIM) increase in frontal brain regions in persons with BPD compared with matched controls. Conclusions Our findings support the notion of alterations in a frontal theta network in BPD, which may be underlying core symptoms of the disorder such as deficits in emotion regulation. The results add to the growing body of evidence for altered oscillatory brain dynamics in psychiatric populations, which might be investigated as individualised treatment targets using non-invasive stimulation methods.

Published
2024
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2. EEG-arousal regulation as predictor of treatment response in patients suffering from obsessive compulsive disorder

Author

Anna-Lena Dohrmann, Ina Jahn, Katarina Stengler, Sebastian Olbrich, University of Zurich, and Dohrmann, Anna-Lena

Subjects
Adult, Male, Treatment response, Obsessive-Compulsive Disorder, Multivariate analysis, medicine.medical_treatment, media_common.quotation_subject, 610 Medicine & health, Electroencephalography, 03 medical and health sciences, 2809 Sensory Systems, Young Adult, 0302 clinical medicine, 2737 Physiology (medical), Obsessive compulsive, Predictive Value of Tests, Physiology (medical), medicine, Humans, media_common, Retrospective Studies, medicine.diagnostic_test, Resting state fMRI, Cognitive Behavioral Therapy, Dose-Response Relationship, Drug, Middle Aged, Sensory Systems, 030227 psychiatry, Cognitive behavioral therapy, 2728 Neurology (clinical), Treatment Outcome, Neurology, 10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics, 2808 Neurology, Clinical Global Impression, Female, Neurology (clinical), Psychology, Arousal, 030217 neurology & neurosurgery, Selective Serotonin Reuptake Inhibitors, Vigilance (psychology), Clinical psychology
Abstract

Objectives Aim of this study was to analyze whether electroencephalogram (EEG)-based CNS-arousal markers differ for patients suffering from obsessive compulsive disorder (OCD) that either respond or do not respond to cognitive behavioral therapy (CBT), selective serotonin reuptake inhibitors (SSRIs) or their combination. Further the study aimed to identify specific response-predictors for the different therapy approaches. Methods CNS-arousal from 51 unmedicated patients during fifteen-minute resting state was assessed using VIGALL (Vigilance Algorithm Leipzig). Clinical Global Impression (CGI) scores were used to assess response or non-response after three to six months following therapy (CBT, n = 18; SSRI, n = 11 or combination, n = 22). Differences between Responders (R) and Non-Responders (NR) were identified using multivariate analysis of covariance (MANCOVA) models. Results MANCOVA revealed that Responders spent significant less time at the highest CNS-arousal stage 0. Further, low amounts of the highest CNS-arousal stages were specifically predictive for a response to a combined treatment approach. Conclusions The fact that CNS-arousal markers allowed discrimination between Responders and Non-Responders and also between Responders of different treatment arms underlines a possible clinical value of EEG-based markers. Significance These results encourage further research on EEG-arousal regulation for determining pathophysiological subgroups for treatment response.

Published
2017

3. 19th biennial IPEG Meeting

Author

Sonja Simpraga, Rosanna Tortelli, Jill C. Richardson, Bernhard Mueller, Berrie J.L. Gerrits, Marieke Jepma, Silvia Armenise, Martin F.J. Perescis, Inga Griskova-Bulanova, C. Wintmolders, Haitham S. Mohammed, J. Leon Kenemans, Matteo Demuru, Paolo Ranzi, Jakub Korcak, J. A. Kemp, Georg Gruber, T. A. Iseger, N. Marzano, Giuseppe Bertini, Caitlyn Kruiper, Anke Sambeth, Ronald J. Swatzyna, Iris Schutte, Robert A. Comley, Frans C. T. van der Helm, Juergen Dukart, Robin L. Carhart-Harris, Flavio Nobili, Martin Brunovsky, Maria Vasileva, José Carlos Millán-Calenti, Kelly Holt, Jan A. Freund, S. Deepeshwar, Alexandra Kirsten, Yasser A. Khadrawy, Daniel Brandeis, Martin Bareš, Roshan Cools, Eduardo Ekman Schenberg, Sigita Melynyte, Antonio Ivano Triggiani, Ashley Baddeley, Karlijn I. van Aerde, Gerhard Trube, Leonardo Jose Trejo, Stephane Nave, D. A. Jackson, Tomáš Páleníček, Raffaella Franciotti, A. E. Maqueda, Laura Bonanni, E. Saifutdinova, Rahul Chaudhary, Natasja de Bruin, Christoph Mulert, Gilles van Luijtelaar, Hans-Christian Pape, Jeannette Hofmeijer, Martin Brunovský, Marijtje L.A. Jongsma, L. Raeymaekers, Boris Ferger, Donna Palmer, Robert Aidelbaum, Nash N. Boutros, Hanneke E. M. den Ouden, Genevieve N. Izzo, Jessica I. Määttä, Lucilla Parnetti, Gerald P. Kozlowski, Arjan Hillebrand, C. Bouyssières, Philip L.C. van den Broek, David J. Nutt, Jay D. Tarnow, Vlastimil Koudelka, Paolo Maria Rossini, Anna-Lena Dohrmann, Peter Veselcic, Asbjørn Mohr Drewes, Antonio Giannini, Ole Jensen, Christiane M. Thiel, Grazia Buenza, Tomas Novak, Chris G. Kruse, Alexander Sumich, Gaetano Scianatico, Jan-Mathijs Schoffelen, V. Duveau, K. Tahon, Lana Donse, Vladimir Krajca, Pierre Payoux, Vaclava Sedlamyerova, Else A. Tolner, M. Arns, Jennifer Mollon, Michael Derks, Nazimah Hamid, Andrea Szabo, Loreto Gesualdo, Shelly M. Menolascino, M. A. Mañanas, Thorsten Mikoteit, D. Balschun, Mitchell Belgin, Giacomo Tattoli, Cestmir Vejmola, Bob Oranje, Barbora Kohutova, Giovanni B. Frisoni, Iris E. C. Sommer, Dylan Smith, Rosa van Mourik, Michel D. Ferrari, Christian Zöllner, Maria-Clemancia Hernandez, Nick Seneca, James Miller, Martijn Arns, Timothy K. Murphy, Giancarlo Logroscino, Annika Lüttjohann, Noreen Rahmani, Christopher Timmermann, Martien J H Kas, Grace Y. Wang, Klaus Linkenkaer-Hansen, F. Nobili, Tieme W. P. Janssen, R. Biermans, Fernando H. Lopes da Silva, Bernd Saletu, Brian A. Coffman, Ileana L. Hanganu-Opatz, Sian Lennon-Chrimes, Madelon A. Vollebregt, D. Moechars, Brittany Duncan, Joerg F. Hipp, Y. Roche, Valentina Cardinali, Neveen A. Noor, Christoph Wandel, S. Romero, Anna Bravermanová, J. Koprivova, Gerda M. Saletu-Zyhlarz, Nicola Walter Falasca, Marco Onofrj, Jaap Oosterlaan, J. L. Kenemans, J. Prasko, Jürgen Gallinat, C. Roucard, Vaclava Piorecka, Karsten Wicke, Jennifer C. Swart, Peterjan Ris, Heba S. Aboul Ezz, M Valle, Jesper F. Bastlund, Ivo Heitland, Paul B. Fitzgerald, Katleen Geladé, W. H. Drinkenburg, Lillian E. Fisher, Lars Eichler, J. Riba, Hélène Brisebois, Régis Bordet, Robert Leech, Roberta Lizio, Cornelis J. Stam, M. Avinash, N. K. Manjunath, Parissa Azadi, Raffaele Ferri, Cyril Höschl, Susanna Cordone, Sander Nieuwenhuis, Gregor Leicht, Alexandra J. Roark, Esben Bolvig Mark, Jakub Polak, Alexander T. Sack, Iris Eichler, Heidi Haavik, Athanasios Maras, Dirk J. Heslenfeld, Hans-Peter Landolt, A. Bottelbergs, Galina Surova, Ross Apparies, Lin Tiffany, Angelisa Frasca, Ida A. Nissen, Dario Arnaldi, Alessandro Bertolino, Wilhelmus Drinkenburg, Philip Scheltens, Cristina Bagnoli, Matthijs J.L. Perenboom, Dane M. Chetkovich, Thomas Budde, Annette Beatrix Brühl, Wilfried Dimpfel, Yuan Yang, Jonathan Kelley, Hervé Caci, Christoph Herrmann, Olivier Blin, Robert P. Turner, Georg Dorffner, Michaela Viktorinova, Igor Timofeev, Stephanie Thiebes, Dina Lelic, K. Van Kolen, P. F. Fabene, Frédéric Knoflach, S. Jacob, John Wallerius, Claudio Del Percio, Marina Bentivoglio, Mendel Kaelen, Peter Anderer, Imran Khan Niazi, Iman M. Mourad, S. Barker, Muhammad Samran Navid, Giuseppe Noce, Dean F. Salisbury, Huibert D. Mansvelder, Premysl Vlcek, Marek Adamczyk, Emmanouil Spanakis, Vitoantonio Bevilacqua, Orietta Barulli, Roy P. C. Kessels, Axel Steiger, Darren Bentley, Antonio Brunetti, Clementina M. van Rijn, Nikita van der Vinne, Evian Gordon, Nash Boutros, Lukáš Kadeřábek, Brendan Parsons, A. Ahnaou, Tilman Hensch, Christian Sander, Torsten Meyer, Barbora Cimrová, Marleen C. Tjepkema-Cloostermans, Molly Hyde, Robert Oostenveld, Liesbeth Heijink, Eléonore Czarik, Paolo F. Fabene, Jean-Paul Laurent, Stig Hollup, Leon Kenemans, Ana Buján, Vadim Ilivitsky, Danielle Impey, Alfred C. Schouten, Claudio Babiloni, M. Pawlowski, Ricardo Alvarez-Jimenez, Joop M. A. van Gerven, Filip Tylš, Jan van Egmond, Saskia Steinmann, Caroline Dupont, B. Mandé-Nidergang, Sebastian Olbrich, Geert Jan Groeneveld, H. Huysmans, Kastytis Dapsys, P. Sos, M. Raszka, C. Walsh, Justin Piché, Giovanni Frisoni, Silvia Parapatics, Annika Lütjohann, Simon-Shlomo Poil, Erin K. MacInerney, T. Nekovarova, Jana Nöldeke, Michel J.A.M. van Putten, Ilse E. C. W. van Straaten, Suresh D. Muthukumaraswamy, Mehrnoush Zobeiri, Magda Tsolaki, Ulrich Hegerl, Jaap C. Reijneveld, Patrizia Voehringer, N. V. Manyakov, Sandra K. Loo, Patrick Meuth, Bettina Clausen, Roman Rosipal, David Bartrés Faz, Nenad Polomac, Renata Androvicova, Pantaleo Spagnolo, Pilar Garcés, Andrea Soricelli, Amanda Feilding, R. Maury, Aleksandras Voicikas, Stjepan Curic, Verner Knott, Tabitha A. Iseger, Jiri Horacek, Susanna Lopez, Joelle Choueiry, Gianluigi Forloni, Andrew WThomas, Lyudmila V. Vinogradova, Alida A. Gouw, Sarah M. Haigh, and B. Pouyatos

Subjects
medicine.medical_specialty, 05 social sciences, Clinical Neurology, Neuropsychology, 050105 experimental psychology, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Physiology (medical), Family medicine, medicine, 0501 psychology and cognitive sciences, Psychology, 030217 neurology & neurosurgery
Published
2016

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